Every Pro Baseball Player Charlie Has Seen: S
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
- Kirk Saarloos (pitcher, b. 1979, California)
- 2001: Lexington Legends, South Atlantic League (Low-A) - 1 game 2-Aug
- Donnie Saba (outfielder, b. 1981, Utah)
- 2002: Yakima Bears, Northwest League (short-season) - 1 game 13-Aug
- Bryan Sabatella (infielder, b. 1984, New York)
- CC Sabathia (pitcher, b. 1980, California)
- 2009: New York Yankees, Major League Baseball - 1 game 16-Apr
- 2010: New York Yankees, Major League Baseball - 1 game 17-Aug
- 2011: New York Yankees, Major League Baseball - 1 game 30-Sep
- 2012: New York Yankees, Major League Baseball - 1 game 1-Oct
- 2015: New York Yankees, Major League Baseball - 1 game 20-Sep
- 2016: New York Yankees, Major League Baseball - 2 games 1-Aug 13-Sep
- 2017: New York Yankees, Major League Baseball - 1 game 11-Sep
- 2018: New York Yankees, Major League Baseball - 1 game 9-Oct
- 2019: New York Yankees, Major League Baseball - 1 game 24-Sep
- Steve Sabatino (pitcher, b. 1990, Illinois)
- 2015: Peoria Chiefs, Midwest League (Low-A) - 1 game 4-Sep
- Aaron Sabato (infielder, b. 1999, New York)
- 2021: Fort Myers Mighty Mussels, Low-A Southeast - 4 games 18-Aug 19-Aug 20-Aug 21-Aug
- 2022: Cedar Rapids Kernels, Midwest League (High-A) - 1 game 12-Jul
- 2023: Glendale Desert Dogs, Arizona Fall League - 2 games 12-Oct 14-Oct
- Bret Saberhagen (pitcher, b. 1964, Illinois)
- 1992: New York Mets, National League (MLB) - 1 game 4-Oct
- 1993: New York Mets, National League (MLB) - 1 game 25-Jun
- Miguel Sabino (outfielder, b. 1967, Dominican Republic)
- 1991: Canton-Akron Indians, Eastern League (AA) - 1 game 12-Aug
- Chris Sabo (infielder, b. 1962, Michigan)
- 1993: Cincinnati Reds, National League (MLB) - 2 games 18-Aug 24-Aug
- Blake Sabol (catcher/outfielder, b. 1998, California)
- 2021: Bradenton Marauders, Low-A Southeast - 1 game 22-Jun
- 2022: Surprise Saguaros, Arizona Fall League - 1 game 14-Oct
- Stefan Sabol (outfielder, b. 1992, California)
- 2012: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 2-Aug 9-Sep
- Arman Sabouri (pitcher, b. 1998, California)
- 2019: Rocky Mountain Vibes, Pioneer League (rookie) - 1 game 6-Jul
- Erik Sabrowski (pitcher, b. 1997, Alberta)
- 2024: Cleveland Guardians, Major League Baseball - 1 game 25-Sep
- Craig Saccavino (pitcher, b. 1969)
- 1995: Hardware City Rock Cats, Eastern League (AA) - 1 game 4-Jul
- Mark Saccomanno (infielder, b. 1980, Texas)
- 2005: Corpus Christi Hooks, Texas League (AA) - 1 game 4-Sep
- 2009: Round Rock Express, Pacific Coast League (AAA) - 1 game 15-Aug
- Darren Sack (pitcher, b. 1982, California)
- 2004: Salem-Keizer Volcanoes, Northwest League (short-season) - 1 game 16-Aug
- Druw Sackett (infielder, b. 2000, Colorado)
- 2024: Grand Junction Jackalopes, Pioneer League (independent) - 1 game 16-Jul
- Brian Sackinsky (pitcher, b. 1971, Pennsylvania)
- 1994: Bowie Baysox, Eastern League (AA) - 1 game 10-Jul
- Chris Sadberry (pitcher, b. 1991, Texas)
- 2016: Jupiter Hammerheads, Florida State League (High-A) - 1 game 30-Aug
- Ray Sadecki (pitcher, b. 1940, Kansas; d. 2014, Arizona)
- 1968: San Francisco Giants, National League (MLB) - 1 game 16-Jun
- 1974: New York Mets, National League (MLB) - 1 game 10-Jul
- Al Sadler (pitcher, b. 1972, Georgia)
- 2000: Bridgeport Bluefish, Atlantic League (independent) - 1 game 27-Sep
- Billy Sadler (pitcher, b. 1981, Florida)
- 2006: Connecticut Defenders, Eastern League (AA) - 1 game 13-Apr
- Carl Sadler (pitcher, b. 1976, Florida)
- 2002: Akron Aeros, Eastern League (AA) - 1 game 11-Apr
- Casey Sadler (pitcher, b. 1990, Oklahoma)
- 2013: Indianapolis Indians, International League (AAA) - 1 game 30-Aug
- 2014: Indianapolis Indians, International League (AAA) - 2 games 25-May 23-Aug
- 2021: Seattle Mariners, Major League Baseball - 1 game 3-Aug
- Donnie Sadler (utility, b. 1975, Texas)
- 1996: Trenton Thunder, Eastern League (AA) - 1 game 20-Jul
- 1998: Boston Red Sox, American League (MLB) - 1 game 11-Jul
- 2000: Pawtucket Red Sox, International League (AAA) - 1 game 8-Jul
- 2001: Cincinnati Reds, Major League Baseball - 1 game 14-Apr
- Patrick Sadler (catcher/first base, b. 1983)
- 2005: Ohio Valley Redcoats, Frontier League (independent) - 1 game 20-Aug
- Ray Sadler (outfielder, b. 1980, Texas)
- 2005: Altoona Curve, Eastern League (AA) - 1 game 2-Jul
- 2007: Corpus Christi Hooks, Texas League (AA) - 1 game 8-Aug
- 2012: Kansas City T-bones, American Association (independent) - 1 game 6-Aug
- 2014: Winnipeg Goldeyes, American Association (independent) - 1 game 19-Jun
- Jared Sadlowski (catcher, b. 1974, Pennsylvania)
- 2000: Allentown Ambassadors, Northeast League (independent) - 1 game 4-Jul
- Chad Sadowski (pitcher, b. 1977, Texas)
- 2001: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 7-May
- Connor Sadzeck (pitcher, b. 1991, Illinois)
- 2013: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 25-May
- 2022: Rochester Red Wings, International League (AAA) - 1 game 27-Sep
- 2023: St. Paul Saints, International League (AAA) - 1 game 29-Jun
- Dustin Saenz (pitcher, b. 1999, Texas)
- 2022: Fredericksburg Nationals, Carolina League (Low-A) - 1 game 23-Jun
- 2024: Salt River Rafters, Arizona Fall League - 1 game 10-Oct
- Jason Saenz (pitcher, b. 1977, California)
- 2001: Binghamton Mets, Eastern League (AA) - 1 game 22-Jul
- 2002: Binghamton Mets, Eastern League (AA) - 1 game 4-Jul
- Louie Saenz (utility, b. unknown)
- 2014: Raton Osos, Pecos League (independent) - 1 game 22-Jul
- Olmedo Saenz (infielder, b. 1970, Panama)
- 1993: Birmingham Barons, Southern League (AA) - 1 game 13-Aug
- 1999: Oakland Athletics, American League (MLB) - 1 game 31-Aug
- Jorge Saez (catcher, b. 1990, Florida)
- 2017: Trenton Thunder, Eastern League (AA) - 1 game 15-Apr
- 2018: Trenton Thunder, Eastern League (AA) - 1 game 7-Sep
- Jeff Saffer (first base/outfield, b. 1975, Arizona)
- 1996: Oneonta Yankees, New York-Penn League (short-season) - 1 game 17-Aug
- Jon Saffer (outfielder, b. 1973, California)
- 1994: Vermont Expos, New York-Penn League (short-season) - 1 game 19-Jun
- 1996: Harrisburg Senators, Eastern League (AA) - 3 games 15-Jun 9-Aug 27-Aug
- 1997: Ottawa Lynx, International League (AAA) - 1 game 2-Aug
- Ian Sagdal (first baseman, b. 1993, Washington)
- 2016: Hagerstown Suns, South Atlantic League (Low-A) - 2 games 13-Jun 7-Sep
- 2017: Potomac Nationals, Carolina League (High-A) - 1 game 3-Jul
- 2018: Potomac Nationals, Carolina League (High-A) - 1 game 3-Sep
- A.J. Sager (pitcher, b. 1965, Ohio)
- 1997: Detroit Tigers, American League (MLB) - 1 game 4-Jul g1
- Thomas Saggese (infielder, b. 2002, California)
- 2021: Down East Wood Ducks, Low-A East - 1 game 17-Jun
- 2024: Memphis Redbirds, International League (AAA) - 1 game 19-Jun
- 2024: Glendale Desert Dogs, Arizona Fall League - 2 games 10-Oct 12-Oct
- Marc Sagmoen (outfielder, b. 1971, Washington)
- 2000: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 19-Aug
- Mike Saipe (pitcher, b. 1973, California)
- 1998: Colorado Springs Sky Sox, Pacific Coast League (AAA) - 1 game 21-Aug g1
- Brent Sakurai (infielder, b. 1995, Hawaii)
- 2018: Gateway Grizzlies, Frontier League (independent) - 1 game 26-Aug
- Darlin Saladin (pitcher, b. 2002, Dominican Republic)
- 2024: Palm Beach Cardinals, Florida State League (Low-A) - 1 game 5-Jun
- Tyler Saladino (infielder, b. 1989, California)
- 2011: Winston-Salem Dash, Carolina League (High-A) - 1 game 28-May
- 2013: Birmingham Barons, Southern League (AA) - 1 game 20-Jul
- 2014: Charlotte Knights, International League (AAA) - 1 game 25-May
- Anibal Salas (outfielder, b. 2005, Venezuela)
- Ethan Salas (catcher, b. 2006, Florida)
- 2024: Peoria Javelinas, Arizona Fall League - 2 games 10-Oct 12-Oct
- Fernando Salas (pitcher, b. 1985, Mexico)
- 2016: New York Mets, Major League Baseball - 2 games 18-Sep 25-Sep
- Issmael Salas (infielder, b. 1982, Mexico)
- 2007: Tennessee Smokies, Southern League (AA) - 1 game 3-Sep
- Javier Salas (pitcher, b. 1992, Florida)
- 2016: Salt River Rafters, Arizona Fall League - 1 game 12-Oct
- Jose Salas (catcher/first base, b. 1982, Venezuela)
- 2000: Danville Braves, Appalachian League (rookie) - 1 game 3-Aug
- 2004: Pensacola Pelicans, Central League (independent) - 1 game 3-Jul
- Jose Salas (infielder, b. 1981, Venezuela)
- 2002: Medicine Hat Blue Jays, Pioneer League (rookie) - 2 games 4-Aug 17-Aug g2
- Jose Salas (infielder, b. 2003, Florida)
- 2022: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 19-May
- 2022: Beloit Sky Carp, Midwest League (High-A) - 1 game 12-Jul
- 2022: Mesa Solar Sox, Arizona Fall League - 3 games 12-Oct 14-Oct 15-Oct
- 2023: Cedar Rapids Kernels, Midwest League (High-A) - 2 games 25-Jun g1 25-Jun g2
- Juan Salas (infielder, then pitcher, b. 1978, Dominican Republic)
- 2001: Charleston RiverDogs, South Atlantic League (Low-A) - 2 games 6-Aug 10-Aug
- 2009: AZL Indians, Arizona League (rookie) - 1 game 25-Aug
- Juan Salas (pitcher, b. 2003, Mexico)
- 2024: Palm Beach Cardinals, Florida State League (Low-A) - 1 game 15-Sep
- Mark Salas (catcher, b. 1961, California)
- 1990: Detroit Tigers, American League (MLB) - 1 game 13-Aug
- Michael Salas (catcher, b. 1984, Venezuela)
- 2001: Jamestown Jammers, New York-Penn League (short-season) - 1 game 5-Sep
- William Salas (infielder, b. 1991, Venezuela)
- 2018: Salina Stockade, Can-Am League (independent) - 1 game 28-Jun
- 2022: Schaumburg Boomers, Frontier League (independent) - 1 game 5-Jul
- Alejandro Salazar (infielder, b. 1996, Venezuela)
- 2016: Rome Braves, South Atlantic League (Low-A) - 1 game 15-Sep
- 2017: Florida Fire Frogs, Florida State League (High-A) - 1 game 27-May
- 2019: Mississippi Braves, Southern League (AA) - 3 games 26-Jul 28-Jul 10-Aug
- Argenis Salazar (infielder, b. 1961, Venezuela)
- 1984: Montreal Expos, National League (MLB) - 2 games 17-Apr 23-Sep
- Cesar Salazar (catcher, b. 1996, Mexico)
- 2018: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 22-Jul
- Eduardo Salazar (outfielder, b. 2000, Venezuela)
- Grabiel Salazar (pitcher, b. 2001, Venezuela)
- 2023: FCL Orioles, Florida Complex League (rookie) - 1 game 21-Aug
- 2024: Delmarva Shorebirds, Carolina League (Low-A) - 1 game 12-May
- Jeff Salazar (outfielder, b. 1980, Oklahoma)
- 2002: Tri-City Dust Devils, Northwest League (short-season) - 1 game 13-Aug
- 2003: Asheville Tourists, South Atlantic League (Low-A) - 1 game 19-Jul
- 2010: Norfolk Tides, International League (AAA) - 1 game 29-May
- Jeremy Salazar (catcher, b. 1976, Louisiana)
- 2001: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 8-Jul
- 2003: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 15-Aug
- Johnfrank Salazar (infielder, b. 2003, Venezuela)
- 2022: Salem Red Sox, Carolina League (Low-A) - 1 game 2-Sep
- 2024: Palm Beach Cardinals, Florida State League (Low-A) - 1 game 5-Jun
- Jose Salazar (infielder, b. 1983, Mexico)
- 2006: State College Spikes, New York-Penn League (short-season) - 1 game 4-Jul
- Joseph Salazar (pitcher, b. 1999, Venezuela)
- 2021: Lakeland Flying Tigers, Low-A Southeast - 2 games 8-May 23-Jun
- Juan Salazar (catcher/first base, b. 1977, Venezuela)
- 1997: Williamsport Cubs, New York-Penn League (short-season) - 1 game 19-Jul
- 1998: Rockford Cubbies, Midwest League (Low-A) - 1 game 19-Aug
- Juan Salazar (infielder, b. 1981, Venezuela)
- 2002: Augusta Greenjackets, South Atlantic League (Low-A) - 1 game 24-Aug
- Kleyver Salazar (catcher/first base, b. 2006, Venezuela)
- 2024: FCL Red Sox, Florida Complex League (rookie) - 1 game 7-May
- Luis Salazar (utility, b. 1956, Venezuela)
- 1992: Chicago Cubs, National League (MLB) - 1 game 15-Aug
- Oscar Salazar (infielder, b. 1978, Venezuela)
- 2000: Midland Rockhounds, Texas League (AA) - 1 game 20-Aug
- 2003: Wichita Wranglers, Texas League (AA) - 1 game 8-Aug
- 2007: Bowie Baysox, Eastern League (AA) - 1 game 6-Apr
- Richard Salazar (pitcher, b. 1981, Venezuela)
- 2003: Frederick Keys, Carolina League (High-A) - 1 game 5-Apr
- 2014: Rockland Boulders, Can-Am League (independent) - 1 game 3-Sep
- 2016: Rockland Boulders, Can-Am League (independent) - 1 game 17-Sep
- 2017: Rockland Boulders, Can-Am League (independent) - 2 games 8-Aug 7-Sep
- Ruben Salazar (infielder, b. 1978, Venezuela)
- 2001: New Britain Rock Cats, Eastern League (AA) - 2 games 4-Jul g1 4-Jul g2
- 2005: Fargo-Moorhead RedHawks, Northern League (independent) - 1 game 8-Aug
- Chris Salberg (pitcher, b. 1984, Illinois)
- 2010: York Revolution, Atlantic League (independent) - 2 games 24-Sep 2-Oct
- Andruw Salcedo (catcher, b. 2002, Colombia)
- 2024: Daytona Tortugas, Florida State League (Low-A) - 2 games 16-May g2 17-May
- Edward Salcedo (infielder, b. 1991, Dominican Republic)
- 2011: Rome Braves, South Atlantic League (Low-A) - 1 game 6-Aug
- 2014: Peoria Javelinas, Arizona Fall League - 2 games 9-Oct 10-Oct
- 2017: Dominican Republic, Can-Am League (independent) - 1 game 14-Jun
- Edwin Salcedo (catcher, b. 1970)
- 1994: San Bernardino Spirit, California League (High-A) - 1 game 4-Sep
- Erick Salcedo (infielder, b. 1993, Venezuela)
- 2018: Bowie Baysox, Eastern League (AA) - 2 games 28-May 20-Jun g1
- 2019: Mobile BayBears, Southern League (AA) - 1 game 28-Jul
- Jonathan Salcedo (infielder, b. 1994, Rhode Island)
- Jose Salcedo (pitcher, b. 1973, Dominican Republic)
- 1994: Stockton Ports, California League (High-A) - 1 game 2-Sep
- Abdiel Saldana (pitcher, b. 1996, Panama)
- 2018: Buies Creek Astros, Carolina League (High-A) - 1 game 29-Aug
- Chris Sale (pitcher, b. 1989, Florida)
- 2018: Boston Red Sox, Major League Baseball - 2 games 29-Mar 9-Oct
- 2021: Boston Red Sox, Major League Baseball - 1 game 1-Sep
- Josh Sale (utility, b. 1991, Washington)
- 2021: Gastonia Honey Hunters, Atlantic League (independent) - 2 games 6-Aug 4-Sep
- 2022: Round Rock Express, Pacific Coast League (AAA) - 1 game 3-Aug
- Emeel Salem (outfielder, b. 1985, Alabama)
- 2007: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 29-Aug
- 2009: Charlotte Stone Crabs, Florida State League (High-A) - 1 game 5-Sep
- Frank Salerno (infielder, b. 1991)
- 2015: Fargo-Moorhead RedHawks, American Association (independent) - 1 game 15-Jul
- 2015: New Jersey Jackals, Can-Am League (independent) - 1 game 14-Aug
- Darrell Sales (utility, b. 1985, California)
- 2006: Orem Owlz, Pioneer League (rookie) - 1 game 26-Aug
- Felipe Sales (pitcher, b. 1989, Brazil)
- 2016: Brazil, World Baseball Classic - 1 game 24-Sep
- Bryant Salgado (pitcher, b. 2000, Puerto Rico)
- 2021: Fayetteville Woodpeckers, Low-A East - 1 game 10-Sep
- Ismael Salgado (outfielder, b. 1993, Puerto Rico)
- 2016: Lakeland Flying Tigers, Florida State League (High-A) - 1 game 23-Aug g1
- Felix Salguera (catcher, b. 2002, Venezuela)
- 2022: FCL Rays, Florida Complex League (rookie) - 1 game 13-Aug
- Jhonleider Salinas (pitcher, b. 1995, Venezuela)
- 2017: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 12-Sep
- 2019: Charlotte Stone Crabs, Florida State League (High-A) - 1 game 19-May
- 2019: Montgomery Biscuits, Southern League (AA) - 1 game 27-Jul
- Raimfer Salinas (outfielder, b. 2000, Venezuela)
- Ricky Salinas (pitcher, b. 1996, Texas)
- 2022: Chattanooga Lookouts, Southern League (AA) - 1 game 14-Jul
- Roque Salinas (outfielder, b. 2002, Mexico)
- Royber Salinas (pitcher, b. 2001, Venezuela)
- 2021: FCL Braves, Florida Complex League (rookie) - 1 game 26-Aug g2
- Trey Salinas (utility, b. 1975, Texas)
- 1997: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 14-Aug
- 2004: Coastal Bend Aviators, Central League (independent) - 1 game 3-Jul
- Roger Salkeld (pitcher, b. 1971, California)
- 1998: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 28-Aug
- Andy Salmela (first baseman, b. 1980, Minnesota)
- 2002: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 7-Jul
- Tim Salmon (outfielder, b. 1968, California)
- 1992: California Angels, American League (MLB) - 1 game 23-Aug
- 1997: Anaheim Angels, American League (MLB) - 3 games 27-Aug 28-Aug 31-Aug
- Dereck Salom (infielder, b. 2001, Venezuela)
- 2023: Stockton Ports, California League (Low-A) - 1 game 10-Aug
- Angel Salome (catcher, b. 1986, Dominican Republic)
- 2005: West Virginia Power, South Atlantic League (Low-A) - 1 game 30-Jul
- Dionmy Salon (catcher, b. 2001, Venezuela)
- 2023: Columbia Fireflies, Carolina League (Low-A) - 2 games 16-Jul 8-Sep
- 2024: Columbia Fireflies, Carolina League (Low-A) - 1 game 11-Aug g2
- Nick Salotti (catcher/first base, b. 1984, California)
- Jarrod Saltalamacchia (catcher/first base, b. 1985, Florida)
- 2003: GCL Braves, Gulf Coast League (rookie) - 3 games 25-Aug 26-Aug 27-Aug
- 2008: Texas Rangers, Major League Baseball - 1 game 22-Jun
- 2012: Boston Red Sox, Major League Baseball - 1 game 1-Oct
- 2014: Miami Marlins, Major League Baseball - 1 game 26-May
- Devin Saltiban (infielder, b. 2005, Hawaii)
- Ryan Saltzgaber (infielder, b. 1984)
- 2007: Gateway Grizzlies, Frontier League (independent) - 1 game 7-Aug
- Kidany Salva (catcher, b. 1998, Texas)
- 2016: GCL Twins, Gulf Coast League (rookie) - 1 game 27-Aug
- Greg Salvevold (pitcher, b. 1975, Minnesota)
- 2003: Brockton Rox, Northeast League (independent) - 1 game 4-Sep
- Andrew Salvo (infielder, b. 1979, New York)
- 2001: Bristol Sox, Appalachian League (rookie) - 1 game 5-Aug
- 2003: Capital City Bombers, South Atlantic League (Low-A) - 1 game 1-Aug
- Troy Salvior (pitcher, b. 1968)
- 1990: Hamilton Redbirds, New York-Penn League (short-season) - 1 game 16-Aug
- Jerry Salzano (utility, b. 1974, New Jersey)
- 1995: Williamsport Cubs, New York-Penn League (short-season) - 3 games 25-Jun 16-Jul 20-Aug
- 1997: Durham Bulls, Carolina League (High-A) - 1 game 16-Aug
- 2001: Trenton Thunder, Eastern League (AA) - 3 games 4-Jul g1 4-Jul g2 22-Jul
- 2002: Trenton Thunder, Eastern League (AA) - 2 games 21-Apr 4-Jul
- A.J. Samadani (pitcher, b. 1975, California)
- 1999: Jamestown Jammers, New York-Penn League (short-season) - 1 game 30-Jul
- Tyler Samaniego (pitcher, b. 1999, Alabama)
- 2023: Salt River Rafters, Arizona Fall League - 1 game 11-Oct
- Jeff Samardzija (pitcher, b. 1985, Indiana)
- 2007: Tennessee Smokies, Southern League (AA) - 1 game 3-Sep
- 2011: Chicago Cubs, Major League Baseball - 1 game 11-Sep
- Nelson Samboy (infielder, b. 1976, Dominican Republic)
- 2001: New Jersey Jackals, Northeast League (independent) - 2 games 1-Sep 21-Sep
- Yordanis Samon (first baseman, b. 1981, Cuba)
- 2017: Cuban National Team, Can-Am League (independent) - 1 game 22-Jun
- Derrick Sampel (pitcher, b. 1988)
- 2014: Raton Osos, Pecos League (independent) - 1 game 22-Jul
- Caleb Sampen (pitcher, b. 1996, Indiana)
- 2021: Scottsdale Scorpions, Arizona Fall League - 1 game 16-Oct
- Adrian Sampson (pitcher, b. 1991, Washington)
- 2014: Scottsdale Scorpions, Arizona Fall League - 1 game 8-Oct
- 2019: Texas Rangers, Major League Baseball - 1 game 17-Jul
- 2022: Chicago Cubs, Major League Baseball - 1 game 30-Sep
- Benj Sampson (pitcher, b. 1975, Iowa)
- 1997: New Britain Rock Cats, Eastern League (AA) - 1 game 3-Aug
- Chris Sampson (pitcher, b. 1978, Texas)
- 2005: Corpus Christi Hooks, Texas League (AA) - 1 game 4-Sep
- Julian Sampson (pitcher, b. 1989, Washington)
- 2010: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 9-Aug
- 2011: Brockton Rox, Can-Am League (independent) - 1 game 29-Aug
- 2012: Newark Bears, Can-Am League (independent) - 1 game 28-Aug
- Keyvius Sampson (pitcher, b. 1991, Florida)
- 2014: El Paso Chihuahuas, Pacific Coast League (AAA) - 1 game 25-Jul
- Aaron Sams (pitcher, b. 1976, Maryland)
- 2001: Augusta Greenjackets, South Atlantic League (Low-A) - 1 game 7-Aug
- Kalian Sams (outfielder, b. 1986, Netherlands)
- Nate Samson (infielder, b. 1987, Florida)
- 2011: Tennessee Smokies, Southern League (AA) - 1 game 12-Aug
- 2019: Sioux City Explorers, American Association (independent) - 2 games 1-Jun 7-Jun
- Cody Samuel (first baseman, b. 1974, California)
- 1994: Oneonta Yankees, New York-Penn League (short-season) - 2 games 26-Jun 13-Aug
- 1996: Greensboro Bats, South Atlantic League (Low-A) - 1 game 25-Jul
- 1998: Tampa Yankees, Florida State League (High-A) - 1 game 8-Aug g2
- Juan Samuel (infielder, b. 1960, Dominican Republic)
- 1984: Philadelphia Phillies, National League (MLB) - 1 game 26-Sep
- 1992: Kansas City Royals, American League (MLB) - 1 game 17-Aug
- 1993: Cincinnati Reds, National League (MLB) - 2 games 18-Aug 24-Aug
- 1994: Detroit Tigers, American League (MLB) - 1 game 10-Apr
- 1996: Toronto Blue Jays, American League (MLB) - 1 game 8-Sep
- 1997: Toronto Blue Jays, American League (MLB) - 1 game 21-Sep
- Scott Samuels (outfielder, b. 1971, Ohio)
- 2000: Allentown Ambassadors, Northeast League (independent) - 1 game 4-Jul
- 2003: New Jersey Jackals, Northeast League (independent) - 2 games 4-Sep 5-Sep
- Andy Samuelson (pitcher, b. 1999, Indiana)
- 2019: GCL Braves, Gulf Coast League (rookie) - 1 game 21-Aug g1
- 2021: FCL Braves, Florida Complex League (rookie) - 1 game 23-Aug g1
- Mark Samuelson (infielder, b. 1987)
- 2012: London Rippers, Frontier League (independent) - 1 game 26-May
- Carlos Sanabria (pitcher, b. 1997, Venezuela)
- 2019: Corpus Christi Hooks, Texas League (AA) - 1 game 11-Jul
- 2021: Omaha Storm Chasers, Triple-A East - 1 game 8-Aug
- Jose Sanabria (outfielder, b. 2005, Venezuela)
- 2024: FCL Rays, Florida Complex League (rookie) - 1 game 22-Jun
- Romeo Sanabria (infielder, b. 2002, Florida)
- 2024: Peoria Javelinas, Arizona Fall League - 2 games 10-Oct 12-Oct
- Nolan Sanburn (pitcher, b. 1991, Indiana)
- 2016: Glendale Desert Dogs, Arizona Fall League - 1 game 14-Oct
- Brian Sanches (pitcher, b. 1978, Texas)
- 2006: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 4-Jul
- 2011: Florida Marlins, Major League Baseball - 1 game 8-Aug
- 2012: Lehigh Valley IronPigs, International League (AAA) - 1 game 22-Jul
- Aaron Sanchez (pitcher, b. 1992, California)
- 2014: New Hampshire Fisher Cats, Eastern League (AA) - 1 game 3-Apr
- 2015: Toronto Blue Jays, Major League Baseball - 1 game 12-Sep g1
- Adrian Sanchez (infielder, b. 1990, Venezuela)
- 2011: Hagerstown Suns, South Atlantic League (Low-A) - 1 game 2-Jul
- 2012: Potomac Nationals, Carolina League (High-A) - 1 game 8-Aug
- 2014: Harrisburg Senators, Eastern League (AA) - 1 game 3-Aug
- 2016: Harrisburg Senators, Eastern League (AA) - 2 games 21-Aug 5-Sep
- 2017: Washington Nationals, Major League Baseball - 1 game 4-Jul
- 2022: Rochester Red Wings, International League (AAA) - 1 game 27-Sep
- Aldenis Sanchez (outfielder, b. 1998, Dominican Republic)
- 2022: Hudson Valley Renegades, South Atlantic League (High-A) - 1 game 4-May
- Alex Sanchez (outfielder, b. 1976, Cuba)
- 1997: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 14-Aug
- 1999: Orlando Rays, Southern League (AA) - 1 game 3-Jul
- 2004: Detroit Tigers, Major League Baseball - 1 game 17-Jun
- 2007: Charlotte Knights, International League (AAA) - 1 game 2-Sep
- Alex Sanchez (infielder, b. 1990, Dominican Republic)
- 2012: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 2-Aug
- 2013: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 14-Aug
- Ali Sanchez (catcher, b. 1997, Venezuela)
- 2016: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 3-Aug 14-Aug
- 2018: Scottsdale Scorpions, Arizona Fall League - 3 games 6-Nov 7-Nov 13-Nov
- 2019: Scottsdale Scorpions, Arizona Fall League - 3 games 14-Oct 15-Oct 19-Oct
- 2023: Reno Aces, Pacific Coast League (AAA) - 1 game 8-Aug
- Angel Sanchez (infielder, b. 1983, Puerto Rico)
- 2010: Pawtucket Red Sox, International League (AAA) - 1 game 29-May
- 2013: Somerset Patriots, Atlantic League (independent) - 4 games 7-Aug 20-Sep 28-Sep 29-Sep
- Angel Sanchez (utility, b. 1985, California)
- 2008: St. George Roadrunners, Golden League (independent) - 1 game 30-Jul
- Braulio Sanchez (outfielder, b. 1982, Dominican Republic)
- 2002: Missoula Osprey, Pioneer League (rookie) - 1 game 10-Aug
- Brian Sanchez (outfielder, b. 2004, Venezuela)
- Carlos Sanchez (infielder, b. 1992, Venezuela)
- 2014: Charlotte Knights, International League (AAA) - 1 game 25-May
- 2014: Chicago White Sox, Major League Baseball - 1 game 26-Aug
- Carlos Sanchez (catcher/first base, b. 1996, Venezuela)
- 2016: GCL Mets, Gulf Coast League (rookie) - 2 games 29-Aug g1 29-Aug g2
- 2017: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 16-Aug
- 2018: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 15-Jun 18-Jun
- 2018: Columbia Fireflies, South Atlantic League (Low-A) - 2 games 17-Jul 30-Aug
- 2019: Columbia Fireflies, South Atlantic League (Low-A) - 1 game 30-Apr
- Carlos Sanchez (infielder, b. 2005, Dominican Republic)
- 2024: Daytona Tortugas, Florida State League (Low-A) - 1 game 28-Aug g2
- Cristopher Sanchez (pitcher, b. 1996, Dominican Republic)
- 2018: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 9-Sep
- 2019: Charlotte Stone Crabs, Florida State League (High-A) - 1 game 20-Aug
- 2022: Lehigh Valley IronPigs, International League (AAA) - 1 game 24-Sep
- Danilo Sanchez (catcher, b. 1980, Dominican Republic)
- 2002: Lakeland Tigers, Florida State League (High-A) - 1 game 23-Aug
- 2003: Oneonta Tigers, New York-Penn League (short-season) - 1 game 11-Aug
- 2006: Erie SeaWolves, Eastern League (AA) - 1 game 3-Jul
- Duaner Sanchez (pitcher, b. 1979, Dominican Republic)
- 2008: New York Mets, Major League Baseball - 1 game 6-Jul
- 2010: Sussex Skyhawks, Can-Am League (independent) - 1 game 16-Aug
- Edgar Sanchez (pitcher, b. 2000, Dominican Republic)
- 2021: Jupiter Hammerheads, Low-A Southeast - 1 game 22-Jun
- 2023: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 27-Jul
- Eduardo Sanchez (pitcher, b. 1989, Pennsylvania)
- 2013: Iowa Cubs, Pacific Coast League (AAA) - 1 game 29-Aug
- Edward Sanchez (infielder, b. 2001, Dominican Republic)
- 2022: FCL Yankees, Florida Complex League (rookie) - 1 game 18-Jun
- Emmanuel Sanchez (infielder, b. 2001, Dominican Republic)
- Feliberto Sanchez (pitcher, b. 1993, Dominican Republic)
- 2014: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 4-Jul g2
- Felix Sanchez (outfielder, b. 1990, Dominican Republic)
- Fernelys Sanchez (outfielder, b. 1994, Dominican Republic)
- 2016: Birmingham-Bloomfield Beavers, United Shore League (independent) - 1 game 6-Aug
- Franklin Sanchez (pitcher, b. 2000, Dominican Republic)
- 2022: St. Lucie Mets, Florida State League (Low-A) - 1 game 10-Aug
- 2023: Beloit Sky Carp, Midwest League (High-A) - 1 game 25-Jun g2
- Freddy Sanchez (infielder, b. 1977, California)
- 2001: Trenton Thunder, Eastern League (AA) - 1 game 22-Jul
- 2002: Trenton Thunder, Eastern League (AA) - 2 games 21-Apr 4-Jul
- Gaby Sanchez (first baseman, b. 1983, Florida)
- 2010: Florida Marlins, Major League Baseball - 1 game 6-Sep day
- 2011: Florida Marlins, Major League Baseball - 1 game 8-Aug
- 2012: Pittsburgh Pirates, Major League Baseball - 1 game 25-Sep
- Gary Sanchez (catcher, b. 1992, Dominican Republic)
- Gordon Sanchez (catcher, b. 1970)
- 1992: Albany-Colonie Yankees, Eastern League (AA) - 1 game 7-Aug
- Hector Sanchez (catcher, b. 1989, Venezuela)
- 2013: San Francisco Giants, Major League Baseball - 1 game 28-Aug
- 2016: San Diego Padres, Major League Baseball - 1 game 1-Sep
- 2019: Long Island Ducks, Atlantic League (independent) - 1 game 14-Jul
- 2022: Cleburne Railroaders, American Association (independent) - 1 game 10-Jul
- Jadiel Sanchez (outfielder, b. 2001, Puerto Rico)
- Jesus Sanchez (pitcher, b. 1974, Dominican Republic)
- 1997: Binghamton Mets, Eastern League (AA) - 1 game 20-Jul
- Jesus Sanchez (pitcher, b. 1987, Venezuela)
- 2009: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 15-Sep
- 2013: Nashville Sounds, Pacific Coast League (AAA) - 1 game 21-Jul
- 2019: Cleburne Railroaders, American Association (independent) - 1 game 9-Jun g1
- Jesus Sanchez (outfielder, b. 1997, Dominican Republic)
- 2019: Montgomery Biscuits, Southern League (AA) - 2 games 28-May 29-May
- 2021: Jacksonville Jumbo Shrimp, Triple-A East - 1 game 11-Aug
- 2021: Miami Marlins, Major League Baseball - 4 games 24-Sep 25-Sep 26-Sep 30-Sep
- 2022: Miami Marlins, Major League Baseball - 1 game 24-May
- 2022: Jacksonville Jumbo Shrimp, International League (AAA) - 2 games 30-Aug 22-Sep
- 2023: Miami Marlins, Major League Baseball - 5 games 25-Jul 26-Jul 29-Aug 30-Aug 29-Sep
- 2024: Miami Marlins, Major League Baseball - 2 games 4-Jun 29-Sep
- Jesus Sanchez (pitcher, b. 1999, Panama)
- 2021: Jupiter Hammerheads, Low-A Southeast - 2 games 22-Jun 30-Jul
- JJ Sanchez (pitcher, b. 1999, Texas)
- Jonathan Sanchez (pitcher, b. 1982, Puerto Rico)
- 2009: San Francisco Giants, Major League Baseball - 1 game 21-Aug
- 2013: Albuquerque Isotopes, Pacific Coast League (AAA) - 1 game 23-Jul
- Jonathan Sanchez (outfielder, b. 1985, Dominican Republic)
- 2006: Hagerstown Suns, South Atlantic League (Low-A) - 1 game 26-Apr
- 2006: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 28-Jul
- 2018: York Revolution, Atlantic League (independent) - 1 game 26-Jul g2
- Jose Sanchez (infielder, b. 2000, Venezuela)
- 2018: Auburn Doubledays, New York-Penn League (short-season) - 2 games 27-Jul 6-Sep
- 2021: Fredericksburg Nationals, Low-A East - 1 game 15-Jun
- Josh Sanchez (infielder, b. 1980, California)
- 2005: Florence Freedom, Frontier League (independent) - 1 game 29-Jul
- Juan Sanchez (utility, b. 1987, Venezuela)
- 2009: Wisconsin Timber Rattlers, Midwest League (Low-A) - 2 games 28-Jul 29-Jul
- 2011: Brevard County Manatees, Florida State League (High-A) - 1 game 10-Aug
- Juan Sanchez (pitcher, b. 2003, Dominican Republic)
- 2023: FCL Braves, Florida Complex League (rookie) - 1 game 8-Jul 17-Aug
- 2024: FCL Braves, Florida Complex League (rookie) - 1 game 7-May
- Juan Sanchez (catcher, then pitcher, b. 2003, Venezuela)
- 2023: FCL Yankees, Florida Complex League (rookie) - 1 game
- 2024: Tampa Tarpons, Florida State League (Low-A) - 1 game 15-Jun
- Junior Sanchez (infielder, b. 2002, Dominican Republic)
- 2024: Jupiter Hammerheads, Florida State League (Low-A) - 2 games 30-Jul 31-Jul
- Karexon Sanchez (infielder, b. 1987, Venezuela)
- 2008: Lake County Captains, South Atlantic League (Low-A) - 1 game 3-Apr
- 2009: Lake County Captains, South Atlantic League (Low-A) - 1 game 6-Aug
- 2011: Akron Aeros, Eastern League (AA) - 1 game 3-Aug
- Kleyder Sanchez (catcher, b. 1999, Venezuela)
- 2019: Great Falls Voyagers, Pioneer League (rookie) - 1 game 4-Jul
- Kris Sanchez (first baseman, b. 1984, Arizona)
- Leonel Sanchez (infielder, b. 2002, Dominican Republic)
- 2021: FCL Orioles Orange, Florida Complex League (rookie) - 1 game 17-Aug
- Lolo Sanchez (outfielder, b. 1999, Dominican Republic)
- 2019: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 1-May
- 2019: Bradenton Marauders, Florida State League (High-A) - 2 games 3-Aug 9-Aug
- 2021: Greensboro Grasshoppers, High-A East - 1 game 1-Jul
- Luany Sanchez (catcher, b. 1985, Dominican Republic)
- 2007: Rio Grande Valley WhiteWings, United League (independent) - 1 game 14-Aug
- Lucas Sanchez (pitcher, b. 1991, New Mexico)
- 2021: Santa Fe Fuego, Pecos League (independent) - 1 game 20-Jul
- Luis Sanchez (infielder, b. 1987, Puerto Rico)
- 2006: Pulaski Blue Jays, Appalachian League (rookie) - 1 game 19-Aug
- Luis Sanchez (infielder, b. 2004, Panama)
- 2023: FCL Braves, Florida Complex League (rookie) - 1 game 8-Jul
- Marcos Sanchez (catcher, b. 1974, Dominican Republic)
- 1995: Idaho Falls Padres, Pioneer League (rookie) - 1 game 10-Aug
- 1999: Rockford Reds, Midwest League (Low-A) - 1 game 5-Sep
- 2007: Bridgeport Bluefish, Atlantic League (independent) - 1 game 14-Sep
- Mario Sanchez (pitcher, b. 1994, Venezuela)
- 2014: Auburn Doubledays, New York-Penn League (short-season) - 2 games 4-Jul g2 15-Aug
- Matthew Sanchez (pitcher, b. 1997)
- 2021: Santa Fe Fuego, Pecos League (independent) - 1 game 20-Jul
- Miguel Sanchez (pitcher, b. 1993, Dominican Republic)
- 2018: Peoria Javelinas, Arizona Fall League - 2 games 9-Nov 14-Nov
- 2019: San Antonio Missions, Pacific Coast League (AAA) - 1 game 15-Jul
- Orlando Sanchez (infielder, b. 1978, Mexico)
- 1996: Lowell Spinners, New York-Penn League (short-season) - 1 game 3-Aug
- 1997: Michigan Battle Cats, Midwest League (Low-A) - 1 game 5-Jul
- Paul Sanchez (pitcher, b. 1975, California)
- 2000: Newark Bears, Atlantic League (independent) - 1 game 6-Jul
- Rafael Sanchez (pitcher, b. 1999, Cuba)
- 2022: Dunedin Blue Jays, Florida State League (Low-A) - 1 game 13-Sep
- 2023: Dunedin Blue Jays, Florida State League (Low-A) - 1 game 16-Aug
- Ramon Sanchez (pitcher, b. 1984, Dominican Republic)
- 2009: Visalia Rawhide, California League (High-A) - 1 game 27-Aug
- Raydel Sanchez (pitcher, b. 1990, Cuba)
- 2017: Ottawa Champions, Can-Am League (independent) - 1 game 21-Jul
- Rey Sanchez (infielder, b. 1967, Puerto Rico)
- Ricardo Sanchez (pitcher, b. 1997, Venezuela)
- 2014: AZL Angels, Arizona League (rookie) - 1 game 20-Jul
- 2022: Lehigh Valley IronPigs, International League (AAA) - 1 game 16-Jul
- Rodolfo Sanchez (pitcher, b. 2000, Dominican Republic)
- Romulo Sanchez (pitcher, b. 1984, Venezuela)
- 2005: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 30-Jul
- Salvador Sanchez (pitcher, b. 1985, New York)
- 2014: New Jersey Jackals, Can-Am League (independent) - 5 games 8-Aug 11-Aug 3-Sep 4-Sep 6-Sep
- 2014: Somerset Patriots, Atlantic League (independent) - 1 game 27-Sep
- Sergio Sanchez (infielder, b. 1971)
- 1993: Elmira Pioneers, New York-Penn League (short-season) - 1 game 5-Sep
- Sergio Sanchez (pitcher, b. 2000, Venezuela)
- 2022: FCL Phillies, Florida Complex League (rookie) - 2 games 16-Jun 20-Jun
- Sixto Sanchez (pitcher, b. 1998, Dominican Republic)
- 2019: Jacksonville Jumbo Shrimp, Southern League (AA) - 1 game 10-Aug
- Tony Sanchez (catcher, b. 1988, Florida)
- 2011: Altoona Curve, Eastern League (AA) - 1 game 27-Aug
- 2014: Indianapolis Indians, International League (AAA) - 1 game 23-Aug
- Tyler Sanchez (catcher, b. 1993, Florida)
- 2016: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 18-Aug
- Vic Sanchez (catcher/first base, b. 1971, California)
- 2000: El Paso Diablos, Texas League (AA) - 1 game 21-Aug
- Victor Sanchez (infielder, b. 1988, California)
- 2010: Batavia Muckdogs, New York-Penn League (short-season) - 1 game 5-Aug
- Wellington Sanchez (infielder, b. 1977, Dominican Republic)
- 2002: Road Warriors, Atlantic League (independent) - 1 game 21-Jul
- 2003: Road Warriors, Atlantic League (independent) - 3 games 12-Sep g1 12-Sep g2 14-Sep
- Wilber Sanchez (infielder, b. 2002, Venezuela)
- 2021: Kannapolis Cannon Ballers, Low-A East - 1 game 10-Sep
- 2024: Kannapolis Cannon Ballers, Carolina League (Low-A) - 1 game 12-May
- Yan Sanchez (infielder, b. 1996, Dominican Republic)
- 2017: Hillsboro Hops, Northwest League (short-season) - 1 game 29-Jul
- Yeral Sanchez (outfielder, b. 1985, Cuba)
- 2013: Trenton Thunder, Eastern League (AA) - 1 game 5-Sep
- Yolbert Sanchez (infielder, b. 1997, Cuba)
- 2022: Charlotte Knights, International League (AAA) - 2 games 16-Jul 22-Sep
- 2023: Charlotte Knights, International League (AAA) - 1 game 9-May
- Yolmer Sanchez (infielder, b. 1992, Venezuela)
- 2018: Chicago White Sox, Major League Baseball - 1 game 20-Sep
- 2019: Chicago White Sox, Major League Baseball - 1 game 1-Jun
- Yosber Sanchez (pitcher, b. 2001, Dominican Republic)
- 2023: FCL Tigers, Florida Complex League (rookie) - 1 game 19-Aug
- 2024: Lakeland Flying Tigers, Florida State League (Low-A) - 3 games 5-Apr 29-May 1-Jun
- Yunesky Sanchez (infielder, b. 1984, Cuba)
- 2008: Mobile BayBears, Southern League (AA) - 1 game 14-Aug
- 2011: Altoona Curve, Eastern League (AA) - 1 game 27-Aug
- 2012: Somerset Patriots, Atlantic League (independent) - 1 game 22-Aug
- 2013: Somerset Patriots, Atlantic League (independent) - 3 games 20-Sep 28-Sep 29-Sep
- Yuri Sanchez (infielder, b. 1973, Dominican Republic)
- 2001: Camden Riversharks, Atlantic League (independent) - 1 game 13-May
- 2002: Camden Riversharks, Atlantic League (independent) - 2 games 6-Sep 11-Sep
- 2003: North Shore Spirit, Northeast League (independent) - 1 game 21-Jul
- 2004: North Shore Spirit, Northeast League (independent) - 1 game 16-Sep
- 2005: North Shore Spirit, Can-Am League (independent) - 2 games 25-Jun 23-Jul
- Cord Sandberg (outfielder, b. 1995, Florida)
- 2015: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 10-Aug
- 2017: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 15-Apr night
- 2017: Reading Fightin Phils, Eastern League (AA) - 1 game 4-Jul
- 2018: Reading Fightin Phils, Eastern League (AA) - 2 games 26-May g2 4-Jun
- Eric Sandberg (first baseman, b. 1979, Washington)
- 2000: Quad City River Bandits, Midwest League (Low-A) - 1 game 12-Aug
- Jared Sandberg (infielder, b. 1978, Washington)
- 2000: Orlando Rays, Southern League (AA) - 1 game 1-Aug
- 2005: Portland Sea Dogs, Eastern League (AA) - 1 game 10-Sep
- Ryne Sandberg (infielder, b. 1959, Washington)
- 1984: Chicago Cubs, National League (MLB) - 1 game 8-Sep
- 1992: Chicago Cubs, National League (MLB) - 1 game 15-Aug
- 1993: Chicago Cubs, National League (MLB) - 1 game 11-Aug
- George Sandel (infielder, b. 1980, Florida)
- 2005: Somerset Patriots, Atlantic League (independent) - 2 games 12-Jun 24-Jul
- 2006: Somerset Patriots, Atlantic League (independent) - 1 game 16-Aug
- 2008: Southern Maryland Blue Crabs, Atlantic League (independent) - 1 game 21-Jun
- 2008: York Revolution, Atlantic League (independent) - 2 games 20-Sep 24-Sep
- Anthony Sanders (outfielder, b. 1974, Arizona)
- 1997: Knoxville Smokies, Southern League (AA) - 1 game 10-Aug
- 2003: New Haven Ravens, Eastern League (AA) - 1 game 10-Sep
- 2006: Newark Bears, Atlantic League (independent) - 5 games 15-Jul 16-Jul 1-Aug 16-Aug 10-Sep
- Cam Sanders (pitcher, b. 1996, California)
- 2024: Iowa Cubs, International League (AAA) - 1 game 21-Sep
- Deion Sanders (outfielder, b. 1967, Florida)
- 1992: Atlanta Braves, National League (MLB) - 2 games 31-Aug g1 31-Aug g2
- 1993: Atlanta Braves, National League (MLB) - 1 game 17-Aug
- Doug Sanders (infielder, b. 1985, Illinois)
- 2008: Reno Silver Sox, Golden League (independent) - 1 game 31-Jul
- Marcus Sanders (infielder, b. 1985, Florida)
- Michael Sanders (first baseman, b. 1986)
- 2011: Newark Bears, Can-Am League (independent) - 1 game 3-Aug
- Phoenix Sanders (pitcher, b. 1995, Germany)
- 2018: Peoria Javelinas, Arizona Fall League - 3 games 5-Nov 10-Nov 14-Nov
- 2019: Montgomery Biscuits, Southern League (AA) - 1 game 28-May
- 2022: Tampa Bay Rays, Major League Baseball - 3 games 14-Apr 26-Apr 29-Apr
- Reggie Sanders (outfielder, b. 1967, South Carolina)
- 1993: Cincinnati Reds, National League (MLB) - 1 game 24-Aug
- 1995: Cincinnati Reds, National League (MLB) - 1 game 23-Sep
- 1997: Cincinnati Reds, National League (MLB) - 1 game 25-Aug day
- 1998: Cincinnati Reds, National League (MLB) - 1 game 19-Aug
- 2000: Atlanta Braves, Major League Baseball - 2 games 9-Jul 26-Sep
- 2003: Pittsburgh Pirates, Major League Baseball - 1 game 3-Jul
- 2006: Kansas City Royals, Major League Baseball - 1 game 6-Aug
- Scott Sanders (pitcher, b. 1969, Missouri)
- 1994: San Diego Padres, National League (MLB) - 1 game 22-Jul g2
- 1999: Chicago Cubs, National League (MLB) - 1 game 23-Jul
- Tracy Sanders (first base/outfield, b. 1969, North Carolina)
- 1997: Carolina Mudcats, Southern League (AA) - 1 game 11-Aug
- Scott Sanderson (pitcher, b. 1956, Michigan; d. 2019, Illinois)
- 1992: New York Yankees, American League (MLB) - 2 games 23-Aug 27-Sep
- Jorge Sandes (outfielder, b. 1985, Venezuela)
- 2006: Casper Rockies, Pioneer League (rookie) - 1 game 24-Aug
- Darian Sandford (outfielder, b. 1987, Missouri)
- 2015: Garden State Grays, Can-Am League (independent) - 1 game 24-Aug
- 2017: Harrisburg Senators, Eastern League (AA) - 1 game 3-Sep
- 2021: Lexington Legends, Atlantic League (independent) - 1 game 19-Sep
- Michael Sandle (outfielder, b. 1998, Ohio)
- 2021: Fayetteville Woodpeckers, Low-A East - 1 game 10-Sep
- 2022: Asheville Tourists, South Atlantic League (High-A) - 2 games 4-Jul 17-Jul
- Nick Sandlin (pitcher, b. 1997, Georgia)
- 2023: Cleveland Guardians, Major League Baseball - 1 game 30-Sep
- Rob Sandora (catcher/outfielder, b. 1981, New York)
- 2008: Long Island Ducks, Atlantic League (independent) - 2 games 24-Aug 17-Sep
- Brandon Sandoval (outfielder, b. 1995, California)
- 2017: Inland Empire 66ers, California League (High-A) - 1 game 31-Jul
- Danny Sandoval (infielder, b. 1979, Venezuela)
- 1998: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 29-Aug
- 2006: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 4-Jul
- 2007: Ottawa Lynx, International League (AAA) - 1 game 28-Aug
- Freddy Sandoval (infielder, b. 1982, Mexico)
- 2007: Arkansas Travelers, Texas League (AA) - 1 game 8-Aug
- Jjallil Sandoval (infielder, b. 1979, California)
- 2002: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 7-Jul
- Jose Sandoval (infielder, b. 1977, California)
- 2003: Richmond Roosters, Frontier League (independent) - 1 game 26-Jul
- Joshuan Sandoval (first baseman, b. 1997, Puerto Rico)
- 2023: FCL Rays, Florida Complex League (rookie) - 1 game 8-Jul
- Juan Sandoval (pitcher, b. 1981, Dominican Republic)
- 2003: Wisconsin Timber Rattlers, Midwest League (Low-A) - 1 game 30-Jul
- 2004: Inland Empire 66ers, California League (High-A) - 1 game 8-Aug
- 2005: San Antonio Missions, Texas League (AA) - 1 game 4-Sep
- Marcos Sandoval (pitcher, b. 1980, Venezuela)
- 2003: Charleston Alley Cats, South Atlantic League (Low-A) - 1 game 13-Jul
- Michael Sandoval (infielder, b. 1981, Venezuela)
- 2003: Fort Myers Miracle, Florida State League (High-A) - 2 games 31-Aug g1 31-Aug g2
- 2009: Newark Bears, Atlantic League (independent) - 1 game 16-Jul
- Pablo Sandoval (infielder, b. 1986, Venezuela)
- 2006: Augusta Greenjackets, South Atlantic League (Low-A) - 2 games 14-Sep 15-Sep
- 2009: San Francisco Giants, Major League Baseball - 2 games 21-Aug 28-Aug
- 2012: San Francisco Giants, Major League Baseball - 1 game 4-Jul
- 2013: San Francisco Giants, Major League Baseball - 3 games 31-Jul 28-Aug 18-Sep
- 2017: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 30-Jul
- 2021: Atlanta Braves, Major League Baseball - 3 games 30-Apr 1-May 30-Jun
- Patrick Sandoval (pitcher, b. 1996, California)
- 2018: Inland Empire 66ers, California League (High-A) - 1 game 10-Aug
- 2021: Los Angeles Angels, Major League Baseball - 2 games 27-Jun 18-Jul
- 2022: Los Angeles Angels, Major League Baseball - 1 game 25-Aug
- 2024: Los Angeles Angels, Major League Baseball - 1 game 15-Apr
- Rylan Sandoval (infielder, b. 1987, California)
- Jayvien Sandridge (pitcher, b. 1999, Maryland)
- 2019: GCL Orioles, Gulf Coast League (rookie) - 2 games 20-Aug 24-Aug g1
- 2022: Daytona Tortugas, Florida State League (Low-A) - 2 games 15-Apr 14-May
- Carson Sands (pitcher, b. 1995, Florida)
- 2014: AZL Cubs, Arizona League (rookie) - 1 game 20-Jul
- Cole Sands (pitcher, b. 1997, Florida)
- 2024: Minnesota Twins, Major League Baseball - 1 game 2-Sep
- Donny Sands (catcher, b. 1996, Arizona)
- Jerry Sands (outfielder, b. 1987, New York)
- 2013: Indianapolis Indians, International League (AAA) - 1 game 30-Aug
- 2015: Cleveland Indians, Major League Baseball - 2 games 20-Aug 25-Aug
- 2017: Somerset Patriots, Atlantic League (independent) - 2 games 13-May g1 13-May g2
- Jerry Sands (outfielder, b. 1987, New York)
- 2018: Richmond Flying Squirrels, Eastern League (AA) - 1 game 4-Jun
- Tim Sandy (outfielder, b. 1971)
- Francisco Saneaux (pitcher, b. 1974, Dominican Republic)
- 1997: Frederick Keys, Carolina League (High-A) - 1 game 6-Apr
- Chance Sanford (infielder, b. 1972, Texas)
- 1994: Salem Buccaneers, Carolina League (High-A) - 1 game 7-Aug
- 2000: Atlantic City Surf, Atlantic League (independent) - 2 games 3-Jul 7-Aug
- Jake Sanford (outfielder, b. 1997, Nova Scotia)
- Mo Sanford (pitcher, b. 1966, Georgia)
- 1994: Salt Lake Buzz, Pacific Coast League (AAA) - 1 game 11-Sep
- 1999: Massachusetts Mad Dogs, Northeast League (independent) - 1 game 17-Jul
- Shawn Sanford (pitcher, b. 1988, New Jersey)
- 2015: Sussex County Miners, Can-Am League (independent) - 1 game 6-Aug
- 2015: New Jersey Jackals, Can-Am League (independent) - 1 game 18-Sep
- Sang Yang (pitcher, b. 2000, China)
- 2019: Texas AirHogs, American Association (independent) - 1 game 6-Jun
- Brendon Sanger (outfielder, b. 1993, Pennsylvania)
- 2018: Inland Empire 66ers, California League (High-A) - 2 games 10-Aug 12-Aug
- Manny Sanguillen (catcher, b. 1944, Panama)
- 1969: Pittsburgh Pirates, National League (MLB) - 1 game 29-Jun
- Tony Sanguinetti (catcher, b. 1981)
- 2005: Richmond Roosters, Frontier League (independent) - 1 game 6-Aug
- Jose Sanjurjo (outfielder, b. 1973, Puerto Rico)
- 1991: Bristol Tigers, Appalachian League (rookie) - 1 game 16-Aug
- Brian Sankey (first baseman, b. 1974, Massachusetts)
- 1997: Savannah Sand Gnats, South Atlantic League (Low-A) - 2 games 12-Aug g1 12-Aug g2
- 1998: Vero Beach Dodgers, Florida State League (High-A) - 1 game 8-Aug g2
- Reiver Sanmartin (pitcher, b. 1996, Colombia)
- 2019: Daytona Tortugas, Florida State League (High-A) - 1 game 14-Apr
- Edwin Sano (infielder, b. 1998, Dominican Republic)
- 2019: Rocky Mountain Vibes, Pioneer League (rookie) - 1 game 6-Jul
- Miguel Sano (infielder, b. 1993, Dominican Republic)
- 2018: Minnesota Twins, Major League Baseball - 1 game 25-Apr
- 2021: Minnesota Twins, Major League Baseball - 1 game 5-Jul
- 2022: Minnesota Twins, Major League Baseball - 1 game 30-Apr
- 2024: Los Angeles Angels, Major League Baseball - 4 games 15-Apr 16-Apr 17-Apr 18-Apr
- Javier Sanoja (utility, b. 2002, Venezuela)
- 2022: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 20-Aug
- 2023: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 27-Jul
- 2024: Jacksonville Jumbo Shrimp, International League (AAA) - 1 game 19-Jun
- John Sansone (infielder, b. 1993, Pennsylvania)
- 2019: Lincoln Saltdogs, American Association (independent) - 2 games 31-May 6-Jun
- Kevin Santa (infielder, b. 1995, Puerto Rico)
- 2019: Tacoma Rainiers, Pacific Coast League (AAA) - 1 game 2-Sep
- 2022: Ponce Leones, Liga Clemente (winter) - 2 games 30-Nov 2-Dec
- Roberto Santa (first baseman, b. 1972, Puerto Rico)
- 1994: Hudson Valley Renegades, New York-Penn League (short-season) - 2 games 19-Jun 26-Jul
- JJ Santa Cruz (pitcher, b. 1996, Arizona)
- 2018: Augusta GreenJackets, South Atlantic League (Low-A) - 1 game 31-Aug
- Jahdiel Santamaria (first base/outfield, b. 1987, Panama)
- 2008: Staten Island Yankees, New York-Penn League (short-season) - 1 game 5-Sep
- 2009: Rome Braves, South Atlantic League (Low-A) - 1 game 3-Jul
- Alex Santana (utility, b. 1993, Florida)
- 2014: Great Lakes Loons, Midwest League (Low-A) - 1 game 28-Aug
- Alexander Santana (pitcher, b. 1993, Dominican Republic)
- 2015: South Bend Cubs, Midwest League (Low-A) - 1 game 26-Aug
- Angel Santana (pitcher, b. 2002, Dominican Republic)
- 2022: FCL Blue Jays, Florida Complex League (rookie) - 2 games 16-Jun 2-Jul
- Carlos Santana (catcher/first base, b. 1986, Dominican Republic)
- 2007: Great Lakes Loons, Midwest League (Low-A) - 1 game 6-Aug
- 2008: Akron Aeros, Eastern League (AA) - 1 game 31-Aug
- 2009: Akron Aeros, Eastern League (AA) - 1 game 29-Jul
- 2010: Cleveland Indians, Major League Baseball - 1 game 31-Jul
- 2011: Cleveland Indians, Major League Baseball - 1 game 4-Sep
- 2014: Cleveland Indians, Major League Baseball - 1 game 26-Aug
- 2015: Cleveland Indians, Major League Baseball - 2 games 20-Aug 25-Aug
- 2017: Cleveland Indians, Major League Baseball - 1 game 2-Sep
- 2018: Philadelphia Phillies, Major League Baseball - 4 games 14-Jun 9-Jul g1 9-Jul g2 28-Sep
- 2019: Cleveland Indians, Major League Baseball - 3 games 1-Jun 30-Aug 19-Sep
- 2021: Kansas City Royals, Major League Baseball - 2 games 25-May 16-Sep
- 2023: Pittsburgh Pirates, Major League Baseball - 1 game 4-May
- 2023: Milwaukee Brewers, Major League Baseball - 1 game 1-Oct
- 2024: Minnesota Twins, Major League Baseball - 2 games 2-Sep 5-Sep
- Cristian Santana (infielder, b. 1997, Dominican Republic)
- 2018: Rancho Cucamonga Quakes, California League (High-A) - 2 games 12-Aug 17-Aug
- 2019: Tulsa Drillers, Texas League (AA) - 1 game 22-Jul
- Cristian Santana (infielder, b. 2003, Dominican Republic)
* Cristobal Santana - see Mayobanex Santana
- Danny Santana (utility, b. 1990, Dominican Republic)
- 2019: Texas Rangers, Major League Baseball - 2 games 17-Jul 19-Jul
- Debby Santana (infielder, b. 2000, Dominican Republic)
- Dennis Santana (pitcher, b. 1996, Dominican Republic)
- 2019: Oklahoma City Dodgers, Pacific Coast League (AAA) - 1 game 21-Jul
- Domingo Santana (outfielder, b. 1992, Dominican Republic)
- 2010: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 22-Apr
- 2011: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 24-Jul
- 2015: Milwaukee Brewers, Major League Baseball - 2 games 23-Aug 25-Aug
- 2017: Milwaukee Brewers, Major League Baseball - 1 game 29-May
- 2018: Milwaukee Brewers, Major League Baseball - 2 games 13-Apr 22-Sep
- Edgar Santana (pitcher, b. 1991, Dominican Republic)
- 2016: Surprise Saguaros, Arizona Fall League - 1 game 12-Oct
- 2017: Indianapolis Indians, International League (AAA) - 1 game 1-Sep
- 2021: Atlanta Braves, Major League Baseball - 3 games 30-Apr 1-May 30-Jun
- Enrique Santana (pitcher, b. 1997, Dominican Republic)
- Francisco Santana (outfielder, b. 1988, Dominican Republic)
- 2009: Staten Island Yankees, New York-Penn League (short-season) - 1 game 20-Jul
- Gabriel Santana (infielder, b. 1992, Venezuela)
- 2015: Beloit Snappers, Midwest League (Low-A) - 1 game 5-Sep
- Geralmi Santana (pitcher, b. 2000, Dominican Republic)
- 2023: FCL Yankees, Florida Complex League (rookie) - 1 game 16-Jun
- Johan Santana (pitcher, b. 1979, Venezuela)
- 2008: New York Mets, Major League Baseball - 2 games 22-Aug 23-Sep
- Jose Santana (infielder, b. 1993, Dominican Republic)
- 1993: Asheville Tourists, South Atlantic League (Low-A) - 1 game 19-Aug
- 1995: Quad City River Bandits, Midwest League (Low-A) - 1 game 6-Aug
- Juan Santana (infielder, b. 1994, Dominican Republic)
- 2024: Charleston Dirty Birds, Atlantic League (independent) - 1 game 8-Aug
- Julio Santana (pitcher, b. 1973, Dominican Republic)
- 2000: Montreal Expos, Major League Baseball - 1 game 11-Sep g2
- 2012: Rockland Boulders, Can-Am League (independent) - 1 game 30-Jul g1
- Luis Santana (pitcher, b. 1999, Dominican Republic)
- 2022: Asheville Tourists, South Atlantic League (High-A) - 1 game 4-Jul
- Manny Santana (catcher/first base, b. 1980, Puerto Rico)
- Mayobanex Santana (infielder, b. 1981, Dominican Republic)
- 2000: Bristol Sox, Appalachian League (rookie) - 2 games 29-Jul 4-Aug
- 2002: Missoula Osprey, Pioneer League (rookie) - 2 games 5-Aug 10-Aug
- 2004: Modesto A's, California League (High-A) - 3 games 11-Aug 19-Aug g1 19-Aug g2
- 2011: Rockland Boulders, Can-Am League (independent) - 2 games (as Cristobal Santana) 4-Jul 24-Aug
- Osmany Santana (outfielder, b. 1976, Cuba)
- 1999: Kinston Indians, Carolina League (High-A) - 2 games 9-Aug 15-Aug
- Pedro Santana (infielder, b. 1976, Dominican Republic)
- 1998: West Michigan Whitecaps, Midwest League (Low-A) - 1 game 16-Aug
- 2000: Jacksonville Suns, Southern League (AA) - 1 game 1-Aug
- 2005: Calgary Vipers, Northern League (independent) - 2 games 9-Aug 12-Aug
- Pedro Santana (outfielder, b. 1979, Dominican Republic)
- 1999: Staten Island Yankees, New York-Penn League (short-season) - 1 game 29-Jul
- 2000: Staten Island Yankees, New York-Penn League (short-season) - 2 games 4-Sep 9-Sep
- Rafael Santana (infielder, b. 1958, Dominican Republic)
- 1984: New York Mets, National League (MLB) - 2 games 23-Sep 26-Sep
- 1985: New York Mets, National League (MLB) - 1 game 9-Apr
- 1986: New York Mets, National League (MLB) - 1 game 14-Apr
- Ravel Santana (outfielder, b. 1992, Dominican Republic)
- 2012: Staten Island Yankees, New York-Penn League (short-season) - 1 game 23-Aug
- Ralph Santana (utility, b. 1980, Florida)
- 2004: Clearwater Threshers, Florida State League (High-A) - 1 game 28-Aug
- 2005: Winnipeg Goldeyes, Northern League (independent) - 1 game 9-Aug
- 2006: Sioux Falls Canaries, American Association (independent) - 1 game 6-Aug
- 2007: Southern Illinois Miners, Frontier League (independent) - 1 game 7-Aug
- Ramon Santana (infielder, b. 1986, Venezuela)
- 2009: New Britain Rock Cats, Eastern League (AA) - 1 game 13-Sep
- Raul Santana (catcher, b. 1972, Dominican Republic)
- 1992: Rockford Expos, Midwest League (Low-A) - 1 game 13-Aug
- Rico Santana (outfielder, b. 1979)
- 2006: Rockford RiverHawks, Frontier League (independent) - 1 game 8-Aug
- 2007: Atlantic City Surf, Can-Am League (independent) - 1 game 4-Jul
- Ruben Santana (infielder, b. 1970, Dominican Republic)
- 1999: Adirondack Lumberjacks, Northeast League (independent) - 1 game 18-Jun
- Ruben Santana (infielder, b. 1997, Dominican Republic)
- Sandy Santana (infielder, b. 1980, Dominican Republic)
- 2000: Johnson City Cardinals, Appalachian League (rookie) - 1 game 2-Aug
- Tyler Santana (pitcher, b. 1998, Florida)
- 2023: Mesa Solar Sox, Arizona Fall League - 1 game 11-Oct
- Victor Santana (outfielder, b. 1984, Dominican Republic)
- 2006: Pulaski Blue Jays, Appalachian League (rookie) - 1 game 19-Aug
- Yeison Santana (pitcher, b. 1996, Dominican Republic)
- 2017: Hillsboro Hops, Northwest League (short-season) - 1 game 29-Jul
- Yeison Santana (infielder, b. 2000, Dominican Republic)
- 2022: South Bend Cubs, Midwest League (High-A) - 1 game 25-Jun
- Yury Santana (infielder, then pitcher, b. 1982, Dominican Republic)
- 2005: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 4-Aug 26-Aug g1
- Anthony Santander (outfielder, b. 1994, Venezuela)
- 2016: Lynchburg Hillcats, Carolina League (High-A) - 1 game 4-Sep
- 2018: Bowie Baysox, Eastern League (AA) - 2 games 28-May 20-Jun g1
- 2019: Norfolk Tides, International League (AAA) - 1 game 27-May
- 2019: Baltimore Orioles, Major League Baseball - 2 games 3-Sep g1 3-Sep g2
- 2021: Baltimore Orioles, Major League Baseball - 2 games 16-Aug 19-Aug
- 2022: Baltimore Orioles, Major League Baseball - 2 games 9-Apr 5-May
- 2024: Baltimore Orioles, Major League Baseball - 5 games 7-Jun 8-Jun 9-Jun 10-Jun 18-Sep
- Juan Santander (catcher/first base, b. 2002, Venezuela)
- 2023: Fayetteville Woodpeckers, Carolina League (Low-A) - 1 game 5-Sep
- F.P. Santangelo (outfielder, b. 1967, Michigan)
- 1992: Indianapolis Indians, American Association (AAA) - 1 game 9-Aug
- 1995: Montreal Expos, National League (MLB) - 1 game 10-Sep
- 1998: Montreal Expos, National League (MLB) - 2 games 9-Jul 20-Sep
- 2002: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 15-Aug
- Lou Santangelo (catcher/first base, b. 1983, New York)
- 2006: Salem Avalanche, Carolina League (High-A) - 1 game 14-Apr
- 2007: Corpus Christi Hooks, Texas League (AA) - 1 game 8-Aug
- Andres Santiago (pitcher, b. 1989, Puerto Rico)
- 2012: Chattanooga Lookouts, Southern League (AA) - 1 game 12-Aug
- 2016: Sussex County Miners, Can-Am League (independent) - 1 game 30-May
- 2017: Florida Fire Frogs, Florida State League (High-A) - 1 game 28-May
- Antonio Santiago (pitcher, b. 1976, Puerto Rico)
- 1997: Williamsport Cubs, New York-Penn League (short-season) - 1 game 19-Jul
- Arnold Santiago (infielder, b. 1974, Puerto Rico)
- 1994: Burlington Indians, Appalachian League (rookie) - 1 game 3-Jul
- Benito Santiago (catcher, b. 1965, Puerto Rico)
- 1992: San Diego Padres, National League (MLB) - 1 game 20-Aug
- 1993: Florida Marlins, National League (MLB) - 1 game 11-Aug
- 1996: Philadelphia Phillies, National League (MLB) - 2 games 28-Jun 21-Sep
- 1997: Toronto Blue Jays, American League (MLB) - 2 games 19-Sep 21-Sep
- 2001: San Francisco Giants, Major League Baseball - 1 game 24-Aug
- Carlos Santiago (infielder, b. 2001, Venezuela)
- 2022: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 20-Aug
- Carlos Santiago (infielder, b. 2001, Venezuela)
- Derek Santiago (pitcher, b. 1975, California)
- 2002: Adirondack Lumberjacks, Northeast League (independent) - 1 game 10-Sep
- Glenn Santiago (first base/outfield, b. 2000, Puerto Rico)
- Hector Santiago (pitcher, b. 1987, New Jersey)
- 2011: Birmingham Barons, Southern League (AA) - 1 game 11-Aug
- 2013: Chicago White Sox, Major League Baseball - 1 game 18-Aug
- 2018: Chicago White Sox, Major League Baseball - 1 game 20-Sep
- 2021: Seattle Mariners, Major League Baseball - 1 game 11-Jul
- 2022: Carolina Gigantes, Liga Clemente (winter) - 1 game 2-Dec
- John Santiago (infielder, b. 1984, Puerto Rico)
- 2003: GCL Pirates, Gulf Coast League (rookie) - 2 games 26-Aug 27-Aug
- 2005: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 23-Jun
- Jorge Santiago (infielder, b. 1975, New York)
- 1997: Pittsfield Mets, New York-Penn League (short-season) - 2 games 25-Jul 4-Aug
- Jose Santiago (pitcher, b. 1974, Puerto Rico)
- 1996: Lansing Lugnuts, Midwest League (Low-A) - 1 game 13-Aug
- 2001: Philadelphia Phillies, Major League Baseball - 1 game 3-Sep
- Jose Santiago (pitcher, b. 1981, Dominican Republic)
- 2003: GCL Braves, Gulf Coast League (rookie) - 1 game 25-Aug
- Kevin Santiago (infielder, b. 1997, Puerto Rico)
- 2016: GCL Rays, Gulf Coast League (rookie) - 1 game 26-Aug
- 2017: Princeton Rays, Appalachian League (rookie) - 1 game 29-Aug
- 2019: Bowling Green Hot Rods, Midwest League (Low-A) - 1 game 30-May
- Kevin Santiago (outfielder, b. 1998, Puerto Rico)
- 2024: Northern Colorado Owlz, Pioneer League (independent) - 2 games 5-Jul g1 16-Jul
- Ramon Santiago (infielder, b. 1979, Dominican Republic)
- 2004: Tacoma Rainiers, Pacific Coast League (AAA) - 1 game 15-Aug
- 2009: Detroit Tigers, Major League Baseball - 1 game 6-Sep
- 2010: Detroit Tigers, Major League Baseball - 2 games 17-Aug 2-Sep
- 2014: Cincinnati Reds, Major League Baseball - 1 game 22-Aug
- Rudy Santiago (outfielder, b. 1979, Dominican Republic)
- 2002: Missoula Osprey, Pioneer League (rookie) - 2 games 5-Aug 10-Aug
- Danny Santiesteban (outfielder, b. 1985, Florida)
- Tony Santillan (pitcher, b. 1997, Texas)
- Nick Santomauro (outfielder, b. 1988, New Jersey)
- 2009: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 2-Sep 8-Sep
- 2011: New Jersey Jackals, Can-Am League (independent) - 4 games 22-Jul 2-Aug 16-Aug 26-Aug g2
- 2012: Newark Bears, Can-Am League (independent) - 1 game 18-Jun
- 2012: Quebec Les Capitales, Can-Am League (independent) - 1 game 25-Jun
- Justin Santonocito (infielder, b. 1976, New York)
- 1998: South Bend Silver Hawks, Midwest League (Low-A) - 1 game 16-Aug
- John Santor (infielder, b. 1981, California)
- 2001: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 26-Aug
- 2002: New Jersey Cardinals, New York-Penn League (short-season) - 2 games 30-Aug g1 30-Aug g2
- 2003: Peoria Chiefs, Midwest League (Low-A) - 1 game 31-Jul
- Jack Santora (infielder, b. 1976, California)
- Pat Santoro (infielder, b. 1978, Illinois)
- 1998: Lowell Spinners, New York-Penn League (short-season) - 1 game 25-Jul
- Adalberto Santos (utility, b. 1987, New York)
- 2010: State College Spikes, New York-Penn League (short-season) - 1 game 29-Jul
- 2014: Indianapolis Indians, International League (AAA) - 1 game 25-May
- 2014: Fresno Grizzlies, Pacific Coast League (AAA) - 1 game 25-Jul
- Alex Santos (pitcher, b. 1977, New York)
- 2004: Quebec Les Capitales, Northeast League (independent) - 1 game 18-Jun
- Alex Santos (pitcher, b. 2002, New York)
- 2024: Surprise Saguaros, Arizona Fall League - 1 game 11-Oct
- Angel Santos (infielder, b. 1979, Puerto Rico)
- 1998: Lowell Spinners, New York-Penn League (short-season) - 1 game 25-Jul
- 2000: Trenton Thunder, Eastern League (AA) - 1 game 8-Apr
- 2001: Trenton Thunder, Eastern League (AA) - 2 games 29-Apr 22-Jul
- Angeudis Santos (infielder, b. 2001, Dominican Republic)
- 2021: Jupiter Hammerheads, Low-A Southeast - 2 games 22-Jun 30-Jul
- Antonio Santos (pitcher, b. 1996, Dominican Republic)
- 2018: Lancaster JetHawks, California League (High-A) - 1 game 16-Aug
- 2019: Salt River Rafters, Arizona Fall League - 1 game 14-Oct
- Arthur Santos (pitcher, b. 1982, Florida)
- 2007: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 25-Aug
- Bernaldo Santos (pitcher, b. 1979, Dominican Republic)
- 2001: Pittsfield Astros, New York-Penn League (short-season) - 1 game 26-Aug
- Chad Santos (first baseman, b. 1981, Hawaii)
- 2001: Burlington Bees, Midwest League (Low-A) - 1 game 28-Jul
- 2003: Wichita Wranglers, Texas League (AA) - 1 game 8-Aug
- Dahian Santos (pitcher, b. 2003, Venezuela)
- 2022: Dunedin Blue Jays, Florida State League (Low-A) - 3 games 3-Jun 10-Jun 30-Jul
- 2024: Dunedin Blue Jays, Florida State League (Low-A) - 1 game 1-Jul
- Francisco Santos (first base/outfield, b. 1974, Dominican Republic)
- Gerald Santos (pitcher, b. 1969, Virginia)
- 1993: Arkansas Travelers, Texas League (AA) - 1 game 14-Aug
- Gregory Santos (pitcher, b. 1999, Dominican Republic)
- 2021: Scottsdale Scorpions, Arizona Fall League - 1 game 16-Oct
- Jhonny Santos (outfielder, b. 1996, Panama)
- 2017: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 24-Aug
- 2018: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 30-May
- Jose Santos (infielder, b. 1974, Dominican Republic)
- 1999: Kane County Cougars, Midwest League (Low-A) - 1 game 5-Sep
- 2002: Portland Sea Dogs, Eastern League (AA) - 1 game 21-Apr
- 2003: Jupiter Hammerheads, Florida State League (High-A) - 2 games 26-Aug 29-Aug
- Junior Santos (pitcher, b. 2001, Dominican Republic)
- 2022: Brooklyn Cyclones, South Atlantic League (High-A) - 1 game 8-May g1
- Luis Santos (infielder, b. 2000, Mexico)
- Madison Santos (outfielder, b. 1999, Dominican Republic)
- Nolan Santos (pitcher, b. 2000, Florida)
- 2023: Fort Myers Mighty Mussels, Florida State League (Low-A) - 1 game 3-Sep
- 2024: Fort Myers Mighty Mussels, Florida State League (Low-A) - 2 games 9-Apr 12-Apr
- Oliver Santos (infielder, b. 1987)
- 2010: Billings Mustangs, Pioneer League (rookie) - 1 game 27-Aug
- Omir Santos (catcher, b. 1981, Puerto Rico)
- 2001: Staten Island Yankees, New York-Penn League (short-season) - 2 games 5-Sep 6-Sep
- 2002: Staten Island Yankees, New York-Penn League (short-season) - 2 games 7-Sep 12-Sep
- 2005: Trenton Thunder, Eastern League (AA) - 2 games 14-Jun 10-Sep
- 2006: Trenton Thunder, Eastern League (AA) - 2 games 13-Apr 7-Sep
- 2009: New York Mets, Major League Baseball - 1 game 4-Sep
- 2013: Columbus Clippers, International League (AAA) - 1 game 24-Apr
- Pedro Santos (pitcher, b. 2000, Cuba)
- 2021: Mesa Solar Sox, Arizona Fall League - 1 game 20-Oct
- Ramon Santos (pitcher, b. 1994, Dominican Republic)
- 2017: Palm Beach Cardinals, Florida State League (High-A) - 1 game 27-May
- Reid Santos (pitcher, b. 1982, Hawaii)
- Reyson Santos (pitcher, b. 1999, Dominican Republic)
- 2021: St. Lucie Mets, Low-A Southeast - 1 game 14-Aug g2
- Roel Santos (outfielder, b. 1987, Cuba)
- Sandy Santos (outfielder, b. 1994, Dominican Republic)
- 2016: West Virginia Black Bears, New York-Penn League (short-season) - 1 game 14-Aug
- Sergio Santos (infielder, then pitcher, b. 1983, California)
- 2002: Missoula Osprey, Pioneer League (rookie) - 2 games 5-Aug 10-Aug
- 2008: Rochester Red Wings, International League (AAA) - 1 game 7-Jun
- 2014: Buffalo Bisons, International League (AAA) - 1 game 17-Aug
- Trae Santos (first baseman, b. 1992, Guam)
- 2018: Gateway Grizzlies, Frontier League (independent) - 1 game 26-Aug
- Victor Santos (pitcher, b. 1976, Dominican Republic)
- 2005: Milwaukee Brewers, Major League Baseball - 1 game 3-Aug
- 2009: Newark Bears, Atlantic League (independent) - 2 games 31-Aug 27-Sep
- Yasiel Santoya (first baseman, b. 1987, Cuba)
- 2016: Cuban National Team, Can-Am League (independent) - 1 game 23-Jun
- Steve Santucci (outfielder, b. 1971)
- 1994: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 26-Jul
- Marino Santy (pitcher, b. 2002, Dominican Republic)
- 2023: Myrtle Beach Pelicans, Carolina League (Low-A) - 1 game 8-Sep
- Luis Sanz (pitcher, b. 1987, Venezuela)
- 2014: Rockland Boulders, Can-Am League (independent) - 2 games 3-Sep 8-Sep
- Damian Sapp (catcher/first base, b. 1976, Utah)
- 2000: Trenton Thunder, Eastern League (AA) - 1 game 8-Apr
- 2001: Nashua Pride, Atlantic League (independent) - 2 games 3-Sep 22-Sep
- 2003: Nashua Pride, Atlantic League (independent) - 2 games 22-Jun g2 25-Jul
- Dave Sappelt (outfielder, b. 1987, New York)
- 2009: Sarasota Reds, Florida State League (High-A) - 1 game 5-Sep
- 2011: Louisville Bats, International League (AAA) - 1 game 1-Aug
- 2011: Cincinnati Reds, Major League Baseball - 1 game 26-Sep
- 2013: Iowa Cubs, Pacific Coast League (AAA) - 1 game 29-Aug
- Mark Sappington (pitcher, b. 1990, Missouri)
- 2015: Montgomery Biscuits, Southern League (AA) - 1 game 25-Jul
- Eliott Sarabia (infielder, b. 1976, California)
- 1999: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 30-Jul
- Mike Sarbaugh (infielder, b. 1967, Pennsylvania)
- 1993: Canton-Akron Indians, Eastern League (AA) - 1 game 9-Aug
- 1994: Canton-Akron Indians, Eastern League (AA) - 2 games 21-Aug g1 21-Aug g2
- Luis Sardinas (infielder, b. 1993, Venezuela)
- 2016: San Diego Padres, Major League Baseball - 2 games 28-Aug 1-Sep
- Bronson Sardinha (utility, b. 1983, Hawaii)
- 2002: Greensboro Bats, South Atlantic League (Low-A) - 2 games 24-Jun 14-Jul
- 2002: Staten Island Yankees, New York-Penn League (short-season) - 2 games 7-Sep 12-Sep
- 2004: Trenton Thunder, Eastern League (AA) - 3 games 21-Jun 3-Aug g1 3-Aug g2
- 2005: Trenton Thunder, Eastern League (AA) - 2 games 14-Jun 10-Sep
- 2006: Trenton Thunder, Eastern League (AA) - 1 game 13-Apr
- 2007: New York Yankees, Major League Baseball - 2 games 22-Sep 30-Sep
- 2008: Akron Aeros, Eastern League (AA) - 3 games 23-Aug 31-Aug 14-Sep
- 2011: Tulsa Drillers, Texas League (AA) - 1 game 2-Sep
- Dane Sardinha (catcher, b. 1979, Hawaii)
- 2010: Lehigh Valley IronPigs, International League (AAA) - 1 game 29-Jul
- 2011: Lehigh Valley IronPigs, International League (AAA) - 1 game 5-Aug
- Duke Sardinha (infielder, b. 1980, Hawaii)
- 2002: Casper Rockies, Pioneer League (rookie) - 2 games 3-Aug 10-Aug
- 2003: Asheville Tourists, South Atlantic League (Low-A) - 1 game 19-Jul
- Dennis Sarfate (pitcher, b. 1981, New York)
- 2009: Baltimore Orioles, Major League Baseball - 1 game 4-Oct
- Nick Sarianides (pitcher, b. 1989, Georgia)
- 2009: AZL Indians, Arizona League (rookie) - 1 game 25-Aug
- 2011: Kinston Indians, Carolina League (High-A) - 1 game 13-Aug
- 2013: Trois-Rivieres Aigles, Can-Am League (independent) - 1 game 11-Aug
- Manny Sarmiento (pitcher, b. 1956, Venezuela)
- 1976: Cincinnati Reds, National League (MLB) - 1 game 14-Aug
- Kazuhiro Sasaki (pitcher, b. 1968, Japan)
- 2001: Seattle Mariners, Major League Baseball - 1 game 2-Sep
- Shane Sasaki (outfielder, b. 2000, Hawaii)
- 2019: GCL Rays, Gulf Coast League (rookie) - 1 game 9-Aug
- 2023: Peoria Javelinas, Arizona Fall League - 2 games 11-Oct 14-Oct
- Mackey Sasser (catcher/first base, b. 1962, Georgia)
- Rob Sasser (infielder, b. 1975, Pennsylvania)
- 1996: Macon Braves, South Atlantic League (Low-A) - 1 game 30-Aug
- 1998: Tulsa Drillers, Texas League (AA) - 1 game 23-Aug
- Josh Satin (infielder, b. 1984, California)
- 2008: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 21-Aug 27-Aug
- 2011: New York Mets, Major League Baseball - 4 games 8-Sep g1 8-Sep g2 11-Sep 26-Sep
- 2012: Buffalo Bisons, International League (AAA) - 1 game 27-May
- 2013: New York Mets, Major League Baseball - 3 games 4-Jul 9-Sep 18-Sep
- 2014: New York Mets, Major League Baseball - 2 games 20-Apr 15-Sep
- G.G. Sato (catcher, b. 1978, Japan)
- 2003: Lakewood BlueClaws, South Atlantic League (Low-A) - 2 games 6-May 5-Jul
- Reinaldo Sato (infielder, b. 1980, Brazil)
- 2016: Brazil, World Baseball Classic - 1 game 24-Sep
- Troy Satterfield (pitcher, b. 1976, Georgia)
- 1999: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 30-Jul
- Daniel Sattler (pitcher, b. 1983, Indiana)
- 2015: Somerset Patriots, Atlantic League (independent) - 1 game 13-Aug
- Luis Saturria (outfielder, b. 1976, Dominican Republic)
- 2000: Arkansas Travelers, Texas League (AA) - 1 game 21-Aug
- 2001: Memphis Redbirds, Pacific Coast League (AAA) - 1 game 3-Aug
- Tayler Saucedo (pitcher, b. 1993, Hawaii)
- 2021: Toronto Blue Jays, Major League Baseball - 1 game 22-Sep
- 2024: Seattle Mariners, Major League Baseball - 1 game 24-Jun
- Kelena Sauer (pitcher, b. 2002, Hawaii)
- 2023: Dunedin Blue Jays, Florida State League (Low-A) - 1 game 16-Aug
- Matt Sauer (pitcher, b. 1999, California)
- 2018: Staten Island Yankees, New York-Penn League (short-season) - 1 game 15-Jun
- 2021: Tampa Tarpons, Low-A Southeast - 2 games 9-May 12-Jun
- 2023: Mesa Solar Sox, Arizona Fall League - 1 game 11-Oct
- Scott Sauerbeck (pitcher, b. 1971, Ohio)
- 2003: Pittsburgh Pirates, Major League Baseball - 1 game 3-Jul
- Kyle Saukko (outfielder, b. 1988, California)
- 2010: State College Spikes, New York-Penn League (short-season) - 1 game 29-Jul
- Matt Sauls (outfielder, b. 1982)
- 2006: Rockford RiverHawks, Frontier League (independent) - 1 game 8-Aug
- Chris Saunders (infielder, b. 1970, California)
- 1995: Binghamton Mets, Eastern League (AA) - 1 game 21-Jul
- 1996: Binghamton Mets, Eastern League (AA) - 2 games 9-Aug 25-Aug
- 1997: Binghamton Mets, Eastern League (AA) - 1 game 3-Aug
- Doug Saunders (infielder, b. 1969, California)
- Joe Saunders (pitcher, b. 1981, Virginia)
- 2009: Los Angeles Angels of Anaheim, Major League Baseball - 1 game 26-Aug
- 2014: Baltimore Orioles, Major League Baseball - 1 game 22-Sep
- Michael Saunders (outfielder, b. 1986, British Columbia)
- 2013: Seattle Mariners, Major League Baseball - 1 game 23-Aug
- Nick Saunders (infielder, b. 1979, Oklahoma)
- 2004: Windy City Thunderbolts, Frontier League (independent) - 1 game 10-Jul
- 2005: River City Rascals, Frontier League (independent) - 1 game 6-Aug
- Warren Saunders (infielder, b. 1998, Bahamas)
- Erik Sauve (infielder, b. 1972)
- 1994: Hudson Valley Renegades, New York-Penn League (short-season) - 2 games 19-Jun 26-Jul
- Rich Sauveur (pitcher, b. 1963, Virginia)
- 1998: Nashville Sounds, Pacific Coast League (AAA) - 1 game 28-Aug
- Jason Savacool (pitcher, b. 2002, New York)
- 2024: Palm Beach Cardinals, Florida State League (Low-A) - 1 game 28-Aug g2
- Jim Savage (infielder, b. 1969)
- 1990: Batavia Clippers, New York-Penn League (short-season) - 1 game 16-Aug
- Will Savage (pitcher, b. 1984, California)
- 2006: Lakewood BlueClaws, South Atlantic League (Low-A) - 2 games 15-Aug 6-Sep
- 2011: Chattanooga Lookouts, Southern League (AA) - 1 game 11-Aug
- Robert Savarese (pitcher, b. 1986)
- 2012: Rockland Boulders, Can-Am League (independent) - 1 game 26-Aug
- Joe Savery (pitcher, b. 1985, Texas)
- 2011: Lehigh Valley IronPigs, International League (AAA) - 3 games 5-Aug 17-Aug 16-Sep
- John Saviano (pitcher, b. 1996, New Jersey)
- 2019: Roswell Invaders, Pecos League (independent) - 1 game 13-Jul
- Russell Savickas (pitcher, b. 1983, Rhode Island)
- 2002: Medicine Hat Blue Jays, Pioneer League (rookie) - 1 game 17-Aug g1
- Warren Sawkiw (utility, b. 1968, Ontario)
- 1998: Elmira Pioneers, Northeast League (independent) - 1 game 7-Aug
- Chris Sawyer (outfielder, b. 1973, Connecticut)
- 2001: Quebec Les Capitales, Northeast League (independent) - 1 game 20-Jul
- 2002: Berkshire Black Bears, Northeast League (independent) - 1 game 28-Jun g2
- Wynston Sawyer (catcher, b. 1991, California)
- 2011: Aberdeen IronBirds, New York-Penn League (short-season) - 2 games 21-Jul 21-Aug
- Dave Sax (catcher/first base, b. 1958, California)
- 1992: Columbus Clippers, International League (AAA) - 1 game 19-Aug
- Steve Sax (infielder, b. 1960, California)
- 1991: New York Yankees, American League (MLB) - 2 games 12-Sep 6-Oct
- 1992: Chicago White Sox, American League (MLB) - 1 game 15-Aug
- C.J. Saylor (pitcher, b. 1993, California)
- 2019: Palm Beach Cardinals, Florida State League (High-A) - 1 game 11-May g1
- Drew Saylor (infielder, b. 1984, Ohio)
- 2009: Lake Erie Crushers, Frontier League (independent) - 1 game 27-Jul
- Jamie Saylor (infielder, b. 1974, Ohio)
- 1999: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 4-Jul
- 2000: El Paso Diablos, Texas League (AA) - 1 game 21-Aug
- 2001: Binghamton Mets, Eastern League (AA) - 1 game 22-Jul
- Alec Sayre (outfielder, b. 2000, Ohio)
- Josh Sborz (pitcher, b. 1993, District of Columbia)
- 2021: Texas Rangers, Major League Baseball - 2 games 15-Apr 14-Sep
- 2023: Texas Rangers, Major League Baseball - 2 games 10-Jun 7-Aug
- Rob Scahill (pitcher, b. 1987, Illinois)
- 2017: Milwaukee Brewers, Major League Baseball - 1 game 29-May
- 2018: Chicago White Sox, Major League Baseball - 1 game 20-Sep
- Dany Scalabrini (infielder, b. 1975)
- 2006: Quebec Les Capitales, Can-Am League (independent) - 1 game 14-Aug
- Pat Scalabrini (infielder, b. 1977, Quebec)
- 2001: Quebec Les Capitales, Northeast League (independent) - 1 game 20-Jul
- 2008: Quebec Les Capitales, Can-Am League (independent) - 2 games 20-Aug 11-Sep
- Rich Scalamandre (pitcher, b. 1980, New York)
- 2003: Peoria Chiefs, Midwest League (Low-A) - 1 game 31-Jul
- 2003: Palm Beach Cardinals, Florida State League (High-A) - 1 game 28-Aug
- 2008: Newark Bears, Atlantic League (independent) - 1 game 19-Jun
- Bobby Scales (utility, b. 1977, Michigan)
- 2004: Portland Beavers, Pacific Coast League (AAA) - 1 game 20-Aug
- 2006: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 4-Jul
- 2008: Iowa Cubs, Pacific Coast League (AAA) - 1 game 29-Jul
- 2009: Chicago Cubs, Major League Baseball - 1 game 4-Sep
- Will Scalzitti (catcher, b. 1972)
- Bob Scanlan (pitcher, b. 1966, California)
- 1993: Chicago Cubs, National League (MLB) - 1 game 11-Aug
- 1999: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 4-Jul
- Matt Scanlon (utility, b. 1978, Minnesota)
- 1999: Quad City River Bandits, Midwest League (Low-A) - 1 game 4-Sep
- 2000: Quad City River Bandits, Midwest League (Low-A) - 1 game 12-Aug
- 2002: New Britain Rock Cats, Eastern League (AA) - 1 game 30-Jun
- 2004: New Britain Rock Cats, Eastern League (AA) - 1 game 21-Jun
- Nate Scantlin (outfielder, b. 1999, Kansas)
- 2019: Billings Mustangs, Pioneer League (rookie) - 1 game 4-Jul
- Mike Scanzano (infielder, b. 1981)
- 2005: Fort Worth Cats, Central League (independent) - 1 game 3-Sep
- 2007: Southern Illinois Miners, Frontier League (independent) - 1 game 7-Aug
- 2009: New Jersey Jackals, Can-Am League (independent) - 5 games 7-Aug 10-Aug 13-Aug 1-Sep 3-Sep
- Evan Scavotto (outfielder, b. 2001, Washington)
- Anthony Scelfo (utility, b. 1986, Louisiana)
- 2008: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 6-Aug
- 2012: Laredo Lemurs, American Association (independent) - 1 game 28-Jul
- Mac Sceroler (pitcher, b. 1995, Louisiana)
- 2019: Daytona Tortugas, Florida State League (High-A) - 2 games 18-Apr 23-Aug
- Corey Schaefer (outfielder, b. 1968)
- 1990: Welland Pirates, New York-Penn League (short-season) - 1 game 17-Aug
- Chris Schaeffer (catcher, b. 1987, Florida)
- 2014: Lansing Lugnuts, Midwest League (Low-A) - 1 game 24-Aug
- Jon Schaeffer (catcher/first base, b. 1976, California)
- 1998: Fort Wayne Wizards, Midwest League (Low-A) - 1 game 15-Aug
- Jordan Schafer (outfielder, b. 1986, Indiana)
- 2008: Mississippi Braves, Southern League (AA) - 1 game 14-Aug
- 2012: Houston Astros, Major League Baseball - 1 game 29-Jul
- 2014: Atlanta Braves, Major League Baseball - 1 game 20-Apr
- Justin Schafer (infielder, b. 1988, California)
- 2010: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 5-Aug 8-Sep
- Logan Schafer (outfielder, b. 1986, California)
- 2013: Milwaukee Brewers, Major League Baseball - 1 game 17-Aug
- 2014: Nashville Sounds, Pacific Coast League (AAA) - 1 game 21-Aug g1
- 2016: Minnesota Twins, Major League Baseball - 1 game 18-Sep
- Jacob Schaffer (infielder, b. 1975, Minnesota)
- 1997: Jamestown Jammers, New York-Penn League (short-season) - 1 game 26-Jul
- Jeremy Schaffer (first baseman, b. 1990, Texas)
- 2012: Johnson City Cardinals, Appalachian League (rookie) - 2 games 16-Aug 17-Aug g1
- Eric Schaffner (pitcher, b. 1974, Oregon)
- 1997: Greensboro Bats, South Atlantic League (Low-A) - 1 game 15-Aug
- Brian Schales (infielder, b. 1996, California)
- 2015: Greensboro Grasshoppers, South Atlantic League (Low-A) - 2 games 15-Apr 10-Aug
- 2016: Jupiter Hammerheads, Florida State League (High-A) - 2 games 27-Aug 30-Aug
- 2018: Jacksonville Jumbo Shrimp, Southern League (AA) - 1 game 27-Aug
- 2019: Fort Myers Miracle, Florida State League (High-A) - 3 games 20-Aug 28-Aug g1 28-Aug g2
- Gene Schall (first base/outfield, b. 1970, Pennsylvania)
- 1994: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 12-Aug
- 1995: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 30-Apr
- 1995: Philadelphia Phillies, National League (MLB) - 1 game 23-Sep
- 1996: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 2 games 24-Aug 25-Aug
- 1996: Philadelphia Phillies, National League (MLB) - 2 games 21-Sep 29-Sep
- 2000: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 2 games 8-Jul 23-Jul
- Reid Schaller (pitcher, b. 1997, Indiana)
- 2022: Harrisburg Senators, Eastern League (AA) - 1 game 5-May
- Nolan Schanuel (first baseman, b. 2002, Florida)
- Jim Scharrer (first baseman, b. 1976, Pennsylvania)
- 1999: Myrtle Beach Pelicans, Carolina League (High-A) - 1 game 8-Aug
- Carl Scheafer (pitcher, b. 1983, New York)
- 2007: Pensacola Pelicans, American Association (independent) - 1 game 12-Aug
- Scott Schebler (outfielder, b. 1990, Iowa)
- 2014: Glendale Desert Dogs, Arizona Fall League - 1 game 9-Oct
- 2016: Cincinnati Reds, Major League Baseball - 1 game 7-Aug
- Kristopher (Kit) Scheetz (pitcher, b. 1994, Virginia)
- 2017: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 22-Jul
- 2019: Round Rock Express, Pacific Coast League (AAA) - 1 game 23-Jul
- Craig Scheffler (pitcher, b. 1971, Wisconsin)
- 1994: Yakima Bears, Northwest League (short-season) - 1 game 8-Sep
- Jordan Scheftz (pitcher, b. 1995, Ontario)
- 2018: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 2-Aug
- Ben Scheinbaum (pitcher, b. 1981)
- 2004: Staten Island Yankees, New York-Penn League (short-season) - 1 game 16-Jul g1
- Jake Scheiner (infielder, b. 1995, California)
- Barry Schell (outfielder, b. 1977, California)
- 1999: Utica Blue Sox, New York-Penn League (short-season) - 1 game 29-Jul
- Mike Schellinger (pitcher, b. 1982, New York)
- 2009: Sussex Skyhawks, Can-Am League (independent) - 1 game 11-Aug
- Jonathan Schemmel (infielder, b. 1983, Kansas)
- 2006: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 26-Jul 28-Jul
- Tom Schenbeck (pitcher, b. 1972, Texas)
- 1994: Stockton Ports, California League (High-A) - 1 game 2-Sep
- Tanner Scheppers (pitcher, b. 1987, California)
- 2011: Round Rock Express, Pacific Coast League (AAA) - 1 game 1-Sep
- 2015: Texas Rangers, Major League Baseball - 1 game 22-May
- Alex Scherff (pitcher, b. 1998, Texas)
- 2019: Greenville Drive, South Atlantic League (Low-A) - 1 game 12-Aug
- Max Scherzer (pitcher, b. 1984, Missouri)
- 2007: Mobile BayBears, Southern League (AA) - 1 game 17-Aug
- 2019: Washington Nationals, Major League Baseball - 1 game 18-Sep
- 2021: Los Angeles Dodgers, Major League Baseball - 1 game 18-Sep
- 2023: New York Mets, Major League Baseball - 1 game 7-Jun
- John Scheschuk (first baseman, b. 1977, Texas)
- 2001: Mobile BayBears, Southern League (AA) - 1 game 8-Aug
- Heath Schesser (infielder, b. 1976, Kansas)
- 1997: Jamestown Jammers, New York-Penn League (short-season) - 1 game 26-Jul
- Matt Scheuing (pitcher, b. 1981, Pennsylvania)
- 2004: Bangor Lumberjacks, Northeast League (independent) - 2 games 31-Jul 27-Aug
- 2005: Lancaster Barnstormers, Atlantic League (independent) - 2 games 12-Jun 10-Jul
- 2007: Atlantic City Surf, Can-Am League (independent) - 1 game 4-Jul
- Nate Schierholtz (outfielder, b. 1984, Nevada)
- 2004: San Jose Giants, California League (High-A) - 1 game 17-Aug
- 2006: Connecticut Defenders, Eastern League (AA) - 1 game 13-Apr
- 2009: San Francisco Giants, Major League Baseball - 1 game 21-Aug
- 2012: San Francisco Giants, Major League Baseball - 1 game 4-Jul
- 2012: Philadelphia Phillies, Major League Baseball - 1 game 17-Sep
- 2014: Chicago Cubs, Major League Baseball - 1 game 20-Jul
- Tony Schifano (infielder, b. 1974, California)
- 2000: Tennessee Smokies, Southern League (AA) - 1 game 1-Aug
- Wes Schill (utility, b. 1989, Texas)
- 2012: Auburn Doubledays, New York-Penn League (short-season) - 1 game 21-Jul
- Curt Schilling (pitcher, b. 1966, Alaska)
- 1996: Philadelphia Phillies, National League (MLB) - 1 game 21-Sep
- Garrett Schilling (pitcher, b. 1995, Michigan)
- 2017: Boise Hawks, Northwest League (short-season) - 1 game
- Micah Schilling (infielder, b. 1982, Louisiana)
- 2003: Lake County Captains, South Atlantic League (Low-A) - 1 game 1-Aug
- 2007: Brooklyn Cyclones, New York-Penn League (short-season) - 3 games 29-Aug 5-Sep 10-Sep
- Ryan Schimpf (infielder, b. 1988, Louisiana)
- 2011: Dunedin Blue Jays, Florida State League (High-A) - 1 game 10-Aug
- 2014: New Hampshire Fisher Cats, Eastern League (AA) - 1 game 3-Apr
- 2014: Buffalo Bisons, International League (AAA) - 1 game 17-Aug
- 2016: San Diego Padres, Major League Baseball - 3 games 13-Aug 28-Aug 1-Sep
- Tyler Schimpf (pitcher, b. 1995, California)
- 2019: Scottsdale Scorpions, Arizona Fall League - 2 games 14-Oct 19-Oct
- 2021: Eugene Emeralds, High-A West - 1 game 13-Jul
- Lukas Schiraldi (pitcher, b. 1993, Texas)
- 2015: Clinton LumberKings, Midwest League (Low-A) - 1 game 31-Aug
- Ike Schlabach (pitcher, b. 1996, Ohio)
- Braeden Schlehuber (catcher, b. 1988, Utah)
- 2009: Rome Braves, South Atlantic League (Low-A) - 1 game 3-Jul
- 2015: Mississippi Braves, Southern League (AA) - 1 game 26-Jul
- 2016: Gwinnett Braves, International League (AAA) - 2 games 1-Sep 14-Sep
- Jared Schlehuber (infielder, b. 1988, Colorado)
- Daniel Schlereth (pitcher, b. 1986, Alaska)
- 2010: Detroit Tigers, Major League Baseball - 1 game 17-Aug
- 2011: Detroit Tigers, Major League Baseball - 1 game 30-Sep
- 2019: Sugar Land Skeeters, Atlantic League (independent) - 1 game 14-Jul
- B.J. Schlicher (first baseman, b. 1977, Indiana)
- 1996: Martinsville Phillies, Appalachian League (rookie) - 1 game 27-Jul g2
- Fred Schlichtholz (pitcher, b. 1995, California)
- 2017: Tri-City Dust Devils, Northwest League (short-season) - 1 game 5-Aug
- 2021: Fort Wayne TinCaps, High-A Central - 1 game 18-Sep
- Brian Schlitter (pitcher, b. 1985, Illinois)
- 2019: Las Vegas Aviators, Pacific Coast League (AAA) - 1 game 2-Sep
- Craig Schlitter (pitcher, b. 1992, Connecticut)
- 2018: Hartford Yard Goats, Eastern League (AA) - 2 games 9-May 26-May g2
- Cam Schlittler (pitcher, b. 2001, Massachusetts)
- 2023: FCL Yankees, Florida Complex League (rookie) - 1 game 16-Jun
- Gus Schlosser (pitcher, b. 1988, Florida)
- 2011: Rome Braves, South Atlantic League (Low-A) - 1 game 6-Aug
- 2014: Atlanta Braves, Major League Baseball - 1 game 20-Apr
- 2015: Somerset Patriots, Atlantic League (independent) - 1 game 25-Sep
- Mark Schlosser (infielder, b. 1974, Saskatchewan)
- 2000: New Jersey Jackals, Northeast League (independent) - 1 game 4-Jul
- Alex Schmarzo (pitcher, b. 1989, Ohio)
- 2012: Delmarva Shorebirds, South Atlantic League (Low-A) - 1 game 21-Aug
- Jadd Schmeltzer (pitcher, b. 1988, New Jersey)
- 2014: Trois-Rivieres Aigles, Can-Am League (independent) - 1 game 26-Jul
- Alberto Schmidt (catcher, b. 1997, Puerto Rico)
- 2018: Lowell Spinners, New York-Penn League (short-season) - 1 game 31-Jul
- 2021: Schaumburg Boomers, Frontier League (independent) - 1 game 2-Jul
- Clarke Schmidt (pitcher, b. 1996, Georgia)
- 2019: Tampa Tarpons, Florida State League (High-A) - 1 game 16-Apr
- 2024: New York Yankees, Major League Baseball - 1 game 10-May
- Curt Schmidt (pitcher, b. 1970, Montana)
- 1995: Ottawa Lynx, International League (AAA) - 1 game 2-Sep
- 1998: Somerset Patriots, Atlantic League (independent) - 1 game 12-Jul
- Dave Schmidt (catcher, b. 1973, Washington)
- 1996: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 4-Jul
- David Schmidt (pitcher, b. 1993, Missouri)
- 2015: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 4-Aug
- Greg Schmidt (utility, b. 1977, New Jersey)
- 2002: Road Warriors, Atlantic League (independent) - 1 game 21-Jul
- J.P. Schmidt (utility, b. 1980, California)
- 2004: Aces, Northeast League (independent) - 1 game 9-Jul
- 2005: San Angelo Colts, Central League (independent) - 2 games 16-Aug 3-Sep
- Jacob Schmidt (pitcher, b. 1987, Minnesota)
- 2010: St. Paul Saints, American Association (independent) - 1 game 21-Aug
- Jarrod Schmidt (catcher/outfielder, b. 1980, District of Columbia)
- Jeff Schmidt (pitcher, b. 1971, Minnesota)
- 1994: Lake Elsinore Storm, California League (High-A) - 2 games 28-Aug 30-Aug
- Jeff Schmidt (infielder, b. 1985, California)
- 2003: Bristol Sox, Appalachian League (rookie) - 1 game 12-Jul
- Josh Schmidt (pitcher, b. 1982, California)
- 2005: Staten Island Yankees, New York-Penn League (short-season) - 2 games 5-Sep 15-Sep
- 2010: Trenton Thunder, Eastern League (AA) - 3 games 30-May 9-Sep 18-Sep
- Keith Schmidt (outfielder, b. 1971)
- 1992: Kane County Cougars, Midwest League (Low-A) - 1 game 11-Aug
- Konrad Schmidt (catcher, b. 1984, California)
- 2009: Visalia Rawhide, California League (High-A) - 1 game 27-Aug
- Kyle Schmidt (catcher/first base, b. 1997, Texas)
- Mike Schmidt (infielder, b. 1949, Ohio)
- 1981: Philadelphia Phillies, National League (MLB) - 1 game 14-Aug
- 1982: Philadelphia Phillies, National League (MLB) - 1 game 13-Apr
- 1983: Philadelphia Phillies, National League (MLB) - 1 game 5-Apr
- 1984: Philadelphia Phillies, National League (MLB) - 1 game 26-Sep
- Todd Schmidt (catcher, b. 1974, Missouri)
- 1998: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 30-Jul
- Tom Schmidt (infielder, b. 1973, Maryland)
- Tyler Schmidt (pitcher/outfielder, b. 1996, Michigan)
- 2020: Indy Windstorm, Liberation League (independent) - 1 game 22-Sep
- Zach Schmidt (infielder, b. 1981, Ohio)
- 2005: Florence Freedom, Frontier League (independent) - 1 game 29-Jul
- Billy Schmitt (infielder, b. 1982, Nevada)
- 2001: New Jersey Cardinals, New York-Penn League (short-season) - 2 games 19-Jul 26-Aug
- 2002: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 30-Aug g1
- 2003: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 19-Aug
- Brian Schmitt (first baseman, b. 1979, Texas)
- 2001: Lexington Legends, South Atlantic League (Low-A) - 1 game 2-Aug
- 2002: Lexington Legends, South Atlantic League (Low-A) - 1 game 14-Jul
- Casey Schmitt (infielder, b. 1999, California)
- 2022: Richmond Flying Squirrels, Eastern League (AA) - 1 game 1-Sep
- 2023: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 9-Aug
- 2024: San Francisco Giants, Major League Baseball - 1 game 18-Sep
- Eric Schmitt (pitcher, b. 1978, Virginia)
- 2000: Staten Island Yankees, New York-Penn League (short-season) - 1 game 9-Sep
- Todd Schmitt (pitcher, b. 1970, Michigan)
- 1994: Rancho Cucamonga Quakes, California League (High-A) - 1 game 29-Aug
- John Schmitz (outfielder, b. 1975)
- 2003: North Shore Spirit, Northeast League (independent) - 1 game 21-Jul
- 2006: Sioux Falls Canaries, American Association (independent) - 1 game 6-Aug
- Nick Schnabel (infielder, b. 1978, California)
- 2001: Vermont Expos, New York-Penn League (short-season) - 1 game 9-Jul
- Dave Schneck (outfielder, b. 1949, Pennsylvania)
- 1974: New York Mets, National League (MLB) - 1 game 10-Jul
- Brian Schneider (catcher, b. 1976, Florida)
- 1999: Harrisburg Senators, Eastern League (AA) - 2 games 10-Apr g1 6-Sep
- 2000: Montreal Expos, Major League Baseball - 2 games 11-Sep g1 11-Sep g2
- 2001: Montreal Expos, Major League Baseball - 1 game 5-Oct
- 2003: Montreal Expos, Major League Baseball - 1 game 6-Sep
- 2004: Montreal Expos, Major League Baseball - 1 game 2-Oct
- 2006: Washington Nationals, Major League Baseball - 1 game 22-Sep
- 2007: Washington Nationals, Major League Baseball - 2 games 23-Sep 26-Sep
- 2008: New York Mets, Major League Baseball - 5 games 6-Jul 8-Aug 22-Aug 25-Aug 10-Sep
- 2009: New York Mets, Major League Baseball - 2 games 19-Jun 18-Sep
- 2010: Philadelphia Phillies, Major League Baseball - 1 game 6-Sep day
- 2011: Philadelphia Phillies, Major League Baseball - 1 game 23-Jul
- Davis Schneider (utility, b. 1999, New Jersey)
- 2024: Toronto Blue Jays, Major League Baseball - 2 games 31-Mar 29-Sep
- John Schneider (catcher, b. 1980, New Jersey)
- 2003: Charleston Alley Cats, South Atlantic League (Low-A) - 1 game 6-May
- Matt Schneider (outfielder, b. 1978, Florida)
- 1999: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 30-Jul
- Gary Schneidmiller (infielder, b. 1980, California)
- 2007: Amarillo Dillas, United League (independent) - 2 games 10-Aug 13-Aug
- 2008: Amarillo Dillas, United League (independent) - 1 game 13-Aug
- Nick Schnell (outfielder, b. 2000, Indiana)
- 2022: Charleston RiverDogs, Carolina League (Low-A) - 1 game 22-Jun
- 2023: Bowling Green Hot Rods, South Atlantic League (High-A) - 1 game 21-Jun
- 2024: Montgomery Biscuits, Southern League (AA) - 1 game 18-Jun
- Aaron Schnurbusch (outfielder, b. 1994, Missouri)
- 2017: Kannapolis Intimidators, South Atlantic League (Low-A) - 2 games 15-Aug 24-Aug
- Tanner Schobel (infielder, b. 2001, Florida)
- 2022: Fort Myers Mighty Mussels, Florida State League (Low-A) - 1 game 13-Sep
- 2023: Cedar Rapids Kernels, Midwest League (High-A) - 1 game 25-Jun g2
- Alan Schoenberger (infielder, b. 1989, Australia)
- 2010: Lakewood BlueClaws, South Atlantic League (Low-A) - 2 games 11-Sep 17-Sep
- 2011: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 25-May
- Scott Schoeneweis (pitcher, b. 1973, New Jersey)
- 2007: New York Mets, Major League Baseball - 3 games 27-Aug 16-Sep 26-Sep
- 2008: New York Mets, Major League Baseball - 1 game 6-Jul
- Brent Schoening (pitcher, b. 1978, Louisiana; d. 2009, Texas)
- 2001: New Britain Rock Cats, Eastern League (AA) - 1 game 4-Jul g2
- Garrett Schoenle (pitcher, b. 1998, Indiana)
- 2023: Birmingham Barons, Southern League (AA) - 1 game 20-Apr
- Dick Schofield (infielder, b. 1962, Illinois)
- Jesse Scholtens (pitcher, b. 1994, California)
- 2019: Amarillo Sod Poodles, Texas League (AA) - 1 game 20-Jul
- 2023: Charlotte Knights, International League (AAA) - 1 game 9-May
- Jonathan Schoop (infielder, b. 1991, Curacao)
- 2012: Bowie Baysox, Eastern League (AA) - 1 game 1-Sep g1
- 2014: Baltimore Orioles, Major League Baseball - 3 games 18-Apr 10-Aug 22-Sep
- 2015: Baltimore Orioles, Major League Baseball - 1 game 8-Sep
- 2016: Baltimore Orioles, Major League Baseball - 2 games 20-Aug 1-Oct
- 2017: Baltimore Orioles, Major League Baseball - 1 game 24-Sep
- 2018: Baltimore Orioles, Major League Baseball - 1 game 13-May
- 2018: Milwaukee Brewers, Major League Baseball - 1 game 22-Sep
- 2022: Detroit Tigers, Major League Baseball - 1 game 16-May
- 2023: Detroit Tigers, Major League Baseball - 2 games 30-Mar 2-Apr
- Sharlon Schoop (infielder, b. 1987, Curacao)
- 2016: Norfolk Tides, International League (AAA) - 1 game 30-May
- Dustin Schorie (pitcher, b. 1999, Arizona)
- 2024: Grand Junction Jackalopes, Pioneer League (independent) - 1 game 16-Jul
- Steve Schorzman (pitcher, b. 1974, Idaho)
- 1998: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 29-Aug
- Pete Schourek (pitcher, b. 1969, Texas)
- Jake Schrader (first baseman, b. 1991, Texas)
- 2015: Carolina Mudcats, Carolina League (High-A) - 1 game 23-May
- Jesse Schrader (pitcher, b. 1979, Ohio)
- 2003: Florence Freedom, Frontier League (independent) - 1 game 4-Jul
- Tony Schrager (infielder, b. 1977, Nebraska)
- 1998: Rockford Cubbies, Midwest League (Low-A) - 1 game 19-Aug
- 2001: West Tenn Diamond Jaxx, Southern League (AA) - 1 game 4-Aug
- 2003: Portland Sea Dogs, Eastern League (AA) - 2 games 4-Aug 12-Aug
- RJ Schreck (outfielder, b. 2000, California)
- 2023: Modesto Nuts, California League (Low-A) - 1 game 10-Aug
- Troy Schreffler (outfielder, b. 2000, Pennsylvania)
- John Schreiber (pitcher, b. 1994, Michigan)
- 2017: West Michigan Whitecaps, Midwest League (Low-A) - 1 game 21-Aug
- 2018: Mesa Solar Sox, Arizona Fall League - 1 game 7-Nov
- Scott Schreiber (first base/outfield, b. 1995, Wisconsin)
- 2022: Surprise Saguaros, Arizona Fall League - 1 game 14-Oct
- Zach Schreiber (pitcher, b. 1982, Iowa)
- 2006: Mississippi Braves, Southern League (AA) - 1 game 2-Sep
- Eric Schreimann (catcher/outfielder, b. 1975, Missouri)
- 1995: Batavia Clippers, New York-Penn League (short-season) - 1 game 20-Aug
- Steve Schrenk (pitcher, b. 1968, Illinois)
- 1998: Pawtucket Red Sox, International League (AAA) - 1 game 1-Aug
- 1999: Philadelphia Phillies, National League (MLB) - 2 games 17-Sep 3-Oct
- 2000: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 23-Jul
- Max Schrock (infielder, b. 1994, Washington)
- 2016: Mesa Solar Sox, Arizona Fall League - 2 games 11-Oct 13-Oct
- 2018: Memphis Redbirds, Pacific Coast League (AAA) - 1 game 18-Sep
- 2021: Cincinnati Reds, Major League Baseball - 2 games 18-Sep 1-Oct
- Chris Schroder (pitcher, b. 1978, Oklahoma)
- 2001: Vermont Expos, New York-Penn League (short-season) - 1 game 9-Jul
- 2004: Edmonton Trappers, Pacific Coast League (AAA) - 1 game 15-Aug
- 2007: Washington Nationals, Major League Baseball - 1 game 26-Sep
- Myles Schroder (utility, b. 1987, California)
- 2018: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 15-Aug
- 2019: High Point Rockers, Atlantic League (independent) - 1 game 3-May
- Casey Schroeder (catcher, b. 1993, Ohio)
- 2017: Kannapolis Intimidators, South Atlantic League (Low-A) - 2 games 15-Aug 24-Aug
- Chad Schroeder (pitcher, b. 1973, Michigan)
- 1996: Jamestown Jammers, New York-Penn League (short-season) - 1 game 16-Aug
- James Schroeder (infielder, b. 1986, Texas)
- 2010: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 8-Sep 14-Sep
- Ryan Schroeder (pitcher, b. 1998, California)
- 2021: Wasco Reserve, Pecos League (independent) - 1 game 17-Jul
- Hunter Schryver (pitcher, b. 1995, Pennsylvania)
- 2017: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 9-Sep
- 2019: Birmingham Barons, Southern League (AA) - 1 game 29-May
- Rick Schu (infielder, b. 1962, Pennsylvania)
- 1984: Philadelphia Phillies, National League (MLB) - 1 game 26-Sep
- 1995: Oklahoma City 89ers, American Association (AAA) - 1 game 17-Aug
- Gunnar Schubert (infielder, b. 1996, Washington)
- 2019: Jupiter Hammerheads, Florida State League (High-A) - 1 game 22-Aug
- Justin Schuda (first baseman, b. 1981, California)
- 2001: Charleston RiverDogs, South Atlantic League (Low-A) - 2 games 6-Aug 10-Aug
- 2005: Windy City Thunderbolts, Frontier League (independent) - 1 game 29-Jul
- Jay Schueler (pitcher, b. 2001, Illinois)
- 2024: Dunedin Blue Jays, Florida State League (Low-A) - 2 games 22-Aug 25-Aug
- Max Schuemann (utility, b. 1997, Michigan)
- 2018: Vermont Lake Monsters, New York-Penn League (short-season) - 2 games 29-Jul 30-Jul
- 2023: Las Vegas Aviators, Pacific Coast League (AAA) - 1 game 9-Aug
- 2024: Oakland Athletics, Major League Baseball - 1 game 30-May
- Jonathan Schuerholz (infielder, b. 1980, Missouri)
- 2003: Rome Braves, South Atlantic League (Low-A) - 1 game 19-Jul
- A.J. Schugel (pitcher, b. 1989, Florida)
- 2010: Orem Owlz, Pioneer League (rookie) - 1 game 27-Aug
- Max Schuh (pitcher, b. 1992, California)
- 2019: Sioux City Explorers, American Association (independent) - 2 games 1-Jun 7-Jun
- Matt Schuldt (pitcher, b. 1975, South Dakota)
- 1999: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 11-Aug
- Austin Schulfer (pitcher, b. 1995, Wisconsin)
- 2023: St. Paul Saints, International League (AAA) - 1 game 29-Jun
- Jim Schult (pitcher, b. 1989)
- 2011: New York Federals, Can-Am League (independent) - 2 games 22-Jul 28-Jul
- John Schulte (utility, b. 1972)
- 1990: Welland Pirates, New York-Penn League (short-season) - 1 game 17-Aug
- Troy Schulte (pitcher, b. 1971)
- 1994: Auburn Astros, New York-Penn League (short-season) - 1 game 13-Aug
- Andrew Schultz (pitcher, b. 1997, Georgia)
- 2024: Clearwater Threshers, Florida State League (Low-A) - 1 game 26-Apr
- Austin Schultz (outfielder, b. 2000, Nebraska)
- Bo Schultz (pitcher, b. 1985, Texas)
- 2015: Toronto Blue Jays, Major League Baseball - 1 game 12-Sep g2
- Cory Schultz (pitcher, b. 1980, Iowa)
- 2003: Clearwater Phillies, Florida State League (High-A) - 1 game 31-Aug g1
- Jaime Schultz (pitcher, b. 1991, New York)
- 2013: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 14-Aug
- 2019: Oklahoma City Dodgers, Pacific Coast League (AAA) - 1 game 21-Jul
- John Schultz (outfielder, b. 1989, Pennsylvania)
- 2017: Evansville Otters, Frontier League (independent) - 1 game 31-Aug
- 2018: Sussex County Miners, Can-Am League (independent) - 1 game 12-Jun g1
- Nick Schulz (outfielder, b. 1991, California)
- 2019: Lincoln Saltdogs, American Association (independent) - 1 game 31-May
- Brett Schulze (pitcher, b. 1997, Minnesota)
- 2022: FCL Phillies, Florida Complex League (rookie) - 1 game 2-Jul
- 2022: Surprise Saguaros, Arizona Fall League - 1 game 14-Oct
- 2024: York Revolution, Atlantic League (independent) - 1 game 7-Aug
- Nick Schumacher (pitcher, b. 1985, California)
- 2009: Fort Wayne TinCaps, Midwest League (Low-A) - 1 game 28-Jul
- 2011: York Revolution, Atlantic League (independent) - 1 game 12-Sep
- Shawn Schumacher (catcher, b. 1976, Iowa)
- 2001: New Haven Ravens, Eastern League (AA) - 1 game 15-Jul
- Skip Schumaker (outfielder, b. 1980, California)
- 2001: New Jersey Cardinals, New York-Penn League (short-season) - 2 games 19-Jul 26-Aug
- 2014: Cincinnati Reds, Major League Baseball - 1 game 22-Aug
- Justin Schumer (pitcher, b. 1988, Texas)
- 2011: Augusta GreenJackets, South Atlantic League (Low-A) - 1 game 6-Aug
- Aaron Schunk (infielder, b. 1997, Georgia)
- 2019: Boise Hawks, Northwest League (short-season) - 1 game 5-Jul
- 2021: Spokane Indians, High-A West - 1 game 13-Jul
- Jerry Schunk (infielder, b. 1965, Ohio)
- 1990: Syracuse Chiefs, International League (AAA) - 1 game 18-Aug
- 1994: Portland Sea Dogs, Eastern League (AA) - 2 games 24-Jul 20-Aug
- 1995: Charlotte Knights, International League (AAA) - 1 game 5-Aug
- Ryan Schurman (pitcher, b. 1976, California)
- 2001: Camden Riversharks, Atlantic League (independent) - 2 games 13-May 7-Sep
- 2003: Camden Riversharks, Atlantic League (independent) - 2 games 28-May 20-Aug
- 2005: Atlantic City Surf, Atlantic League (independent) - 1 game 27-Sep
- 2006: Atlantic City Surf, Atlantic League (independent) - 2 games 15-Jul 1-Aug
- 2007: Camden Riversharks, Atlantic League (independent) - 1 game 3-Jul
- Patrick Schuster (pitcher, b. 1990, Florida)
- 2016: Philadelphia Phillies, Major League Baseball - 1 game 25-Sep
- Doug Schutt (outfielder, b. 1979)
- 2005: Windy City Thunderbolts, Frontier League (independent) - 1 game 29-Jul
- Drew Schutt (utility, b. 1996, Alabama)
- 2020: Baseball Resume Bandits, Liberation League (independent) - 1 game 22-Sep
- Jason Schutt (pitcher, b. 1983, North Dakota)
- 2008: Quebec Les Capitales, Can-Am League (independent) - 1 game 20-Aug
- 2009: Quebec Les Capitales, Can-Am League (independent) - 1 game 7-Aug
- Andy Schutzenhofer (first baseman, b. 1981, Illinois)
- 2003: Palm Beach Cardinals, Florida State League (High-A) - 2 games 28-Aug 29-Aug
- Chris Schwab (first base/outfield, b. 1974, Minnesota)
- 1996: Delmarva Shorebirds, South Atlantic League (Low-A) - 1 game 25-Jul
- 1998: Harrisburg Senators, Eastern League (AA) - 1 game 17-Sep
- Davis Schwab (pitcher, b. 1997, Kansas)
- 2019: GCL Braves, Gulf Coast League (rookie) - 1 game 5-Aug g2
- Matt Schwager (pitcher, b. 1977, Nebraska)
- 2003: Somerset Patriots, Atlantic League (independent) - 1 game 14-Aug
- 2004: Somerset Patriots, Atlantic League (independent) - 2 games 19-Jun g1 28-Jul
- Nick Schwaner (utility, b. 1988, Louisiana)
- 2010: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 5-Sep
- Kyle Schwarber (outfielder, b. 1993, Ohio)
- 2018: Chicago Cubs, Major League Baseball - 2 games 30-Mar 4-Aug
- 2021: Washington Nationals, Major League Baseball - 1 game 28-Apr
- 2021: Boston Red Sox, Major League Baseball - 3 games 30-Aug 1-Sep 29-Sep
- 2022: Philadelphia Phillies, Major League Baseball - 1 game 25-Sep
- 2024: Philadelphia Phillies, Major League Baseball - 2 games 19-Sep 23-Sep
- Blake Schwartz (pitcher, b. 1989, Minnesota)
- 2012: Hagerstown Suns, South Atlantic League (Low-A) - 1 game 9-Aug
- Garrison Schwartz (outfielder, b. 1996, Arizona)
- 2017: Danville Braves, Appalachian League (rookie) - 1 game 28-Aug
- 2019: Florida Fire Frogs, Florida State League (High-A) - 3 games 8-May 17-Aug g1 17-Aug g2
- 2019: Scottsdale Scorpions, Arizona Fall League - 1 game 19-Oct
- Josh Schwartz (pitcher, b. 1982, New Jersey)
- 2006: New Jersey Jackals, Can-Am League (independent) - 1 game 3-Jun g2
- JT Schwartz (first baseman, b. 1999, California)
- 2021: St. Lucie Mets, Low-A Southeast - 2 games 13-Aug 14-Aug g1
- 2022: Brooklyn Cyclones, South Atlantic League (High-A) - 2 games 8-May g1 8-May g2
- 2023: Binghamton Rumble Ponies, Eastern League (AA) - 1 game 26-Sep
- 2023: Glendale Desert Dogs, Arizona Fall League - 1 game 12-Oct
- Mike Schwartz (outfielder, b. 1987, New Jersey)
- 2015: Ottawa Champions, Can-Am League (independent) - 2 games 19-Jun 15-Aug
- 2016: Trois-Rivieres Aigles, Can-Am League (independent) - 1 game 9-Aug
- Nick Schwartz (catcher, b. 2001, New York)
- 2023: Las Vegas Aviators, Pacific Coast League (AAA) - 1 game 9-Aug
- Dan Schwartzbauer (infielder, b. 1981, Pennsylvania)
- 2005: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 30-Jul
- JJ Schwarz (catcher/first base, b. 1996, Florida)
- 2023: Las Vegas Aviators, Pacific Coast League (AAA) - 1 game 9-Aug
- Brian Schweiger (catcher/first base, b. 1982, California)
- 2004: Everett Aquasox, Northwest League (short-season) - 1 game 14-Aug
- Jared Schweitzer (infielder, b. 1983, Alberta)
- 2006: State College Spikes, New York-Penn League (short-season) - 1 game 4-Jul
- Matt Schweitzer (pitcher, b. 1978, Illinois)
- 2002: Richmond Roosters, Frontier League (independent) - 1 game 27-Jul
- 2003: Richmond Roosters, Frontier League (independent) - 1 game 26-Jul
- 2006: Schaumburg Flyers, Northern League (independent) - 1 game 5-Aug
- 2009: Southern Maryland Blue Crabs, Atlantic League (independent) - 1 game 1-Oct
- Scott Schweitzer (pitcher, b. 1980, Kentucky)
- 2002: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 30-Aug g2
- Matt Schwenke (catcher, b. 1972, Illinois; d. 2009, California)
- 1994: Bakersfield Dodgers, California League (High-A) - 1 game 2-Sep
- Frank Schwindel (catcher/first base, b. 1992, New Jersey)
- 2015: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 23-May
- 2018: Omaha Storm Chasers, Pacific Coast League (AAA) - 1 game 7-Aug
- Chris Schwinden (pitcher, b. 1986, California)
- 2011: New York Mets, Major League Baseball - 2 games 8-Sep g1 26-Sep
- 2012: Buffalo Bisons, International League (AAA) - 1 game 27-May
- 2014: Lancaster Barnstormers, Atlantic League (independent) - 1 game 28-Sep
- Michael Scimanico (pitcher, b. 1993)
- 2019: Milwaukee Milkmen, American Association (independent) - 1 game 31-May
- Nick Sciortino (catcher, b. 1995, New Jersey)
- 2017: Lowell Spinners, New York-Penn League (short-season) - 1 game 22-Jul
- Kade Scivicque (catcher, b. 1993, Louisiana)
- 2015: West Michigan Whitecaps, Midwest League (Low-A) - 1 game 26-Aug
- 2016: Salt River Rafters, Arizona Fall League - 1 game 14-Oct
- Anthony Sclafani (pitcher, b. 1981, New York)
- 2001: Augusta Greenjackets, South Atlantic League (Low-A) - 1 game 7-Aug
- Joe Sclafani (infielder, b. 1990, California)
- Jason Scobie (pitcher, b. 1979, Ohio)
- 2004: Binghamton Mets, Eastern League (AA) - 1 game 3-Aug g1
- Clark Scolamiero (outfielder, b. 1996, South Carolina)
- 2018: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 2-Aug
- Don Scolaro (infielder, b. 1972)
- 1994: Auburn Astros, New York-Penn League (short-season) - 1 game 13-Aug
- Ryan Scoma (first base/outfield, b. 1987, California)
- Alan Scott (pitcher, b. 1990)
- 2014: Raton Osos, Pecos League (independent) - 1 game 22-Jul
- Braden Scott (pitcher, b. 1998, Indiana)
- 2022: Dunedin Blue Jays, Florida State League (Low-A) - 1 game 3-Jun
- Brian Scott (pitcher, b. 1976, California)
- 1998: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 29-Aug
- Christian Scott (pitcher, b. 1999, Florida)
- 2022: Peoria Javelinas, Arizona Fall League - 1 game 12-Oct
- 2023: Binghamton Rumble Ponies, Eastern League (AA) - 1 game 26-Sep
- 2024: New York Mets, Major League Baseball - 1 game 4-May
- Connor Scott (outfielder, b. 1999, Florida)
- 2019: Jupiter Hammerheads, Florida State League (High-A) - 1 game 22-Aug
- Cory Scott (pitcher, b. 1977, North Carolina)
- 2001: Albany-Colonie Diamond Dogs, Northeast League (independent) - 1 game 1-Sep
- Eddie Scott (outfielder, b. 1979, Louisiana)
- 2002: Albany-Colonie Diamond Dogs, Northeast League (independent) - 1 game 1-Sep
- Kevin Scott (catcher/infielder, b. 1967)
- 1993: Jackson Generals, Texas League (AA) - 2 games 14-Aug 16-Aug
- Lorenzo Scott (outfielder, b. 1982, Missouri)
- 2005: Aberdeen IronBirds, New York-Penn League (short-season) - 1 game 7-Sep
- Luke Scott (outfielder, b. 1978, Florida)
- 2003: Akron Aeros, Eastern League (AA) - 1 game 10-Sep
- 2009: Baltimore Orioles, Major League Baseball - 2 games 23-Apr 4-Oct
- 2015: Buffalo Bisons, International League (AAA) - 1 game 5-Jul
- Mike Scott (pitcher, b. 1955, California)
- 1981: New York Mets, National League (MLB) - 1 game 14-Aug
- Robby Scott (pitcher, b. 1989, Florida)
- 2014: Surprise Saguaros, Arizona Fall League - 1 game 9-Oct
- Ron Scott (pitcher, b. 1971, Pennsylvania)
- 2000: Aberdeen Arsenal, Atlantic League (independent) - 2 games 6-Jul 14-Sep
- Ryan Scott (outfielder, b. 1993, Arkansas)
- 2016: Lowell Spinners, New York-Penn League (short-season) - 1 game 8-Aug
- 2017: Greenville Drive, South Atlantic League (Low-A) - 1 game 23-Aug
- Stephen Scott (catcher, b. 1997, North Carolina)
- 2022: Scottsdale Scorpions, Arizona Fall League - 1 game 15-Oct
- Tanner Scott (pitcher, b. 1994, Ohio)
- 2016: Peoria Javelinas, Arizona Fall League - 1 game 11-Oct
- 2019: Norfolk Tides, International League (AAA) - 1 game 27-May
- 2022: Miami Marlins, Major League Baseball - 1 game 16-Apr
- 2023: Miami Marlins, Major League Baseball - 2 games 30-Aug 29-Sep
- 2024: Miami Marlins, Major League Baseball - 1 game 4-Jun
- 2024: San Diego Padres, Major League Baseball - 2 games 30-Aug 1-Sep
- Tayler Scott (pitcher, b. 1992, South Africa)
- 2016: Salt River Rafters, Arizona Fall League - 1 game 13-Oct
- 2023: Las Vegas Aviators, Pacific Coast League (AAA) - 1 game 9-Aug
- 2024: Houston Astros, Major League Baseball - 1 game 12-Aug
- Tim Scott (pitcher, b. 1966, California)
- 1992: San Diego Padres, National League (MLB) - 1 game 20-Aug
- 1993: Montreal Expos, National League (MLB) - 2 games 19-Sep 24-Sep
- Tom Scott (outfielder, b. 1973, Oregon)
- 1995: Billings Mustangs, Pioneer League (rookie) - 1 game 10-Aug
- Travis Scott (catcher, b. 1985, Wisconsin)
- 2013: Sugar Land Skeeters, Atlantic League (independent) - 1 game 20-Sep
- 2016: Sugar Land Skeeters, Atlantic League (independent) - 1 game 6-Sep
- Victor Scott (outfielder, b. 2001, Georgia)
- 2022: Palm Beach Cardinals, Florida State League (Low-A) - 3 games 10-Aug 8-Sep 9-Sep
- 2023: Peoria Chiefs, Midwest League (High-A) - 1 game 24-Jun
- 2023: Scottsdale Scorpions, Arizona Fall League - 2 games 11-Oct 12-Oct
- 2024: St. Louis Cardinals, Major League Baseball - 1 game 5-Aug
- Deik Scram (outfielder, b. 1984, Kansas)
- 2008: Erie SeaWolves, Eastern League (AA) - 2 games 4-Jul 31-Aug
- Evan Scribner (pitcher, b. 1985, Connecticut)
- 2012: Oakland Athletics, Major League Baseball - 1 game 22-Sep
- 2018: New Britain Bees, Atlantic League (independent) - 2 games 10-Jun 16-Jun
- Mike Scripture (catcher, b. 1985)
- 2008: Rockford RiverHawks, Frontier League (independent) - 1 game 16-Aug
- Andre Scrubb (pitcher, b. 1995, Virginia)
- 2018: Glendale Desert Dogs, Arizona Fall League - 2 games 5-Nov 7-Nov
- Xavier Scruggs (first baseman, b. 1987, California)
- 2008: Batavia Muckdogs, New York-Penn League (short-season) - 1 game 16-Jul
- 2016: Miami Marlins, Major League Baseball - 1 game 28-Aug
- Jake Scudder (infielder, b. 1995, Illinois)
- 2017: Auburn Doubledays, New York-Penn League (short-season) - 1 game 4-Sep
- 2018: Hagerstown Suns, South Atlantic League (Low-A) - 2 games 23-May 4-Jul
- Mike Scuglik (pitcher, b. 1977, Wisconsin)
- 2001: Savannah Sand Gnats, South Atlantic League (Low-A) - 1 game 10-Aug
- Chris Scura (outfielder, b. 1993, New York)
- 2019: Alpine Cowboys, Pecos League (independent) - 1 game 13-Jul
- Marco Scutaro (infielder, b. 1975, Venezuela)
- 2002: New York Mets, Major League Baseball - 3 games 3-Sep g1 3-Sep g2 29-Sep
- 2005: Oakland Athletics, Major League Baseball - 1 game 7-Aug
- 2008: Toronto Blue Jays, Major League Baseball - 1 game 29-Aug
- 2013: San Francisco Giants, Major League Baseball - 2 games 31-Jul 28-Aug
- Ajay Sczepkowski (outfielder, b. 1998, Pennsylvania)
- 2024: Glacier Range Riders, Pioneer League (independent) - 2 games 6-Jul 7-Jul
- Scott Seabol (infielder, b. 1975, Pennsylvania)
- 1996: Oneonta Yankees, New York-Penn League (short-season) - 1 game 17-Aug
- 1997: Greensboro Bats, South Atlantic League (Low-A) - 1 game 15-Aug
- 1998: Greensboro Bats, South Atlantic League (Low-A) - 1 game 29-Aug
- 2004: Memphis Redbirds, Pacific Coast League (AAA) - 1 game 9-Aug
- Corey Seager (infielder, b. 1994, North Carolina)
- 2016: Los Angeles Dodgers, Major League Baseball - 1 game 13-Sep
- 2019: Los Angeles Dodgers, Major League Baseball - 1 game 21-May
- 2020: Los Angeles Dodgers, Major League Baseball - 1 game 13-Oct
- 2021: Los Angeles Dodgers, Major League Baseball - 1 game 18-Sep
- 2022: Texas Rangers, Major League Baseball - 1 game 16-Sep
- 2023: Texas Rangers, Major League Baseball - 4 games 5-Jun 10-Jun 7-Aug 11-Aug
- 2024: Texas Rangers, Major League Baseball - 2 games 1-Apr 3-Apr
- Justin Seager (infielder, b. 1992, North Carolina)
- 2013: Everett AquaSox, Northwest League (short-season) - 1 game 21-Aug
- Kyle Seager (infielder, b. 1987, North Carolina)
- 2013: Seattle Mariners, Major League Baseball - 1 game 23-Aug
- 2014: Seattle Mariners, Major League Baseball - 1 game 18-Aug
- 2017: Seattle Mariners, Major League Baseball - 1 game 22-Aug
- 2018: Seattle Mariners, Major League Baseball - 1 game 21-Jun
- 2019: Seattle Mariners, Major League Baseball - 1 game 19-Aug
- 2021: Seattle Mariners, Major League Baseball - 4 games 18-Jul 2-Aug 3-Aug 4-Aug
- Chandler Seagle (catcher, b. 1996, North Carolina)
- 2017: Tri-City Dust Devils, Northwest League (short-season) - 1 game 5-Aug
- 2021: Peoria Javelinas, Arizona Fall League - 1 game 19-Oct
- Ray Searage (pitcher, b. 1955, New York)
- 1981: New York Mets, National League (MLB) - 1 game 14-Aug
- Ryan Searage (outfielder, b. 1982, New York)
- 2005: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 23-Jun
- Steve Searcy (pitcher, b. 1964, Tennessee)
- 1990: Detroit Tigers, American League (MLB) - 1 game 15-Aug
- Ryan Searle (pitcher, b. 1989, Australia)
- 2011: Tennessee Smokies, Southern League (AA) - 1 game 12-Aug
- Jon Searles (pitcher, b. 1981, New York)
- 2003: Brevard County Manatees, Florida State League (High-A) - 2 games 24-Aug g1 29-Aug
- Andrew Sears (pitcher, b. 2002, Rhode Island)
- Todd Sears (first baseman, b. 1975, Iowa)
- 1999: Salem Avalanche, Carolina League (High-A) - 1 game 9-Aug
- 2002: Edmonton Trappers, Pacific Coast League (AAA) - 1 game 7-Aug
- 2003: Rochester Red Wings, International League (AAA) - 1 game 15-Aug
- Ross Seaton (pitcher, b. 1989, Oklahoma)
- 2017: Bridgeport Bluefish, Atlantic League (independent) - 1 game 17-Sep
- Mark Seaver (pitcher, b. 1975, Pennsylvania)
- 2001: Camden Riversharks, Atlantic League (independent) - 1 game 13-May
- 2001: Lehigh Valley Black Diamonds, Atlantic League (independent) - 2 games 15-Aug 30-Aug g1
- Tom Seaver (pitcher, b. 1944, California; d. 2020, California)
- 1969: New York Mets, National League (MLB) - 1 game 29-Jun
- 1983: New York Mets, National League (MLB) - 1 game 5-Apr
- Bobby Seay (pitcher, b. 1978, Florida)
- 2000: Orlando Rays, Southern League (AA) - 1 game 1-Aug
- Jason Secoda (pitcher, b. 1974, California)
- 2002: Calgary Cannons, Pacific Coast League (AAA) - 1 game 7-Aug
- Kelly Secrest (pitcher, b. 1991, North Carolina)
- 2014: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 13-Aug g2
- 2016: St. Lucie Mets, Florida State League (High-A) - 1 game 26-Aug
- Reed Secrist (utility, b. 1970, Utah)
- 1994: Salem Buccaneers, Carolina League (High-A) - 1 game 7-Aug
- Chad Sedio (utility, b. 1994, Ohio)
- 2017: West Michigan Whitecaps, Midwest League (Low-A) - 1 game 21-Aug
- 2019: Lakeland Flying Tigers, Florida State League (High-A) - 3 games 23-Apr 30-Jul 7-Aug
- 2021: Florence Y'alls, Frontier League (independent) - 1 game 7-Aug
- Colt Sedbrook (infielder, b. 1985, Colorado)
- 2008: Batavia Muckdogs, New York-Penn League (short-season) - 1 game 16-Jul
- Chris Seddon (pitcher, b. 1983, California)
- 2004: Montgomery Biscuits, Southern League (AA) - 1 game 4-Jul
- Shawn Sedlacek (pitcher, b. 1977, Iowa)
- 2003: Wichita Wranglers, Texas League (AA) - 1 game 8-Aug
- Andrew See (outfielder, then pitcher, b. 1979, Michigan)
- 2003: Chillicothe Paints, Frontier League (independent) - 1 game 28-Jul
- Tate Seefried (first baseman, b. 1972, Washington)
- 1995: Norwich Navigators, Eastern League (AA) - 1 game 2-Jul
- 1997: Binghamton Mets, Eastern League (AA) - 1 game 20-Jul
- Matt Seelinger (pitcher, b. 1995, New York)
- 2018: Bowling Green Hot Rods, Midwest League (Low-A) - 1 game 27-Aug
- Joseph Seestadt (catcher/outfield, b. 1978)
- 2001: Kalamazoo Kings, Frontier League (independent) - 1 game 7-Jul
- Mike Seestedt (catcher, b. 1977, Michigan)
- 2001: Delmarva Shorebirds, South Atlantic League (Low-A) - 1 game 7-May
- 2003: Bowie Baysox, Eastern League (AA) - 1 game 6-Jul night
- Brian Seever (outfielder, b. 1976, California)
- 2000: Cedar Rapids Kernels, Midwest League (Low-A) - 1 game 13-Aug
- Kevin Sefcik (utility, b. 1971, Illinois)
- 1995: Reading Phillies, Eastern League (AA) - 1 game 21-Jul
- 1996: Philadelphia Phillies, National League (MLB) - 3 games 21-Sep 28-Sep 29-Sep
- 1997: Philadelphia Phillies, National League (MLB) - 2 games 15-Sep g2 27-Sep
- 1998: Philadelphia Phillies, National League (MLB) - 2 games 13-Sep 20-Sep
- 1999: Philadelphia Phillies, National League (MLB) - 3 games 17-Sep 26-Sep 3-Oct
- 2000: Philadelphia Phillies, Major League Baseball - 2 games 11-Sep g1 11-Sep g2
- 2001: Buffalo Bisons, International League (AAA) - 1 game 8-Jul
- 2002: Altoona Curve, Eastern League (AA) - 1 game 8-May
- 2003: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 15-Aug
- Darren Seferina (infielder, b. 1994, Curacao)
- 2014: State College Spikes, New York-Penn League (short-season) - 1 game 2-Aug
- 2015: Peoria Chiefs, Midwest League (Low-A) - 1 game 4-Sep
- 2017: Palm Beach Cardinals, Florida State League (High-A) - 1 game 27-May
- Alex Segal (pitcher, b. 1998, Arizona)
- 2022: Scottsdale Scorpions, Arizona Fall League - 1 game 15-Oct
- Jeff Segar (first base/outfield, b. 1978, New York)
- 2001: Staten Island Yankees, New York-Penn League (short-season) - 1 game 6-Jul
- 2002: Greensboro Bats, South Atlantic League (Low-A) - 2 games 24-Jun 14-Jul
- Rob Segedin (infielder, b. 1988, New Jersey)
- 2012: Trenton Thunder, Eastern League (AA) - 2 games 4-Jul 15-Sep
- 2014: Trenton Thunder, Eastern League (AA) - 1 game 3-Apr
- 2016: Los Angeles Dodgers, Major League Baseball - 1 game 13-Sep
- Alejandro Segovia (first baseman, b. 1990, Venezuela)
- 2017: Evansville Otters, Frontier League (independent) - 1 game 31-Aug
- Eduar Segovia (pitcher, b. 2001, Venezuela)
- Gregori Segovia (pitcher, b. 2000, Venezuela)
- 2021: FCL Red Sox, Florida Complex League (rookie) - 1 game 23-Aug g1
- Joantgel Segovia (outfielder, b. 1996, Venezuela)
- 2018: Carolina Mudcats, Carolina League (High-A) - 1 game 2-Sep
- 2019: Biloxi Shuckers, Southern League (AA) - 2 games 10-Sep 11-Sep
- Luis Segovia (infielder, b. 1986, Venezuela)
- 2006: Lowell Spinners, New York-Penn League (short-season) - 1 game 13-Aug
- Rolando Segovia (infielder, b. 1994, Venezuela)
- 2014: Bluefield Blue Jays, Appalachian League (rookie) - 1 game 19-Aug
- Zack Segovia (pitcher, b. 1983, Texas)
- 2009: Washington Nationals, Major League Baseball - 1 game 20-Sep
- 2013: York Revolution, Atlantic League (independent) - 1 game 4-Sep
- David Segui (first base/outfield, b. 1966, Kansas)
- 1991: Baltimore Orioles, American League (MLB) - 1 game 15-Sep
- 1994: New York Mets, National League (MLB) - 3 games 15-Apr 16-Apr 17-Jul
- 1995: Montreal Expos, National League (MLB) - 1 game 10-Sep
- 1996: Montreal Expos, National League (MLB) - 1 game 28-Jun
- 1997: Montreal Expos, National League (MLB) - 2 games 13-Sep 14-Sep
- 2005: Kansas City T-bones, Northern League (independent) - 1 game 11-Aug
- Fernando Seguignol (first base/outfield, b. 1975, Panama)
- 1994: Oneonta Yankees, New York-Penn League (short-season) - 2 games 26-Jun 13-Aug
- 1998: Montreal Expos, National League (MLB) - 2 games 20-Sep 23-Sep
- 1999: Montreal Expos, National League (MLB) - 1 game 3-Oct
- 2000: Montreal Expos, Major League Baseball - 1 game 11-Sep g2
- Enrique Segura (pitcher, b. 2004, Dominican Republic)
- Jean Segura (infielder, b. 1990, Dominican Republic)
- 2013: Milwaukee Brewers, Major League Baseball - 1 game 17-Aug
- 2015: Milwaukee Brewers, Major League Baseball - 2 games 23-Aug 25-Aug
- 2016: Arizona Diamondbacks, Major League Baseball - 1 game 10-Aug
- 2017: Seattle Mariners, Major League Baseball - 1 game 22-Aug
- 2019: Philadelphia Phillies, Major League Baseball - 1 game 26-Sep
- 2021: Philadelphia Phillies, Major League Baseball - 4 games 15-May 29-May 9-Sep 28-Sep
- 2022: Philadelphia Phillies, Major League Baseball - 1 game 25-Sep
- 2023: Miami Marlins, Major League Baseball - 2 games 4-Apr 25-Jul
- Phil Seibel (pitcher, b. 1979, Kentucky)
- 2002: Binghamton Mets, Eastern League (AA) - 1 game 4-Jul
- Antron Seiber (outfielder, b. 1980, Louisiana)
- 2001: Augusta Greenjackets, South Atlantic League (Low-A) - 1 game 7-Aug
- 2002: Augusta Greenjackets, South Atlantic League (Low-A) - 1 game 24-Aug
- Kevin Seibert (pitcher, b. 1979, Texas)
- 2004: Coastal Bend Aviators, Central League (independent) - 1 game 3-Jul
- Mac Seibert (infielder, b. 1993, Florida)
- 2016: GCL Rays, Gulf Coast League (rookie) - 1 game 26-Aug
- R.J. Seidel (pitcher, b. 1987, Wisconsin)
- 2009: Wisconsin Timber Rattlers, Midwest League (Low-A) - 1 game 29-Jul
- 2013: Nashville Sounds, Pacific Coast League (AAA) - 1 game 23-Jul
- Ryan Seidel (outfielder, b. 1973, California)
- 1995: Williamsport Cubs, New York-Penn League (short-season) - 3 games 25-Jun 16-Jul 20-Aug
- Trevor Seidenberger (pitcher, b. 1992, Texas)
- 2013: Helena Brewers, Pioneer League (rookie) - 1 game 27-Aug
- Billy Seidl (pitcher, b. 1999, Massachusetts)
- 2024: Kannapolis Cannon Ballers, Carolina League (Low-A) - 1 game 12-May
- 2024: Winston-Salem Dash, South Atlantic League (High-A) - 1 game 9-Aug
- Mike Seifert (pitcher, b. 1981, Ohio)
- 2002: Medicine Hat Blue Jays, Pioneer League (rookie) - 1 game 6-Aug
- Cole Seifrig (infielder, b. 1984, Indiana)
- 2005: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 9-Jul
- Richard Seigel (first base/outfield, b. 1991, California)
- 2015: Gateway Grizzlies, Frontier League (independent) - 1 game 30-Aug
- 2016: Florence Freedom, Frontier League (independent) - 1 game 3-Jul
- Anthony Seigler (catcher, b. 1999, Arizona)
- Javier Sein (first baseman, b. 1978, Puerto Rico)
- 2002: Road Warriors, Atlantic League (independent) - 1 game 21-Jul
- 2003: Road Warriors, Atlantic League (independent) - 2 games 12-Sep g2 14-Sep
- Zach Seipel (pitcher, b. 1996, Minnesota)
- 2019: GCL Braves, Gulf Coast League (rookie) - 1 game 21-Aug g2
- Christopher Seise (infielder, b. 1999, New York)
- 2022: Santurce Cangrejeros, Liga Clemente (winter) - 1 game 3-Dec
- Jerry Seitz (catcher, b. 1994, Venezuela)
- 2016: Staten Island Yankees, New York-Penn League (short-season) - 1 game 8-Aug
- 2018: Staten Island Yankees, New York-Penn League (short-season) - 2 games 15-Jun 1-Jul
- 2018: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 30-Aug
- Brad Seitzer (infielder, b. 1970, Illinois)
- 1993: Frederick Keys, Carolina League (High-A) - 1 game 8-Aug
- 1999: Tacoma Rainiers, Pacific Coast League (AAA) - 1 game 21-Aug
- Kevin Seitzer (infielder, b. 1962, Illinois)
- 1992: Milwaukee Brewers, American League (MLB) - 2 games 14-Aug g1 14-Aug g2
- 1996: Milwaukee Brewers, American League (MLB) - 1 game 4-Jul
- 1997: Cleveland Indians, American League (MLB) - 1 game 27-Aug
- Jason Sekany (pitcher, b. 1975, California)
- 1999: Trenton Thunder, Eastern League (AA) - 1 game 13-Sep
- 2000: Chattanooga Lookouts, Southern League (AA) - 1 game 1-Aug
- 2001: Pawtucket Red Sox, International League (AAA) - 1 game 13-Jul
- 2001: Trenton Thunder, Eastern League (AA) - 1 game 22-Jul
- Craig Selander (outfielder, b. 1976, Minnesota)
- 1999: Quad City River Bandits, Midwest League (Low-A) - 1 game 4-Sep
- Bill Selby (infielder, b. 1970, Alabama)
- 1992: Elmira Pioneers, New York-Penn League (short-season) - 1 game 9-Aug g2
- 1994: New Britain Red Sox, Eastern League (AA) - 2 games 21-Aug g1 21-Aug g2
- 1995: Trenton Thunder, Eastern League (AA) - 2 games 3-Jul 19-Aug
- 2001: Louisville RiverBats, International League (AAA) - 1 game 1-Aug
- Colin Selby (pitcher, b. 1997, Virginia)
- 2021: Greensboro Grasshoppers, High-A East - 1 game 1-Jul
- 2022: Surprise Saguaros, Arizona Fall League - 1 game 15-Oct
- 2023: Pittsburgh Pirates, Major League Baseball - 2 games 27-Sep 29-Sep
- Aaron Sele (pitcher, b. 1970, Minnesota)
- 1993: Boston Red Sox, American League (MLB) - 2 games 11-Sep 17-Sep
- 1996: Boston Red Sox, American League (MLB) - 2 games 3-Aug day 22-Sep
- 1997: Boston Red Sox, American League (MLB) - 2 games 27-Jul 16-Sep g1
- 1998: Texas Rangers, American League (MLB) - 1 game 24-Aug
- 2007: New York Mets, Major League Baseball - 2 games 27-Aug 11-Sep
- Alejandro Selen (utility, b. 1989, Dominican Republic)
- 2012: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 11-Jul
- Tyler Selesky (outfielder, b. 1993, Georgia)
- 2017: Fort Wayne TinCaps, Midwest League (Low-A) - 1 game 19-Aug
- Derek Self (pitcher, b. 1990, Kentucky)
- 2014: Potomac Nationals, Carolina League (High-A) - 1 game 24-May
- 2014: Harrisburg Senators, Eastern League (AA) - 1 game 3-Aug
- 2021: Lexington Legends, Atlantic League (independent) - 1 game 19-Sep
- Todd Self (outfielder, b. 1978, Louisiana)
- 2001: Pittsfield Astros, New York-Penn League (short-season) - 2 games 19-Jul 26-Aug
- 2007: Corpus Christi Hooks, Texas League (AA) - 1 game 8-Aug
- Chip Sell (outfielder, b. 1971, California)
- 1994: Yakima Bears, Northwest League (short-season) - 1 game 8-Sep
- Jeff Sellers (pitcher, b. 1964, California)
- 1994: Central Valley Rockies, California League (High-A) - 1 game 3-Sep
- Justin Sellers (infielder, b. 1986, California)
- 2013: Albuquerque Isotopes, Pacific Coast League (AAA) - 1 game 23-Jul
- Neil Sellers (infielder, b. 1982, Kentucky)
- 2005: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 17-Jul
- 2006: Salem Avalanche, Carolina League (High-A) - 1 game 14-Apr
- 2008: Reading Phillies, Eastern League (AA) - 2 games 4-Aug 1-Sep
- 2009: Reading Phillies, Eastern League (AA) - 1 game 11-Apr
- 2010: Lehigh Valley IronPigs, International League (AAA) - 1 game 29-Jul
- 2011: Jacksonville Suns, Southern League (AA) - 1 game 7-Aug
- Rick Sellers (catcher, b. 1967, Michigan)
- Brian Sellier (outfielder, b. 1978, Arizona)
- 2000: Queens Kings, New York-Penn League (short-season) - 2 games 26-Aug 9-Sep
- Dick Selma (pitcher, b. 1943, California; d. 2001, California)
- 1968: New York Mets, National League (MLB) - 2 games 16-Jun 15-Sep
- Sam Selman (pitcher, b. 1990, Texas)
- 2014: Peoria Javelinas, Arizona Fall League - 1 game 10-Oct
- Ryan Selmer (pitcher, b. 1994, Maryland)
- 2018: Brooklyn Cyclones, New York-Penn League (short-season) - 3 games 15-Jun 18-Jun 1-Jul
- 2018: Columbia Fireflies, South Atlantic League (Low-A) - 1 game 30-Aug
- Brock Selvidge (pitcher, b. 2002, Texas)
- 2022: FCL Yankees, Florida Complex League (rookie) - 2 games 18-Jun 25-Jul g2
- 2023: Tampa Tarpons, Florida State League (Low-A) - 1 game 15-Jun
- Rob Semerano (pitcher, b. 1981, New York)
- 2006: Kane County Cougars, Midwest League (Low-A) - 1 game 7-Aug
- Marcus Semien (infielder, b. 1990, California)
- Adam Seminaris (pitcher, b. 1998, California)
- 2023: Nashville Sounds, International League (AAA) - 1 game 23-Sep
- Leonardo Seminati (utility, b. 1999, Italy)
- Rich Seminoff (first baseman, b. 1970, Arizona)
- 1993: Elmira Pioneers, New York-Penn League (short-season) - 1 game 5-Sep
- Montana Semmel (pitcher, b. 2002, Connecticut)
- Shawn Semple (pitcher, b. 1995, New Jersey)
- 2018: Staten Island Yankees, New York-Penn League (short-season) - 1 game 1-Jul
- Emmanuel Sena (infielder, b. 1984, Domincian Republic)
- 2005: Auburn Doubledays, New York-Penn League (short-season) - 2 games 1-Aug 15-Sep
- Giornale Sena (pitcher, b. 1986, Dominican Republic)
- 2006: Missoula Osprey, Pioneer League (rookie) - 1 game 24-Aug
- Hiroshi Senda (outfielder, b. unknown)
- 2014: Taos Blizzard, Pecos League (independent) - 1 game 21-Jul
- Hayden Senger (catcher, b. 1997, Ohio)
- 2021: Salt River Rafters, Arizona Fall League - 1 game 18-Oct
- 2023: Binghamton Rumble Ponies, Eastern League (AA) - 1 game 26-Sep
- 2024: St. Lucie Mets, Florida State League (Low-A) - 2 games 5-Sep 7-Sep
- 2024: Syracuse Mets, International League (AAA) - 1 game 20-Sep
- Guye Senjem (catcher/outfield, b. 1975, Minnesota)
- 1998: St. Paul Saints, Northern League (independent) - 1 game 18-Aug
- Aaron Senne (first base/outfield, b. 1987, Minnesota)
- 2010: Jamestown Jammers, New York-Penn League (short-season) - 1 game 8-Sep
- Juan Senreiso (outfielder, b. 1981, Dominican Republic)
- 2005: Frisco Roughriders, Texas League (AA) - 1 game 14-Aug
- Steven Sensley (infielder, b. 1995, Louisiana)
- Antonio Senzatela (pitcher, b. 1995, Venezuela)
- 2021: Colorado Rockies, Major League Baseball - 1 game 9-Sep
- Nick Senzel (outfielder, b. 1995, Georgia)
- 2023: Cincinnati Reds, Major League Baseball - 1 game 24-Sep
- Jae Seo (pitcher, b. 1977, South Korea)
- 2007: Durham Bulls, International League (AAA) - 1 game 2-Sep
- Carlos Sepulveda (outfielder, b. 1978, Texas)
- 2002: Albany-Colonie Diamond Dogs, Northeast League (independent) - 1 game 1-Sep
- 2003: North Shore Spirit, Northeast League (independent) - 1 game 21-Jul
- Carlos Sepulveda (infielder, b. 1996, Mexico)
- 2021: Tennessee Smokies, Double-A South - 1 game 23-Jul
- Maikel Sepulveda (pitcher, b. 1996, Dominican Republic)
- 2017: Greeneville Astros, Appalachian League (rookie) - 1 game 29-Aug
- Jorge Sequea (infielder, b. 1980, Venezuela)
- 2003: Syracuse SkyChiefs, International League (AAA) - 1 game 17-Aug
- Anthony Sequeira (pitcher, b. 1992, California)
- 2015: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 13-Sep
- Gabriel Sequeira (pitcher, b. 1997, Texas)
- Leonel Sequera (pitcher, b. 2005, Venezuela)
- 2024: Palm Beach Cardinals, Florida State League (Low-A) - 1 game 15-Sep
- Manuel Sequera (utility, b. 2002, Venezuela)
- Ricardo Serafin (outfielder, b. 1977)
- 1996: Martinsville Phillies, Appalachian League (rookie) - 1 game 27-Jul g1
- Dan Serafini (pitcher, b. 1974, California)
- 2001: Norfolk Tides, International League (AAA) - 1 game 1-Aug
- Matt Serafini (catcher/first base, b. 1980, Illinois)
- 2002: Ogden Raptors, Pioneer League (rookie) - 2 games 3-Aug 16-Aug
- Anthony Seratelli (utility, b. 1983, New Jersey)
- 2013: Omaha Storm Chasers, Pacific Coast League (AAA) - 2 games 29-Aug 17-Sep
- Jordan Serena (utility, b. 1992, Colorado)
- 2016: Great Britain, World Baseball Classic - 3 games 23-Sep 24-Sep 25-Sep
- 2017: Inland Empire 66ers, California League (High-A) - 1 game 31-Jul
- Joe Serfass (pitcher, b. 1981, Connecticut)
- 2006: Hagerstown Suns, South Atlantic League (Low-A) - 1 game 26-Apr
- Joe Sergent (pitcher, b. 1978, California)
- 2008: Calgary Vipers, Golden League (independent) - 1 game 27-Jul
- Tom Sergio (infielder, b. 1975, Pennsylvania)
- 2001: Allentown Ambassadors, Northeast League (independent) - 1 game 20-Jul
- 2002: Trenton Thunder, Eastern League (AA) - 2 games 21-Apr 4-Jul
- Nick Serino (pitcher, b. 1988, Massachusetts)
- 2012: Worcester Tornadoes, Can-Am League (independent) - 1 game 20-Aug
- Jose Sermo (infielder, b. 1991, Puerto Rico)
- 2015: Gary Southshore RailCats, American Association (independent) - 1 game 6-Sep
- 2016: Salem Red Sox, Carolina League (High-A) - 1 game 4-Sep
- 2019: Sioux City Explorers, American Association (independent) - 2 games 1-Jun 7-Jun
- Jared Serna (infielder, b. 2002, Mexico)
- KC Serna (infielder, b. 1989, California)
- 2015: Reading Fightin Phils, Eastern League (AA) - 1 game 17-Jun
- 2016: Reading Fightin Phils, Eastern League (AA) - 2 games 8-Sep 10-Sep
- Luis Serna (pitcher, b. 2004, Mexico)
- Eli Serrano (outfielder, b. 2003, Virginia)
- 2024: St. Lucie Mets, Florida State League (Low-A) - 3 games 3-Sep 6-Sep 7-Sep
- Elio Serrano (pitcher, b. 1978, Venezuela)
- 2001: Reading Phillies, Eastern League (AA) - 1 game 8-Sep
- Jhoniel Serrano (pitcher, b. 2003, Venezuela)
- 2023: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 9-Sep
- Juan Serrano (utility, b. 1985)
- 2008: St. George Roadrunners, Golden League (independent) - 1 game 30-Jul
- Mark Serrano (pitcher, b. 1985, California)
- 2012: Pensacola Blue Wahoos, Southern League (AA) - 1 game 12-Aug
- Ray Serrano (catcher, b. 1981, Puerto Rico)
- 2006: Mississippi Braves, Southern League (AA) - 1 game 2-Sep
- 2009: Sussex Skyhawks, Can-Am League (independent) - 1 game 11-Aug
- Joe Serrapica (pitcher, b. 1994, New Jersey)
- 2016: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 3-Aug
- Martin Serrata (outfielder, b. 1988, Dominican Republic)
- 2011: Aberdeen IronBirds, New York-Penn League (short-season) - 2 games 21-Jul 21-Aug
- Barrett Serrato (first base/outfield, b. 1990, Illinois)
- 2013: Spokane Indians, Northwest League (short-season) - 1 game 22-Aug
- Oscar Serratos (infielder, b. 1999, California)
- 2024: Great Falls Voyagers, Pioneer League (independent) - 2 games 6-Jul 7-Jul
- Danny Serretti (infielder, b. 2000, New Jersey)
- 2023: Erie SeaWolves, Eastern League (AA) - 1 game 26-Sep
- Scott Servais (catcher, b. 1967, Wisconsin)
- 1992: Houston Astros, National League (MLB) - 3 games 15-Aug 22-Aug 5-Sep
- 1993: Houston Astros, National League (MLB) - 1 game 15-Aug
- 1994: Houston Astros, National League (MLB) - 1 game 15-Apr
- Brian Serven (catcher, b. 1995, California)
- 2018: Lancaster JetHawks, California League (High-A) - 2 games 12-Aug 16-Aug
- 2019: Salt River Rafters, Arizona Fall League - 2 games 14-Oct 18-Oct
- 2024: Toronto Blue Jays, Major League Baseball - 2 games 30-Mar 31-Mar
- Scott Service (pitcher, b. 1967, Ohio)
- 1993: Cincinnati Reds, National League (MLB) - 1 game 24-Aug
- John Servidio (outfielder, b. 1985, Florida)
- 2009: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 8-Sep
- Adam Serwinowski (pitcher, b. 2004, South Carolina)
- 2024: Daytona Tortugas, Florida State League (Low-A) - 1 game 14-May
- Adam Seuss (outfielder, b. 1980, California)
- 2002: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 7-Jul
- Joe Sever (infielder, b. 1990, California)
- 2012: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 5-Aug
- Anderson Severino (pitcher, b. 1994, Dominican Republic)
- 2019: Tampa Tarpons, Florida State League (High-A) - 1 game 23-Aug g2
- 2021: Birmingham Barons, Double-A South - 1 game 12-May
- Atahualpa Severino (pitcher, b. 1984, Dominican Republic)
- 2011: Syracuse Chiefs, International League (AAA) - 1 game 20-Aug
* Cleris Severino - see Juan Frias
- Jesus Severino (outfielder, b. 2000, Venezuela)
- 2019: GCL Yankees West, Gulf Coast League (rookie) - 1 game 2-Aug g2
- Jose Severino (pitcher, b. 1973, Dominican Republic)
- 1995: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 25-Jun
- Luis Severino (pitcher, b. 1994, Dominican Republic)
- 2016: New York Yankees, Major League Baseball - 1 game 1-Oct
- 2018: New York Yankees, Major League Baseball - 1 game 21-Jun
- 2021: Tampa Tarpons, Low-A Southeast - 1 game 6-Jun
- 2024: New York Mets, Major League Baseball - 2 games 5-May 19-Sep
- Pedro Severino (catcher, b. 1993, Dominican Republic)
- 2014: Mesa Solar Sox, Arizona Fall League - 1 game 10-Oct
- 2015: Washington Nationals, Major League Baseball - 1 game 4-Oct
- 2018: Washington Nationals, Major League Baseball - 1 game 4-Jul
- 2019: Baltimore Orioles, Major League Baseball - 2 games 3-Sep g1 3-Sep g2
- 2021: Baltimore Orioles, Major League Baseball - 2 games 19-Aug 29-Sep
- Jehisbert Sevilla (infielder, b. 2003, Venezuela)
- Johnny Sewald (outfielder, b. 1993, Nevada)
- 2015: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 4-Aug
- Paul Sewald (pitcher, b. 1990, Nevada)
- 2012: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 9-Sep
- 2014: Scottsdale Scorpions, Arizona Fall League - 1 game 9-Oct
- 2015: Binghamton Mets, Eastern League (AA) - 1 game 16-Aug
- 2017: New York Mets, Major League Baseball - 2 games 29-May 27-Sep
- 2018: New York Mets, Major League Baseball - 3 games 1-Apr 9-Jul g2 12-Sep
- 2019: New York Mets, Major League Baseball - 1 game 29-Sep
- 2021: Seattle Mariners, Major League Baseball - 2 games 18-Jul 3-Aug
- Richie Sexson (first base/outfield, b. 1974, Oregon)
- 1997: Buffalo Bisons, American Association (AAA) - 2 games 9-Aug g1 9-Aug g2
- 1998: Cleveland Indians, American League (MLB) - 2 games 9-Aug 21-Sep
- 1999: Cleveland Indians, American League (MLB) - 2 games 31-Jul 21-Aug
- 2000: Milwaukee Brewers, Major League Baseball - 1 game 13-Sep
- 2001: Milwaukee Brewers, Major League Baseball - 2 games 31-Jul 19-Aug
- Chris Sexton (infielder, b. 1971, Ohio)
- 1995: New Haven Ravens, Eastern League (AA) - 1 game 12-Sep
- 1998: Colorado Springs Sky Sox, Pacific Coast League (AAA) - 2 games 21-Aug g1 21-Aug g2
- 1999: Colorado Springs Sky Sox, Pacific Coast League (AAA) - 1 game 21-Aug
- 2001: Louisville RiverBats, International League (AAA) - 1 game 1-Aug
- Greg Sexton (infielder, b. 1985, Virginia)
- 2009: Charlotte Stone Crabs, Florida State League (High-A) - 1 game 5-Sep
- Jeff Sexton (pitcher, b. 1971, California)
- 1997: Buffalo Bisons, American Association (AAA) - 1 game 9-Aug g2
- 1999: Akron Aeros, Eastern League (AA) - 1 game 1-Aug
- Michael Sexton (infielder, b. 1995, Washington)
- 2017: Salem-Keizer Volcanoes, Northwest League (short-season) - 1 game 3-Aug
- Tim Sexton (pitcher, b. 1987, Maryland)
- 2009: Inland Empire 66ers, California League (High-A) - 1 game 26-Aug
- Mark Seyler (pitcher, b. 1994, California)
- 2019: Sioux Falls Canaries, American Association (independent) - 1 game 6-Jun
- Anfernee Seymour (utility, b. 1995, Bahamas)
- 2016: Rome Braves, South Atlantic League (Low-A) - 1 game 15-Sep
- 2017: Florida Fire Frogs, Florida State League (High-A) - 2 games 27-May 28-May
- 2018: Jacksonville Jumbo Shrimp, Southern League (AA) - 1 game 27-Aug
- 2019: Jacksonville Jumbo Shrimp, Southern League (AA) - 1 game 10-Aug
- Bob Seymour (first baseman, b. 1998, Illinois)
- 2022: Charleston RiverDogs, Carolina League (Low-A) - 1 game 22-Jun
- 2023: Bowling Green Hot Rods, South Atlantic League (High-A) - 1 game 21-Jun
- Carson Seymour (pitcher, b. 1998, California)
- 2022: St. Lucie Mets, Florida State League (Low-A) - 1 game 17-Apr
- Ian Seymour (pitcher, b. 1998, Connecticut)
- 2023: FCL Rays, Florida Complex League (rookie) - 1 game 8-Jul
- 2024: Montgomery Biscuits, Southern League (AA) - 1 game 18-Jun
- Adam Shabala (outfielder, b. 1978, Illinois)
- Ronnie Shaban (pitcher, b. 1990, Virginia)
- 2012: Johnson City Cardinals, Appalachian League (rookie) - 1 game 17-Aug g2
- 2017: Somerset Patriots, Atlantic League (independent) - 2 games 13-Aug 17-Sep
- Aaron Shackelford (infielder, b. 1996, California)
- 2023: Indianapolis Indians, International League (AAA) - 1 game 1-Jul
- Stephen Shackleford (pitcher, b. 1989, Florida)
- 2014: Jackson Generals, Southern League (AA) - 1 game 20-Aug
- 2015: Reading Fightin Phils, Eastern League (AA) - 1 game 9-Aug
- Adam Shadburne (pitcher, b. 1974)
- 1996: Batavia Clippers, New York-Penn League (short-season) - 1 game 16-Aug
- Carson Shaddy (infielder, b. 1994, Arkansas)
- 2018: Auburn Doubledays, New York-Penn League (short-season) - 2 games 27-Jul 6-Sep
- Colby Shade (outfielder, b. 2001, Wyoming)
- Corey Shafer (outfielder, b. 1982, Oklahoma)
- 2005: Aberdeen IronBirds, New York-Penn League (short-season) - 2 games 17-Jul 7-Sep
- David Shafer (pitcher, b. 1982, Arizona)
- 2002: Billings Mustangs, Pioneer League (rookie) - 1 game 16-Aug
- Justin Shafer (pitcher, b. 1992, Florida)
- 2016: Dunedin Blue Jays, Florida State League (High-A) - 1 game 24-Aug
- 2018: Buffalo Bisons, International League (AAA) - 1 game 1-Aug g2
- 2019: Toronto Blue Jays, Major League Baseball - 1 game 6-Sep
- Ben Shaffar (pitcher, b. 1977, Kentucky)
- 2000: Lansing Lugnuts, Midwest League (Low-A) - 1 game 21-Jul
- 2003: Altoona Curve, Eastern League (AA) - 1 game 3-Apr
- Brian Shaffer (pitcher, b. 1996, Maryland)
- 2019: Montgomery Biscuits, Southern League (AA) - 2 games 28-May 27-Jul
- Josh Shaffer (infielder, b. 1980, California)
- 2000: Cedar Rapids Kernels, Midwest League (Low-A) - 1 game 13-Aug
- Richie Shaffer (infielder, b. 1991, New Jersey)
- 2012: Hudson Valley Renegades, New York-Penn League (short-season) - 4 games 26-Aug 9-Sep 12-Sep 13-Sep
- 2016: Durham Bulls, International League (AAA) - 1 game 1-Sep
- Asif Shah (outfielder, b. 1985, Ohio)
- 2010: Normal CornBelters, Frontier League (independent) - 1 game 3-Sep
- 2013: Quebec Les Capitales, Can-Am League (independent) - 3 games 9-Aug 6-Sep 7-Sep
- 2014: Quebec Les Capitales, Can-Am League (independent) - 1 game 4-Aug
- 2016: Quebec Les Capitales, Can-Am League (independent) - 1 game 12-Sep
- Raul Shah (infielder, b. 1993, Maryland)
- 2021: Ogden Raptors, Pioneer League (independent) - 1 game 9-Jul
- Joe Shallenberger (infielder, b. 1980, Texas)
- 2003: St. Paul Saints, Northern League (independent) - 1 game 27-Jul
- Ken Shamburg (infielder, b. 1967, California)
- 1991: Hagerstown Suns, Eastern League (AA) - 1 game 12-Aug
- Art Shamsky (outfielder, b. 1941, Missouri)
- 1968: New York Mets, National League (MLB) - 1 game 15-Sep
- 1970: New York Mets, National League (MLB) - 1 game 13-Sep
- Chris Shank (pitcher, b. 1981, Massachusetts)
- 2005: Worcester Tornadoes, Can-Am League (independent) - 2 games 19-Jun 31-Aug
- 2006: Worcester Tornadoes, Can-Am League (independent) - 1 game 3-Jun g2
- Zach Shank (utility, b. 1991, Pennsylvania)
- 2017: Tacoma Rainiers, Pacific Coast League (AAA) - 1 game 6-Aug
- Eric Shanks (infielder, b. 1978, North Carolina)
- 2003: Frederick Keys, Carolina League (High-A) - 1 game 5-Apr
- James Shanks (outfielder, b. 1979, Georgia)
- 2008: Southern Maryland Blue Crabs, Atlantic League (independent) - 3 games 21-Jun 1-Sep 14-Sep
- 2009: Southern Maryland Blue Crabs, Atlantic League (independent) - 1 game 1-Oct
- 2010: York Revolution, Atlantic League (independent) - 3 games 6-Sep 24-Sep 2-Oct
- 2011: York Revolution, Atlantic League (independent) - 2 games 26-Jul 12-Sep
- Josey Shannon (first base/outfield, b. 1979, Alabama)
- 2004: Pensacola Pelicans, Central League (independent) - 1 game 3-Jul
- Mark Shannon (outfielder, b. 1991, Colorado)
- 2013: Orem Owlz, Pioneer League (rookie) - 1 game 19-Aug
- Matt Shannon (pitcher, b. 1995, Texas)
- A.J. Shappi (pitcher, b. 1982, California)
- 2007: Mobile BayBears, Southern League (AA) - 1 game 17-Aug
- Brian Sharp (infielder, b. 1997, Missouri)
- 2018: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 15-Jun
- 2019: Columbia Fireflies, South Atlantic League (Low-A) - 1 game 30-Apr
- Daniel Sharp (pitcher, b. 1990)
- 2014: Trinidad Triggers, Pecos League (independent) - 1 game 22-Jul
- Blake Sharpe (infielder, b. 1983, California)
- 2006: Yakima Bears, Northwest League (short-season) - 1 game 23-Aug
- Chris Sharpe (outfielder, b. 1996, Massachusetts)
- Steven Sharpe (pitcher, b. 1981, Missouri)
- 2006: Stockton Ports, California League (High-A) - 1 game 21-Aug
- Zarion Sharpe (pitcher, b. 1998, North Carolina)
- 2021: Fort Myers Mighty Mussels, Low-A Southeast - 1 game 20-Aug
- Owen Sharts (pitcher, b. 1999, California)
- 2022: FCL Pirates, Florida Complex League (rookie) - 1 game 22-Aug
- 2023: Bradenton Marauders, Florida State League (Low-A) - 2 games 16-May 21-May
- Scott Sharts (pitcher, b. 1969)
- 1991: Watertown Indians, New York-Penn League (short-season) - 1 game 11-Aug
- Andy Shatley (infielder, b. 1976, Arkansas)
- 1996: St. Catharines Stompers, New York-Penn League (short-season) - 1 game 15-Aug
- Jon Shave (infielder, b. 1967, Georgia)
- 2000: Oklahoma Redhawks, Pacific Coast League (AAA) - 1 game 19-Aug
- 2001: Pawtucket Red Sox, International League (AAA) - 1 game 13-Jul
- A.J. Shaver (outfielder, b. 2001, Florida)
- Chris Shaver (pitcher, b. 1981, Virginia)
- 2009: Camden Riversharks, Atlantic League (independent) - 1 game 7-Sep
- Colton Shaver (first baseman, b. 1995, Utah)
- 2017: Tri-City ValleyCats, New York-Penn League (short-season) - 2 games 12-Aug g1 12-Aug g2
- 2018: Buies Creek Astros, Carolina League (High-A) - 1 game 2-Sep
- 2019: Fayetteville Woodpeckers, Carolina League (High-A) - 1 game 4-May
- 2019: Corpus Christi Hooks, Texas League (AA) - 3 games 10-Jul 11-Jul 18-Jul
- 2019: Peoria Javelinas, Arizona Fall League - 2 games 16-Oct 18-Oct
- Ryan Shaver (pitcher, b. 1984, Alaska)
- 2006: Augusta Greenjackets, South Atlantic League (Low-A) - 1 game 15-Sep
- 2010: Sioux Falls Pheasants, American Association (independent) - 1 game 24-Aug g2
- Bryan Shaw (pitcher, b. 1987, California)
- 2014: Cleveland Indians, Major League Baseball - 1 game 26-Aug
- 2015: Cleveland Indians, Major League Baseball - 2 games 20-Aug 25-Aug
- 2017: Cleveland Indians, Major League Baseball - 1 game 2-Sep
- 2018: Colorado Rockies, Major League Baseball - 2 games 6-May 23-Aug
- 2023: Charlotte Knights, International League (AAA) - 1 game 9-May
- Chris Shaw (first base/outfield, b. 1993, Massachusetts)
- 2017: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 30-Jul
- Curtis Shaw (pitcher, b. 1969, North Carolina)
- 1997: Carolina Mudcats, Southern League (AA) - 1 game 11-Aug
- Don Shaw (pitcher, b. 1944, Pennsylvania)
- 1968: New York Mets, National League (MLB) - 1 game 16-Jun
- Elliott Shaw (pitcher, b. 1979, California)
- 2005: Coastal Bend Aviators, Central League (independent) - 1 game 18-Aug
- Jeff Shaw (pitcher, b. 1966, Ohio)
- 1990: Cleveland Indians, American League (MLB) - 1 game 13-Aug
- 1991: Cleveland Indians, American League (MLB) - 1 game 6-Oct
- 1993: Montreal Expos, National League (MLB) - 1 game 18-Sep
- 1997: Cincinnati Reds, National League (MLB) - 1 game 25-Aug day
- Matt Shaw (infielder, b. 2001, Massachusetts)
- 2024: Iowa Cubs, International League (AAA) - 1 game 21-Sep
- Nick Shaw (infielder, b. 1988, Florida)
- 2014: Huntsville Stars, Southern League (AA) - 1 game 20-Aug
- 2015: Biloxi Shuckers, Southern League (AA) - 1 game 29-Jul
- Sam Shaw (outfielder, b. 2005, British Columbia)
- Scott Shaw (pitcher, b. 1986, Illinois)
- 2008: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 21-Aug
- Travis Shaw (first baseman, b. 1990, Ohio)
- 2015: Boston Red Sox, Major League Baseball - 1 game 28-Sep
- 2016: Boston Red Sox, Major League Baseball - 1 game 25-Aug
- 2017: Milwaukee Brewers, Major League Baseball - 1 game 29-May
- 2018: Milwaukee Brewers, Major League Baseball - 2 games 13-Apr 22-Sep
- 2019: Milwaukee Brewers, Major League Baseball - 1 game 4-Jun
- 2019: San Antonio Missions, Pacific Coast League (AAA) - 2 games 15-Jul 21-Jul
- 2021: Boston Red Sox, Major League Baseball - 1 game 29-Sep
- Mike Shawaryn (pitcher, b. 1994, New Jersey)
- Anthony Shawler (pitcher, b. 1987)
- 2008: Oneonta Tigers, New York-Penn League (short-season) - 1 game 27-Aug
- Elliot Shea (outfielder, b. 1984, New Hampshire)
- 2006: Nashua Pride, Can-Am League (independent) - 1 game 9-Jul
- John Shea (pitcher, b. 1966, Connecticut)
- 1990: Syracuse Chiefs, International League (AAA) - 1 game 18-Aug
- 1992: Syracuse Chiefs, International League (AAA) - 1 game 19-Aug
- Danny Sheaffer (catcher/first base, b. 1961, Florida)
- 1988: Pawtucket Red Sox, International League (AAA) - 1 game 29-Jul
- 1993: Colorado Rockies, National League (MLB) - 1 game 15-Aug
- David Sheaffer (utility, b. 1995, North Carolina)
- 2021: Arkansas Travelers, Double-A Central - 1 game 15-Sep
- Jon Sheaffer (outfielder, b. 1980, Illinois)
- 2002: Staten Island Yankees, New York-Penn League (short-season) - 1 game 12-Sep
- Ryan Shealy (first baseman, b. 1979, Florida)
- 2002: Casper Rockies, Pioneer League (rookie) - 2 games 3-Aug 10-Aug
- 2006: Kansas City Royals, Major League Baseball - 1 game 6-Aug
- Tanner Shears (pitcher, b. 2000, California)
- 2022: Schaumburg Boomers, Frontier League (independent) - 1 game 5-Jul
- Chris Sheehan (pitcher, b. 1969, Minnesota)
- 1994: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 4-Aug
- John Sheehan (pitcher, b. 1990, Massachusetts)
- 2016: New Jersey Jackals, Can-Am League (independent) - 1 game 27-May
- Sam Sheehan (pitcher, b. 1993, California)
- 2018: Stockton Ports, California League (High-A) - 1 game 16-Aug
- 2018: Mesa Solar Sox, Arizona Fall League - 1 game 7-Nov
- Matt Sheely (outfielder, b. 1986, Florida)
- 2010: Portland Sea Dogs, Eastern League (AA) - 2 games 30-May 1-Aug
- Andy Sheets (infielder, b. 1971, Louisiana)
- 1997: Seattle Mariners, American League (MLB) - 1 game 3-Sep
- 2000: Pawtucket Red Sox, International League (AAA) - 1 game 8-Jul
- 2002: Tampa Bay Devil Rays, Major League Baseball - 1 game 25-Sep
- Ben Sheets (pitcher, b. 1978, Louisiana)
- 2001: Milwaukee Brewers, Major League Baseball - 1 game 31-Jul
- 2006: Milwaukee Brewers, Major League Baseball - 1 game 16-Apr
- Gavin Sheets (first baseman, b. 1996, Maryland)
- 2017: Kannapolis Intimidators, South Atlantic League (Low-A) - 2 games 15-Aug 24-Aug
- 2018: Winston-Salem Dash, Carolina League (High-A) - 1 game 1-Sep
- 2019: Birmingham Barons, Southern League (AA) - 3 games 28-May 29-May 27-Jul
- 2019: Glendale Desert Dogs, Arizona Fall League - 2 games 15-Oct 19-Oct
- 2021: Chicago White Sox, Major League Baseball - 2 games 5-Jul 3-Oct
- 2021: Charlotte Knights, Triple-A East - 1 game 11-Aug
- 2023: Chicago White Sox, Major League Baseball - 1 game 23-Apr
- 2024: Chicago White Sox, Major League Baseball - 2 games 7-May 8-May
- Larry Sheets (outfielder, b. 1959, Virginia)
- 1990: Detroit Tigers, American League (MLB) - 2 games 13-Aug 15-Aug
- Chris Sheff (outfielder, b. 1971, California)
- 1994: Portland Sea Dogs, Eastern League (AA) - 1 game 24-Jul
- 1995: Portland Sea Dogs, Eastern League (AA) - 1 game 27-Aug
- 1996: Portland Sea Dogs, Eastern League (AA) - 1 game 5-Apr
- 1996: Charlotte Knights, International League (AAA) - 1 game 31-Aug
- Gary Sheffield (utility, b. 1968, Florida)
- 1990: Milwaukee Brewers, American League (MLB) - 1 game 15-Aug
- 1992: San Diego Padres, National League (MLB) - 1 game 20-Aug
- 1993: Florida Marlins, National League (MLB) - 1 game 11-Aug
- 1996: Florida Marlins, National League (MLB) - 2 games 9-Sep 10-Sep
- 1997: Florida Marlins, National League (MLB) - 1 game 27-Sep
- 2002: Atlanta Braves, Major League Baseball - 2 games 29-Jun 29-Sep
- 2003: Atlanta Braves, Major League Baseball - 2 games 20-Jul 28-Sep
- 2004: New York Yankees, Major League Baseball - 2 games 21-Sep 6-Oct
- 2005: New York Yankees, Major League Baseball - 1 game 21-Sep
- 2006: New York Yankees, Major League Baseball - 1 game 27-Sep
- 2009: New York Mets, Major League Baseball - 2 games 19-Jun 18-Sep
- Jordan Sheffield (pitcher, b. 1995, Tennessee)
- 2018: Glendale Desert Dogs, Arizona Fall League - 1 game 7-Nov
- Justus Sheffield (pitcher, b. 1996, Tennessee)
- 2017: Trenton Thunder, Eastern League (AA) - 1 game 13-Sep
- 2018: Scranton/Wilkes-Barre RailRiders, International League (AAA) - 3 games 2-Aug 11-Sep 15-Sep
- Chris Shehan (outfielder, b. 1987, Pennsylvania)
- 2009: Rome Braves, South Atlantic League (Low-A) - 1 game 3-Jul
- Anthony Shelby (pitcher, b. 1973, Illinois)
- 2002: Atlantic City Surf, Atlantic League (independent) - 2 games 17-Sep 19-Sep
- John Shelby (outfielder, b. 1958, Kentucky)
- 1990: Detroit Tigers, American League (MLB) - 1 game 15-Aug
- John Shelby (utility, b. 1985, Maryland)
- 2012: Gateway Grizzlies, Frontier League (independent) - 1 game 26-May
- Kyle Sheldon (pitcher, b. 1976, Florida)
- 2001: Lehigh Valley Black Diamonds, Atlantic League (independent) - 1 game 15-Aug
- Ole Sheldon (first baseman, b. 1982, Oregon)
- 2010: St. Paul Saints, American Association (independent) - 1 game 21-Aug
- Scott Sheldon (infielder, b. 1968, Indiana)
- 2000: Texas Rangers, Major League Baseball - 1 game 25-Aug
- Stephen Shell (pitcher, b. 1983, Texas)
- 2008: Washington Nationals, Major League Baseball - 1 game 22-Jun
- Jason Shelley (pitcher, b. 1977, Illinois)
- 2004: Huntsville Stars, Southern League (AA) - 1 game 4-Jul
- Ben Shelton (first baseman, b. 1969, Illinois)
- 1995: Trenton Thunder, Eastern League (AA) - 1 game 19-Aug
- Chris Shelton (catcher/first base, b. 1980, Utah)
- 2003: Lynchburg Hillcats, Carolina League (High-A) - 1 game 5-Apr
- Kyle Shelton (infielder, b. 1986, Virginia)
- 2011: Birmingham Barons, Southern League (AA) - 1 game 29-May
- Hayden Shenefield (pitcher, b. 1995, California)
- 2021: Daytona Tortugas, Low-A Southeast - 1 game 25-Jun g2
- Austin Shenton (first baseman, b. 1998, Washington)
- Chance Shepard (first baseman, b. 1994, North Carolina)
- 2017: Auburn Doubledays, New York-Penn League (short-season) - 1 game 4-Sep
- 2018: Southern Illinois Miners, Frontier League (independent) - 3 games 4-Aug 25-Aug g1 25-Aug g2
- Dave Shepard (pitcher, b. 1974, New York)
- 2000: Newark Bears, Atlantic League (independent) - 1 game 6-Jul
- 2001: Newark Bears, Atlantic League (independent) - 3 games 30-Aug g2 22-Sep 3-Oct
- 2004: Trenton Thunder, Eastern League (AA) - 3 games 3-Aug g1 3-Aug g2 4-Sep
- 2005: Long Island Ducks, Atlantic League (independent) - 1 game 17-Sep
- 2006: Newark Bears, Atlantic League (independent) - 1 game
- Steve Shepard (pitcher, b. 1986, New Hampshire)
- 2009: New Jersey Jackals, Can-Am League (independent) - 1 game 10-Aug
- Chandler Shepherd (pitcher, b. 1992, Kentucky)
- 2014: Lowell Spinners, New York-Penn League (short-season) - 1 game 13-Aug g1
- JaRon Shepherd (outfielder, b. 1988, Texas)
- 2014: New Jersey Jackals, Can-Am League (independent) - 1 game 19-Jun
- Matt Shepherd (infielder, b. 1988, Massachusetts)
- Zach Shepherd (infielder, b. 1995, Australia)
- 2016: Lakeland Flying Tigers, Florida State League (High-A) - 2 games 23-Aug g1 23-Aug g2
- 2017: Lakeland Flying Tigers, Florida State League (High-A) - 1 game 28-May
- 2019: Lakeland Flying Tigers, Florida State League (High-A) - 3 games 9-Apr 23-Apr 8-May
- Greg Sheppard (utility, b. 1975, California)
- 1997: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 15-Aug
- 1999: Winston-Salem Warthogs, Carolina League (High-A) - 1 game 8-Aug
- Tyler Shepple (pitcher, b. 1980, Ohio)
- 2002: Ogden Raptors, Pioneer League (rookie) - 1 game 16-Aug
- Jimmie Sherfy (pitcher, b. 1991, California)
- 2018: Reno Aces, Pacific Coast League (AAA) - 1 game 15-Aug
- Ryan Sherriff (pitcher, b. 1990, California)
- 2016: Glendale Desert Dogs, Arizona Fall League - 1 game 14-Oct
- 2021: Tampa Bay Rays, Major League Baseball - 4 games 29-Jul 1-Aug 3-Aug 4-Aug
- 2022: Clearwater Threshers, Florida State League (Low-A) - 1 game 9-Jun
- Eric Sheridan (pitcher, b. 1983, Illinois)
- 2008: Chico Outlaws, Golden League (independent) - 1 game 31-Jul
- Michael Sheridan (first base/outfield, b. 1987, District of Columbia)
- 2008: Hudson Valley Renegades, New York-Penn League (short-season) - 2 games 6-Aug 5-Sep
- 2009: Bowling Green Hot Rods, South Atlantic League (Low-A) - 2 games 3-Jul 8-Aug
- Pat Sheridan (outfielder, b. 1957, Michigan)
- 1991: New York Yankees, American League (MLB) - 1 game 12-Sep
- Luke Sherley (infielder, b. 1996, Texas)
- 2019: Lakeland Flying Tigers, Florida State League (High-A) - 1 game 7-Aug
- Brian Sherlock (infielder, b. 1976, New Jersey)
- 2001: Camden Riversharks, Atlantic League (independent) - 1 game 13-May
- Steve Sherman (outfielder, b. 1981, Texas)
- Cam Sherrer (utility, b. 1988)
- 2015: Schaumburg Boomers, Frontier League (independent) - 2 games 27-Aug 30-Aug
- Ryan Sherriff (pitcher, b. 1990, California)
- 2019: Charlotte Stone Crabs, Florida State League (High-A) - 1 game 24-Aug
- George Sherrill (pitcher, b. 1977, Tennessee)
- 2009: Baltimore Orioles, Major League Baseball - 1 game 23-Apr
- Justin Sherrod (utility, b. 1978, Florida)
- 2002: Trenton Thunder, Eastern League (AA) - 1 game 21-Apr
- 2003: Portland Sea Dogs, Eastern League (AA) - 2 games 4-Aug 12-Aug
- Anthony Sherwin (infielder, b. 2002, Ohio)
- 2024: Asheville Tourists, South Atlantic League (High-A) - 1 game 6-Aug
- Braden Shewmake (infielder, b. 1997, Texas)
- 2023: Gwinnett Stripers, International League (AAA) - 1 game 29-Jun
- 2024: Chicago White Sox, Major League Baseball - 1 game 8-May
- Andy Shibilo (pitcher, b. 1976, New York)
- 2000: Lehigh Valley Black Diamonds, Atlantic League (independent) - 1 game 2-Jul g1
- 2005: Bridgeport Bluefish, Atlantic League (independent) - 1 game 15-Jun
- 2008: Newark Bears, Atlantic League (independent) - 2 games 1-Sep 17-Sep
- James Shields (pitcher, b. 1981, California)
- 2001: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 10-Aug
- 2010: Tampa Bay Rays, Major League Baseball - 1 game 21-Sep
- 2014: Kansas City Royals, Major League Baseball - 1 game 5-Sep
- 2018: Chicago White Sox, Major League Baseball - 1 game 20-Sep
- Jeff Shields (pitcher, b. 1990, Georgia)
- 2013: Trois-Rivieres Aigles, Can-Am League (independent) - 1 game 11-Aug
- Robbie Shields (infielder, b. 1987, Illinois)
- 2009: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 8-Sep
- Scot Shields (pitcher, b. 1975, Florida)
- 2010: Los Angeles Angels of Anaheim, Major League Baseball - 1 game 22-Aug
- Tommy Shields (infielder, b. 1964, Virginia)
- 1992: Rochester Red Wings, International League (AAA) - 1 game 8-Aug
- Pete Shier (infielder, b. 1981, Ohio)
- 2000: Bluefield Orioles, Appalachian League (rookie) - 1 game 5-Aug g2
- 2007: Camden Riversharks, Atlantic League (independent) - 1 game 31-Aug
- Steve Shifflett (pitcher, b. 1966, Missouri)
- 1992: Kansas City Royals, American League (MLB) - 1 game 17-Aug
- Jun-Seok Shim (pitcher, b. 2004, South Korea)
- 2024: Peoria Javelinas, Arizona Fall League - 1 game 12-Oct
- Brandon Shimo (pitcher, b. 1990, Pennsylvania)
- 2015: Sussex County Miners, Can-Am League (independent) - 1 game 18-Aug
- 2019: Chicago Dogs, American Association (independent) - 1 game 1-Jun
- Razor Shines (first baseman, b. 1956, North Carolina)
- 1984: Montreal Expos, National League (MLB) - 1 game 23-Sep
- 1992: Indianapolis Indians, American Association (AAA) - 1 game 9-Aug
- Tsuyoshi Shinjo (outfielder, b. 1972, Japan)
- Yuichi Shiota (pitcher, b. 1997, Japan)
- 2023: New Jersey Jackals, Frontier League (independent) - 1 game 14-Jul
- Braden Shipley (pitcher, b. 1992, Oregon)
- 2013: South Bend Silver Hawks, Midwest League (Low-A) - 1 game 31-Aug
- Craig Shipley (infielder, b. 1963, Australia)
- 1988: Tidewater Tides, International League (AAA) - 1 game 29-Jul
- 1992: San Diego Padres, National League (MLB) - 1 game 20-Aug
- 1993: San Diego Padres, National League (MLB) - 1 game 2-Jul g1
- 1994: San Diego Padres, National League (MLB) - 2 games 17-Jul 22-Jul g2
- 1996: San Diego Padres, National League (MLB) - 1 game 10-Aug
- 1997: San Diego Padres, National League (MLB) - 1 game 22-Aug
- Aaron Shipman (outfielder, b. 1992, Georgia)
- 2011: Vermont Lake Monsters, New York-Penn League (short-season) - 1 game 31-Aug
- Brian Shipp (infielder, b. 1978, Louisiana)
- 2002: Binghamton Mets, Eastern League (AA) - 1 game 4-Jul
- Kevin Shipp (pitcher, b. 1975, Louisiana)
- 1997: Batavia Clippers, New York-Penn League (short-season) - 1 game 19-Jul
- Skip Shipp (catcher/first base, b. 1976, Georgia)
- 1996: Erie SeaWolves, New York-Penn League (short-season) - 3 games 4-Aug 14-Aug 22-Aug
- Jeff Shireman (infielder, b. 1966, Iowa)
- 1993: Arkansas Travelers, Texas League (AA) - 1 game 14-Aug
- Mike Shirley (outfielder, b. 1970, Indiana)
- 1991: Watertown Indians, New York-Penn League (short-season) - 1 game 11-Aug
- Andrew Shive (pitcher, b. 1985, California)
- 2008: Staten Island Yankees, New York-Penn League (short-season) - 1 game 16-Jul
- 2010: Staten Island Yankees, New York-Penn League (short-season) - 1 game 9-Aug
- Ben Shivers (pitcher, b. 1987, Oregon)
- 2009: Kalamazoo Kings, Frontier League (independent) - 1 game 27-Jul
- Ben Shockey (pitcher, b. 1986, Florida)
- 2008: Chico Outlaws, Golden League (independent) - 2 games 31-Jul 1-Aug
- Dylan Shockley (catcher, b. 1997, Ohio)
- 2019: GCL Pirates, Gulf Coast League (rookie) - 1 game 24-Aug g1
- 2021: Greensboro Grasshoppers, High-A East - 1 game 1-Jul
- Greg Shockey (outfielder, b. 1970, California)
- 1993: Fort Myers Miracle, Florida State League (High-A) - 1 game 12-Aug
- Keith Shockley (pitcher, b. 1976, Kansas)
- 1996: Martinsville Phillies, Appalachian League (rookie) - 1 game 27-Jul g2
- Brady Shoemaker (first base/outfield, b. 1987, Indiana)
- 2015: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 27-Jul
- Steve Shoemaker (pitcher, b. 1973, Pennsylvania)
- 1994: Oneonta Yankees, New York-Penn League (short-season) - 1 game 13-Aug
- 1996: Salem Avalanche, Carolina League (High-A) - 1 game 28-Jul
- Sean Shoffit (utility, b. 1985, California)
- 2005: Auburn Doubledays, New York-Penn League (short-season) - 1 game 15-Sep
- 2006: Lansing Lugnuts, Midwest League (Low-A) - 1 game 12-Aug
- Kodey Shojinaga (infielder, b. 2003, Hawaii)
- TJ Shook (pitcher, b. 1998, South Carolina)
- 2022: Biloxi Shuckers, Southern League (AA) - 1 game 12-Jun
- Kelly Shoppach (catcher, b. 1980, Texas)
- 2003: Portland Sea Dogs, Eastern League (AA) - 2 games 4-Aug 12-Aug
- 2008: Cleveland Indians, Major League Baseball - 1 game 31-Aug
- 2009: Cleveland Indians, Major League Baseball - 1 game 16-Apr
- 2012: New York Mets, Major League Baseball - 5 games 19-Aug 29-Aug 11-Sep 17-Sep 25-Sep
- Scott Shores (outfielder, b. 1972, Arizona)
- 1996: Reading Phillies, Eastern League (AA) - 1 game 5-Apr
- Adam Shorsher (catcher, b. 1980, California)
- 2004: New Haven County Cutters, Northeast League (independent) - 1 game 6-Aug
- 2005: Calgary Vipers, Northern League (independent) - 2 games 9-Aug 12-Aug
- 2008: Southern Maryland Blue Crabs, Atlantic League (independent) - 1 game 14-Sep
- Brandon Short (outfielder, b. 1988, Maryland)
- 2010: Winston-Salem Dash, Carolina League (High-A) - 1 game 7-Aug
- 2011: Birmingham Barons, Southern League (AA) - 2 games 29-May 11-Aug
- Josh Short (outfielder, b. 1987, Washington)
- 2009: Kalamazoo Kings, Frontier League (independent) - 2 games 25-Jul 27-Jul
- 2010: Lake County Fielders, Northern League (independent) - 2 games 23-Aug 4-Sep
- Rick Short (infielder, b. 1972, Illinois)
- 1996: Frederick Keys, Carolina League (High-A) - 1 game 26-Jul
- 1997: Frederick Keys, Carolina League (High-A) - 1 game 6-Apr
- 2000: Bowie Baysox, Eastern League (AA) - 1 game 24-Apr
- 2002: Salt Lake Stingers, Pacific Coast League (AAA) - 1 game 15-Aug
- 2004: Edmonton Trappers, Pacific Coast League (AAA) - 1 game 15-Aug
- Wyatt Short (pitcher, b. 1994, Tennessee)
- 2021: Tennessee Smokies, Double-A South - 1 game 23-Jul
- Zack Short (infielder, b. 1995, New York)
- 2019: Mesa Solar Sox, Arizona Fall League - 3 games 15-Oct 18-Oct 19-Oct
- 2021: Detroit Tigers, Major League Baseball - 1 game 3-Oct
- 2023: Detroit Tigers, Major League Baseball - 1 game 30-Sep
- Matt Shortall (outfielder, b. 1990, Texas)
- 2014: Williamsport Crosscutters, New York-Penn League (short-season) - 2 games 4-Jul g1 4-Jul g2
- Aaron Shortridge (pitcher, b. 1997, California)
- 2019: Bradenton Marauders, Florida State League (High-A) - 3 games 10-Apr 8-May 3-Aug
- 2024: Bradenton Marauders, Florida State League (Low-A) - 1 game 28-Jun
- Josh Shortslef (pitcher, b. 1982, New York)
- 2002: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 25-Jul
- 2006: Altoona Curve, Eastern League (AA) - 1 game 14-Apr
- 2008: Altoona Curve, Eastern League (AA) - 1 game 1-Sep
- 2009: Reading Phillies, Eastern League (AA) - 1 game 11-Apr
- Brian Shouse (pitcher, b. 1968, Illinois)
- 2006: Milwaukee Brewers, Major League Baseball - 1 game 4-Aug
- Zack Showalter (pitcher, b. 2004, Florida)
- 2024: Palm Beach Cardinals, Florida State League (Low-A) - 1 game 5-Jun
- Chasen Shreve (pitcher, b. 1990, Nevada)
- 2015: New York Yankees, Major League Baseball - 3 games 22-May 8-Sep 12-Sep g1
- 2018: New York Yankees, Major League Baseball - 1 game 25-Apr
- 2021: Pittsburgh Pirates, Major League Baseball - 1 game 19-Jul
- 2023: Detroit Tigers, Major League Baseball - 2 games 30-Mar 2-Apr
- Colby Shreve (pitcher, b. 1988, Nevada)
- 2011: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 25-May
- 2013: Reading Fightin Phils, Eastern League (AA) - 2 games 4-Aug 13-Aug
- Brian Shubsda (catcher, b. 1987)
- 2009: Newark Bears, Atlantic League (independent) - 1 game 16-Jul
- J.B. Shuck (outfielder, b. 1987, Ohio)
- 2013: Los Angeles Angels of Anaheim, Major League Baseball - 2 games 12-Aug 23-Aug
- 2017: Rochester Red Wings, International League (AAA) - 1 game 20-Aug
- Paul Shuey (pitcher, b. 1970, Ohio)
- 1998: Cleveland Indians, American League (MLB) - 2 games 9-Aug 21-Sep
- 1999: Cleveland Indians, American League (MLB) - 1 game 31-Jul
- Dalton Shuffield (utility, b. 1999, Texas)
- 2023: Fort Myers Mighty Mussels, Florida State League (Low-A) - 3 games 12-Apr 14-Apr 15-Apr
- Shawn Shugars (outfielder, b. 1971)
- 1994: Hudson Valley Renegades, New York-Penn League (short-season) - 2 games 19-Jun 26-Jul
- Jakob Shuler (catcher/first base, b. 1997, Kentucky)
- 2020: California Dogecoin, Liberation League (independent) - 1 game 23-Sep
- 2021: Roswell Invaders, Pecos League (independent) - 1 game 20-Jul
- Stephen Shults (utility, b. 1986, Tennessee)
- 2009: Rome Braves, South Atlantic League (Low-A) - 1 game 3-Jul
- 2010: Florence Freedom, Frontier League (independent) - 1 game 3-Sep
- Brian Shultz (outfielder, b. 1976, Nevada)
- 2001: Schaumburg Flyers, Northern League (independent) - 1 game 29-Jul
- Anthony Shumaker (pitcher, b. 1973, Arizona)
- 1995: Batavia Clippers, New York-Penn League (short-season) - 1 game 20-Aug
- 1998: Reading Phillies, Eastern League (AA) - 1 game 30-Aug
- Scott Shuman (pitcher, b. 1988, Georgia)
- 2017: Lancaster Barnstormers, Atlantic League (independent) - 1 game 13-Aug
- Derek Shumpert (outfielder, b. 1975, Missouri)
- 1994: Oneonta Yankees, New York-Penn League (short-season) - 2 games 26-Jun 13-Aug
- 1996: Greensboro Bats, South Atlantic League (Low-A) - 1 game 25-Jul
- 1997: Greensboro Bats, South Atlantic League (Low-A) - 1 game 15-Aug
- Terry Shumpert (infielder, b. 1966, Kentucky)
- 1995: Pawtucket Red Sox, International League (AAA) - 2 games 30-Jul 4-Aug
- 1999: Colorado Rockies, National League (MLB) - 1 game 3-Sep
- Clayton Shunick (pitcher, b. 1986, Georgia)
- 2011: Carolina Mudcats, Southern League (AA) - 1 game 29-May
- Jared Shuster (pitcher, b. 1998, Massachusetts)
- 2022: Gwinnett Stripers, International League (AAA) - 1 game 30-Aug
- 2024: Chicago White Sox, Major League Baseball - 1 game 6-May
- Mike Siani (outfielder, b. 1999, Pennsylvania)
- 2021: Dayton Dragons, High-A Central - 1 game 18-Sep
- 2021: Surprise Saguaros, Arizona Fall League - 1 game 21-Oct
- 2022: Chattanooga Lookouts, Southern League (AA) - 1 game 14-Jul
- 2022: Cincinnati Reds, Major League Baseball - 1 game 30-Sep
- 2023: Louisville Bats, International League (AAA) - 1 game 1-Jul
- Sammy Siani (outfielder, b. 2000, Pennsylvania)
- 2019: GCL Pirates, Gulf Coast League (rookie) - 3 games 3-Aug 24-Aug g1 24-Aug g2
- 2021: Bradenton Marauders, Low-A Southeast - 6 games 14-May 3-Jun 5-Jun 22-Jun 11-Sep 12-Sep
- 2022: Greensboro Grasshoppers, South Atlantic League (High-A) - 1 game 31-Aug
- 2023: Greensboro Grasshoppers, South Atlantic League (High-A) - 1 game 10-May
- 2024: Scottsdale Scorpions, Arizona Fall League - 1 game 12-Oct
- Jose Sibrian (catcher, b. 1998, Venezuela)
- 2021: Carolina Mudcats, Low-A East - 1 game 5-Sep
- David Sick (pitcher, b. 1971, Pennsylvania)
- 1994: Boise Hawks, Northwest League (short-season) - 1 game 8-Sep
- Jeremy Sickles (catcher, b. 1978, California)
- 1999: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 30-Jul
- Brett Siddall (outfielder, b. 1994, Ontario)
- 2017: Stockton Ports, California League (High-A) - 1 game 31-Jul
- 2018: Stockton Ports, California League (High-A) - 1 game 16-Aug
- Joe Siddall (catcher, b. 1967, Ontario)
- 1993: Montreal Expos, National League (MLB) - 1 game 19-Sep
- 1996: Charlotte Knights, International League (AAA) - 1 game 31-Aug
- 1998: Detroit Tigers, American League (MLB) - 1 game 24-Aug
- Joey Side (outfielder, b. 1983, Georgia)
- 2006: Yakima Bears, Northwest League (short-season) - 1 game 23-Aug
- 2014: Trois-Rivieres Aigles, Can-Am League (independent) - 1 game 26-Jul
- Grant Sides (pitcher, b. 1989, Alabama)
- 2018: York Revolution, Atlantic League (independent) - 1 game 26-Jul g2
- Chris Sidick (outfielder, b. 1983, Pennsylvania)
- 2006: Washington Wild Things, Frontier League (independent) - 1 game 8-Aug
- Kevin Siegrist (pitcher, b. 1989, New York)
- 2014: St. Louis Cardinals, Major League Baseball - 1 game 10-Aug
- 2017: St. Louis Cardinals, Major League Baseball - 1 game 16-Apr
- Vinny Siena (infielder, b. 1993, Connecticut)
- 2015: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 19-Aug
- 2016: St. Lucie Mets, Florida State League (High-A) - 1 game 26-Aug
- 2018: New Britain Bees, Atlantic League (independent) - 2 games 10-Jun 16-Jun
- Ryan Sienko (catcher/first base, b. 1975, Illinois)
- 2001: Schaumburg Flyers, Northern League (independent) - 1 game 29-Jul
- 2003: Joliet Jackhammers, Northern League (independent) - 1 game 27-Jul
- Anibal Sierra (infielder, b. 1994, Cuba)
- 2017: Buies Creek Astros, Carolina League (High-A) - 2 games 11-Jun 3-Jul
- 2019: Corpus Christi Hooks, Texas League (AA) - 2 games 11-Jul 18-Jul
- Armando Sierra (first base/outfield, b. 2004, Dominican Republic)
- 2024: FCL Red Sox, Florida Complex League (rookie) - 1 game 7-May
- Carlos Sierra (pitcher, b. 1994, Cuba)
- 2019: Sioux City Explorers, American Association (independent) - 1 game 7-Jun
- Jefry Sierra (utility, b. 1990, Dominican Republic)
- 2010: Billings Mustangs, Pioneer League (rookie) - 1 game 27-Aug
- Jonathan Sierra (first base/outfield, b. 1998, Dominican Republic)
- 2021: Myrtle Beach Pelicans, Low-A East - 1 game 18-Jun
- 2022: South Bend Cubs, Midwest League (High-A) - 1 game 25-Jun
- Luis Sierra (catcher/infielder, b. 1987, Colombia)
- 2011: Winston-Salem Dash, Carolina League (High-A) - 1 game 28-May
- Magneuris Sierra (outfielder, b. 1996, Dominican Republic)
- Miguelangel Sierra (infielder, b. 1997, Venezuela)
- 2017: Tri-City ValleyCats, New York-Penn League (short-season) - 2 games 22-Jul 12-Aug g1
- 2019: Fayetteville Woodpeckers, Carolina League (High-A) - 1 game 4-May
- Moises Sierra (outfielder, b. 1988, Dominican Republic)
- 2011: New Hampshire Fisher Cats, Eastern League (AA) - 3 games 5-May 4-Aug 10-Sep
- 2017: New Orleans Baby Cakes, Pacific Coast League (AAA) - 1 game 30-Jul
- Ruben Sierra (outfielder, b. 1965, Puerto Rico)
- 1992: Texas Rangers, American League (MLB) - 1 game 12-Aug
- 1995: New York Yankees, American League (MLB) - 1 game 24-Sep
- 1996: New York Yankees, American League (MLB) - 2 games 4-Jul 13-Jul g1
- 2000: Oklahoma Redhawks, Pacific Coast League (AAA) - 1 game 19-Aug
- 2004: New York Yankees, Major League Baseball - 2 games 20-Sep 6-Oct
- Josiah Sightler (first baseman, b. 1999, South Carolina)
- 2023: FCL Pirates, Florida Complex League (rookie) - 1 game 9-Jun
- 2023: Bradenton Marauders, Florida State League (Low-A) - 1 game 3-Jul
- Jackson Sigman (pitcher, b. 1995, Texas)
- 2021: Ogden Raptors, Pioneer League (independent) - 1 game 9-Jul
- Ken Sikes (pitcher, b. 1973)
- 1994: Yakima Bears, Northwest League (short-season) - 1 game 8-Sep
- Phillip Sikes (outfielder, b. 1999, Texas)
- 2021: FCL Red Sox, Florida Complex League (rookie) - 1 game 23-Aug g1
- 2022: Greenville Drive, South Atlantic League (High-A) - 1 game 16-Aug
- 2024: Worcester Red Sox, International League (AAA) - 1 game 22-Sep
- Brian Sikorski (pitcher, b. 1974, Michigan)
- 1998: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 28-Aug
- Easton Sikorski (pitcher, b. 2000, Michigan)
- 2023: Daytona Tortugas, Florida State League (Low-A) - 2 games 11-May 11-Jun
- Arik Sikula (pitcher, b. 1988, California)
- 2018: Quebec Les Capitales, Can-Am League (independent) - 1 game 5-Sep
- Tom Silicato (pitcher, b. 1971, Delaware)
- 1998: Elmira Pioneers, Northeast League (independent) - 1 game 7-Aug
- Mike Sillman (pitcher, b. 1981, Nebraska)
- 2004: New Jersey Cardinals, New York-Penn League (short-season) - 2 games 16-Jul g1 2-Aug
- 2007: Springfield Cardinals, Texas League (AA) - 1 game 15-Aug
- Brahian Silva (catcher/first base, b. 2002, Venezuela)
- 2024: FCL Phillies, Florida Complex League (rookie) - 1 game 23-Jul
- Carlos Silva (pitcher, b. 1979, Venezuela)
- 2003: Philadelphia Phillies, Major League Baseball - 1 game 2-Aug g2
- Efrain Silva (pitcher, b. 1978, California)
- 2003: Vero Beach Dodgers, Florida State League (High-A) - 1 game 28-Aug
- Rubi Silva (utility, b. 1989, Cuba)
- 2017: Sussex County Miners, Can-Am League (independent) - 2 games 8-Aug 11-Aug
- 2018: Sussex County Miners, Can-Am League (independent) - 2 games 12-Jun g1 12-Jun g2
- 2018: Long Island Ducks, Atlantic League (independent) - 1 game 23-Sep
- William Silva (pitcher, b. 2001, Florida)
- 2022: FCL Braves, Florida Complex League (rookie) - 1 game 13-Aug
- Alfredo Silverio (outfielder, b. 1987, Dominican Republic)
- 2011: Chattanooga Lookouts, Southern League (AA) - 2 games 7-Aug 11-Aug
- 2018: Road Warriors, Atlantic League (independent) - 2 games 26-Jul g1 26-Jul g2
- Carlos Silverio (pitcher, b. 1979, Dominican Republic)
- 2002: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 24-Jun
- Gresuan Silverio (catcher/first base, b. 1999, Dominican Republic)
- 2018: Connecticut Tigers, New York-Penn League (short-season) - 1 game 30-Jul
- 2021: Lakeland Flying Tigers, Low-A Southeast - 1 game 31-Aug
- Juan Silverio (infielder, b. 1991, Dominican Republic)
- 2015: Laredo Lemurs, American Association (independent) - 1 game 31-Jul
- 2019: Sugar Land Skeeters, Atlantic League (independent) - 2 games 3-May 14-Jul
- 2021: Lexington Legends, Atlantic League (independent) - 1 game 19-Sep
- Luis Silverio (outfielder, b. 1995, Florida)
- 2018: Visalia Rawhide, California League (High-A) - 1 game 14-Aug
- Oscar Silverio (catcher, b. 2001, Dominican Republic)
- 2024: Tampa Tarpons, Florida State League (Low-A) - 2 games 13-Jun 15-Jun
- Rigoberto Silverio (infielder, b. 1986, Dominican Republic)
- 2006: Jamestown Jammers, New York-Penn League (short-season) - 1 game 4-Jul
- 2007: Jamestown Jammers, New York-Penn League (short-season) - 1 game 4-Aug
- Scott Silverstein (pitcher, b. 1990, Maryland)
- 2014: Lansing Lugnuts, Midwest League (Low-A) - 1 game 24-Aug
- Hector Silvestre (pitcher, b. 1992, Dominican Republic)
- 2017: Potomac Nationals, Carolina League (High-A) - 1 game 3-Jul
- Juan Silvestre (outfielder, b. 1976, Dominican Republic)
- 2002: Adirondack Lumberjacks, Northeast League (independent) - 3 games 9-Sep 10-Sep 14-Sep
- Pedro Silvestre (pitcher, b. 1989, Dominican Republic)
- 2012: Princeton Rays, Appalachian League (rookie) - 1 game 17-Aug g2
- Dave Silvestri (infielder, b. 1967, Missouri)
- 1992: Columbus Clippers, International League (AAA) - 1 game 19-Aug
- 1992: New York Yankees, American League (MLB) - 1 game 27-Sep
- 1996: Montreal Expos, National League (MLB) - 1 game 28-Jun
- 1999: Edmonton Trappers, Pacific Coast League (AAA) - 1 game 4-Jul
- Brian Silvia (catcher, b. 1971)
- 1994: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 26-Jul
- John Silviano (catcher, b. 1994, Florida)
- 2016: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 22-Aug
- 2018: Jacksonville Jumbo Shrimp, Southern League (AA) - 1 game 27-Aug
- Michel Simard (pitcher, b. 1981, Quebec)
- 2007: Quebec Les Capitales, Can-Am League (independent) - 1 game 31-Jul
- Bill Simas (pitcher, b. 1971, California)
- 1994: Lake Elsinore Storm, California League (High-A) - 1 game 30-Aug
- 1999: Chicago White Sox, American League (MLB) - 1 game 31-Jul
- 2004: Long Island Ducks, Atlantic League (independent) - 2 games 9-May 26-Sep
- Karson Simas (utility, b. 2001, California)
- 2019: GCL Red Sox, Gulf Coast League (rookie) - 1 game 21-Aug g2
- 2021: FCL Red Sox, Florida Complex League (rookie) - 1 game 23-Aug g1
- 2022: Salem Red Sox, Carolina League (Low-A) - 1 game 23-Jun
- A.J. Simcox (infielder, b. 1994, Tennessee)
- Rafael Sime (outfielder, b. 1976, Venezuela)
- 1996: Utica Blue Sox, New York-Penn League (short-season) - 1 game 6-Jul
- Samuel Sime (infielder, b. 1987, Dominican Republic)
- 2009: Rome Braves, South Atlantic League (Low-A) - 1 game 3-Jul
- Andrelton Simmons (infielder, b. 1989, Curacao)
- 2014: Atlanta Braves, Major League Baseball - 2 games 20-Apr 22-Aug
- 2015: Atlanta Braves, Major League Baseball - 1 game 23-Sep
- 2017: Los Angeles Angels of Anaheim, Major League Baseball - 1 game 21-Jun
- 2018: Los Angeles Angels, Major League Baseball - 1 game 11-Aug
- 2021: Minnesota Twins, Major League Baseball - 1 game 5-Jul
- Brian Simmons (outfielder, b. 1973, Pennsylvania)
- 1999: Chicago White Sox, American League (MLB) - 2 games 31-Jul 22-Sep
- 2003: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 15-Aug
- Dylan Simmons (pitcher, b. 2000, Florida)
- 2024: Daytona Tortugas, Florida State League (Low-A) - 2 games 17-May 21-Jun
- James Simmons (outfielder, b. 1985, Texas)
- 2013: Bridgeport Bluefish, Atlantic League (independent) - 1 game 7-Aug
- Jerry Simmons (outfielder, b. 1976, South Carolina)
- 1999: Jamestown Jammers, New York-Penn League (short-season) - 1 game 30-Jul
- Kendall Simmons (infielder, b. 2000, Georgia)
- Kevin Simmons (pitcher, b. 1993, Alabama)
- 2018: Gateway Grizzlies, Frontier League (independent) - 1 game 26-Aug
- Kyle Simmons (infielder, b. 1996, Bahamas)
- Seth Simmons (pitcher, b. 1988, North Carolina)
- 2019: High Point Rockers, Atlantic League (independent) - 1 game 3-May
- Shae Simmons (pitcher, b. 1990, Missouri)
- 2012: Danville Braves, Appalachian League (rookie) - 2 games 14-Aug 18-Aug
- 2013: Rome Braves, South Atlantic League (Low-A) - 1 game 26-May
- 2016: Atlanta Braves, Major League Baseball - 1 game 1-Sep
- Ted Simmons (catcher/first baseman, b. 1949, Michigan)
- 1970: St. Louis Cardinals, National League (MLB) - 1 game 13-Sep
- 1972: St. Louis Cardinals, National League (MLB) - 1 game 25-Jun g2
- Walt Simmons (outfielder, b. 1980)
- 2003: Kalamazoo Kings, Frontier League (independent) - 1 game 28-Jul
- John Simms (pitcher, b. 1992, Texas)
- 2018: Syracuse Chiefs, International League (AAA) - 1 game 2-May
- Mike Simms (first base/outfield, b. 1967, California)
- 1998: Texas Rangers, American League (MLB) - 1 game 24-Aug
- Adam Simon (pitcher, b. 1984, California)
- 2007: State College Spikes, New York-Penn League (short-season) - 1 game 22-Jul
- Alfredo Simon (pitcher, b. 1981, Dominican Republic)
- 2010: Baltimore Orioles, Major League Baseball - 1 game 8-Aug
- Ben Simon (pitcher, b. 1974, Ohio)
- 2003: Camden Riversharks, Atlantic League (independent) - 1 game 25-Jul
- 2004: Camden Riversharks, Atlantic League (independent) - 1 game 17-Jul
- Brandon Simon (outfielder, b. 1980, California)
- 2002: Missoula Osprey, Pioneer League (rookie) - 1 game 5-Aug
- Jake Simon (pitcher, b. 1997, Texas)
- 2018: Columbia Fireflies, South Atlantic League (Low-A) - 1 game 17-Jul
- Johan Simon (pitcher, b. 2001, Dominican Republic)
- 2022: FCL Blue Jays, Florida Complex League (rookie) - 1 game 2-Jul
- 2023: FCL Blue Jays, Florida Complex League (rookie) - 2 games 29-Jul 5-Aug
- Keanon Simon (outfielder, b. 1984, Oklahoma)
- 2007: State College Spikes, New York-Penn League (short-season) - 1 game 22-Jul
- Kyle Simon (pitcher, b. 1990, California)
- 2013: Reading Fightin Phils, Eastern League (AA) - 1 game 4-Aug
- 2018: New Britain Bees, Atlantic League (independent) - 1 game 4-Sep
- Mark Simon (pitcher, b. 1995, Texas)
- 2021: Missoula PaddleHeads, Pioneer League (independent) - 1 game 9-Jul
- Randall Simon (first baseman, b. 1975, Curacao)
- Ronny Simon (infielder, b. 2000, Dominican Republic)
- 2022: Mesa Solar Sox, Arizona Fall League - 2 games 13-Oct 15-Oct
- Scott Simon (first baseman, b. 1983)
- 2007: Southern Illinois Miners, Frontier League (independent) - 1 game 7-Aug
- William Simoneit (catcher, b. 1996, Illinois)
- 2024: Iowa Cubs, International League (AAA) - 1 game 21-Sep
- Doug Simons (pitcher, b. 1966, California)
- 1992: Montreal Expos, National League (MLB) - 1 game 5-Sep
- Mitch Simons (infielder, b. 1968, Oklahoma)
- 1995: Salt Lake Buzz, Pacific Coast League (AAA) - 1 game 15-Aug
- Zach Simons (pitcher, b. 1985, Idaho)
- 2011: Jacksonville Suns, Southern League (AA) - 1 game 12-Aug
- Benji Simonton (first base/outfield, b. 1972, California)
- 1994: San Jose Giants, California League (High-A) - 2 games 4-Sep 6-Sep
- 1998: Shreveport Captains, Texas League (AA) - 2 games 23-Aug 25-Aug
- 1999: Erie SeaWolves, Eastern League (AA) - 1 game 10-Apr g2
- Andre Simpson (pitcher, b. 1980, California)
- 2000: Burlington Bees, Midwest League (Low-A) - 1 game 13-Aug
- 2003: Evansville Otters, Frontier League (independent) - 1 game 26-Jul
- 2008: Orange County Flyers, Golden League (independent) - 1 game 26-Jul
- Caleb Simpson (pitcher, b. 1991, Oklahoma)
- 2017: San Jose Giants, California League (High-A) - 1 game 1-Aug
- 2018: Richmond Flying Squirrels, Eastern League (AA) - 1 game 4-Jun
- Chandler Simpson (outfielder, b. 2000, Georgia)
- 2023: Charleston RiverDogs, Carolina League (Low-A) - 1 game 9-May
- 2024: Montgomery Biscuits, Southern League (AA) - 1 game 18-Jun
- Chase Simpson (infielder, b. 1992, Texas)
- 2019: Cleburne Railroaders, American Association (independent) - 4 games 6-Jun 9-Jun g1 9-Jun g2 16-Jul
- 2022: Cleburne Railroaders, American Association (independent) - 1 game 10-Jul
- Creede Simpson (utility, b. 1989, Alabama)
- 2012: Aberdeen IronBirds, New York-Penn League (short-season) - 2 games 7-Aug 26-Aug
- Jay Simpson (outfielder, b. 1970)
- 1994: Lake Elsinore Storm, California League (High-A) - 2 games 28-Aug 30-Aug
- Jeramie Simpson (outfielder, b. 1974, Oklahoma)
- 1996: Capital City Bombers, South Atlantic League (Low-A) - 1 game 29-Aug
- Josh Simpson (pitcher, b. 1997, Connecticut)
- 2021: Mesa Solar Sox, Arizona Fall League - 1 game 18-Oct
- 2023: Jacksonville Jumbo Shrimp, International League (AAA) - 1 game 23-Sep
- Will Simpson (first baseman, b. 2001, Virginia)
- 2023: Stockton Ports, California League (Low-A) - 1 game 10-Aug
- Bryson Sims (outfielder, b. 1988)
- 2014: Trinidad Triggers, Pecos League (independent) - 1 game 22-Jul
- Demetrius Sims (infielder, b. 1995, Michigan)
- 2018: Batavia Muckdogs, New York-Penn League (short-season) - 1 game 29-Jul
- 2019: Jupiter Hammerheads, Florida State League (High-A) - 1 game 22-Aug
- 2021: Pensacola Blue Wahoos, Double-A South - 2 games 12-May 24-Jul
- Jake Sims (pitcher, b. 1997, Ontario)
- 2019: Tri-City Dust Devils, Northwest League (short-season) - 1 game 5-Jul
- Justin Sims (outfielder, b. 1980, Tennessee)
- 2003: Elizabethton Twins, Appalachian League (rookie) - 1 game 12-Jul
- Kenny Sims (pitcher, b. 1975, South Carolina)
- 2001: Bowie Baysox, Eastern League (AA) - 1 game 22-Aug
- Lucas Sims (pitcher, b. 1994, Georgia)
- 2015: Mississippi Braves, Southern League (AA) - 1 game 26-Jul
- 2017: Atlanta Braves, Major League Baseball - 2 games 22-Aug 25-Sep g1
- 2021: Cincinnati Reds, Major League Baseball - 1 game 1-Oct
- 2023: Cincinnati Reds, Major League Baseball - 1 game 24-Sep
- 2024: Cincinnati Reds, Major League Baseball - 1 game 28-Jul
- Taylor Sinclair (pitcher, b. 1985, Iowa)
- 2012: Somerset Patriots, Atlantic League (independent) - 1 game 25-Jul
- Brandon Sing (utility, b. 1981, Illinois)
- 2002: Daytona Cubs, Florida State League (High-A) - 1 game 23-Aug
- 2007: Bowie Baysox, Eastern League (AA) - 1 game 6-Apr
- 2010: Sioux Falls Pheasants, American Association (independent) - 1 game 24-Aug g2
- 2012: Long Island Ducks, Atlantic League (independent) - 3 games 20-Sep 29-Sep 6-Oct
- Brady Singer (pitcher, b. 1996, Florida)
- 2022: Kansas City Royals, Major League Baseball - 1 game 19-Aug
- Jeff Singer (pitcher, b. 1993, Pennsylvania)
- 2021: Lehigh Valley IronPigs, Triple-A East - 1 game 7-Sep
- Kirk Singer (infielder, then pitcher, b. 1989, California)
- 2011: State College Spikes, New York-Penn League (short-season) - 1 game 18-Aug
- Matt Singer (outfielder, b. 1978, Ohio)
- 2003: Florence Freedom, Frontier League (independent) - 1 game 4-Jul
- Dan Singletary (outfielder, b. 1975, New Jersey)
- 2001: Elmira Pioneers, Northeast League (independent) - 1 game 21-Sep
- 2002: Albany-Colonie Diamond Dogs, Northeast League (independent) - 2 games 28-Jun g2 1-Sep
- Chris Singleton (outfielder, b. 1972, California)
- 1994: San Jose Giants, California League (High-A) - 2 games 4-Sep 6-Sep
- 1999: Chicago White Sox, American League (MLB) - 1 game 22-Sep
- Chris Singleton (outfielder, b. 1996, South Carolina)
- 2018: South Bend Cubs, Midwest League (Low-A) - 1 game 3-Aug
- Duane Singleton (outfielder, b. 1972, New York)
- 1998: Bridgeport Bluefish, Atlantic League (independent) - 1 game 27-Jul
- 1999: Bridgeport Bluefish, Atlantic League (independent) - 1 game 20-Jun
- Jon Singleton (first baseman, b. 1991, California)
- 2010: Lakewood BlueClaws, South Atlantic League (Low-A) - 2 games 11-Sep 17-Sep
- 2023: Nashville Sounds, International League (AAA) - 1 game 19-Apr
- 2024: Houston Astros, Major League Baseball - 1 game 12-Aug
- Justin Singleton (outfielder, b. 1979, Maryland)
- 2003: New Haven Ravens, Eastern League (AA) - 2 games 27-Jun 10-Sep
- 2004: New Hampshire Fisher Cats, Eastern League (AA) - 1 game 1-Aug
- 2007: York Revolution, Atlantic League (independent) - 2 games 21-Jul 26-Aug
- Ken Singleton (outfielder, b. 1947, New York)
- 1970: New York Mets, National League (MLB) - 1 game 13-Sep
- 1971: New York Mets, National League (MLB) - 1 game 12-Sep
- Matt Singleton (catcher, b. 1983, Indiana)
- 2006: Stockton Ports, California League (High-A) - 1 game 21-Aug
- Steve Singleton (infielder, b. 1985, California)
- 2009: New Britain Rock Cats, Eastern League (AA) - 1 game 13-Sep
- 2010: New Britain Rock Cats, Eastern League (AA) - 3 games 30-May 27-Jul 5-Sep
- 2011: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 24-Jul
- 2011: Reading Phillies, Eastern League (AA) - 1 game 10-Sep
- Vincent Sinisi (first base/outfield, b. 1981, Texas)
- 2005: Frisco Roughriders, Texas League (AA) - 1 game 14-Aug
- Brett Sinkbeil (pitcher, b. 1984, Oklahoma)
- 2011: Altoona Curve, Eastern League (AA) - 1 game 27-Aug
- Brandon Sinnery (pitcher, b. 1990, New Jersey)
- 2012: Lincoln Saltdogs, American Association (independent) - 1 game 24-Aug
- Tony Sipp (pitcher, b. 1983, Mississippi)
- 2008: Akron Aeros, Eastern League (AA) - 1 game 14-Sep
- 2011: Cleveland Indians, Major League Baseball - 1 game 4-Sep
- 2013: Arizona Diamondbacks, Major League Baseball - 1 game 4-Jul
- 2016: Houston Astros, Major League Baseball - 1 game 20-Aug
- Dalbert Siri (pitcher, b. 1995, Dominican Republic)
- 2018: Glendale Desert Dogs, Arizona Fall League - 2 games 5-Nov 15-Nov
- Jose Siri (outfielder, b. 1995, Dominican Republic)
- Raul Siri (infielder, b. 1994, Dominican Republic)
- 2019: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 1-May
- 2019: Bradenton Marauders, Florida State League (High-A) - 1 game 23-Aug
- A.J. Sirianni (pitcher, b. 1975, Connecticut)
- 1998: Adirondack Lumberjacks, Northeast League (independent) - 1 game 19-Jul
- Jay Sirianni (pitcher, b. 1975, Iowa)
- 1999: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 10-Sep
- Andrew Sisco (pitcher, b. 1983, Colorado)
- 2005: Kansas City Royals, Major League Baseball - 1 game 7-Aug
- 2012: Somerset Patriots, Atlantic League (independent) - 1 game 22-Aug
- Chance Sisco (catcher, b. 1995, California)
- 2015: Bowie Baysox, Eastern League (AA) - 1 game 22-Aug
- 2017: Baltimore Orioles, Major League Baseball - 1 game 24-Sep
- 2018: Baltimore Orioles, Major League Baseball - 1 game 13-May
- 2019: Norfolk Tides, International League (AAA) - 1 game 27-May
- 2019: Baltimore Orioles, Major League Baseball - 1 game 3-Sep g1
- 2021: Norfolk Tides, Triple-A East - 1 game 16-Jun
- Steve Sisco (infielder, b. 1969, California)
- 1994: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 4-Aug
- 1998: Omaha Royals, Pacific Coast League (AAA) - 2 games 21-Aug g1 21-Aug g2
- Aaron Sisk (infielder, b. 1978, Texas)
- 2006: Connecticut Defenders, Eastern League (AA) - 1 game 13-Apr
- Brandon Sisk (pitcher, b. 1985, Texas)
- 2015: New Jersey Jackals, Can-Am League (independent) - 3 games 14-Aug 11-Sep 18-Sep
- 2016: Somerset Patriots, Atlantic League (independent) - 1 game 31-Jul g2
- Doug Sisk (pitcher, b. 1957, Washington)
- 1983: New York Mets, National League (MLB) - 1 game 5-Apr
- 1984: New York Mets, National League (MLB) - 3 games 17-Apr 8-Sep 26-Sep
- 1985: New York Mets, National League (MLB) - 1 game 9-Apr
- Evan Sisk (pitcher, b. 1997, South Carolina)
- 2021: Wichita Wind Surge, Double-A Central - 1 game 15-Sep
- 2021: Scottsdale Scorpions, Arizona Fall League - 2 games 18-Oct 21-Oct
- Bobby Sismondo (pitcher, b. 1976, Ohio)
- 2001: Reading Phillies, Eastern League (AA) - 1 game 5-Apr
- Brandyn Sittinger (pitcher, b. 1994, Ohio)
- 2019: Lakeland Flying Tigers, Florida State League (High-A) - 2 games 14-May 16-May
- Kraig Sitton (pitcher, b. 1988, Oregon)
- 2015: New Britain Rock Cats, Eastern League (AA) - 1 game 16-Aug
- Jay Sitzman (outfielder, b. 1978, Colorado)
- 1999: Batavia Muckdogs, New York-Penn League (short-season) - 1 game 28-Aug
- 2002: Reading Phillies, Eastern League (AA) - 1 game 11-Apr
- 2003: Reading Phillies, Eastern League (AA) - 2 games 3-Apr 27-Jun
- Misael Siverio (pitcher, b. 1989, Cuba)
- 2015: Jackson Generals, Southern League (AA) - 1 game 25-Jul
- Anyesber Sivira (infielder, b. 2000, Venezuela)
- 2019: Augusta GreenJackets, South Atlantic League (Low-A) - 1 game 12-Aug
- Yonathan Sivira (outfielder, b. 1984, Venezuela)
- 2005: New Jersey Cardinals, New York-Penn League (short-season) - 3 games 23-Jun 27-Jun 5-Sep
- Grady Sizemore (outfielder, b. 1982, Washington)
- 2003: Akron Aeros, Eastern League (AA) - 1 game 10-Sep
- 2004: Buffalo Bisons, International League (AAA) - 1 game 5-Sep
- 2008: Cleveland Indians, Major League Baseball - 1 game 31-Aug
- 2009: Cleveland Indians, Major League Baseball - 1 game 16-Apr
- 2014: Boston Red Sox, Major League Baseball - 1 game 18-Apr
- 2014: Philadelphia Phillies, Major League Baseball - 1 game 18-Aug
- Scott Sizemore (infielder, b. 1985, Virginia)
- 2011: Oakland Athletics, Major League Baseball - 1 game 23-Aug
- 2014: Scranton/Wilkes-Barre RailRiders, International League (AAA) - 1 game 1-Sep
- Tyler Skaggs (pitcher, b. 1991, California; d. 2019, Texas)
- 2018: Los Angeles Angels, Major League Baseball - 1 game 11-Aug
- Andy Skeels (catcher, b. 1965, New Zealand)
- 1998: Somerset Patriots, Atlantic League (independent) - 1 game 12-Jul
- 2001: Newark Bears, Atlantic League (independent) - 1 game 30-Aug g1
- James Skelton (catcher/infielder, b. 1985, California)
- 2008: Erie SeaWolves, Eastern League (AA) - 1 game 31-Aug
- 2009: Visalia Rawhide, California League (High-A) - 1 game 27-Aug
- 2013: Somerset Patriots, Atlantic League (independent) - 1 game 7-Aug
- 2015: Somerset Patriots, Atlantic League (independent) - 2 games 13-Aug 17-Aug
- 2016: New Britain Bees, Atlantic League (independent) - 1 game 24-Jul
- 2018: New Britain Bees, Atlantic League (independent) - 3 games 10-Jun 16-Jun 4-Sep
- Will Skett (outfielder, b. 1974, California)
- 1996: St. Catharines Stompers, New York-Penn League (short-season) - 1 game 15-Aug
- 1997: Knoxville Smokies, Southern League (AA) - 1 game 10-Aug
- Joel Skinner (catcher, b. 1961, California)
- 1991: Cleveland Indians, American League (MLB) - 1 game 15-Sep
- 1993: Canton-Akron Indians, Eastern League (AA) - 1 game 9-Aug
- Keith Skinner (catcher/first base, b. 1994, New Jersey)
- 2017: Staten Island Yankees, New York-Penn League (short-season) - 3 games 9-Aug 9-Sep 12-Sep
- Kyle Skipworth (catcher, b. 1990, California)
- 2011: Jacksonville Suns, Southern League (AA) - 1 game 12-Aug
- 2013: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 21-Jul
- Matt Skirving (catcher/first base, b. 1989, Michigan)
- 2010: State College Spikes, New York-Penn League (short-season) - 1 game 29-Jul
- 2011: State College Spikes, New York-Penn League (short-season) - 1 game 18-Aug
- Eric Skoglund (pitcher, b. 1992, Florida)
- 2015: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 23-May
- Jake Skole (outfielder, b. 1992, Georgia)
- 2021: Gastonia Honey Hunters, Atlantic League (independent) - 2 games 6-Aug 4-Sep
- Matt Skole (infielder, b. 1989, Georgia)
- 2012: Hagerstown Suns, South Atlantic League (Low-A) - 1 game 9-Aug
- 2014: Harrisburg Senators, Eastern League (AA) - 1 game 3-Aug
- 2016: Syracuse Chiefs, International League (AAA) - 1 game 5-Aug
- 2019: Charlotte Knights, International League (AAA) - 1 game 1-May
- Jon Skorupski (first baseman, b. 1983, Indiana)
- 2005: New Jersey Cardinals, New York-Penn League (short-season) - 3 games 23-Jun 27-Jun 29-Jun
- Matt Skrmetta (pitcher, b. 1972, Mississippi)
- 1999: Mobile BayBears, Southern League (AA) - 1 game 3-Jul
- Mark Skrukrud (pitcher, b. unknown, Minnesota)
- 2003: Chillicothe Paints, Frontier League (independent) - 1 game 28-Jul
- Tarik Skubal (pitcher, b. 1996, California)
- 2019: Lakeland Flying Tigers, Florida State League (High-A) - 1 game 16-May
- 2024: Detroit Tigers, Major League Baseball - 1 game 22-Apr
- Nick Skuse (pitcher, b. 1972, California)
- 1994: Boise Hawks, Northwest League (short-season) - 1 game 8-Sep
- Nick Slack (pitcher, b. 1983, Connecticut)
- 2004: High Desert Mavericks, California League (High-A) - 1 game 11-Aug
- Anthony Slagle (utility, b. 1981)
- 2005: River City Rascals, Frontier League (independent) - 1 game 6-Aug
- Doug Slaten (pitcher, b. 1980, California; d. 2016, Florida)
- 2009: Reno Aces, Pacific Coast League (AAA) - 1 game 22-Aug
- 2010: Washington Nationals, Major League Baseball - 2 games 2-Oct 3-Oct
- Justin Slaten (pitcher, b. 1997, Texas)
- 2024: Boston Red Sox, Major League Baseball - 1 game 20-May
- Michael Slaten (pitcher, b. 1997, Texas)
- 2022: Schaumburg Boomers, Frontier League (independent) - 1 game 5-Jul
- Austin Slater (outfielder, b. 1992, Florida)
- 2023: San Francisco Giants, Major League Baseball - 1 game 11-Aug
- 2024: Cincinnati Reds, Major League Baseball - 2 games 26-Jul 28-Jul
- 2024: Baltimore Orioles, Major League Baseball - 1 game 18-Sep
- Wayne Slater (outfielder, b. 1975, New York)
- 1998: Massachusetts Mad Dogs, Northeast League (independent) - 1 game 3-Jul
- 1998: New Jersey Jackals, Northeast League (independent) - 1 game 7-Aug
- Don Slaught (catcher, b. 1958, California)
- 1992: Pittsburgh Pirates, National League (MLB) - 1 game 20-Aug
- 1993: Pittsburgh Pirates, National League (MLB) - 1 game 11-Sep
- Garland Slaughter (pitcher, b. 1966)
- 1990: Batavia Clippers, New York-Penn League (short-season) - 1 game 16-Aug
- Jake Slaughter (infielder, b. 1996, Louisiana)
- Jeremy Slayden (outfielder, b. 1982, Kentucky)
- 2006: Lakewood BlueClaws, South Atlantic League (Low-A) - 5 games 26-Apr 26-Jun 6-Sep 14-Sep 15-Sep
- 2008: Reading Phillies, Eastern League (AA) - 2 games 4-Aug 1-Sep
- 2011: New Jersey Jackals, Can-Am League (independent) - 3 games 8-Jun 22-Jun 23-Jun
- 2011: Rockland Boulders, Can-Am League (independent) - 1 game 24-Aug
- Terrmel Sledge (outfielder, b. 1977, North Carolina)
- 2004: Montreal Expos, Major League Baseball - 1 game 2-Oct
- Aaron Slegers (pitcher, b. 1992, California)
- 2021: Los Angeles Angels, Major League Baseball - 1 game 10-Apr
- David Slevin (infielder, b. 1981, Florida)
- 2003: Staten Island Yankees, New York-Penn League (short-season) - 1 game 21-Aug
- Brandon Sloan (pitcher, b. 1977, Kansas)
- 2002: Portland Sea Dogs, Eastern League (AA) - 1 game 21-Apr
- 2003: Jupiter Hammerheads, Florida State League (High-A) - 1 game 26-Aug
- Heathcliff Slocumb (pitcher, b. 1966, New York)
- 1992: Chicago Cubs, National League (MLB) - 1 game 15-Aug
- 1994: Philadelphia Phillies, National League (MLB) - 1 game 22-Jul g1
- Bob Slomkowski (pitcher, b. 1975, New Jersey)
- 1998: Lowell Spinners, New York-Penn League (short-season) - 1 game 25-Jul
- Ryan Sloniger (catcher, b. 1997, Pennsylvania)
- Joe Slusarski (pitcher, b. 1966, Indiana)
- 1998: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 28-Aug
- Aaron Small (pitcher, b. 1971, California)
- 1995: Charlotte Knights, International League (AAA) - 1 game 5-Aug
- 1997: Oakland Athletics, American League (MLB) - 1 game 1-Sep
- 2004: Albuquerque Isotopes, Pacific Coast League (AAA) - 1 game 10-Aug g2
- Andrew Small (infielder, b. 1970)
- 1993: Elmira Pioneers, New York-Penn League (short-season) - 1 game 5-Sep
- Ethan Small (pitcher, b. 1997, Tennessee)
- 2023: Nashville Sounds, International League (AAA) - 1 game 19-Apr
- Colby Smelley (catcher, b. 2000, Alabama)
- 2022: Winston-Salem Dash, South Atlantic League (High-A) - 1 game 31-Aug
- 2024: Winston-Salem Dash, South Atlantic League (High-A) - 1 game 9-Aug
- Devin Smeltzer (pitcher, b. 1995, New Jersey)
- 2018: Chattanooga Lookouts, Southern League (AA) - 1 game 27-Aug
- 2018: Salt River Rafters, Arizona Fall League - 1 game 12-Nov
- Steve Smetana (pitcher, b. 1973, Ohio)
- 1996: Lowell Spinners, New York-Penn League (short-season) - 1 game 3-Aug
- 1998: Trenton Thunder, Eastern League (AA) - 1 game 1-Jul
- 1999: Trenton Thunder, Eastern League (AA) - 1 game 13-Sep
- John Smiley (pitcher, b. 1965, Pennsylvania)
- 1990: Pittsburgh Pirates, National League (MLB) - 1 game 12-Aug
- Rueben Smiley (outfielder, b. 1968, California)
- 1994: Phoenix Firebirds, Pacific Coast League (AAA) - 1 game 31-Aug
- Jason Smit (first base/outfield, b. 1989, Australia)
- 2009: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 14-Sep
- Alex Smith (pitcher, b. 1989, Connecticut)
- 2014: Scottsdale Scorpions, Arizona Fall League - 1 game 8-Oct
- Armani Smith (outfielder, b. 1998, California)
- 2021: Eugene Emeralds, High-A West - 1 game 13-Jul
- 2022: Richmond Flying Squirrels, Eastern League (AA) - 1 game 1-Sep
- Austen Smith (first base/outfield, b. 1992, Florida)
- 2015: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 15-Apr
- Austin Smith (pitcher, b. 1999, Texas)
- 2022: Rome Braves, South Atlantic League (High-A) - 1 game 4-Jul
- 2022: Scottsdale Scorpions, Arizona Fall League - 1 game 15-Oct
- Blake Smith (outfielder, then pitcher, b. 1987, California)
- 2009: Ogden Raptors, Pioneer League (rookie) - 1 game 17-Aug
- 2014: Glendale Desert Dogs, Arizona Fall League - 1 game 9-Oct
- Bobby Smith (infielder, b. 1974, California)
- 1997: Richmond Braves, International League (AAA) - 1 game 20-Jul
- 1998: Tampa Bay Devil Rays, American League (MLB) - 2 games 9-Aug 27-Sep
- Bradley Smith (infielder, b. 1978, Missouri)
- Brandon Smith (pitcher, b. 1980, Texas)
- 2002: Lowell Spinners, New York-Penn League (short-season) - 1 game 6-Jul
- Brendon Smith (pitcher, b. 1986)
- 2010: Lincoln Saltdogs, American Association (independent) - 1 game 21-Aug
- Brian Smith (infielder, b. 1977, California)
- 1999: Newark Bears, Atlantic League (independent) - 2 games 31-May 11-Jul
- Bryn Smith (pitcher, b. 1955, Georgia)
- 1984: Montreal Expos, National League (MLB) - 1 game 17-Apr
- Bryon Smith (infielder, b. 1979, Arizona)
- 2005: Fort Worth Cats, Central League (independent) - 1 game 3-Sep
- Bryson Smith (outfielder, b. 1988, Georgia)
- 2012: Pensacola Blue Wahoos, Southern League (AA) - 1 game 12-Aug
- Bubba Smith (first baseman, b. 1969, North Carolina)
- 2006: Sioux Falls Canaries, American Association (independent) - 1 game 6-Aug
- Cade Smith (pitcher, b. 1999, British Columbia)
- 2022: Peoria Javelinas, Arizona Fall League - 1 game 12-Oct
- 2024: Cleveland Guardians, Major League Baseball - 1 game 25-Sep
- Cade Smith (pitcher, b. 2002, Tennessee)
- 2024: Tampa Tarpons, Florida State League (Low-A) - 1 game 15-Jun
- Caleb Smith (pitcher, b. 1991, Texas)
- 2016: Trenton Thunder, Eastern League (AA) - 1 game 10-Sep
- 2018: Miami Marlins, Major League Baseball - 1 game 30-Mar
- 2019: Miami Marlins, Major League Baseball - 2 games 1-Apr 4-Aug
- 2021: Arizona Diamondbacks, Major League Baseball - 1 game 19-Jul
- Cam Smith (pitcher, b. 1973, New York)
- 2001: Chattanooga Lookouts, Southern League (AA) - 1 game 9-Aug
- 2003: Somerset Patriots, Atlantic League (independent) - 1 game 14-Aug
- 2004: Somerset Patriots, Atlantic League (independent) - 1 game 19-Jun g2
- Carlton Smith (pitcher, b. 1986, New Jersey)
- 2007: Lake County Captains, South Atlantic League (Low-A) - 1 game 30-Aug
- Carson Smith (pitcher, b. 1989, Texas)
- 2018: Boston Red Sox, Major League Baseball - 2 games 29-Mar 31-Mar
- Casey Smith (catcher, b. 1977, Texas)
- 1997: Columbus RedStixx, South Atlantic League (Low-A) - 1 game 12-Aug g2
- 2001: Akron Aeros, Eastern League (AA) - 1 game 5-Apr
- Casey Smith (outfielder, b. 1984, Texas)
- 2006: Eugene Emeralds, Northwest League (short-season) - 1 game 22-Aug
- Chad Smith (pitcher, b. 1977, Indiana)
- 1999: Batavia Muckdogs, New York-Penn League (short-season) - 1 game 28-Aug
- Chad Smith (pitcher, b. 1995, Alabama)
- 2017: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 24-Aug
- 2018: Salt River Rafters, Arizona Fall League - 2 games 12-Nov 15-Nov
- 2019: Jupiter Hammerheads, Florida State League (High-A) - 1 game 15-May g2
- Chris Smith (pitcher, b. 1981, California)
- 2002: Lowell Spinners, New York-Penn League (short-season) - 1 game 4-Jul
- 2003: Sarasota Red Sox, Florida State League (High-A) - 1 game 30-Aug
- Chris Smith (infielder, b. 1984)
- 2008: Shreveport Sports, American Association (independent) - 1 game 12-Aug
- Cliff Smith (pitcher, b. 1979, Maine)
- 2005: Lancaster Barnstormers, Atlantic League (independent) - 1 game 12-Jun
- Clint Smith (pitcher, b. 1977, Texas)
- Coby Smith (outfielder, b. 1980, Alabama)
- 2004: Aces, Northeast League (independent) - 1 game 9-Jul
- 2005: Shreveport Sports, Central League (independent) - 1 game 16-Aug
- 2007: Arkansas Travelers, Texas League (AA) - 1 game 8-Aug
- Cody Smith (pitcher, b. 1982, California)
- 2004: Stockton Ports, California League (High-A) - 1 game 19-Aug g2
- Corey Smith (infielder, b. 1982, New Jersey)
- Curt Smith (first baseman, b. 1986, Curacao)
- 2019: Lincoln Saltdogs, American Association (independent) - 3 games 31-May 6-Jun 16-Jul
- Dan Smith (pitcher, b. 1978, Missouri)
- 2004: Gateway Grizzlies, Frontier League (independent) - 1 game 25-Jul
- Dan Smith (pitcher, b. 1983, Maryland)
- 2003: GCL Braves, Gulf Coast League (rookie) - 2 games 25-Aug 27-Aug
- D'Andre Smith (infielder, b. 2001, California)
- 2022: St. Lucie Mets, Florida State League (Low-A) - 1 game 18-Sep
- 2023: Glendale Desert Dogs, Arizona Fall League - 2 games 12-Oct 14-Oct
- David Smith (outfielder, b. 1981, West Virginia)
- 2002: Medicine Hat Blue Jays, Pioneer League (rookie) - 2 games 4-Aug 17-Aug g2
- 2003: Charleston Alley Cats, South Atlantic League (Low-A) - 2 games 5-Jul 13-Jul
- David Smith (utility, b. 2001, Pennsylvania)
- Demond Smith (outfielder, b. 1972, California)
- 1994: Boise Hawks, Northwest League (short-season) - 1 game 8-Sep
- 1999: Greenville Braves, Southern League (AA) - 1 game 12-Aug
- Dominic Smith (first base/outfield, b. 1995, California)
- Drew Smith (pitcher, b. 1993, Texas)
- 2021: New York Mets, Major League Baseball - 1 game 15-May
- 2022: New York Mets, Major League Baseball - 1 game 3-May g1
- Dustin Smith (catcher, b. 1981, New Jersey)
- 2004: Stockton Ports, California League (High-A) - 1 game 19-Aug g2
- Dwight Smith (outfielder, b. 1963, Florida; d. 2022, Georgia)
- 1993: Chicago Cubs, National League (MLB) - 1 game 11-Aug
- 1996: Atlanta Braves, National League (MLB) - 1 game 14-Sep
- Dwight Smith (outfielder, b. 1992, Georgia)
- Ed Smith (infielder, b. 1969)
- 1995: Canton-Akron Indians, Eastern League (AA) - 2 games 3-Jul 19-Aug
- Eric Smith (pitcher, b. 1988, Connecticut)
- 2014: New Jersey Jackals, Can-Am League (independent) - 1 game 6-Sep
- Ethan Smith (outfielder, b. 1999, Washington)
- 2024: Grand Junction Jackalopes, Pioneer League (independent) - 1 game 16-Jul
- Greg Smith (pitcher, b. 1983, Louisiana)
- 2013: Lehigh Valley IronPigs, International League (AAA) - 1 game 2-Sep
- 2014: Lehigh Valley IronPigs, International League (AAA) - 1 game 1-Sep
- Harrison Smith (pitcher/infielder, b. 1996, South Carolina)
- 2019: Chicago Dogs, American Association (independent) - 1 game 1-Jun
- Hut Smith (pitcher, b. 1973, North Carolina)
- 1997: Bowie Baysox, Eastern League (AA) - 1 game 17-Aug
- 2002: Newark Bears, Atlantic League (independent) - 1 game 17-Sep
- 2003: Newark Bears, Atlantic League (independent) - 2 games 22-Jun g2 3-Aug
- Ira Smith (outfielder, b. 1967, Maryland)
- 1998: Toledo Mud Hens, International League (AAA) - 1 game 14-Aug
- Jack Smith (infielder, b. 1964, Florida)
- 1990: Williamsport Bills, Eastern League (AA) - 1 game 11-Aug
- Jake Smith (infielder, b. 1987, Alabama)
- 2010: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 9-Aug
- Jared Smith (pitcher, b. 1978, Louisiana)
- 2001: Pittsfield Astros, New York-Penn League (short-season) - 1 game 21-Jul
- Jarod Smith (pitcher, b. 1972)
- 1998: Albany-Colonie Diamond Dogs, Northeast League (independent) - 1 game 22-Jul
- Jason Smith (catcher, b. 1970, Florida)
- 1992: Elmira Pioneers, New York-Penn League (short-season) - 1 game 9-Aug g2
- Jason Smith (catcher/first base, b. 1970, Texas)
- 1994: New Haven Ravens, Eastern League (AA) - 1 game 24-Jul
- Jason Smith (infielder, b. 1977, Mississippi)
- 1997: Williamsport Cubs, New York-Penn League (short-season) - 1 game 19-Jul
- 1998: Rockford Cubbies, Midwest League (Low-A) - 1 game 19-Aug
- 2004: Detroit Tigers, Major League Baseball - 1 game 17-Jun
- Jason Smith (pitcher, b. 1982, Oregon)
- 2001: Staten Island Yankees, New York-Penn League (short-season) - 1 game 5-Sep
- Jaylen Smith (pitcher, b. 1999, Texas)
- 2019: GCL Phillies West, Gulf Coast League (rookie) - 2 games 22-Aug 26-Aug g2
- Jeff Smith (pitcher, b. 1970, Florida)
- 1994: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 4-Aug
- Jeff Smith (catcher, b. 1974, Ohio)
- 1997: New Britain Rock Cats, Eastern League (AA) - 1 game 3-Aug
- 1998: New Britain Rock Cats, Eastern League (AA) - 1 game 2-Aug
- Jeremy Smith (infielder, b. 1979, Texas)
- 2001: Schaumburg Flyers, Northern League (independent) - 1 game 29-Jul
- Jesse Smith (pitcher, b. 1980, Nebraska)
- 2006: Arkansas Travelers, Texas League (AA) - 1 game 3-Sep
- Joe Smith (pitcher, b. 1984, Ohio)
- 2006: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 28-Jul
- 2007: New York Mets, Major League Baseball - 2 games 16-Sep 26-Sep
- 2008: New York Mets, Major League Baseball - 2 games 6-Jul 10-Sep
- 2010: Cleveland Indians, Major League Baseball - 1 game 31-Jul
- 2011: Cleveland Indians, Major League Baseball - 1 game 4-Sep
- 2018: Houston Astros, Major League Baseball - 1 game 29-Sep g1
- 2021: Seattle Mariners, Major League Baseball - 1 game 2-Aug
- 2022: Minnesota Twins, Major League Baseball - 1 game 30-Apr
- John Smith (infielder, b. 1982, Georgia)
- 2003: GCL Pirates, Gulf Coast League (rookie) - 1 game 26-Aug
- John Smith (pitcher, b. 1982)
- 2006: Rockford RiverHawks, Frontier League (independent) - 1 game 8-Aug
- 2007: Laredo Broncos, United League (independent) - 1 game 10-Aug
- Jon Smith (outfielder, b. 1988, New York)
- 2012: Rockland Boulders, Can-Am League (independent) - 1 game 26-Aug
- 2013: Trois-Rivieres Aigles, Can-Am League (independent) - 1 game 11-Aug
- Jordan Smith (pitcher, b. 1986, Utah)
- 2011: Louisville Bats, International League (AAA) - 1 game 1-Aug
- Jordan Smith (outfielder, b. 1990, Minnesota)
- 2014: Akron RubberDucks, Eastern League (AA) - 1 game 3-Aug
- 2014: Peoria Javelinas, Arizona Fall League - 1 game 10-Oct
- 2015: Akron RubberDucks, Eastern League (AA) - 1 game 3-Jul
- Josh Smith (pitcher, b. 1987, Florida)
- 2017: Nashville Sounds, Pacific Coast League (AAA) - 1 game 21-Aug
- Josh Smith (pitcher, b. 1989, Missouri)
- 2015: Altoona Curve, Eastern League (AA) - 1 game 22-Aug
- 2017: Portland Sea Dogs, Eastern League (AA) - 1 game 18-Aug g1
- 2018: Pawtucket Red Sox, International League (AAA) - 2 games 14-Jun 31-Jul
- 2019: Miami Marlins, Major League Baseball - 1 game 27-Sep
- Josh Smith (utility, b. 1997, Louisiana)
- 2021: Tampa Tarpons, Low-A Southeast - 1 game 6-Jun
- 2022: Texas Rangers, Major League Baseball - 1 game 16-Sep
- 2023: Texas Rangers, Major League Baseball - 1 game 11-Aug
- 2024: Texas Rangers, Major League Baseball - 2 games 1-Apr 3-Apr
- Juan Carlos Smith (outfielder, b. 1997, Dominican Republic)
- Keilan Smith (pitcher, b. 1973, Tennessee)
- 1998: Jacksonville Suns, Southern League (AA) - 1 game 27-Aug
- Kevan Smith (catcher, b. 1988, Pennsylvania)
- 2018: Chicago White Sox, Major League Baseball - 1 game 20-Sep
- 2021: Atlanta Braves, Major League Baseball - 1 game 30-Jun
- Kevin Smith (first baseman, b. 1984, California)
- 2006: Staten Island Yankees, New York-Penn League (short-season) - 3 games 18-Jul 28-Jul 13-Sep
- 2009: Trenton Thunder, Eastern League (AA) - 1 game 8-Apr
- Kevin Smith (infielder, b. 1996, New York)
- 2017: Bluefield Blue Jays, Appalachian League (rookie) - 1 game 28-Aug
- 2019: Scottsdale Scorpions, Arizona Fall League - 1 game 15-Oct
- 2022: Oakland Athletics, Major League Baseball - 3 games 12-Apr 13-Apr 14-Apr
- 2023: Las Vegas Aviators, Pacific Coast League (AAA) - 1 game 9-Aug
- Kevin Smith (pitcher, b. 1997, Georgia)
- 2019: St. Lucie Mets, Florida State League (High-A) - 1 game 15-Apr
- 2021: Norfolk Tides, Triple-A East - 1 game 16-Jun
- Lee Smith (pitcher, b. 1957, Louisiana)
- 1988: Boston Red Sox, American League (MLB) - 1 game 27-Jun
- 1991: St. Louis Cardinals, National League (MLB) - 1 game 22-Sep
- 1993: St. Louis Cardinals, National League (MLB) - 1 game 25-Jun
- 1993: New York Yankees, American League (MLB) - 3 games 17-Sep 22-Sep 1-Oct
- Lonnie Smith (outfielder, b. 1955, Illinois)
- 1985: St. Louis Cardinals, National League (MLB) - 1 game 9-Apr
- 1992: Atlanta Braves, National League (MLB) - 1 game 31-Aug g1
- Malcolm Smith (outfielder, b. 1997, California)
- 2021: Bakersfield Train Robbers, Pecos League (independent) - 1 game 17-Jul
- Mallex Smith (outfielder, b. 1993, Florida)
- 2014: Surprise Saguaros, Arizona Fall League - 1 game 9-Oct
- 2016: Atlanta Braves, Major League Baseball - 2 games 3-May 21-Sep
- 2017: Tampa Bay Rays, Major League Baseball - 1 game 24-Sep
- 2018: Tampa Bay Rays, Major League Baseball - 4 games 29-Mar 31-Mar 13-May 21-Sep
- 2019: Seattle Mariners, Major League Baseball - 1 game 19-Aug
- Mark Smith (outfielder, b. 1970, California)
- 1994: Rochester Red Wings, International League (AAA) - 1 game 12-Aug
- 1995: Baltimore Orioles, American League (MLB) - 1 game 1-Oct
- 1997: Pittsburgh Pirates, National League (MLB) - 1 game 24-Sep
- 1998: Pittsburgh Pirates, National League (MLB) - 1 game 18-Jul
- 1998: Nashville Sounds, Pacific Coast League (AAA) - 2 games 26-Aug 28-Aug
- 2001: Montreal Expos, Major League Baseball - 1 game 5-Oct
- 2002: Calgary Cannons, Pacific Coast League (AAA) - 2 games 7-Aug 9-Aug
- Mark L Smith (pitcher, b. 1968, Texas)
- 1993: Frederick Keys, Carolina League (High-A) - 1 game 8-Aug
- Matt Smith (first baseman, b. 1976, California)
- 1995: Springfield Sultans, Midwest League (Low-A) - 1 game 18-Aug
- 1996: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 28-Jul
- Matt Smith (pitcher, b. 1976, New Jersey)
- 2000: Newark Bears, Atlantic League (independent) - 2 games 6-Jul 6-Sep
- 2009: Newark Bears, Atlantic League (independent) - 2 games 25-Sep 26-Sep
- 2010: Newark Bears, Atlantic League (independent) - 1 game 14-Aug
- 2011: Bridgeport Bluefish, Atlantic League (independent) - 1 game 18-Sep
- Matt Smith (pitcher, b. 1978, Illinois)
- 2000: Pittsfield Mets, New York-Penn League (short-season) - 1 game 26-Aug
- 2001: Kannapolis Intimidators, South Atlantic League (Low-A) - 1 game 2-Aug
- Matt Smith (pitcher, b. 1979, Nevada)
- 2005: Trenton Thunder, Eastern League (AA) - 1 game 14-Jun
- Matt Smith (pitcher, b. 1984, Florida)
- 2008: Amarillo Dillas, United League (independent) - 1 game 13-Aug
- Michael Smith (outfielder, b. 1997, Texas)
- 2017: Princeton Rays, Appalachian League (rookie) - 1 game 29-Aug
- 2018: Hudson Valley Renegades, New York-Penn League (short-season) - 4 games 18-Jun 31-Jul 6-Sep 9-Sep
- 2019: Bowling Green Hot Rods, Midwest League (Low-A) - 1 game 30-May
- 2019: Charlotte Stone Crabs, Florida State League (High-A) - 2 games 20-Aug 24-Aug
- 2021: Montgomery Biscuits, Double-A South - 1 game 24-Jul
- Mike Smith (pitcher, b. 1963, Texas)
- 2002: Newark Bears, Atlantic League (independent) - 1 game 19-Sep
- 2004: Coastal Bend Aviators, Central League (independent) - 1 game 3-Jul
- 2004: Newark Bears, Atlantic League (independent) - 1 game 29-Aug
- Mike Smith (catcher, b. 1965)
- 1986: Utica Blue Sox, New York-Penn League (short-season) - 1 game 15-Aug
- Mike Smith (infielder, b. 1969; aka Alex Smith)
- 1994: High Desert Mavericks, California League (High-A) - 1 game 28-Aug
- Mike Smith (pitcher, b. 1977, Massachusetts)
- 2006: Minnesota Twins, Major League Baseball - 1 game 6-Aug
- Murphy Smith (pitcher, b. 1987, New Hampshire)
- 2018: Buffalo Bisons, International League (AAA) - 1 game 1-Aug g2
- Nate Smith (outfielder, b. 1974, Oregon)
- 1998: New Jersey Cardinals, New York-Penn League (short-season) - 2 games 25-Jul 30-Jul
- Nestor Smith (outfielder, b. 1978, Venezuela)
- 2001: New Britain Rock Cats, Eastern League (AA) - 1 game 4-Jul g2
- 2003: Brockton Rox, Northeast League (independent) - 1 game 5-Sep
- 2006: Quebec Les Capitales, Can-Am League (independent) - 1 game 14-Aug
- Ozzie Smith (infielder, b. 1954, Alabama)
- 1985: St. Louis Cardinals, National League (MLB) - 1 game 9-Apr
- 1986: St. Louis Cardinals, National League (MLB) - 1 game 14-Apr
- 1990: St. Louis Cardinals, National League (MLB) - 1 game 12-Aug
- 1991: St. Louis Cardinals, National League (MLB) - 1 game 22-Sep
- 1992: St. Louis Cardinals, National League (MLB) - 2 games 22-Apr 18-Aug
- 1993: St. Louis Cardinals, National League (MLB) - 1 game 25-Jun
- Patrick Smith (outfielder, b. 1991, Georgia)
- 2012: Connecticut Tigers, New York-Penn League (short-season) - 1 game 2-Aug
- Pavin Smith (infielder, b. 1996, Michigan)
- 2017: Hillsboro Hops, Northwest League (short-season) - 1 game 4-Aug
- 2018: Visalia Rawhide, California League (High-A) - 1 game 14-Aug
- 2018: Salt River Rafters, Arizona Fall League - 3 games 9-Nov 12-Nov 15-Nov
- 2019: Jackson Generals, Southern League (AA) - 3 games 26-Jul 10-Sep 11-Sep
- 2021: Arizona Diamondbacks, Major League Baseball - 1 game 19-Jul
- 2023: Reno Aces, Pacific Coast League (AAA) - 1 game 8-Aug
- Pete Smith (pitcher, b. 1966, Massachusetts)
- 1992: Atlanta Braves, National League (MLB) - 1 game 31-Aug g2
- 1994: New York Mets, National League (MLB) - 2 games 15-Apr 17-Jul
- Pete Smith (pitcher, b. 1976)
- 1999: Waterbury Spirit, Northeast League (independent) - 1 game 20-Jun
- Rand Smith (outfielder, b. 1987, North Carolina)
- 2009: Jamestown Jammers, New York-Penn League (short-season) - 1 game 20-Jul
- Rashad Smith (outfielder, b. 1980, Tennessee)
- 2002: Idaho Falls Padres, Pioneer League (rookie) - 1 game 14-Aug
- Rob Smith (outfielder, b. 1965)
- 1990: Beloit Brewers, Midwest League (Low-A) - 1 game 14-Aug
- Robbie Smith (infielder, b. 1969)
- 1991: Watertown Indians, New York-Penn League (short-season) - 1 game 11-Aug
- Rod Smith (infielder, b. 1975, Kentucky)
- 1996: Greensboro Bats, South Atlantic League (Low-A) - 1 game 25-Jul
- 1997: Greensboro Bats, South Atlantic League (Low-A) - 1 game 15-Aug
- 1998: Tampa Yankees, Florida State League (High-A) - 1 game 8-Aug g2
- 2000: Orlando Rays, Southern League (AA) - 1 game 1-Aug
- 2001: Elmira Pioneers, Northeast League (independent) - 1 game 21-Sep
- Roy Smith (pitcher, b. 1976, Florida)
- 2001: Buffalo Bisons, International League (AAA) - 1 game 8-Jul
- Russell Smith (pitcher, b. 1998, Texas)
- 2023: Biloxi Shuckers, Southern League (AA) - 1 game 20-Jun
- Ryan Smith (pitcher, b. 1971, Ohio)
- 1998: Nashua Pride, Atlantic League (independent) - 1 game 4-Jul
- Ryan Smith (catcher, b. 1979, Pennsylvania)
- 2002: Berkshire Black Bears, Northeast League (independent) - 1 game 28-Jun g2
- 2002: Albany-Colonie Diamond Dogs, Northeast League (independent) - 1 game 1-Sep
- 2004: Elmira Pioneers, Northeast League (independent) - 1 game 31-Jul
- 2007: Charlotte Knights, International League (AAA) - 1 game 2-Sep
- Ryan Smith (pitcher, b. 1989, Texas)
- 2010: Billings Mustangs, Pioneer League (rookie) - 1 game 27-Aug
- 2019: Texas AirHogs, American Association (independent) - 1 game 6-Jun
- Sam Smith (infielder, b. 1979, Texas)
- 1999: Asheville Tourists, South Atlantic League (Low-A) - 1 game 11-Aug
- 2002: Tri-City Dust Devils, Northwest League (short-season) - 1 game 13-Aug
- Sam Smith (pitcher, b. 1979, California)
- 2002: Missoula Osprey, Pioneer League (rookie) - 1 game 5-Aug
- 2004: Lancaster JetHawks, California League (High-A) - 1 game 7-Aug
- Sean Smith (outfielder, b. 1982, California)
- Sean Smith (infielder, b. 1983, California)
- 2006: Missoula Osprey, Pioneer League (rookie) - 1 game 24-Aug
- Seth Smith (outfielder, b. 1982, Mississippi)
- 2009: Colorado Rockies, Major League Baseball - 2 games 21-Aug 28-Aug
- 2012: Oakland Athletics, Major League Baseball - 1 game 22-Sep
- Shawn Smith (pitcher, b. 1990, California)
- 2013: Quebec Les Capitales, Can-Am League (independent) - 1 game 7-Sep
- Sincere Smith (utility, b. 2000, North Carolina)
- Slade Smith (pitcher, b. 1990, Alabama)
- 2014: Erie SeaWolves, Eastern League (AA) - 1 game 4-Jul
- Sloan Smith (outfielder, b. 1972, Ohio)
- 1994: Oneonta Yankees, New York-Penn League (short-season) - 1 game 26-Jun
- Stantrel Smith (outfielder, b. 1983, Georgia)
- Steve Smith (catcher, b. 1982)
- 2005: Winnipeg Goldeyes, Northern League (independent) - 1 game 9-Aug
- Steve Smith (pitcher, b. 1986, Michigan)
- 2013: Chattanooga Lookouts, Southern League (AA) - 1 game 20-Jul
- Tim Smith (pitcher, b. 1968)
- 1994: New Britain Red Sox, Eastern League (AA) - 1 game 21-Aug g1
- Tim Smith (pitcher, b. 1969)
- 1993: Huntsville Stars, Southern League (AA) - 1 game 13-Aug
- 1995: Winnipeg Goldeyes, Northern League (independent) - 1 game 8-Aug
- Tim Smith (first base/outfield, b. 1986, Ontario)
- 2015: Quebec Les Capitales, Can-Am League (independent) - 2 games 14-Aug 21-Aug
- Toby Smith (pitcher, b. 1971, Oklahoma)
- 1995: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 31-Aug
- Toebius Smith (pitcher, b. 1979, North Carolina)
- 2000: Danville Braves, Appalachian League (rookie) - 1 game 3-Aug
- Tyler Smith (infielder, b. 1991, California)
- 2014: Jackson Generals, Southern League (AA) - 1 game 20-Aug
- 2015: Jackson Generals, Southern League (AA) - 2 games 25-Jul 29-Jul
- Tyler Smith (pitcher, b. 1995, Pennsylvania)
- 2021: Tri-City Dust Devils, High-A West - 1 game 10-Jul
- Will Smith (outfielder, b. 1977, Alabama)
- 2001: Augusta Greenjackets, South Atlantic League (Low-A) - 1 game 7-Aug
- Will Smith (outfielder, b. 1981, Louisiana)
- 2003: Frisco Roughriders, Texas League (AA) - 1 game 8-Aug
- 2005: Oklahoma Redhawks, Pacific Coast League (AAA) - 1 game 19-Aug
- Will Smith (pitcher, b. 1989, Georgia)
- 2015: Milwaukee Brewers, Major League Baseball - 1 game 25-Aug
- 2021: Atlanta Braves, Major League Baseball - 2 games 1-May 28-Sep
- 2022: Atlanta Braves, Major League Baseball - 1 game 3-May g2
- 2022: Houston Astros, Major League Baseball - 1 game 20-Sep
- 2023: Texas Rangers, Major League Baseball - 4 games 5-Jun 10-Jun 7-Aug 11-Aug
- Will Smith (catcher, b. 1995, Kentucky)
- 2020: Los Angeles Dodgers, Major League Baseball - 1 game 13-Oct
- Zane Smith (pitcher, b. 1960, Wisconsin)
- 1992: Pittsburgh Pirates, National League (MLB) - 1 game 4-Oct
- Zack Smithlin (outfielder, b. 1980, New Jersey)
- Canaan Smith-Njigba (outfielder, b. 1999, Texas)
- 2018: Staten Island Yankees, New York-Penn League (short-season) - 2 games (as Canaan Smith) 15-Jun 1-Jul
- 2019: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game (as Canaan Smith) 11-Aug
- 2021: Peoria Javelinas, Arizona Fall League - 1 game 20-Oct
- 2023: Indianapolis Indians, International League (AAA) - 1 game 1-Jul
- AJ Smith-Shawver (pitcher, b. 2002, Texas)
- 2021: FCL Braves, Florida Complex League (rookie) - 1 game 23-Aug g1
- Justin Smoak (first baseman, b. 1986, South Carolina)
- 2013: Seattle Mariners, Major League Baseball - 1 game 23-Aug
- 2015: Toronto Blue Jays, Major League Baseball - 2 games 12-Sep g1 12-Sep g2
- 2018: Toronto Blue Jays, Major League Baseball - 1 game 16-Sep
- Josh Smoker (pitcher, b. 1988, Georgia)
- 2016: New York Mets, Major League Baseball - 3 games 18-Sep 21-Sep 2-Oct
- 2017: New York Mets, Major League Baseball - 1 game 25-Sep g1
- Jake Smolinski (outfielder, b. 1989, Illinois)
- 2011: Jacksonville Suns, Southern League (AA) - 2 games 7-Aug 12-Aug
- John Smoltz (pitcher, b. 1967, Michigan)
- 1992: Atlanta Braves, National League (MLB) - 1 game 31-Aug g1
- 1993: Atlanta Braves, National League (MLB) - 1 game 17-Aug
- 1997: Atlanta Braves, National League (MLB) - 1 game 13-Aug
- 2002: Atlanta Braves, Major League Baseball - 1 game 29-Jun
- 2003: Atlanta Braves, Major League Baseball - 1 game 20-Jul
- Allen Smoot (infielder, b. 1994, California)
- 2018: Hudson Valley Renegades, New York-Penn League (short-season) - 2 games 18-Jun 31-Jul
- Drew Smyly (pitcher, b. 1989, Arkansas)
- 2021: Atlanta Braves, Major League Baseball - 1 game 30-Apr
- 2023: Chicago Cubs, Major League Baseball - 1 game 1-Oct
- Paul Smyth (catcher/outfielder, b. 1983, California)
- 2006: Lowell Spinners, New York-Penn League (short-season) - 1 game 13-Aug
- 2015: Somerset Patriots, Atlantic League (independent) - 1 game 13-Aug
- Christian Snavely (outfielder, b. 1982, Ohio)
- 2003: Auburn Doubledays, New York-Penn League (short-season) - 1 game 16-Aug
- Esix Snead (outfielder, b. 1976, Florida)
- 1998: New Jersey Cardinals, New York-Penn League (short-season) - 2 games 25-Jul 30-Jul
- 2001: New Haven Ravens, Eastern League (AA) - 1 game 15-Jul
- 2002: Binghamton Mets, Eastern League (AA) - 1 game 4-Jul
- 2002: New York Mets, Major League Baseball - 4 games 3-Sep g1 3-Sep g2 7-Sep 29-Sep
- Kirby Snead (pitcher, b. 1994, Alabama)
- 2018: New Hampshire Fisher Cats, Eastern League (AA) - 1 game 7-Sep
- 2022: Oakland Athletics, Major League Baseball - 2 games 12-Apr 13-Apr
- 2023: Oakland Athletics, Major League Baseball - 1 game 7-Aug
- John Sneed (pitcher, b. 1976, Texas)
- 1998: Hagerstown Suns, South Atlantic League (Low-A) - 1 game 11-Jul
- Kramer Sneed (pitcher, b. 1988, North Carolina)
- 2010: Staten Island Yankees, New York-Penn League (short-season) - 1 game 9-Aug
- Blake Snell (pitcher, b. 1992, Washington)
- 2018: Tampa Bay Rays, Major League Baseball - 1 game 13-May
- 2019: Tampa Bay Rays, Major League Baseball - 3 games 28-Mar 24-Apr 12-May
- Ian Snell (pitcher, b. 1981, Delaware)
- 2003: Lynchburg Hillcats, Carolina League (High-A) - 1 game (as Ian Oquendo) 5-Apr
- Clay Snellgrove (infielder, b. 1974, Georgia)
- 1998: Clinton LumberKings, Midwest League (Low-A) - 1 game 20-Aug
- Allen Snelling (infielder, b. 1973)
- 1996: St. Catharines Stompers, New York-Penn League (short-season) - 1 game 15-Aug
- D.J. Snelten (pitcher, b. 1992, Illinois)
- 2017: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 30-Jul
- 2023: Scranton/Wilkes-Barre RailRiders, International League (AAA) - 1 game 15-Jul
- Collin Snider (pitcher, b. 1995, Tennessee)
- 2017: Lexington Legends, South Atlantic League (Low-A) - 1 game 30-Aug g2
- 2018: Lexington Legends, South Atlantic League (Low-A) - 1 game 13-Sep
- Travis Snider (outfielder, b. 1988, Washington)
- 2006: Pulaski Blue Jays, Appalachian League (rookie) - 1 game 19-Aug
- 2008: Toronto Blue Jays, Major League Baseball - 1 game 29-Aug
- 2009: Toronto Blue Jays, Major League Baseball - 1 game 4-Oct
- 2010: Toronto Blue Jays, Major League Baseball - 1 game 31-Jul
- 2013: Indianapolis Indians, International League (AAA) - 1 game 30-Aug
- 2013: Pittsburgh Pirates, Major League Baseball - 1 game 1-Sep
- Troy Snitker (catcher, b. 1988, Georgia)
- 2012: Danville Braves, Appalachian League (rookie) - 2 games 14-Aug 18-Aug
- Scott Snodgress (pitcher, b. 1989, California)
- 2014: Glendale Desert Dogs, Arizona Fall League - 1 game 9-Oct
- Forrest Snow (pitcher, b. 1988, Washington)
- 2018: Durham Bulls, International League (AAA) - 1 game 11-Sep
- J.T. Snow (first baseman, b. 1968, California)
- 1992: New York Yankees, American League (MLB) - 1 game 27-Sep
- 1997: San Francisco Giants, National League (MLB) - 2 games 31-Aug 1-Sep
- 2000: San Francisco Giants, Major League Baseball - 1 game 2-Sep
- 2004: San Francisco Giants, Major League Baseball - 1 game 25-Jul
- Chris Snusz (catcher, b. 1972, New York)
- 1995: Batavia Clippers, New York-Penn League (short-season) - 1 game 20-Aug
- 2000: Ottawa Lynx, International League (AAA) - 1 game 23-Jul
- 2001: Norwich Navigators, Eastern League (AA) - 1 game 15-Jul
- Bill Snyder (pitcher, b. 1975, New York)
- 1998: West Michigan Whitecaps, Midwest League (Low-A) - 1 game 16-Aug
- 2000: Jacksonville Suns, Southern League (AA) - 1 game 1-Aug
- 2002: Albany-Colonie Diamond Dogs, Northeast League (independent) - 1 game 1-Sep
- Brandon Snyder (catcher/infielder, b. 1986, Nevada)
- 2009: Norfolk Tides, International League (AAA) - 1 game 5-Jul
- 2010: Norfolk Tides, International League (AAA) - 1 game 29-May
- 2015: Bowie Baysox, Eastern League (AA) - 2 games 3-Jul 22-Aug
- 2016: Atlanta Braves, Major League Baseball - 1 game 1-Sep
- 2018: Durham Bulls, International League (AAA) - 3 games 11-Sep 15-Sep 18-Sep
- Brian Snyder (infielder, b. 1982, Florida)
- 2006: Stockton Ports, California League (High-A) - 1 game 21-Aug
- Chris Snyder (catcher, b. 1981, Texas)
- 2010: Pittsburgh Pirates, Major League Baseball - 1 game 15-Sep
- 2012: Houston Astros, Major League Baseball - 1 game 29-Jul
- Cory Snyder (outfielder, b. 1962, California)
- 1988: Cleveland Indians, American League (MLB) - 1 game 27-Jun
- 1990: Cleveland Indians, American League (MLB) - 1 game 13-Aug
- 1993: Los Angeles Dodgers, National League (MLB) - 1 game 17-Aug
- Earl Snyder (infielder, b. 1976, Connecticut)
- 1998: Pittsfield Mets, New York-Penn League (short-season) - 1 game 30-Jul
- 2001: Binghamton Mets, Eastern League (AA) - 1 game 22-Jul
- 2002: Buffalo Bisons, International League (AAA) - 1 game 1-Sep
- 2005: Durham Bulls, International League (AAA) - 1 game 28-Aug
- 2007: Charlotte Knights, International League (AAA) - 1 game 2-Sep
- Jared Snyder (catcher, b. 1970)
- 1993: Geneva Cubs, New York-Penn League (short-season) - 1 game 5-Sep
- Justin Snyder (infielder, b. 1986, California)
- Mason Snyder (infielder, b. 1993, Illinois)
- 2015: Joliet Slammers, Frontier League (independent) - 1 game 30-Aug
- Matt Snyder (pitcher, b. 1974, Ohio)
- 2001: West Tenn Diamond Jaxx, Southern League (AA) - 1 game 4-Aug
- Matt Snyder (first baseman, b. 1990, Virginia)
- 2015: Trenton Thunder, Eastern League (AA) - 1 game 17-Jun
- Michael Snyder (infielder, b. 1990, Washington)
- 2015: Arkansas Travelers, Texas League (AA) - 1 game 30-Jul
- 2017: Southern Maryland Blue Crabs, Atlantic League (independent) - 2 games 13-May g1 13-May g2
- Michael Snyder (infielder, b. 2000, California)
- 2024: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 2-Aug
- Mike Snyder (first baseman, b. 1981, California)
- 2000: Queens Kings, New York-Penn League (short-season) - 2 games 26-Aug 9-Sep
- 2003: Dunedin Blue Jays, Florida State League (High-A) - 1 game 25-Aug
- Nick Snyder (pitcher, b. 1995, Florida)
- 2019: Hickory Crawdads, South Atlantic League (Low-A) - 2 games 30-Apr 11-Aug
- Randy Snyder (catcher, b. 1967, Washington)
- 1990: Beloit Brewers, Midwest League (Low-A) - 1 game 14-Aug
- Ryan Snyder (pitcher, b. 1977, Texas)
- 2005: Shreveport Sports, Central League (independent) - 1 game 16-Aug
- Taylor Snyder (infielder, b. 1994, Utah)
- 2023: Birmingham Barons, Southern League (AA) - 1 game 20-Apr
- Trey Snyder (infielder, b. 2005, Missouri)
- Brandon Soat (outfielder, b. 1993, Indiana)
- 2017: Evansville Otters, Frontier League (independent) - 1 game 31-Aug
- Aaron Sobieraj (infielder, then pitcher, b. 1981, New York)
- 2002: Salem-Keizer Volcanoes, Northwest League (short-season) - 1 game 11-Aug
- Jeff Sobkoviak (pitcher, b. 1971, Illinois)
- Scott Sobkowiak (pitcher, b. 1977, Illinois)
- 1999: Myrtle Beach Pelicans, Carolina League (High-A) - 2 games 8-Aug 13-Aug
- 2005: Somerset Patriots, Atlantic League (independent) - 1 game 12-Jun
- Mark Sobolewski (infielder, b. 1986, Connecticut)
- 2011: New Hampshire Fisher Cats, Eastern League (AA) - 2 games 5-May 4-Aug
- 2012: New Hampshire Fisher Cats, Eastern League (AA) - 2 games 5-Apr 28-May
- Chad Sobotka (pitcher, b. 1993, Florida)
- 2018: Atlanta Braves, Major League Baseball - 1 game 28-Sep
- Miguel Socolovich (pitcher, b. 1986, Venezuela)
- 2011: Birmingham Barons, Southern League (AA) - 1 game 11-Aug
- 2017: St. Louis Cardinals, Major League Baseball - 1 game 16-Apr
- 2017: Memphis Redbirds, Pacific Coast League (AAA) - 1 game 19-Sep
- Michael Sodders (infielder, b. 1988, California)
- 2010: Orem Owlz, Pioneer League (rookie) - 1 game 27-Aug
- Tyler Soderstrom (catcher/first base, b. 2001, California)
- 2023: Oakland Athletics, Major League Baseball - 1 game 7-Aug
- 2024: Oakland Athletics, Major League Baseball - 1 game 30-May
- Clint Sodowsky (pitcher, b. 1972, Oklahoma)
- 1995: Detroit Tigers, American League (MLB) - 1 game 1-Oct
- 1997: Pittsburgh Pirates, National League (MLB) - 1 game 24-Sep
- Eric Sogard (infielder, b. 1986, Arizona)
- 2008: Lake Elsinore Storm, California League (High-A) - 1 game 2-Aug
- 2011: Oakland Athletics, Major League Baseball - 1 game 23-Aug
- 2018: Milwaukee Brewers, Major League Baseball - 1 game 13-Apr
- 2019: Tampa Bay Rays, Major League Baseball - 5 games 19-Aug 30-Aug 3-Sep g1 3-Sep g2 6-Sep
- Nick Sogard (infielder, b. 1997, California)
- 2022: Worcester Red Sox, International League (AAA) - 1 game 27-Sep
- Andrew Sohn (infielder, b. 1993, Michigan)
- 2018: Winnipeg Goldeyes, American Association (independent) - 1 game 24-Aug
- Steve Soja (pitcher, b. 1980)
- 2005: Mid-Missouri Mavericks, Frontier League (independent) - 1 game 20-Aug
- Luis Sojo (infielder, b. 1965, Venezuela)
- 1992: California Angels, American League (MLB) - 1 game 23-Aug
- 1994: Seattle Mariners, American League (MLB) - 2 games 23-Jul g1 23-Jul g2
- 1996: New York Yankees, American League (MLB) - 4 games 8-Sep 19-Sep g2 25-Sep g1 25-Sep g2
- 1997: New York Yankees, American League (MLB) - 1 game 13-Jul
- 1998: New York Yankees, American League (MLB) - 1 game 27-Sep
- 1999: New York Yankees, American League (MLB) - 2 games 31-Aug 22-Sep
- 2000: New York Yankees, Major League Baseball - 2 games 25-Sep 1-Oct
- Nick Solak (infielder, b. 1995, Illinois)
- 2017: Trenton Thunder, Eastern League (AA) - 1 game 13-Sep
- 2018: Durham Bulls, International League (AAA) - 1 game 18-Sep
- 2019: Nashville Sounds, Pacific Coast League (AAA) - 1 game 15-Jul
- 2021: Texas Rangers, Major League Baseball - 4 games 13-Apr 14-Apr 15-Apr 14-Sep
- Danny Solano (infielder, b. 1975, Dominican Republic)
- 2003: New Haven Ravens, Eastern League (AA) - 1 game 27-Jun
- Donovan Solano (infielder, b. 1987, Colombia)
- 2005: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 5-Sep
- 2011: Springfield Cardinals, Texas League (AA) - 1 game 2-Sep
- 2012: Miami Marlins, Major League Baseball - 2 games 10-Aug 21-Sep
- 2013: Miami Marlins, Major League Baseball - 1 game 13-Sep
- 2014: Miami Marlins, Major League Baseball - 2 games 15-Sep 17-Sep
- 2015: Miami Marlins, Major League Baseball - 1 game 16-Sep
- 2016: Scranton/Wilkes-Barre RailRiders, International League (AAA) - 2 games 5-Aug 14-Sep
- 2017: Scranton/Wilkes-Barre RailRiders, International League (AAA) - 1 game 10-Sep
- 2022: Cincinnati Reds, Major League Baseball - 1 game 30-Sep
- 2023: Minnesota Twins, Major League Baseball - 1 game 4-Apr
- 2024: San Diego Padres, Major League Baseball - 3 games 30-Aug 31-Aug 1-Sep
- Euvi Solano (infielder, b. 1982, Dominican Republic)
- 2005: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 23-Jun
- 2007: Sussex Skyhawks, Can-Am League (independent) - 2 games 31-Jul 23-Aug
- Fausto Solano (infielder, b. 1974, Dominican Republic)
- 1997: Knoxville Smokies, Southern League (AA) - 1 game 10-Aug
- 2001: Nashua Pride, Atlantic League (independent) - 1 game 3-Sep
- Issac Solano (pitcher, b. 2001, Dominican Republic)
- 2022: FCL Orioles, Florida Complex League (rookie) - 1 game 1-Aug
- 2023: FCL Orioles, Florida Complex League (rookie) - 1 game 9-Jun
- Javier Solano (pitcher, b. 1990, Mexico)
- 2009: Ogden Raptors, Pioneer League (rookie) - 1 game 17-Aug
- 2011: Chattanooga Lookouts, Southern League (AA) - 1 game 11-Aug
- Jhonatan Solano (catcher, b. 1985, Colombia)
- 2009: Harrisburg Senators, Eastern League (AA) - 1 game 11-Apr
- 2011: Syracuse Chiefs, International League (AAA) - 3 games 23-Apr g1 3-Jul 20-Aug
- 2012: Washington Nationals, Major League Baseball - 1 game 4-Jul
- 2012: Harrisburg Senators, Eastern League (AA) - 1 game 1-Sep g1
- 2015: New Orleans Zephyrs, Pacific Coast League (AAA) - 1 game 27-Jul
- 2016: Syracuse Chiefs, International League (AAA) - 1 game 5-Aug
- Kevin Solano (pitcher, b. 2002, Panama)
- 2022: FCL Braves, Florida Complex League (rookie) - 1 game 13-Aug
- Ramon Solano (infielder, b. 1967)
- 1997: Catskill Cougars, Northeast League (independent) - 2 games 3-Aug 8-Aug
- Solamdi Solano (infielder, b. 1983, Dominican Republic)
- 2003: GCL Pirates, Gulf Coast League (rookie) - 2 games 26-Aug 27-Aug
- Wilfredo Solano (infielder, b. 1993, Dominican Republic)
- 2012: Vermont Lake Monsters, New York-Penn League (short-season) - 1 game 4-Aug
- Angel Solarte (outfielder, b. 2001, Venezuela)
- 2021: Fort Wayne TinCaps, High-A Central - 1 game 18-Sep
- Jhon Solarte (outfielder, b. 2000, Venezuela)
- Yangervis Solarte (infielder, b. 1987, Venezuela)
- 2009: New Britain Rock Cats, Eastern League (AA) - 1 game 13-Sep
- 2010: New Britain Rock Cats, Eastern League (AA) - 1 game 30-May
- 2013: Round Rock Express, Pacific Coast League (AAA) - 1 game 22-Jul
- 2016: San Diego Padres, Major League Baseball - 3 games 13-Aug 28-Aug 1-Sep
- 2018: Toronto Blue Jays, Major League Baseball - 2 games 16-Sep 21-Sep
- Markus Solbach (pitcher, b. 1991, Germany)
- 2017: Rockland Boulders, Can-Am League (independent) - 1 game 17-Aug
- Alec Sole (shortstop, b. 1993, New York)
- 2014: Hudson Valley Renegades, New York-Penn League (short-season) - 2 games 28-Jul 2-Aug
- Austin Solecitto (pitcher, b. 1994, New Jersey)
- 2016: Sussex County Miners, Can-Am League (independent) - 1 game 16-Aug g2
- 2018: Salina Stockade, Can-Am League (independent) - 1 game 28-Jun
- Jorge Soler (outfielder, b. 1992, Cuba)
- 2019: Kansas City Royals, Major League Baseball - 1 game 24-Apr
- 2021: Kansas City Royals, Major League Baseball - 1 game 25-May
- 2021: Atlanta Braves, Major League Baseball - 1 game 28-Sep
- 2022: Miami Marlins, Major League Baseball - 2 games 16-Apr 24-May
- 2023: Miami Marlins, Major League Baseball - 6 games 4-Apr 25-Jul 26-Jul 29-Aug 28-Sep 29-Sep
- Chase Solesky (pitcher, b. 1997, Florida)
- 2021: Kannapolis Cannon Ballers, Low-A East - 1 game 17-Jun
- 2022: Winston-Salem Dash, South Atlantic League (High-A) - 1 game 17-Jul
- 2022: Glendale Desert Dogs, Arizona Fall League - 1 game 13-Oct
- 2024: Salt River Rafters, Arizona Fall League - 1 game 12-Oct
- Ali Solis (catcher, b. 1987, Mexico)
- 2017: Iowa Cubs, Pacific Coast League (AAA) - 1 game 21-Aug
- Chris Solis (catcher, b. 1986, Texas)
- 2008: Vermont Lake Monsters, New York-Penn League (short-season) - 1 game 6-Aug
- Hairo Solis (pitcher, b. 1984, Dominican Republic)
- Jency Solis (pitcher, b. 1993, Dominican Republic)
- 2013: Missoula Osprey, Pioneer League (rookie) - 1 game 19-Aug
- 2015: Kane County Cougars, Midwest League (Low-A) - 1 game 29-Aug g1
- Ricardo Solis (infielder, b. 1980, Texas)
- 2002: Great Falls Dodgers, Pioneer League (rookie) - 1 game 14-Aug
- Sammy Solis (pitcher, b. 1988, Minnesota)
- 2015: Washington Nationals, Major League Baseball - 1 game 4-Oct
- Steve Soliz (catcher, b. 1971, California)
- 1994: Canton-Akron Indians, Eastern League (AA) - 1 game 21-Aug g2
- 1995: Canton-Akron Indians, Eastern League (AA) - 1 game 19-Aug
- 1997: Buffalo Bisons, American Association (AAA) - 1 game 9-Aug g2
- Scott Sollmann (outfielder, b. 1975, Ohio)
- 1996: Jamestown Jammers, New York-Penn League (short-season) - 1 game 16-Aug
- 2000: Tennessee Smokies, Southern League (AA) - 1 game 1-Aug
- 2001: Chattanooga Lookouts, Southern League (AA) - 1 game 9-Aug
- Anthony Solometo (pitcher, b. 2002, New Jersey)
- 2022: Bradenton Marauders, Florida State League (Low-A) - 2 games 9-Jun 7-Sep
- Andre Solomon (pitcher, b. 1989, Pennsylvania)
- 2020: California Dogecoin, Liberation League (independent) - 1 game 23-Sep
- Jared Solomon (pitcher, b. 1997, Pennsylvania)
- 2023: Louisville Bats, International League (AAA) - 1 game 1-Jul
- Steve Solomon (outfielder, b. 1970, California)
- Jesus Solorzano (outfielder, b. 1990, Venezuela)
- 2015: Joplin Blasters, American Association (independent) - 1 game 31-Jul
- Casey Soltis (outfielder, b. 1995, California)
- 2015: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 15-Apr
- 2016: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 22-Aug
- Saul Solveson (pitcher, b. 1979)
- 2005: Somerset Patriots, Atlantic League (independent) - 3 games 18-Sep 29-Sep 1-Oct
- 2007: Somerset Patriots, Atlantic League (independent) - 3 games 21-Jul 23-Sep 24-Sep
- 2008: York Revolution, Atlantic League (independent) - 1 game 20-Sep
- Tommy Sommer (pitcher, b. 1998, Indiana)
- 2022: Winston-Salem Dash, South Atlantic League (High-A) - 1 game 31-Aug
- Luke Sommerfeld (pitcher, b. 1996, Missouri)
- 2021: Lakeland Flying Tigers, Low-A Southeast - 1 game 5-May
- Jake Sommers (pitcher, b. 1997, Wisconsin)
- 2021: Spokane Indians, High-A West - 1 game 13-Jul
- Matt Sommo (pitcher, b. 1988)
- 2014: Somerset Patriots, Atlantic League (independent) - 1 game 7-Aug
- 2015: Sussex County Miners, Can-Am League (independent) - 1 game 15-Jul
- Ho-young Son (infielder, b. 1994, Korea)
- 2014: AZL Cubs, Arizona League (rookie) - 1 game 20-Jul
- Adam Sonabend (catcher, b. 1992, California)
- 2017: Augusta GreenJackets, South Atlantic League (Low-A) - 1 game 30-Aug g1
- Noah Song (pitcher, b. 1997, California)
- 2023: Clearwater Threshers, Florida State League (Low-A) - 2 games 4-Jul 7-Jul
- Angelo Songco (first base/outfield, b. 1988, California)
- 2013: Chattanooga Lookouts, Southern League (AA) - 1 game 20-Jul
- 2015: St. Paul Saints, American Association (independent) - 1 game 1-Sep
- 2017: Long Island Ducks, Atlantic League (independent) - 3 games 15-Jun 22-Sep 23-Sep
- 2018: New Britain Bees, Atlantic League (independent) - 1 game 4-Sep
- Andy Sonnanstine (pitcher, b. 1983, Ohio)
- 2006: Montgomery Biscuits, Southern League (AA) - 1 game 2-Sep
- 2009: Tampa Bay Rays, Major League Baseball - 1 game 19-Jun
- 2010: Tampa Bay Rays, Major League Baseball - 1 game 21-Sep
- Shawn Sonnier (pitcher, b. 1976, Louisiana)
- 1999: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 15-Aug
- Eligio Sonoqui (first baseman, b. 1988, Arizona)
- 2009: Hudson Valley Renegades, New York-Penn League (short-season) - 2 games 5-Aug 2-Sep
- Alan Sontag (pitcher, b. 1963, New York)
- 1998: Bridgeport Bluefish, Atlantic League (independent) - 1 game 27-Jul
- 2000: Bridgeport Bluefish, Atlantic League (independent) - 1 game 27-Sep
- David Sopilka (catcher, b. 1993, Venezuela)
- 2014: Lowell Spinners, New York-Penn League (short-season) - 1 game 13-Aug g1
- 2016: Salem Red Sox, Carolina League (High-A) - 1 game 4-Sep
- Mark Sopko (pitcher, b. 1981, Illinois)
- 2003: Auburn Doubledays, New York-Penn League (short-season) - 1 game 16-Aug
- Nick Sorensen (outfielder, b. 1981)
- 2005: Shreveport Sports, Central League (independent) - 1 game 16-Aug
- Zach Sorensen (infielder, b. 1977, Utah)
- 1999: Kinston Indians, Carolina League (High-A) - 2 games 9-Aug 15-Aug
- 2001: Akron Aeros, Eastern League (AA) - 1 game 5-Apr
- 2002: Buffalo Bisons, International League (AAA) - 1 game 1-Sep
- 2004: Salt Lake Stingers, Pacific Coast League (AAA) - 1 game 13-Aug
- Jay Sorg (infielder, b. 1973, Kentucky)
- 1995: Billings Mustangs, Pioneer League (rookie) - 1 game 10-Aug
- Dan Soria (pitcher, b. 1980, Indiana)
- 2004: Gary Southshore RailCats, Northern League (independent) - 1 game 11-Jul
- Joakim Soria (pitcher, b. 1984, Mexico)
- 2018: Milwaukee Brewers, Major League Baseball - 1 game 22-Sep
- 2021: Arizona Diamondbacks, Major League Baseball - 1 game 19-Jul
- Zack Soria (catcher, b. 1993, Illinois)
- 2019: Florida Fire Frogs, Florida State League (High-A) - 1 game 17-Aug g1
- Alfonso Soriano (utility, b. 1976, Dominican Republic)
- 1999: Norwich Navigators, Eastern League (AA) - 1 game 29-Apr
- 1999: New York Yankees, American League (MLB) - 1 game 22-Sep
- 2000: New York Yankees, Major League Baseball - 2 games 25-Sep 1-Oct
- 2001: New York Yankees, Major League Baseball - 1 game 28-Aug
- 2002: New York Yankees, Major League Baseball - 1 game 25-Sep
- 2006: Washington Nationals, Major League Baseball - 1 game 22-Sep
- 2007: Chicago Cubs, Major League Baseball - 1 game 4-Jul
- 2008: Chicago Cubs, Major League Baseball - 1 game 23-Sep
- 2011: Chicago Cubs, Major League Baseball - 1 game 11-Sep
- 2013: New York Yankees, Major League Baseball - 2 games 12-Aug 25-Sep
- Ariel Soriano (utility, b. 1990, Dominican Republic)
- 2012: Princeton Rays, Appalachian League (rookie) - 1 game 17-Aug g1
- 2013: Hudson Valley Renegades, New York-Penn League (short-season) - 2 games 2-Aug 14-Aug
- Carlos Soriano (infielder, b. 1974, Dominican Republic)
- 1996: Capital City Bombers, South Atlantic League (Low-A) - 1 game 29-Aug
- 1998: Massachusetts Mad Dogs, Northeast League (independent) - 1 game 3-Jul
- Christopher Soriano (pitcher, b. 2001, Dominican Republic)
- Eduardo Soriano (pitcher, b. 2002, Dominican Republic)
- 2024: FCL Twins, Florida Complex League (rookie) - 1 game 25-Jul
- Francisco Soriano (infielder, b. 1987, Dominican Republic)
- 2010: Hagerstown Suns, South Atlantic League (Low-A) - 1 game 22-Apr
- 2012: Potomac Nationals, Carolina League (High-A) - 1 game 8-Aug
- George Soriano (pitcher, b. 1999, Dominican Republic)
- 2022: Jacksonville Jumbo Shrimp, International League (AAA) - 1 game 30-Aug
- 2023: Miami Marlins, Major League Baseball - 2 games 25-Jul 29-Aug
- Jose Soriano (pitcher, b. 1998, Dominican Republic)
- 2023: Los Angeles Angels, Major League Baseball - 1 game 21-Sep
- 2024: Los Angeles Angels, Major League Baseball - 1 game 16-Apr
- Rafael Soriano (pitcher, b. 1979, Dominican Republic)
- 2007: Atlanta Braves, Major League Baseball - 1 game 11-Sep
- 2011: New York Yankees, Major League Baseball - 1 game 19-Sep
- Wilson Soriano (utility, b. 1991, Dominican Republic)
- 2013: Tri-City Dust Devils, Northwest League (short-season) - 1 game 22-Aug
- 2016: Hartford Yard Goats, Eastern League (AA) - 1 game 20-Aug
- Michael Soroka (pitcher, b. 1997, Alberta)
- 2019: Atlanta Braves, Major League Baseball - 2 games 29-Apr 29-Sep
- 2024: Chicago White Sox, Major League Baseball - 1 game 7-May
- Paul Sorrento (first baseman, b. 1965, Massachusetts)
- 1993: Cleveland Indians, American League (MLB) - 2 games 3-Sep 11-Sep
- 1994: Cleveland Indians, American League (MLB) - 1 game 31-Jul
- 1997: Seattle Mariners, American League (MLB) - 1 game 3-Sep
- 1998: Tampa Bay Devil Rays, American League (MLB) - 1 game 9-Aug
- Carlos Sosa (first base/outfield, b. 1981, Dominican Republic)
- 2004: San Jose Giants, California League (High-A) - 2 games 12-Aug 17-Aug
- 2009: Worcester Tornadoes, Can-Am League (independent) - 2 games 1-Sep 3-Sep
- 2010: New Jersey Jackals, Can-Am League (independent) - 3 games 13-Aug g1 13-Aug g2 20-Aug
- Edmundo Sosa (infielder, b. 1996, Panama)
- 2017: Palm Beach Cardinals, Florida State League (High-A) - 2 games 27-May 28-May
- 2018: Memphis Redbirds, Pacific Coast League (AAA) - 1 game 18-Sep
- 2021: St. Louis Cardinals, Major League Baseball - 1 game 17-Sep
- 2022: St. Louis Cardinals, Major League Baseball - 3 games 7-Jun 8-Jun 9-Jun
- 2023: Philadelphia Phillies, Major League Baseball - 1 game 27-Sep
- Eduardo Sosa (outfielder, b. 1991, Venezuela)
- 2010: Staten Island Yankees, New York-Penn League (short-season) - 1 game 9-Aug
- 2012: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 9-Aug
- Francisco Sosa (catcher, b. 1979, Dominican Republic)
- 2000: Kingsport Mets, Appalachian League (rookie) - 1 game 29-Jul
- 2001: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 25-Aug 6-Sep
- Francisco Sosa (outfielder, b. 1990, Dominican Republic)
- 2013: Asheville Tourists, South Atlantic League (Low-A) - 1 game 26-May
- 2015: Ottawa Champions, Can-Am League (independent) - 1 game 19-Jun
- Gustavo Sosa (catcher, b. 2001, New York)
- 2022: FCL Phillies, Florida Complex League (rookie) - 1 game 12-Aug
- 2023: FCL Phillies, Florida Complex League (rookie) - 3 games 10-Jun 3-Aug 22-Aug
- Jorge Sosa (pitcher, b. 1978, DOminican Republic)
- 2007: New York Mets, Major League Baseball - 2 games 27-Aug 16-Sep
- Jose Sosa (pitcher, b. 1972, Dominican Republic)
- 1994: Salem Buccaneers, Carolina League (High-A) - 1 game 7-Aug
- Juan Sosa (infielder, b. 1975, Dominican Republic)
- 1999: Carolina Mudcats, Southern League (AA) - 1 game 12-Aug
- 2003: Scranton/Wilkes-Barre Red Barons, International League (AAA) - 1 game 15-Aug
- Juan Sosa (pitcher, b. 1989, Dominican Republic)
- 2013: Reading Fightin Phils, Eastern League (AA) - 2 games 27-May 13-Aug
- Junior Sosa (outfielder, b. 1990, Venezuela)
- 2016: Jupiter Hammerheads, Florida State League (High-A) - 2 games 27-Aug 30-Aug
- Lee Sosa (pitcher, b. 1991, New York)
- 2015: Beloit Snappers, Midwest League (Low-A) - 1 game 5-Sep
- 2016: New Jersey Jackals, Can-Am League (independent) - 1 game 17-Aug g2
- 2017: New Jersey Jackals, Can-Am League (independent) - 1 game 14-Jun
- Lenyn Sosa (infielder, b. 2000, Venezuela)
- 2022: Charlotte Knights, International League (AAA) - 1 game 22-Sep
- 2023: Chicago White Sox, Major League Baseball - 2 games 21-Apr 23-Apr
- Malfrin Sosa (outfielder, b. 2002, Dominican Republic)
- 2021: FCL Twins, Florida Complex League (rookie) - 1 game 24-Aug g2
- 2022: FCL Twins, Florida Complex League (rookie) - 1 game 1-Aug
- Miguel Sosa (outfielder, b. 2003, Dominican Republic)
- 2023: FCL Pirates, Florida Complex League (rookie) - 1 game 9-Jun
- Ricardo Sosa (infielder, b. 1984, Cuba)
- 2006: South Bend Silver Hawks, Midwest League (Low-A) - 1 game 12-Aug
- Sammy Sosa (outfielder, b. 1968, Dominican Republic)
- 1993: Chicago Cubs, National League (MLB) - 1 game 11-Aug
- 1999: Chicago Cubs, National League (MLB) - 1 game 23-Jul
- 2000: Chicago Cubs, Major League Baseball - 3 games 12-Aug 22-Aug 2-Sep
- 2001: Chicago Cubs, Major League Baseball - 1 game 29-Jul
- 2004: Chicago Cubs, Major League Baseball - 1 game 24-Sep
- Thomas Sosa (outfielder, b. 2005, Dominican Republic)
- 2023: FCL Orioles, Florida Complex League (rookie) - 2 games 19-Jun 21-Aug
- 2024: Delmarva Shorebirds, Carolina League (Low-A) - 1 game 12-May
- Chad Sosebee (pitcher, then infielder, b. 1977, Georgia)
- 2002: Richmond Roosters, Frontier League (independent) - 1 game 27-Jul
- 2005: Kansas City T-bones, Northern League (independent) - 1 game 11-Aug
- 2006: Kansas City T-bones, Northern League (independent) - 1 game 5-Aug
- David Sosebee (pitcher, b. 1993, Georgia)
- 2018: Trenton Thunder, Eastern League (AA) - 1 game 25-Jul
- 2018: Scranton/Wilkes-Barre RailRiders, International League (AAA) - 2 games 2-Aug 11-Sep
- Anthony Sosnoskie (catcher, b. 1988, Pennsylvania)
- 2010: Sussex Skyhawks, Can-Am League (independent) - 1 game 16-Aug
- Chance Sossamon (pitcher, b. 1989, Missouri)
- 2012: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 11-Jul
- Andres Sotillet (pitcher, b. 1997, Venezuela)
- 2019: Northwest Arkansas Naturals, Texas League (AA) - 1 game 20-Jul
- 2021: Venezuela, Americas Olympic Qualifier - 1 game 1-Jun
- Andres Sotillo (catcher, b. 1993, Venezuela)
- 2014: Bluefield Blue Jays, Appalachian League (rookie) - 1 game 19-Aug
- Carlos Soto (catcher/first base, b. 1999, Mexico)
- Charlee Soto (pitcher, b. 2005, Pennsylvania)
- 2024: Fort Myers Mighty Mussels, Florida State League (Low-A) - 1 game 13-Apr
- Darwin Soto (pitcher, b. 1982, Dominican Republic)
- 2004: Inland Empire 66ers, California League (High-A) - 1 game 8-Aug
- Edgar Soto (pitcher, b. 1984, Venezuela)
- 2006: Staten Island Yankees, New York-Penn League (short-season) - 1 game 13-Sep
- Elliot Soto (infielder, b. 1989, Illinois)
- 2015: Tennessee Smokies, Southern League (AA) - 1 game 28-Jul
- 2017: Iowa Cubs, Pacific Coast League (AAA) - 1 game 21-Aug
- 2019: Albuquerque Isotopes, Pacific Coast League (AAA) - 1 game 12-Jul
- 2023: St. Paul Saints, International League (AAA) - 1 game 29-Jun
- Elvin Soto (catcher, b. 1992, New York)
- 2013: Hillsboro Hops, Northwest League (short-season) - 1 game 24-Aug
- 2015: Kane County Cougars, Midwest League (Low-A) - 2 games 29-Aug g2 3-Sep
- 2016: Rockland Boulders, Can-Am League (independent) - 2 games 9-Aug 19-Aug
- Franklin Soto (infielder, b. 1999, Dominican Republic)
- 2019: GCL Cardinals, Gulf Coast League (rookie) - 1 game 8-Aug
- 2021: Palm Beach Cardinals, Low-A Southeast - 1 game 2-Sep g1
- 2022: Palm Beach Cardinals, Florida State League (Low-A) - 1 game 15-Apr
- Geovany Soto (catcher, b. 1983, Puerto Rico)
- 2003: Daytona Cubs, Florida State League (High-A) - 1 game 27-Aug
- 2009: Chicago Cubs, Major League Baseball - 1 game 4-Sep
- 2010: Chicago Cubs, Major League Baseball - 1 game 4-Sep
- 2011: Chicago Cubs, Major League Baseball - 1 game 11-Sep
- Giovanni Soto (pitcher, b. 1991, Puerto Rico)
- 2014: Akron RubberDucks, Eastern League (AA) - 1 game 3-Aug
- Gregory Soto (pitcher, b. 1995, Dominican Republic)
- 2018: Mesa Solar Sox, Arizona Fall League - 1 game 9-Nov
- 2022: Detroit Tigers, Major League Baseball - 2 games 16-May 1-Oct
- 2023: Philadelphia Phillies, Major League Baseball - 1 game 27-Sep
- 2024: Baltimore Orioles, Major League Baseball - 1 game 18-Sep
- Isael Soto (outfielder, b. 1996, Dominican Republic)
- 2015: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 15-Apr
- 2016: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 22-Aug
- 2019: Jupiter Hammerheads, Florida State League (High-A) - 2 games 15-May g1 15-May g2
- Jose Soto (outfielder, b. 1979, Dominican Republic)
- 2001: Utica Blue Sox, New York-Penn League (short-season) - 1 game 21-Jul
- Juan Soto (outfielder, b. 1998, Dominican Republic)
- 2018: Washington Nationals, Major League Baseball - 2 games 4-Jul 15-Jul
- 2019: Washington Nationals, Major League Baseball - 1 game 18-Sep
- 2021: Washington Nationals, Major League Baseball - 1 game 6-Sep
- 2024: New York Yankees, Major League Baseball - 1 game 10-May
- Junior Soto (outfielder, b. 1997, Dominican Republic)
- 2018: Staten Island Yankees, New York-Penn League (short-season) - 2 games 15-Jun 22-Jul
- Leance Soto (infielder, b. 1985, Dominican Republic)
- 2006: Pulaski Blue Jays, Appalachian League (rookie) - 1 game 19-Aug
- Livan Soto (infielder, b. 2000, Venezuela)
- 2021: Tri-City Dust Devils, High-A West - 1 game 10-Jul
- 2022: Rocket City Trash Pandas, Southern League (AA) - 1 game 6-Aug
- 2023: Salt Lake Bees, Pacific Coast League (AAA) - 1 game 8-Aug
- 2024: Baltimore Orioles, Major League Baseball - 1 game 18-Sep
- Marco Soto (infielder, b. 2004, Venezuela)
- Neftali Soto (infielder, b. 1989, Puerto Rico)
- 2009: Sarasota Reds, Florida State League (High-A) - 1 game 5-Sep
- 2011: Carolina Mudcats, Southern League (AA) - 1 game 29-May
- 2013: Louisville Bats, International League (AAA) - 1 game 30-Aug
- Saul Soto (catcher/first base, b. 1978, Mexico)
- 2001: Wilmington Waves, South Atlantic League (Low-A) - 1 game 6-Aug
- Yonardy Soto (infielder, b. 2003, Dominican Republic)
- 2021: FCL Twins, Florida Complex League (rookie) - 1 game 24-Aug g1
- 2022: FCL Twins, Florida Complex League (rookie) - 1 game 1-Aug
- Adriel Sotolongo (utility, b. 1998, Cuba)
- Alerick Soularie (utility, b. 1999, Texas)
- 2021: Fort Myers Mighty Mussels, Low-A Southeast - 4 games 18-Aug 19-Aug 20-Aug 21-Aug
- 2022: Cedar Rapids Kernels, Midwest League (High-A) - 1 game 12-Jul
- 2024: York Revolution, Atlantic League (independent) - 1 game 7-Aug
- Ryan Soules (first baseman, b. 1976, Colorado)
- 1998: Greensboro Bats, South Atlantic League (Low-A) - 1 game 29-Aug
- 2001: Allentown Ambassadors, Northeast League (independent) - 1 game 20-Jul
- Bennett Sousa (pitcher, b. 1995, Florida)
- 2019: Glendale Desert Dogs, Arizona Fall League - 1 game 19-Oct
- Lee Southard (pitcher, b. 1978, Oklahoma)
- 2000: Queens Kings, New York-Penn League (short-season) - 1 game 26-Aug
- Nathan Southard (outfielder, b. 1983, Louisiana)
- 2006: State College Spikes, New York-Penn League (short-season) - 1 game 4-Jul
- Scott Southard (infielder, b. 1971, Florida)
- 1993: Elmira Pioneers, New York-Penn League (short-season) - 1 game 5-Sep
- Deshawn Southward (outfielder, b. 1978, Florida)
- 2000: Quad City River Bandits, Midwest League (Low-A) - 1 game 12-Aug
- Steven Souza (utility, b. 1989, Washington)
- 2010: Hagerstown Suns, South Atlantic League (Low-A) - 1 game 22-Apr
- 2013: Harrisburg Senators, Eastern League (AA) - 1 game 27-May
- 2016: Tampa Bay Rays, Major League Baseball - 2 games 13-Aug 25-Aug
- 2018: Arizona Diamondbacks, Major League Baseball - 1 game 18-Aug
- Josh Sowers (pitcher, b. 1983, Kentucky)
- 2005: Auburn Doubledays, New York-Penn League (short-season) - 1 game 1-Aug
- 2006: Lansing Lugnuts, Midwest League (Low-A) - 1 game 12-Aug
- Wil Sowers (infielder, b. 1977, Maryland)
- 2000: Bluefield Orioles, Appalachian League (rookie) - 2 games 5-Aug g1 5-Aug g2
- 2001: Kalamazoo Kings, Frontier League (independent) - 1 game 18-Aug
- Bobby Spain (infielder, b. 1985, Oklahoma)
- 2007: State College Spikes, New York-Penn League (short-season) - 1 game 22-Jul
- Garrett Spain (outfielder, b. 2000, Tennessee)
- Denard Span (outfielder, b. 1984, Florida)
- 2010: Minnesota Twins, Major League Baseball - 2 games 22-Aug 2-Sep
- 2013: Washington Nationals, Major League Baseball - 1 game 9-Sep
- 2014: Washington Nationals, Major League Baseball - 2 games 31-Mar 26-May
- 2017: San Francisco Giants, Major League Baseball - 1 game 2-Aug
- 2018: Tampa Bay Rays, Major League Baseball - 3 games 29-Mar 31-Mar 13-May
- 2018: Seattle Mariners, Major League Baseball - 1 game 21-Jun
- Chad Spanberger (first baseman, b. 1995, Illinois)
- 2018: Lansing Lugnuts, Midwest League (Low-A) - 1 game 3-Aug
- Cory Spangenberg (utility, b. 1991, Pennsylvania)
- Chad Spann (infielder, b. 1983, Georgia)
- 2005: Portland Sea Dogs, Eastern League (AA) - 1 game 10-Sep
- 2009: Round Rock Express, Pacific Coast League (AAA) - 1 game 15-Aug
- Matt Spann (pitcher, b. 1991, Tennessee)
- 2012: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 13-Sep
- 2014: Potomac Nationals, Carolina League (High-A) - 1 game 24-May
- Joe Spano (pitcher, b. 1989, New Jersey)
- 2013: Vancouver Canadians, Northwest League (short-season) - 1 game 21-Aug
- Don Sparks (infielder, b. 1966, California)
- 1992: Albany-Colonie Yankees, Eastern League (AA) - 1 game 7-Aug
- Greg Sparks (first baseman, b. 1964, Arizona)
- 1994: New Haven Ravens, Eastern League (AA) - 2 games 10-Jul 24-Jul
- Jeff Sparks (pitcher, b. 1972, Texas)
- Lamar Sparks (outfielder, b. 1998, Texas)
- Steve Sparks (pitcher, b. 1965, Oklahoma)
- 1996: Milwaukee Brewers, American League (MLB) - 1 game 25-Sep g1
- 2000: Detroit Tigers, Major League Baseball - 1 game 25-Sep
- Ryan Spataro (outfielder, b. 1982, Ontario)
- 2003: Elizabethton Twins, Appalachian League (rookie) - 1 game 12-Jul
- Matt Spath (first base/outfield, b. 1986, Florida)
- 2006: Greeneville Astros, Appalachian League (rookie) - 1 game 19-Aug
- Brenden Spaulding (outfielder, b. 1998, Ohio)
- 2021: Salina Stockade, Pecos League (independent) - 1 game 21-Jul
- Jemel Spearman (utility, b. 1980, Georgia)
- 2007: Tennessee Smokies, Southern League (AA) - 1 game 3-Sep
- Nate Spears (infielder, b. 1985, Florida)
- 2007: Tennessee Smokies, Southern League (AA) - 1 game 3-Sep
- 2010: Portland Sea Dogs, Eastern League (AA) - 2 games 30-May 1-Aug
- 2011: Pawtucket Red Sox, International League (AAA) - 2 games 1-Aug 20-Aug
- 2014: Lehigh Valley IronPigs, International League (AAA) - 2 games 17-Aug 1-Sep
- 2015: Somerset Patriots, Atlantic League (independent) - 5 games 13-Aug 17-Aug 25-Sep 26-Sep 27-Sep
- Mike Speckhardt (outfielder, b. 1975, New York)
- 1997: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 4-Aug
- Dorian Speed (outfielder, b. 1974, California)
- 1995: Williamsport Cubs, New York-Penn League (short-season) - 2 games 25-Jun 20-Aug
- David Speer (pitcher, b. 1992, Connecticut)
- 2014: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 29-Aug
- 2016: Mesa Solar Sox, Arizona Fall League - 2 games 11-Oct 13-Oct
- Stone Speer (pitcher, b. 1991, Louisiana)
- 2016: Sussex County Miners, Can-Am League (independent) - 2 games 30-May 23-Jun
- Tim Spehr (catcher, b. 1966, Missouri)
- 1993: Montreal Expos, National League (MLB) - 3 games 18-Sep 19-Sep 25-Sep
- 1998: New York Mets, National League (MLB) - 1 game 30-Apr
- 2000: Pawtucket Red Sox, International League (AAA) - 1 game 8-Jul
- 2001: Louisville RiverBats, International League (AAA) - 1 game 1-Aug
- Gabe Speier (pitcher, b. 1995, California)
- 2016: Salt River Rafters, Arizona Fall League - 1 game 12-Oct
- 2021: Kansas City Royals, Major League Baseball - 1 game 16-Sep
- Justin Speier (pitcher, b. 1973, California)
- 1995: Williamsport Cubs, New York-Penn League (short-season) - 2 games 16-Jul 20-Aug
- Ryan Speier (pitcher, b. 1979, Kentucky)
- 2009: Colorado Springs Sky Sox, Pacific Coast League (AAA) - 1 game 22-Aug
- Levale Speigner (pitcher, b. 1980, Georgia)
- 2008: Harrisburg Senators, Eastern League (AA) - 1 game 10-Apr
- 2008: Washington Nationals, Major League Baseball - 1 game 10-Sep
- Cam Spence (pitcher, b. 1974, Georgia)
- 1996: Greensboro Bats, South Atlantic League (Low-A) - 1 game 25-Jul
- 1998: Tampa Yankees, Florida State League (High-A) - 1 game 8-Aug g2
- Josh Spence (pitcher, b. 1988, Australia)
- 2011: San Diego Padres, Major League Baseball - 1 game 23-Jul
- 2013: Scranton/Wilkes-Barre RailRiders, International League (AAA) - 1 game 24-Apr
- Chad Spencer (pitcher, b. 1980, California)
- 2003: Richmond Roosters, Frontier League (independent) - 1 game 26-Jul
- Connor Spencer (first base/outfield, b. 1993, California)
- 2014: Staten Island Yankees, New York-Penn League (short-season) - 1 game 31-Jul
- 2016: Tampa Yankees, Florida State League (High-A) - 1 game 24-Aug
- Corey Spencer (pitcher, b. 1976, Massachusetts)
- 2001: Trenton Thunder, Eastern League (AA) - 1 game 4-Jul g2
- 2002: Trenton Thunder, Eastern League (AA) - 1 game 4-Jul
- Jeff Spencer (utility, b. 1977, Australia)
- 1999: Myrtle Beach Pelicans, Carolina League (High-A) - 2 games 8-Aug 13-Aug
- Jim Spencer (first baseman, b. 1946, Pennsylvania; d. 2002, Florida)
- 1976: Chicago White Sox, American League (MLB) - 1 game 9-Jul
- 1980: New York Yankees, American League (MLB) - 1 game 2-Sep
- Matt Spencer (outfielder, b. 1983)
- 2005: Edinburg Roadrunners, Central League (independent) - 1 game 17-Aug
- Matt Spencer (first base/outfield, b. 1986, Tennessee)
- 2013: York Revolution, Atlantic League (independent) - 1 game 4-Sep
- Robby Spencer (infielder, b. 1993)
- 2015: Schaumburg Boomers, Frontier League (independent) - 1 game 30-Aug
- Sean Spencer (pitcher, b. 1975, Washington)
- 2000: Montreal Expos, Major League Baseball - 1 game 11-Sep g2
- Shane Spencer (outfielder, b. 1972, Florida)
- 1998: New York Yankees, American League (MLB) - 1 game 27-Sep
- 2001: New York Yankees, Major League Baseball - 1 game 28-Aug
- Nick Spera (utility, b. unknown)
- 2000: Nashua Pride, Atlantic League (independent) - 1 game 6-Sep
- Jayme Sperring (pitcher, b. 1978, Texas)
- 2001: Delmarva Shorebirds, South Atlantic League (Low-A) - 1 game 7-May
- 2003: Frederick Keys, Carolina League (High-A) - 1 game 5-Apr
- Rob Sperring (infielder, b. 1949, California)
- 1975: Chicago Cubs, National League (MLB) - 1 game 3-Jul
- Michael Spidale (outfielder, b. 1982, Illinois)
- 2001: Kannapolis Intimidators, South Atlantic League (Low-A) - 1 game 2-Aug
- 2006: Lakewood BlueClaws, South Atlantic League (Low-A) - 5 games 26-Jun 15-Aug 6-Sep 14-Sep 15-Sep
- 2007: Reading Phillies, Eastern League (AA) - 2 games 24-Aug g1 24-Aug g2
- 2009: Reading Phillies, Eastern League (AA) - 1 game 11-Apr
- 2010: Reading Phillies, Eastern League (AA) - 1 game 11-May
- 2011: Reading Phillies, Eastern League (AA) - 2 games 5-May 10-Sep
- 2012: Lehigh Valley IronPigs, International League (AAA) - 1 game 3-Jul
- Mike Spiegel (pitcher, b. 1975, California)
- 1999: Kinston Indians, Carolina League (High-A) - 1 game 15-Aug
- R.D. Spiehs (pitcher, b. 1979, Nebraska)
- Carson Spiers (pitcher, b. 1997, South Carolina)
- 2023: Surprise Saguaros, Arizona Fall League - 1 game 13-Oct
- Bill Spiers (infielder, b. 1966, South Carolina)
- 1990: Milwaukee Brewers, American League (MLB) - 1 game 15-Aug
- 2000: Houston Astros, Major League Baseball - 1 game 22-Aug
- Scott Spiezio (infielder, b. 1972, Illinois)
- 1994: Modesto A's, California League (High-A) - 1 game 6-Sep
- 1997: Oakland Athletics, American League (MLB) - 2 games 29-Aug 1-Sep
- 1999: Oakland Athletics, American League (MLB) - 1 game 31-Aug
- 2006: St. Louis Cardinals, Major League Baseball - 1 game 4-Aug
- John Spikerman (outfielder, b. 2003, Texas)
- Ryan Spikes (infielder, b. 2003, Georgia)
- 2022: Charleston RiverDogs, Carolina League (Low-A) - 1 game 22-Jun
- 2023: Charleston RiverDogs, Carolina League (Low-A) - 2 games 9-May 5-Sep
- Ryan Spilborghs (outfielder, b. 1979, California)
- 2002: Tri-City Dust Devils, Northwest League (short-season) - 1 game 13-Aug
- 2003: Asheville Tourists, South Atlantic League (Low-A) - 1 game 19-Jul
- 2004: Visalia Oaks, California League (High-A) - 2 games 8-Aug 17-Aug
- 2009: Colorado Rockies, Major League Baseball - 2 games 21-Aug 28-Aug
- Scipio Spinks (pitcher, b. 1947, Illinois)
- 1972: St. Louis Cardinals, National League (MLB) - 1 game 25-Jun g1
- Stephen Spitaleri (pitcher, b. 1983)
- 2007: New Jersey Jackals, Can-Am League (independent) - 1 game 2-Aug
- Thomas Spitz (outfielder, b. 1992, Pennsylvania)
- 2015: State College Spikes, New York-Penn League (short-season) - 1 game 8-Aug
- 2017: Palm Beach Cardinals, Florida State League (High-A) - 2 games 27-May 28-May
- Shea Spitzbarth (pitcher, b. 1994, New York)
- 2019: Oklahoma City Dodgers, Pacific Coast League (AAA) - 1 game 21-Jul
- 2023: Louisville Bats, International League (AAA) - 1 game 1-Jul
- Brett Spivey (outfielder, b. 1981, South Carolina)
- 2003: Gateway Grizzlies, Frontier League (independent) - 1 game 29-Jul
- Junior Spivey (infielder, b. 1975, Oklahoma)
- 2005: Washington Nationals, Major League Baseball - 1 game 4-Jul
- Mel Spivey (pitcher, b. 1979, Alabama)
- 2005: Fargo-Moorhead RedHawks, Northern League (independent) - 1 game 8-Aug
- Seth Spivey (utility, b. 1992, Texas)
- Owen Spiwak (catcher, b. 1995, Ontario)
- 2018: Lansing Lugnuts, Midwest League (Low-A) - 1 game 3-Aug
- Paul Splittorff (pitcher, b. 1946, Indiana)
- 1974: Kansas City Royals, American League (MLB) - 1 game 25-Apr
- Harrison Spohn (infielder, b. 1998, California)
- 2023: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 27-Jul
- 2024: Pensacola Blue Wahoos, Southern League (AA) - 1 game 20-Jun
- Paul Spoljaric (pitcher, b. 1970, British Columbia)
- 1995: Syracuse Chiefs, International League (AAA) - 1 game 4-Aug
- 1996: Toronto Blue Jays, American League (MLB) - 2 games 7-Sep 8-Sep
- 1997: Seattle Mariners, American League (MLB) - 1 game 3-Sep
- Brent Spooner (catcher, b. 1977, Florida)
- 1999: Johnson City Cardinals, Appalachian League (rookie) - 1 game 7-Aug g1
- Tim Spooneybarger (pitcher, b. 1979, California)
- 2002: Atlanta Braves, Major League Baseball - 1 game 29-Sep
- J.P. Sportman (outfielder, b. 1992, New York)
- 2014: Vermont Lake Monsters, New York-Penn League (short-season) - 1 game 28-Jul
- Billy Spottiswood (pitcher, b. 1985, Hawaii)
- 2009: Reno Aces, Pacific Coast League (AAA) - 1 game 15-Aug
- Jack Spradlin (pitcher, b. 1984, Nevada)
- 2010: Harrisburg Senators, Eastern League (AA) - 1 game 1-Aug
- Jerry Spradlin (pitcher, b. 1967, California)
- 1993: Cincinnati Reds, National League (MLB) - 2 games 18-Aug 24-Aug
- 1997: Philadelphia Phillies, National League (MLB) - 2 games 15-Sep g1 27-Sep
- 1998: Philadelphia Phillies, National League (MLB) - 1 game 11-Apr
- 2000: Kansas City Royals, Major League Baseball - 1 game 22-Jul day
- Stephen Spragg (pitcher, b. 1983)
- 2006: Washington Wild Things, Frontier League (independent) - 1 game 8-Aug
- Ed Sprague (infielder, b. 1967, California)
- 1990: Syracuse Chiefs, International League (AAA) - 1 game 18-Aug
- 1992: Toronto Blue Jays, American League (MLB) - 1 game 27-Sep
- 1993: Toronto Blue Jays, American League (MLB) - 1 game 21-Aug
- 1996: Toronto Blue Jays, American League (MLB) - 2 games 7-Sep 8-Sep
- 1998: Toronto Blue Jays, American League (MLB) - 1 game 26-Jul
- 2000: Boston Red Sox, Major League Baseball - 1 game 9-Jul
- Holden Sprague (pitcher, b. 1987, California)
- 2010: Jamestown Jammers, New York-Penn League (short-season) - 1 game 8-Sep
- Kevin Sprague (pitcher, b. 1977, Kansas)
- 1999: Johnson City Cardinals, Appalachian League (rookie) - 1 game 7-Aug g2
- 2000: Peoria Chiefs, Midwest League (Low-A) - 1 game 12-Aug
- Graham Spraker (pitcher, b. 1995, Arizona)
- 2017: Bluefield Blue Jays, Appalachian League (rookie) - 1 game 28-Aug
- 2019: Dunedin Blue Jays, Florida State League (High-A) - 2 games 4-Apr 6-Aug
- 2019: Scottsdale Scorpions, Arizona Fall League - 1 game 14-Oct
- 2021: Mesa Solar Sox, Arizona Fall League - 1 game 18-Oct
- Nick Sprengel (pitcher, b. 1997, California)
- 2018: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 9-Sep
- 2019: Bowling Green Hot Rods, Midwest League (Low-A) - 1 game 30-May
- Justin Sprenger (pitcher, b. 1991, Montana)
- 2013: Spokane Indians, Northwest League (short-season) - 1 game 22-Aug
- Matt Spring (catcher/first base, b. 1984, Arizona)
- 2005: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 7-Sep
- 2006: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 13-Aug
- 2012: Portland Sea Dogs, Eastern League (AA) - 1 game 7-Apr
- Tyler Spring (pitcher, b. 1996, Mississippi)
- 2022: Evansville Otters, Frontier League (independent) - 1 game 5-Jul
- Dennis Springer (pitcher, b. 1965, California)
- 1998: Tampa Bay Devil Rays, American League (MLB) - 1 game 27-Sep
- George Springer (outfielder, b. 1989, Connecticut)
- 2015: Houston Astros, Major League Baseball - 1 game 25-May
- 2016: Houston Astros, Major League Baseball - 1 game 20-Aug
- 2017: Houston Astros, Major League Baseball - 1 game 18-Oct
- 2018: Houston Astros, Major League Baseball - 1 game 29-Sep g1
- 2019: Houston Astros, Major League Baseball - 2 games 28-Mar 19-Jul
- 2021: Toronto Blue Jays, Major League Baseball - 5 games 28-Apr 30-Apr 1-May 21-Sep 22-Sep
- 2022: Toronto Blue Jays, Major League Baseball - 1 game 2-Oct
- 2023: Toronto Blue Jays, Major League Baseball - 2 games 22-May 22-Sep
- 2024: Toronto Blue Jays, Major League Baseball - 3 games 29-Mar 30-Mar 31-Mar
- Russ Springer (pitcher, b. 1968, Louisiana)
- 1995: Philadelphia Phillies, National League (MLB) - 1 game 23-Sep
- 2009: Tampa Bay Rays, Major League Baseball - 1 game 6-Sep
- Steve Springer (infielder, b. 1961, California)
- 1988: Tidewater Tides, International League (AAA) - 1 game 29-Jul
- 1995: Toledo Mud Hens, International League (AAA) - 1 game 5-Aug
- Blair Springfield (outfielder, b. 1991, Illinois)
- 2013: Quebec Les Capitales, Can-Am League (independent) - 1 game 9-Aug
- Jeffrey Springs (pitcher, b. 1992, North Carolina)
- Jonathan Sprinkle (pitcher, b. 1998, Kansas)
- 2022: Surprise Saguaros, Arizona Fall League - 1 game 14-Oct
- Ross Spurgeon (pitcher, b. 1992)
- 2015: Gateway Grizzlies, Frontier League (independent) - 1 game 30-Aug
- Logan Spurlin (catcher, b. 1994, Illinois)
- 2016: Birmingham-Bloomfield Beavers, United Shore League (independent) - 1 game 6-Aug
- Tyler Spurlin (pitcher, b. 1991, Texas)
- 2016: Salt River Rafters, Arizona Fall League - 1 game 13-Oct
- 2019: Biloxi Shuckers, Southern League (AA) - 1 game 10-Sep
- Chris Spurling (pitcher, b. 1977, Ohio)
- 2009: Newark Bears, Atlantic League (independent) - 2 games 16-Jul 31-Aug
- Kurt Spyke (pitcher, b. 1979)
- 2001: Kalamazoo Kings, Frontier League (independent) - 1 game 7-Jul
- Payton Squier (outfielder, b. 1995, Arizona)
- 2018: Vermont Lake Monsters, New York-Penn League (short-season) - 2 games 29-Jul 30-Jul
- Brett Squires (first baseman, b. 2000, Texas)
- 2023: Columbia Fireflies, Carolina League (Low-A) - 2 games 16-Jul 8-Sep
- 2024: Surprise Saguaros, Arizona Fall League - 1 game 11-Oct
- Matt Squires (pitcher, b. 1979, Idaho)
- 2002: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 26-Aug
- 2003: Clearwater Phillies, Florida State League (High-A) - 2 games 22-Aug 31-Aug g2
- Jason St. Clair (infielder, b. 1982, California)
- 2001: Princeton Devil Rays, Appalachian League (rookie) - 1 game 5-Aug
- 2002: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 30-Jun
- Randy St. Claire (pitcher, b. 1960, New York)
- 1984: Montreal Expos, National League (MLB) - 1 game 23-Sep
- 1990: Oklahoma City 89ers, American Association (AAA) - 1 game 18-Aug
- 1994: Syracuse Chiefs, International League (AAA) - 1 game 6-Aug g2
- Bill St. Peter (infielder, b. 1967, Michigan)
- 1991: Winston-Salem Spirits, Carolina League (High-A) - 1 game 15-Aug
- Bobby St. Pierre (pitcher, b. 1974, District of Columbia)
- 1999: Newark Bears, Atlantic League (independent) - 1 game 31-May
- Max St. Pierre (catcher, b. 1980, Quebec)
- 2004: Erie SeaWolves, Eastern League (AA) - 2 games 31-Aug 4-Sep
- 2008: Toledo Mud Hens, International League (AAA) - 1 game 30-Aug
- 2009: Toledo Mud Hens, International League (AAA) - 1 game 27-Jul
- Justin Staatz (pitcher, b. 1983, California)
- 2007: Gateway Grizzlies, Frontier League (independent) - 1 game 7-Aug
- Ryan Stadanlick (pitcher, b. 1984, Pennsylvania)
- 2005: Aberdeen IronBirds, New York-Penn League (short-season) - 1 game 7-Sep
- Fitz Stadler (pitcher, b. 1997, Illinois)
- 2023: Dunedin Blue Jays, Florida State League (Low-A) - 2 games 30-May 3-Jun
- Deon Stafford (catcher, b. 1996, Pennsylvania)
- Sammy Stafura (infielder, b. 2004, New York)
- Larry Stahl (outfielder, b. 1941, Illinois)
- 1967: New York Mets, National League (MLB) - 1 game 9-Jul
- 1968: New York Mets, National League (MLB) - 1 game 15-Sep
- Richard Stahl (pitcher, b. 1981, Georgia)
- 2005: Bowie Baysox, Eastern League (AA) - 1 game 27-Jul
- Scott Stahoviak (infielder, b. 1970, Illinois)
- 1993: Minnesota Twins, American League (MLB) - 1 game 22-Sep
- 1994: Salt Lake Buzz, Pacific Coast League (AAA) - 3 games 1-Sep 9-Sep 10-Sep
- 1995: Minnesota Twins, American League (MLB) - 1 game 7-Aug
- 1996: Minnesota Twins, American League (MLB) - 1 game 3-Aug day
- Roy Staiger (infielder, b. 1950, Oklahoma)
- 1976: New York Mets, National League (MLB) - 1 game 14-Aug
- Troy Stainbrook (pitcher, b. 1996, California)
- 2021: Fredericksburg Nationals, Low-A East - 1 game 15-Jun
- Matt Stairs (first base/outfield, b. 1968, New Brunswick)
- 1992: Indianapolis Indians, American Association (AAA) - 1 game 9-Aug
- 1994: New Britain Red Sox, Eastern League (AA) - 1 game 21-Aug g1
- 1997: Oakland Athletics, American League (MLB) - 2 games 29-Aug 1-Sep
- 1999: Oakland Athletics, American League (MLB) - 1 game 31-Aug
- 2001: Chicago Cubs, Major League Baseball - 1 game 29-Jul
- 2003: Pittsburgh Pirates, Major League Baseball - 2 games 3-Jul 24-Sep
- 2005: Kansas City Royals, Major League Baseball - 1 game 7-Aug
- 2007: Toronto Blue Jays, Major League Baseball - 1 game 22-Sep
- 2011: Washington Nationals, Major League Baseball - 1 game 30-May
- Carl Stajduhar (infielder, b. 1996, Colorado)
- 2017: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 16-Aug
- Joe Staley (catcher, b. 1989, Texas)
- 2015: Fargo-Moorhead RedHawks, American Association (independent) - 1 game 15-Jul
- 2015: Joliet Slammers, Frontier League (independent) - 2 games 27-Aug 30-Aug
- Garrett Stallings (pitcher, b. 1997, Virginia)
- 2023: Norfolk Tides, International League (AAA) - 1 game 15-Jul
- Jacob Stallings (catcher, b. 1989, Tennessee)
- 2015: Altoona Curve, Eastern League (AA) - 1 game 22-Aug
- 2018: Pittsburgh Pirates, Major League Baseball - 1 game 22-Sep
- 2021: Pittsburgh Pirates, Major League Baseball - 1 game 19-Jul
- 2022: Miami Marlins, Major League Baseball - 2 games 16-Apr 24-May
- 2023: Miami Marlins, Major League Baseball - 5 games 4-Apr 25-Jul 26-Jul 29-Aug 29-Sep
- Eric Stamets (infielder, b. 1991, Ohio)
- 2019: Columbus Clippers, International League (AAA) - 1 game 17-Sep
- Keith Stamler (pitcher, b. 1979, New Jersey)
- 2000: Pulaski Rangers, Appalachian League (rookie) - 1 game 31-Jul g1
- Craig Stammen (pitcher, b. 1984, Ohio)
- 2005: Vermont Expos, New York-Penn League (short-season) - 1 game 4-Aug
- 2008: Columbus Clippers, International League (AAA) - 1 game 30-Aug
- 2011: Syracuse Chiefs, International League (AAA) - 2 games 23-Apr g2 3-Jul
- 2012: Washington Nationals, Major League Baseball - 1 game 19-Aug
- 2018: San Diego Padres, Major League Baseball - 3 games 18-Aug 19-Aug 23-Aug
- Dale Stanavich (pitcher, b. 1999, New York)
- 2023: Jupiter Hammerheads, Florida State League (Low-A) - 2 games 17-Sep 20-Sep
- Ben Stanczyk (pitcher, b. 1982, Wisconsin)
- 2005: West Virginia Power, South Atlantic League (Low-A) - 1 game 30-Jul
- Mark Stander (pitcher, b. 1979, Colorado)
- 2002: Martinsville Astros, Appalachian League (rookie) - 1 game 14-Jul
- Jason Standridge (pitcher, b. 1978, Alabama)
- 2009: Somerset Patriots, Atlantic League (independent) - 1 game 16-Jul
- Jeff Stanek (first baseman, b. 1980, Michigan)
- 2002: Missoula Osprey, Pioneer League (rookie) - 2 games 5-Aug 10-Aug
- Ryne Stanek (pitcher, b. 1991, Missouri)
- 2016: Durham Bulls, International League (AAA) - 1 game 21-Aug
- 2017: Tampa Bay Rays, Major League Baseball - 2 games 11-Sep 24-Sep
- 2018: Tampa Bay Rays, Major League Baseball - 1 game 28-Aug
- 2019: Tampa Bay Rays, Major League Baseball - 3 games 3-Apr 21-Apr 12-May
- 2019: Miami Marlins, Major League Baseball - 1 game 27-Sep
- 2021: Houston Astros, Major League Baseball - 1 game 2-May
- 2022: Houston Astros, Major League Baseball - 1 game 20-Sep
- 2023: Houston Astros, Major League Baseball - 1 game 24-Apr
- 2024: Seattle Mariners, Major League Baseball - 1 game 24-Jun
- 2024: New York Mets, Major League Baseball - 2 games 5-Aug 19-Sep
- Don Stanford (pitcher, b. 1965)
- 1992: Columbus Clippers, International League (AAA) - 1 game 19-Aug
- Jason Stanford (pitcher, b. 1977, Arizona)
- 2002: Akron Aeros, Eastern League (AA) - 1 game 11-Apr
- Zach Staniewicz (pitcher, b. 1986, Indiana)
- 2015: Sussex County Miners, Can-Am League (independent) - 1 game 15-Jul
- Gage Stanifer (pitcher, b. 2003, Indiana)
- 2023: FCL Blue Jays, Florida Complex League (rookie) - 2 games 29-Jul 5-Aug
- 2024: Dunedin Blue Jays, Florida State League (Low-A) - 3 games 2-Jul 20-Aug 27-Aug
- Rob Stanifer (pitcher, b. 1972, South Carolina)
- 1997: Florida Marlins, National League (MLB) - 1 game 27-Sep
- 2004: Edmonton Trappers, Pacific Coast League (AAA) - 1 game 15-Aug
- Andy Stankiewicz (infielder, b. 1964, California)
- Drew Stankiewicz (infielder, b. 1993, Ohio)
- 2014: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 4-Jul g2
- 2014: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 5-Aug
- 2015: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 10-Aug
- 2016: Clearwater Threshers, Florida State League (High-A) - 1 game 25-Aug
- 2019: Sioux City Explorers, American Association (independent) - 2 games 1-Jun 7-Jun
- John Stankiewicz (pitcher, b. 1998, New Jersey)
- 2021: Fort Myers Mighty Mussels, Low-A Southeast - 1 game 21-Aug
- 2022: Fort Myers Mighty Mussels, Florida State League (Low-A) - 1 game 8-Apr
- Aaron Stanley (outfielder, b. 1979, Arizona)
- 2003: Kenosha Mammoths, Frontier League (independent) - 1 game 29-Jul
- Cody Stanley (catcher/first base, b. 1988, North Carolina)
- 2014: Peoria Javelinas, Arizona Fall League - 2 games 9-Oct 10-Oct
- 2019: Sugar Land Skeeters, Atlantic League (independent) - 1 game 3-May
- Derek Stanley (outfielder, b. 1980, Virginia)
- 2000: Bristol Sox, Appalachian League (rookie) - 2 games 29-Jul 4-Aug
- Henri Stanley (outfielder, b. 1977, South Carolina)
- 2006: Somerset Patriots, Atlantic League (independent) - 1 game 16-Aug
- 2007: New Haven County Cutters, Can-Am League (independent) - 1 game 23-Aug
- Hunter Stanley (pitcher, b. 1997, Louisiana)
- 2022: Peoria Javelinas, Arizona Fall League - 1 game 13-Oct
- Kolin Stanley (pitcher, b. 1992, Ohio)
- 2016: Washington Wild Things, Frontier League (independent) - 1 game 3-Jul
- Mike Stanley (catcher/first base, b. 1963, Florida)
- 1992: New York Yankees, American League (MLB) - 1 game 13-Sep
- 1993: New York Yankees, American League (MLB) - 5 games 2-Sep 3-Sep 17-Sep 1-Oct 3-Oct
- 1994: New York Yankees, American League (MLB) - 3 games 10-Apr 29-Jul 31-Jul
- 1997: Boston Red Sox, American League (MLB) - 1 game 27-Jul
- 1997: New York Yankees, American League (MLB) - 2 games 16-Sep g2 19-Sep
- 1998: Toronto Blue Jays, American League (MLB) - 1 game 26-Jul
- 1999: Boston Red Sox, American League (MLB) - 1 game 19-Sep
- Steve Stanley (outfielder, b. 1979, Ohio)
- 2003: Midland Rockhounds, Texas League (AA) - 1 game 9-Aug
- 2004: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 9-Apr
- Craig Stansberry (infielder, b. 1982, Saudi Arabia)
- 2003: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 19-Aug
- 2005: Altoona Curve, Eastern League (AA) - 1 game 2-Jul
- 2006: Altoona Curve, Eastern League (AA) - 1 game 14-Apr
- 2011: New Hampshire Fisher Cats, Eastern League (AA) - 2 games 5-May 4-Aug
- Cole Stanton (pitcher, b. 1996, California)
- 2022: Joliet Slammers, Frontier League (independent) - 1 game 6-Jul
- Giancarlo Stanton (outfielder, b. 1989, California)
- 2010: Florida Marlins, Major League Baseball - 1 game (as Mike Stanton) 6-Sep day
- 2011: Florida Marlins, Major League Baseball - 1 game (as Mike Stanton) 8-Aug
- 2012: Miami Marlins, Major League Baseball - 1 game 10-Aug
- 2013: Miami Marlins, Major League Baseball - 1 game 13-Sep
- 2014: Miami Marlins, Major League Baseball - 1 game 26-May
- 2016: Miami Marlins, Major League Baseball - 1 game 4-Jul
- 2018: New York Yankees, Major League Baseball - 4 games 25-Apr 21-Jun 16-Sep 9-Oct
- 2019: New York Yankees, Major League Baseball - 1 game 24-Sep
- 2021: New York Yankees, Major League Baseball - 2 games 11-Apr 29-Jul
- 2022: New York Yankees, Major League Baseball - 2 games 20-Jun 4-Sep
- 2023: New York Yankees, Major League Baseball - 1 game 25-Aug
- 2024: New York Yankees, Major League Baseball - 1 game 10-May
- Leroy Stanton (outfielder, b. 1946, South Carolina; d. 2019, South Carolina)
- 1970: New York Mets, National League (MLB) - 1 game 13-Sep
- Mike Stanton (pitcher, b. 1967, Texas)
- 1991: Atlanta Braves, National League (MLB) - 1 game 6-Sep
- 1992: Atlanta Braves, National League (MLB) - 2 games 31-Aug g1 31-Aug g2
- 1997: New York Yankees, American League (MLB) - 2 games 16-Sep g2 21-Sep
- 1999: New York Yankees, American League (MLB) - 2 games 31-Aug 22-Sep
- 2001: New York Yankees, Major League Baseball - 1 game 28-Aug
- 2003: New York Mets, Major League Baseball - 2 games 20-Jul 24-Sep
- 2004: New York Mets, Major League Baseball - 1 game 11-Sep
- Robert Stanton (outfielder, b. 1975, New Jersey)
- 1996: Watertown Indians, New York-Penn League (short-season) - 1 game 6-Jul
- 1997: Watertown Indians, New York-Penn League (short-season) - 1 game 25-Jul
- T.J. Stanton (pitcher, b. 1981, Florida)
- 2008: Quebec Les Capitales, Can-Am League (independent) - 2 games 20-Aug 11-Sep
- 2010: Fargo-Moorhead RedHawks, Northern League (independent) - 1 game 23-Aug
- 2011: Quebec Les Capitales, Can-Am League (independent) - 2 games 13-Sep 14-Sep
- 2012: Quebec Les Capitales, Can-Am League (independent) - 2 games 25-Jun 10-Sep
- Cole Stapler (pitcher, b. 1994, Louisiana)
- 2019: Jackson Generals, Southern League (AA) - 1 game 10-Sep
- Michael Starcevich (pitcher, b. 1996, Iowa)
- 2018: Southern Illinois Miners, Frontier League (independent) - 1 game 4-Aug
- Willie Stargell (first base/outfield, b. 1940, Oklahoma; d. 2001, North Carolina)
- 1968: Pittsburgh Pirates, National League (MLB) - 1 game 15-Sep
- Gabe Starks (pitcher, b. 2001, Arkansas)
- 2024: Daytona Tortugas, Florida State League (Low-A) - 1 game 16-May g1
- Bubba Starling (outfielder, b. 1992, Kansas)
- 2014: Peoria Javelinas, Arizona Fall League - 2 games 9-Oct 10-Oct
- Sammie Starr (infielder, b. 1988, Ontario)
- 2011: Aberdeen IronBirds, New York-Penn League (short-season) - 1 game 21-Jul
- 2012: Delmarva Shorebirds, South Atlantic League (Low-A) - 1 game 21-Aug
- Jason Startari (infielder, b. 1980, Pennsylvania)
- 2002: Albany-Colonie Diamond Dogs, Northeast League (independent) - 2 games 28-Jun g2 1-Sep
- 2005: Grays, Can-Am League (independent) - 1 game 5-Aug
- Will Startup (pitcher, b. 1984, Tennessee)
- 2014: Erie SeaWolves, Eastern League (AA) - 1 game 4-Jul
- Cody Stashak (pitcher, b. 1994, New Jersey)
- 2018: Chattanooga Lookouts, Southern League (AA) - 1 game 27-Aug
- 2022: Minnesota Twins, Major League Baseball - 1 game 30-Apr
- Brock Stassi (utility, b. 1989, California)
- 2012: Lakewood BlueClaws, South Atlantic League (Low-A) - 2 games 11-Jul 21-Aug
- 2015: Reading Fightin Phils, Eastern League (AA) - 2 games 17-Jun 9-Aug
- 2016: Lehigh Valley IronPigs, International League (AAA) - 1 game 30-May
- 2017: Lehigh Valley IronPigs, International League (AAA) - 2 games 26-Jul 10-Sep
- 2018: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 15-Aug
- Max Stassi (catcher, b. 1991, California)
- 2018: Houston Astros, Major League Baseball - 1 game 29-Sep g1
- 2021: Los Angeles Angels, Major League Baseball - 1 game 18-Jul
- Hainley Statia (infielder, b. 1986, Curacao)
- 2013: Nashville Sounds, Pacific Coast League (AAA) - 2 games 21-Jul 23-Jul
- Tyler Statler (pitcher, b. 2001, Illinois)
- 2019: GCL Cardinals, Gulf Coast League (rookie) - 1 game 8-Aug
- Dave Staton (infielder, b. 1968, Washington)
- 1994: Las Vegas Stars, Pacific Coast League (AAA) - 1 game 1-Sep
- T.J. Staton (outfielder, b. 1975, Virginia)
- 1997: Carolina Mudcats, Southern League (AA) - 1 game 11-Aug
- 1998: Nashville Sounds, Pacific Coast League (AAA) - 2 games 26-Aug 28-Aug
- Rusty Staub (first base/outfield, b. 1944, Louisiana; d. 2018, Florida)
- 1974: New York Mets, National League (MLB) - 1 game 10-Jul
- 1975: New York Mets, National League (MLB) - 1 game 3-Jul
- 1984: New York Mets, National League (MLB) - 2 games 17-Apr 8-Sep
- 1985: New York Mets, National League (MLB) - 1 game 9-Apr
- Tim Stauffer (pitcher, b. 1982, Maine)
- 2004: Portland Beavers, Pacific Coast League (AAA) - 1 game 13-Aug
- 2015: New York Mets, Major League Baseball - 1 game 20-Sep
- Josh Staumont (pitcher, b. 1993, California)
- 2016: Surprise Saguaros, Arizona Fall League - 1 game 11-Oct
- 2021: Kansas City Royals, Major League Baseball - 1 game 16-Sep
- Wade Stauss (catcher, b. 1999, Missouri)
- 2021: Palm Beach Cardinals, Low-A Southeast - 1 game 2-Sep g2
- 2022: Palm Beach Cardinals, Florida State League (Low-A) - 1 game 15-Apr
- 2022: Peoria Chiefs, Midwest League (High-A) - 1 game 25-Jun
- Nick Stavinoha (first base/outfield, b. 1982, Texas)
- 2006: Springfield Cardinals, Texas League (AA) - 1 game 3-Sep
- Brian Stavisky (first base/outfield, b. 1980, New York)
- 2004: Modesto A's, California League (High-A) - 3 games 11-Aug 19-Aug g1 19-Aug g2
- 2009: Reading Phillies, Eastern League (AA) - 1 game 11-Apr
- 2010: Reading Phillies, Eastern League (AA) - 1 game 11-May
- John Stearns (catcher, b. 1951, Colorado; d. 2022, Colorado)
- 1975: New York Mets, National League (MLB) - 1 game 3-Jul
- 1977: New York Mets, National League (MLB) - 1 game 12-Jul
- 1981: New York Mets, National League (MLB) - 1 game 14-Aug
- 1982: New York Mets, National League (MLB) - 1 game 13-Apr
- 1984: New York Mets, National League (MLB) - 1 game 26-Sep
- Randy Stearns (outfielder, b. 1974, Wisconsin)
- 1997: Savannah Sand Gnats, South Atlantic League (Low-A) - 1 game 12-Aug g1
- Isaac Stebens (pitcher, b. 2001, Oklahoma)
- 2024: Greenville Drive, South Atlantic League (High-A) - 1 game 9-Aug
- Gene Stechschulte (pitcher, b. 1973, Ohio)
- 1997: New Jersey Cardinals, New York-Penn League (short-season) - 2 games 27-Jun 4-Aug
- Drew Steckenrider (pitcher, b. 1991, Georgia)
- 2016: Mesa Solar Sox, Arizona Fall League - 1 game 13-Oct
- 2018: Miami Marlins, Major League Baseball - 1 game 30-Mar
- 2019: Miami Marlins, Major League Baseball - 1 game 1-Apr
- 2021: Seattle Mariners, Major League Baseball - 2 games 18-Jul 4-Aug
- David Steed (catcher, b. 1973, Georgia)
- 1994: Yakima Bears, Northwest League (short-season) - 1 game 8-Sep
- 2000: Aberdeen Arsenal, Atlantic League (independent) - 2 games 6-Jul 14-Sep
- Rick Steed (pitcher, b. 1970, California)
- 1995: Syracuse Chiefs, International League (AAA) - 1 game 30-Jul
- 1999: Somerset Patriots, Atlantic League (independent) - 1 game 11-Sep g1
- 2001: Somerset Patriots, Atlantic League (independent) - 2 games 7-Sep 2-Oct
- Spencer Steedley (pitcher, b. 1985, North Carolina)
- 2009: New Britain Rock Cats, Eastern League (AA) - 1 game 13-Sep
- 2012: Camden Riversharks, Atlantic League (independent) - 2 games 26-Jul 22-Aug
- Alex Steele (outfielder, b. 1975, New Jersey)
- 1997: Jamestown Jammers, New York-Penn League (short-season) - 1 game 26-Jul
- 1998: West Michigan Whitecaps, Midwest League (Low-A) - 1 game 16-Aug
- Chuck Steele (infielder, b. 1997, California)
- 2021: Ogden Raptors, Pioneer League (independent) - 1 game 9-Jul
- Joey Steele (pitcher, b. 1995, California)
- 2021: Jupiter Hammerheads, Low-A Southeast - 1 game 22-Jun
- Justin Steele (pitcher, b. 1995, Mississippi)
- 2018: Mesa Solar Sox, Arizona Fall League - 1 game 5-Nov
- Wyley Steelmon (first baseman, b. 1975, Oklahoma)
- 1998: South Bend Silver Hawks, Midwest League (Low-A) - 1 game 16-Aug
- Kevin Steen (pitcher, b. 1996, Tennessee)
- 2015: Lowell Spinners, New York-Penn League (short-season) - 1 game 19-Aug
- Ken Steenstra (pitcher, b. 1970, Missouri)
- 1999: Greenville Braves, Southern League (AA) - 1 game 12-Aug
- Spencer Steer (infielder, b. 1997, California)
- 2021: Wichita Wind Surge, Double-A Central - 2 games 22-Jul 15-Sep
- 2022: Cincinnati Reds, Major League Baseball - 1 game 30-Sep
- 2023: Cincinnati Reds, Major League Baseball - 1 game 24-Sep
- 2024: Cincinnati Reds, Major League Baseball - 5 games 26-Jul 27-Jul 28-Jul 25-Sep 28-Sep
- Phillip Steering (first baseman, b. 1996, California)
- 2022: Joliet Slammers, Frontier League (independent) - 1 game 6-Jul
- Michael Stefanic (infielder, b. 1996, Idaho)
- 2023: Salt Lake Bees, Pacific Coast League (AAA) - 1 game 8-Aug
- 2023: Los Angeles Angels, Major League Baseball - 1 game 21-Sep
- Mike Stefanski (catcher, b. 1969, Michigan)
- 1992: Beloit Brewers, Midwest League (Low-A) - 1 game 11-Aug
- 1997: Louisville Redbirds, American Association (AAA) - 1 game 9-Aug g2
- 1998: Memphis Redbirds, Pacific Coast League (AAA) - 1 game 26-Aug
- Jake Steffens (pitcher, b. 1994, Arizona)
- 2017: Eugene Emeralds, Northwest League (short-season) - 1 game 29-Jul
- Jake Steffens (pitcher, b. 1994, Arizona)
- 2018: South Bend Cubs, Midwest League (Low-A) - 1 game 3-Aug
- Randy Stegall (infielder, b. 1975, Florida)
- 1999: Rockford Reds, Midwest League (Low-A) - 1 game 5-Sep
- 2000: Dayton Dragons, Midwest League (Low-A) - 1 game 21-Jul
- Ryan Stegall (infielder, b. 1979, Missouri)
- 2001: Pittsfield Astros, New York-Penn League (short-season) - 3 games 19-Jul 21-Jul 26-Aug
- Keith Stegbauer (infielder, b. 1981)
- 2005: New Haven County Cutters, Can-Am League (independent) - 2 games 25-Jun 3-Jul
- Gus Steiger (utility, b. 1999, Minnesota)
- Bill Stein (infielder, b. 1947, Michigan)
- 1976: Chicago White Sox, American League (MLB) - 1 game 9-Jul
- Ryan Steinbach (infielder, b. 1982, Missouri)
- 2005: Aberdeen IronBirds, New York-Penn League (short-season) - 2 games 17-Jul 7-Sep
- Terry Steinbach (catcher, b. 1962, Minnesota)
- 1992: Oakland Athletics, American League (MLB) - 1 game 21-Aug
- 1995: Oakland Athletics, American League (MLB) - 1 game 7-Aug
- Conor Steinbaugh (pitcher, b. 1999, Illinois)
- 2024: Mesa Solar Sox, Arizona Fall League - 1 game 10-Oct
- Kurt Steinhauer (outfielder, b. 1986, California)
- 2010: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 5-Aug
- Brock Steinke (pitcher, b. 1975)
- 1995: Quad City River Bandits, Midwest League (Low-A) - 1 game 6-Aug
- Hunter Steinmetz (outfielder, b. 1996, Missouri)
- 2019: Dunedin Blue Jays, Florida State League (High-A) - 1 game 10-May
- Duane Stelly (infielder, b. 1972, Louisiana)
- 1998: Massachusetts Mad Dogs, Northeast League (independent) - 1 game 3-Jul
- Nick Stelzner (pitcher, b. 1978, California)
- 2002: Evansville Otters, Frontier League (independent) - 1 game 27-Jul
- Steve Stemle (pitcher, b. 1977, Kentucky)
- 1998: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 25-Jul
- 2001: New Haven Ravens, Eastern League (AA) - 1 game 15-Jul
- Dernell Stenson (outfielder, b. 1978, Georgia)
- 1997: Michigan Battle Cats, Midwest League (Low-A) - 1 game 5-Jul
- 1998: Trenton Thunder, Eastern League (AA) - 2 games 11-Apr 1-Jul
- 2001: Pawtucket Red Sox, International League (AAA) - 1 game 13-Jul
- Brent Stentz (pitcher, b. 1975, Florida)
- 1998: New Britain Rock Cats, Eastern League (AA) - 2 games 30-Aug 17-Sep
- Rod Steph (pitcher, b. 1969, Texas)
- 1994: Canton-Akron Indians, Eastern League (AA) - 1 game 21-Aug g2
- 1995: Canton-Akron Indians, Eastern League (AA) - 1 game 19-Aug
- 1999: Elmira Pioneers, Northeast League (independent) - 1 game 17-Jul
- Todd Stephan (pitcher, b. 1966, Wisconsin)
- 1991: Hagerstown Suns, Eastern League (AA) - 1 game 12-Aug
- 1992: Rochester Red Wings, International League (AAA) - 1 game 8-Aug
- Trevor Stephan (pitcher, b. 1995, Texas)
- 2017: Staten Island Yankees, New York-Penn League (short-season) - 1 game 9-Sep
- 2019: Tampa Tarpons, Florida State League (High-A) - 1 game 2-Aug
- Josh Stephen (outfielder, b. 1997, California)
- Amad Stephens (pitcher, b. 1979, California)
- 2003: Evansville Otters, Frontier League (independent) - 1 game 26-Jul
- Austin Stephens (pitcher, b. 1993, Michigan)
- 2021: Bakersfield Train Robbers, Pecos League (independent) - 1 game 17-Jul
- Bernard Stephens (outfielder, b. 1979, Georgia)
- 2002: Spokane Indians, Northwest League (short-season) - 1 game 11-Aug
- Brett Stephens (pitcher, b. 1980, Oklahoma)
- 2004: Windy City Thunderbolts, Frontier League (independent) - 2 games 10-Jul 25-Jul
- Jackson Stephens (pitcher, b. 1994, Alabama)
- 2022: Atlanta Braves, Major League Baseball - 1 game 25-Sep
- 2023: FCL Braves, Florida Complex League (rookie) - 1 game 8-Jul
- Jason Stephens (pitcher, b. 1975, Louisiana)
- 1996: Cedar Rapids Kernels, Midwest League (Low-A) - 1 game 13-Aug
- Jason Stephens (pitcher, b. 1984, Ohio)
- 2005: Staten Island Yankees, New York-Penn League (short-season) - 1 game 1-Aug
- John Stephens (pitcher, b. 1979, Australia)
- 2006: Reading Phillies, Eastern League (AA) - 1 game 3-Jul
- Landon Stephens (first base/outfield, b. 1998, Ohio)
- 2022: Rome Braves, South Atlantic League (High-A) - 1 game 4-Jul
- Trey Stephens (pitcher, b. 1980)
- 2004: Pensacola Pelicans, Central League (independent) - 1 game 3-Jul
- Neal Stephenson (outfielder, b. 1980, Texas)
- 2002: Aberdeen IronBirds, New York-Penn League (short-season) - 2 games 25-Jul 2-Sep
- Robert Stephenson (pitcher, b. 1993, California)
- Seth Stephenson (outfielder, b. 2001, Texas)
- Tyler Stephenson (catcher, b. 1996, Georgia)
- 2019: Chattanooga Lookouts, Southern League (AA) - 1 game 15-Aug
- 2019: Glendale Desert Dogs, Arizona Fall League - 2 games 15-Oct 19-Oct
- 2021: Cincinnati Reds, Major League Baseball - 2 games 18-Sep 1-Oct
- 2023: Cincinnati Reds, Major League Baseball - 1 game 24-Sep
- 2024: Cincinnati Reds, Major League Baseball - 5 games 26-Jul 27-Jul 28-Jul 25-Sep 28-Sep
- Nick Steppe (outfielder, b. 1979, Florida)
- 2006: Newark Bears, Atlantic League (independent) - 2 games 1-Aug 16-Aug
- Jordan Steranka (first baseman, b. 1989, Pennsylvania)
- 2013: West Virginia Power, South Atlantic League (Low-A) - 1 game 8-Aug
- Chad Sterbens (utility, b. 1980)
- 2004: Mid-Missouri Mavericks, Frontier League (independent) - 1 game 10-Jul
- Adam Stern (outfielder, b. 1980, Ontario)
- 2001: Jamestown Jammers, New York-Penn League (short-season) - 1 game 5-Sep
- 2009: Nashville Sounds, Pacific Coast League (AAA) - 1 game 24-Aug
- Justin Sterner (pitcher, b. 1996, California)
- 2024: Tampa Bay Rays, Major League Baseball - 1 game 4-Jun
- Zack Sterner (pitcher, b. 1985, Pennsylvania)
- 2008: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 18-Aug
- Scott Stetson (utility, b. 1993, California)
- 2018: Salina Stockade, Can-Am League (independent) - 1 game 28-Jun
- Mitchel Stetter (pitcher, b. 1981, Indiana)
- 2004: High Desert Mavericks, California League (High-A) - 1 game 11-Aug
- Bobby Stevens (infielder, b. 1987, Illinois)
- 2009: Frederick Keys, Carolina League (High-A) - 1 game 7-Sep
- 2010: Frederick Keys, Carolina League (High-A) - 1 game 7-Aug
- 2013: Somerset Patriots, Atlantic League (independent) - 3 games 20-Sep 28-Sep 29-Sep
- Chad Stevens (infielder, b. 1999, California)
- 2021: Fayetteville Woodpeckers, Low-A East - 1 game 10-Sep
- 2022: Asheville Tourists, South Atlantic League (High-A) - 1 game 17-Jul
- Dave Stevens (pitcher, b. 1970, California)
- 1994: Salt Lake Buzz, Pacific Coast League (AAA) - 2 games 9-Sep 11-Sep
- 1995: Minnesota Twins, American League (MLB) - 1 game 7-Aug
- Eliezel Stevens (infielder, b. 2000, Dominican Republic)
- Greg Stevens (catcher/infielder, b. 1981, North Carolina)
- 2004: Gateway Grizzlies, Frontier League (independent) - 1 game 25-Jul
- 2007: Quebec Les Capitales, Can-Am League (independent) - 1 game 31-Jul
- 2008: Quebec Les Capitales, Can-Am League (independent) - 2 games 20-Aug 11-Sep
- Jake Stevens (pitcher, b. 1985, Florida)
- 2003: GCL Braves, Gulf Coast League (rookie) - 1 game 26-Aug
- Josh Stevens (pitcher, b. 1979, California)
- 2006: Nashua Pride, Can-Am League (independent) - 1 game 9-Jul
- 2007: Lancaster Barnstormers, Atlantic League (independent) - 1 game 26-Aug
- Kevin Stevens (pitcher, b. 1998, Arizona)
- 2023: Mesa Solar Sox, Arizona Fall League - 2 games 11-Oct 14-Oct
- Lance Stevens (pitcher, b. 1982, California)
- 2007: Nashua Pride, Can-Am League (independent) - 1 game 7-Sep
- Lee Stevens (first base/outfield, b. 1967, Missouri)
- 1999: Texas Rangers, American League (MLB) - 1 game 29-Aug
- 2001: Montreal Expos, Major League Baseball - 1 game 5-Oct
- Matt Stevens (pitcher, b. 1967)
- 1994: Salt Lake Buzz, Pacific Coast League (AAA) - 1 game 1-Sep
- Scott Stevens (pitcher, b. 1969, New Jersey)
- 1990: South Bend White Sox, Midwest League (Low-A) - 1 game 14-Aug
- Ted Stevens (infielder, b. 1972)
- 1994: San Bernardino Spirit, California League (High-A) - 1 game 4-Sep
- Tony Stevens (infielder, b. 1978, Florida)
- Tristan Stevens (pitcher, b. 1997, Missouri)
- 2024: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 15-May
- Tyler Stevens (pitcher, b. 1996, Colorado)
- 2018: Salt Lake Bees, Pacific Coast League (AAA) - 2 games 9-Aug 21-Aug
- Andrew Stevenson (outfielder, b. 1994, Louisiana)
- 2016: Potomac Nationals, Carolina League (High-A) - 1 game 28-May
- 2016: Harrisburg Senators, Eastern League (AA) - 2 games 21-Aug 5-Sep
- 2016: Glendale Desert Dogs, Arizona Fall League - 1 game 14-Oct
- 2018: Syracuse Chiefs, International League (AAA) - 1 game 31-Jul
- 2021: Washington Nationals, Major League Baseball - 2 games 28-Apr 6-Sep
- 2022: Rochester Red Wings, International League (AAA) - 1 game 27-Sep
- 2023: St. Paul Saints, International League (AAA) - 1 game 29-Jun
- Cal Stevenson (outfielder, b. 1996, California)
- Casey Stevenson (infielder, b. 1988, California)
- 2011: Staten Island Yankees, New York-Penn League (short-season) - 2 games 31-Aug 9-Sep
- 2013: Trenton Thunder, Eastern League (AA) - 1 game 4-Aug
- 2014: Trenton Thunder, Eastern League (AA) - 1 game 27-Jul
- 2015: Southern Maryland Blue Crabs, Atlantic League (independent) - 1 game 24-May
- Chad Stevenson (catcher/outfield, b. 1976, California)
- Jake Stevenson (pitcher, b. 1997, Minnesota)
- 2019: Billings Mustangs, Pioneer League (rookie) - 1 game 4-Jul
- Jason Stevenson (pitcher, b. 1974, Georgia)
- 1997: Knoxville Smokies, Southern League (AA) - 1 game 10-Aug
- 2001: Mobile BayBears, Southern League (AA) - 1 game 4-Aug
- Jason Stevenson (pitcher, b. 1981, California)
- 2001: Vermont Expos, New York-Penn League (short-season) - 1 game 9-Jul
- 2003: Brevard County Manatees, Florida State League (High-A) - 1 game 24-Aug g1
- Ryan Stevenson (outfielder, b. 1983)
- 2008: St. George Roadrunners, Golden League (independent) - 1 game 30-Jul
- Trent Stevenson (pitcher, b. 1990, Arizona)
- 2011: State College Spikes, New York-Penn League (short-season) - 1 game 18-Aug
- Todd Steverson (outfielder, b. 1971, California)
- 1993: Dunedin Blue Jays, Florida State League (High-A) - 1 game 12-Aug
- 1995: Detroit Tigers, American League (MLB) - 2 games 24-Sep 1-Oct
- 1998: Memphis Redbirds, Pacific Coast League (AAA) - 1 game 26-Aug
- Casey Steward (pitcher, b. 2001, Kansas)
- Jaime Steward (pitcher, b. 1979, New Jersey)
- 2004: Camden Riversharks, Atlantic League (independent) - 2 games 19-Jun g2 18-Jul
- 2005: Camden Riversharks, Atlantic League (independent) - 2 games 24-Jun 18-Sep
- Andy Stewart (catcher/first base, b. 1970, Ontario)
- 1999: Reading Phillies, Eastern League (AA) - 1 game 6-Sep
- C.J. Stewart (outfielder, b. 1976, Georgia)
- 1997: Williamsport Cubs, New York-Penn League (short-season) - 1 game 19-Jul
- Caleb Stewart (outfielder, b. 1982, Kentucky)
- 2004: Brooklyn Cyclones, New York-Penn League (short-season) - 2 games 23-Aug 26-Aug
- 2005: Brooklyn Cyclones, New York-Penn League (short-season) - 5 games 27-Jun 29-Jun 4-Aug 26-Aug g1 26-Aug g2
- 2009: Binghamton Mets, Eastern League (AA) - 1 game 8-Apr
- 2010: Sussex Skyhawks, Can-Am League (independent) - 2 games 16-Aug 20-Aug
- 2011: Newark Bears, Can-Am League (independent) - 2 games 25-Aug 30-Aug
- Chad Stewart (outfielder, b. 1980, California)
- 2005: Grays, Can-Am League (independent) - 1 game 5-Aug
- Charlie Stewart (outfielder, b. 1990)
- 2012: Newark Bears, Can-Am League (independent) - 2 games 30-Aug 31-Aug
- Chris Stewart (catcher, b. 1982, California)
- 2002: Bristol Sox, Appalachian League (rookie) - 1 game 14-Jul
- 2008: Scranton/Wilkes-Barre Yankees, International League (AAA) - 1 game 7-Sep
- 2009: Scranton/Wilkes-Barre Yankees, International League (AAA) - 3 games 27-Jul 12-Sep 17-Sep
- 2012: New York Yankees, Major League Baseball - 2 games 22-Sep 1-Oct
- 2013: New York Yankees, Major League Baseball - 2 games 12-Aug 25-Sep
- Christin Stewart (outfielder, b. 1993, Georgia)
- 2015: West Michigan Whitecaps, Midwest League (Low-A) - 1 game 26-Aug
- 2016: Salt River Rafters, Arizona Fall League - 3 games 11-Oct 13-Oct 14-Oct
- 2018: Detroit Tigers, Major League Baseball - 1 game 19-Sep
- 2019: Lakeland Flying Tigers, Florida State League (High-A) - 1 game 8-May
- 2019: Detroit Tigers, Major League Baseball - 1 game 19-Sep
- DJ Stewart (outfielder, b. 1993, Florida)
- 2016: Peoria Javelinas, Arizona Fall League - 2 games 11-Oct 14-Oct
- 2018: Baltimore Orioles, Major League Baseball - 2 games 29-Sep g1 29-Sep g2
- 2019: Baltimore Orioles, Major League Baseball - 2 games 3-Sep g1 3-Sep g2
- 2021: Baltimore Orioles, Major League Baseball - 1 game 16-Aug
- 2022: Baltimore Orioles, Major League Baseball - 1 game 9-Apr
- 2022: FCL Orioles, Florida Complex League (rookie) - 1 game 1-Aug
- 2023: New York Mets, Major League Baseball - 1 game 28-Sep
- 2024: New York Mets, Major League Baseball - 3 games 3-May 4-May 5-May
- 2024: Syracuse Mets, International League (AAA) - 1 game 20-Sep
- D.J. Stewart (infielder, b. 1999, Missouri)
- Dave Stewart (pitcher, b. 1957, California)
- 1993: Toronto Blue Jays, American League (MLB) - 1 game 21-Aug
- Ethan Stewart (pitcher, b. 1991, British Columbia)
- 2014: Scottsdale Scorpions, Arizona Fall League - 1 game 8-Oct
- Ian Stewart (infielder, b. 1985, California)
- 2009: Colorado Rockies, Major League Baseball - 2 games 21-Aug 28-Aug
- 2013: Albuquerque Isotopes, Pacific Coast League (AAA) - 1 game 23-Jul
- Jake Stewart (outfielder, b. 1990, Colorado)
- 2012: Connecticut Tigers, New York-Penn League (short-season) - 2 games 2-Aug 25-Aug
- James Stewart (pitcher, b. 1982, Arizona)
- 2002: Great Falls Dodgers, Pioneer League (rookie) - 1 game 14-Aug
- Paxton Stewart (first base/outfield, b. 1974, New York)
- 1996: St. Catharines Stompers, New York-Penn League (short-season) - 1 game 15-Aug
- Quinn Stewart (outfielder, b. 1983, California)
- 2006: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 13-Aug
- 2009: New Jersey Jackals, Can-Am League (independent) - 4 games 7-Aug 10-Aug 13-Aug 3-Sep
- Sal Stewart (infielder, b. 2003, Florida)
- Scott Stewart (pitcher, b. 1975, Massachusetts)
- 2001: Montreal Expos, Major League Baseball - 1 game 5-Oct
- 2003: Montreal Expos, Major League Baseball - 1 game 6-Sep
- Shannon Stewart (outfielder, b. 1974, Ohio)
- 1997: Syracuse SkyChiefs, International League (AAA) - 1 game 2-Aug
- 1997: Toronto Blue Jays, American League (MLB) - 2 games 19-Sep 21-Sep
- 1999: Toronto Blue Jays, American League (MLB) - 1 game 29-Aug
- 2000: Toronto Blue Jays, Major League Baseball - 2 games 25-Aug 13-Sep
- 2001: Toronto Blue Jays, Major League Baseball - 1 game 28-Aug
- 2004: Minnesota Twins, Major League Baseball - 1 game 6-Oct
- Will Stewart (pitcher, b. 1997, Alabama)
- 2017: Williamsport Crosscutters, New York-Penn League (short-season) - 1 game 12-Aug g1
- 2018: Lakewood BlueClaws, South Atlantic League (Low-A) - 1 game 30-May
- Zach Stewart (pitcher, b. 1986, Texas)
- 2010: New Hampshire Fisher Cats, Eastern League (AA) - 1 game 9-Sep
- Sean Stidfole (pitcher, b. 1984, Pennsylvania)
- 2005: Auburn Doubledays, New York-Penn League (short-season) - 1 game 1-Aug
- 2010: York Revolution, Atlantic League (independent) - 1 game 2-Oct
- 2011: York Revolution, Atlantic League (independent) - 1 game 9-Sep
- Dave Stieb (pitcher, b. 1957, California)
- 1998: Toronto Blue Jays, American League (MLB) - 1 game 26-Jul
- Robert Stiehl (pitcher, b. 1980, Louisiana)
- 2006: Salem Avalanche, Carolina League (High-A) - 1 game 14-Apr
- Danny Stienstra (infielder, b. 1989, California)
- 2012: Batavia Muckdogs, New York-Penn League (short-season) - 1 game 4-Aug
- Jon Still (catcher/first base, b. 1984, Mississippi)
- 2006: Lowell Spinners, New York-Penn League (short-season) - 1 game 13-Aug
- Stephen Still (pitcher, b. 2002, Louisiana)
- 2024: Grand Junction Jackalopes, Pioneer League (independent) - 1 game 16-Jul
- Erik Stiller (pitcher, b. 1984, Texas)
- 2006: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 26-Jul
- Will Stillman (pitcher, b. 1993, North Carolina)
- 2017: Tri-City Dust Devils, Northwest League (short-season) - 1 game 5-Aug
- John Stilson (pitcher, b. 1990, Texas)
- 2016: Mesa Solar Sox, Arizona Fall League - 1 game 11-Oct
- Cameron Stimpson (outfielder, b. 1992, Pennsylvania)
- 2021: Wasco Reserve, Pecos League (independent) - 1 game 17-Jul
- Justin Stine (pitcher, b. 1977, Indiana)
- 2001: Elmira Pioneers, Northeast League (independent) - 1 game 21-Sep
- Jesse Stinnett (pitcher, b. 1995, Virginia)
- 2019: Boise Hawks, Northwest League (short-season) - 1 game 5-Jul
- Kelly Stinnett (catcher, b. 1970, Oklahoma)
- 1994: New York Mets, National League (MLB) - 1 game 15-Apr
- 1995: New York Mets, National League (MLB) - 2 games 24-Aug 10-Sep
- 1996: Milwaukee Brewers, American League (MLB) - 1 game 25-Sep g1
- 1998: Arizona Diamondbacks, National League (MLB) - 1 game 6-Sep
- 2001: Cincinnati Reds, Major League Baseball - 2 games 14-Apr 19-Aug
- 2003: Cincinnati Reds, Major League Baseball - 2 games 3-Jul 4-Jul
- 2003: Philadelphia Phillies, Major League Baseball - 1 game 28-Sep
- 2006: New York Mets, Major League Baseball - 1 game 22-Sep
- Josh Stinson (pitcher, b. 1988, Louisiana)
- 2011: Binghamton Mets, Eastern League (AA) - 2 games 20-Aug 27-Aug
- 2011: New York Mets, Major League Baseball - 2 games 11-Sep 26-Sep
- Cole Stobbe (infielder, b. 1997, Nebraska)
- 2017: Williamsport Crosscutters, New York-Penn League (short-season) - 2 games 9-Aug 12-Aug g2
- Richard Stock (catcher, b. 1991, Washington)
- Robert Stock (catcher, then pitcher, b. 1989, Washington)
- 2015: Altoona Curve, Eastern League (AA) - 1 game 22-Aug
- 2016: New Jersey Jackals, Can-Am League (independent) - 3 games 17-Aug g1 19-Aug 9-Sep
- Kevin Stocker (infielder, b. 1970, Washington)
- 1993: Philadelphia Phillies, National League (MLB) - 4 games 12-Sep 13-Sep 18-Sep 19-Sep
- 1994: Philadelphia Phillies, National League (MLB) - 2 games 22-Jul g1 22-Jul g2
- 1995: Philadelphia Phillies, National League (MLB) - 1 game 23-Sep
- 1996: Philadelphia Phillies, National League (MLB) - 2 games 28-Sep 29-Sep
- 1997: Philadelphia Phillies, National League (MLB) - 1 game 15-Sep g1
- Mel Stocker (outfielder, b. 1980, Arizona)
- 2002: Spokane Indians, Northwest League (short-season) - 2 games 11-Aug 12-Aug
- Jason Stockstill (pitcher, b. 1976, California)
- 1998: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 29-Aug
- 2005: Atlantic City Surf, Atlantic League (independent) - 1 game
- Brian Stoecklein (infielder, b. 1980, Pennsylvania)
- Logan Stoelke (pitcher, b. 1995, Texas)
- 2019: Bradenton Marauders, Florida State League (High-A) - 1 game 11-May g2
- Luke Stofel (pitcher, b. 2001, Tennessee)
- 2023: FCL Tigers, Florida Complex League (rookie) - 1 game 19-Aug
- 2024: Lakeland Flying Tigers, Florida State League (Low-A) - 1 game 29-May
- Brian Stokes (pitcher, b. 1979, California)
- James Stokes (pitcher, b. 1990, Pennsylvania)
- 2012: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 5-Aug
- Jason Stokes (first baseman, b. 1982, Texas)
- 2001: Utica Blue Sox, New York-Penn League (short-season) - 1 game 21-Jul
- 2003: Jupiter Hammerheads, Florida State League (High-A) - 2 games 26-Aug 29-Aug
- Madison Stokes (infielder, b. 1996, South Carolina)
- Ray Stokes (utility, b. 1985, California)
- 2011: Rockland Boulders, Can-Am League (independent) - 2 games 4-Jul 24-Aug
- Billy Stokley (pitcher, b. 1977, Texas)
- 2005: Fort Worth Cats, Central League (independent) - 1 game 3-Sep
- Jason Stolz (infielder, b. 1990, Georgia)
- 2013: Asheville Tourists, South Atlantic League (Low-A) - 1 game 26-May
- Adam Stone (pitcher, b. 2001, Connecticut)
- Ashton Stone (pitcher, b. 1980, Mississippi)
- 2003: Bangor Lumberjacks, Northern League (independent) - 1 game
- Bobby Stone (first base/outfield, b. 1989, Texas)
- 2009: Missoula Osprey, Pioneer League (rookie) - 1 game 18-Aug
- Brandon Stone (pitcher, b. 1988)
- 2010: St. Paul Saints, American Association (independent) - 1 game 21-Aug
- Casey Stone (outfielder, b. 1978, South Carolina)
- 2002: Washington Wild Things, Frontier League (independent) - 1 game 28-Jul
- Greg Stone (utility, b. 1981, Oklahoma)
- 2002: Lowell Spinners, New York-Penn League (short-season) - 2 games 4-Jul 6-Jul
- 2003: Sarasota Red Sox, Florida State League (High-A) - 2 games 22-Aug 30-Aug
- 2008: River City Rascals, Frontier League (independent) - 1 game 16-Aug
- Jake Stone (first baseman, b. 1990, Virginia)
- 2014: State College Spikes, New York-Penn League (short-season) - 2 games 2-Aug 15-Aug
- Jake Stone (outfielder, b. 1995, California)
- 2018: Bowling Green Hot Rods, Midwest League (Low-A) - 1 game 27-Aug
- Jeff Stone (outfielder, b. 1960, Missouri)
- 1984: Philadelphia Phillies, National League (MLB) - 1 game 26-Sep
- Jon Stone (catcher, b. 1978, California)
- 2003: Florence Freedom, Frontier League (independent) - 1 game 4-Jul
- Ron Stone (outfielder, b. 1942, California)
- 1971: Philadelphia Phillies, National League (MLB) - 1 game 12-Sep
- Davis Stoneburner (infielder, b. 1985, Virginia)
- 2012: Akron Aeros, Eastern League (AA) - 1 game 15-Sep
- Graham Stoneburner (pitcher, b. 1987, Virginia)
- 2011: Trenton Thunder, Eastern League (AA) - 1 game 3-Aug
- Sequoyah Stonecipher (outfielder, b. 1989, California)
- 2009: Jamestown Jammers, New York-Penn League (short-season) - 1 game 20-Jul
- Mike Stoner (first base/outfield, b. 1973, Kentucky)
- 2004: Gary Southshore RailCats, Northern League (independent) - 1 game 11-Jul
- Nat Stoner (pitcher, b. 1977, South Carolina)
- 2001: Fargo-Moorhead RedHawks, Northern League (independent) - 1 game 29-Jul
- Tobi Stoner (pitcher, b. 1984, Germany)
- 2009: New York Mets, Major League Baseball - 1 game 21-Sep
- 2011: Binghamton Mets, Eastern League (AA) - 1 game 27-Aug
- Jim Stoops (pitcher, b. 1972, New Jersey)
- 1999: Colorado Springs Sky Sox, Pacific Coast League (AAA) - 1 game 21-Aug
- Drew Storen (pitcher, b. 1987, Indiana)
- 2010: Washington Nationals, Major League Baseball - 1 game 3-Oct
- 2012: Washington Nationals, Major League Baseball - 1 game 11-Sep
- 2014: Washington Nationals, Major League Baseball - 1 game 31-Mar
- 2015: Washington Nationals, Major League Baseball - 1 game 23-Aug
- Eric Storey (infielder, b. 1977, Indiana)
- 2005: North Shore Spirit, Can-Am League (independent) - 1 game 23-Jul
- Mickey Storey (pitcher, b. 1986, Florida)
- 2015: Somerset Patriots, Atlantic League (independent) - 1 game 13-Aug
- 2016: Somerset Patriots, Atlantic League (independent) - 2 games 31-Jul g2 6-Sep
- Justin Storm (pitcher, b. 2001, Mississippi)
- 2024: Jupiter Hammerheads, Florida State League (Low-A) - 1 game 27-May
- 2024: Peoria Javelinas, Arizona Fall League - 1 game 10-Oct
- Trevor Story (infielder, b. 1992, Texas)
- 2014: Salt River Rafters, Arizona Fall League - 2 games 8-Oct 10-Oct
- 2018: Colorado Rockies, Major League Baseball - 3 games 6-May 14-Jun 23-Aug
- 2019: Colorado Rockies, Major League Baseball - 1 game 3-Apr
- 2021: Colorado Rockies, Major League Baseball - 1 game 9-Sep
- 2022: Boston Red Sox, Major League Baseball - 1 game 5-Sep
- 2023: Boston Red Sox, Major League Baseball - 1 game 4-Sep
- Thomari Story-Harden (first baseman, b. 1980, California)
- 2002: South Georgia Waves, South Atlantic League (Low-A) - 1 game 24-Aug
- 2004: Mid-Missouri Mavericks, Frontier League (independent) - 1 game 10-Jul
- Bryson Stott (infielder, b. 1997, Nevada)
- 2021: Peoria Javelinas, Arizona Fall League - 3 games 16-Oct 19-Oct 20-Oct
- 2022: Philadelphia Phillies, Major League Baseball - 2 games 16-Apr 25-Sep
- 2023: Philadelphia Phillies, Major League Baseball - 1 game 27-Sep
- 2024: Philadelphia Phillies, Major League Baseball - 2 games 19-Sep 23-Sep
- J.T. Stotts (infielder, b. 1980, California)
- 2005: Trenton Thunder, Eastern League (AA) - 2 games 14-Jun 10-Sep
- 2006: Trenton Thunder, Eastern League (AA) - 2 games 13-Apr 7-Sep
- Levi Stoudt (pitcher, b. 1997, Pennsylvania)
- 2023: Louisville Bats, International League (AAA) - 1 game 1-Jul
- Blake Stouffer (infielder, b. 1985, Texas)
- 2008: Vermont Lake Monsters, New York-Penn League (short-season) - 1 game 6-Aug
- Eric Stout (pitcher, b. 1993, Illinois)
- 2016: Surprise Saguaros, Arizona Fall League - 1 game 12-Oct
- 2018: Omaha Storm Chasers, Pacific Coast League (AAA) - 1 game 7-Aug
- 2022: Indianpolis Indians, International League (AAA) - 1 game 26-Jun
- Darond Stovall (outfielder, b. 1973, Missouri)
- 1996: Harrisburg Senators, Eastern League (AA) - 2 games 9-Aug 27-Aug
- 1997: Ottawa Lynx, International League (AAA) - 1 game 2-Aug
- 1998: Montreal Expos, National League (MLB) - 2 games 9-Jul 18-Jul
- 2001: Somerset Patriots, Atlantic League (independent) - 6 games 1-Jul 3-Sep 7-Sep 19-Sep 2-Oct 3-Oct
- 2002: Berkshire Black Bears, Northeast League (independent) - 1 game 28-Aug
- Hunter Stovall (utility, b. 1996, Alabama)
- 2021: Spokane Indians, High-A West - 1 game 13-Jul
- Peyton Stovall (infielder, b. 2003, Louisiana)
- Ryan Stovall (utility, b. 1986, Florida)
- Chris Stowers (outfielder, b. 1974, Missouri)
- 1996: Vermont Expos, New York-Penn League (short-season) - 1 game 7-Jul
- 1998: Harrisburg Senators, Eastern League (AA) - 1 game 17-Sep
- Josh Stowers (outfielder, b. 1997, Illinois)
- 2019: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 11-Aug
- Kyle Stowers (outfielder, b. 1998, California)
- 2023: Norfolk Tides, International League (AAA) - 1 game 15-Jul
- 2024: Norfolk Tides, International League (AAA) - 1 game 21-Apr
- 2024: Baltimore Orioles, Major League Baseball - 1 game 8-Jun
- Wyatt Strahan (pitcher, b. 1993, California)
- 2018: Scottsdale Scorpions, Arizona Fall League - 2 games 7-Nov 13-Nov
- Matt Strahm (pitcher, b. 1991, North Dakota)
- 2018: San Diego Padres, Major League Baseball - 2 games 4-Aug 19-Aug
- 2024: Philadelphia Phillies, Major League Baseball - 1 game 23-Sep
- Dan Straily (pitcher, b. 1988, California)
- 2016: Cincinnati Reds, Major League Baseball - 1 game 7-Aug
- Connor Strain (pitcher, b. 1994, Indiana)
- 2018: Rancho Cucamonga Quakes, California League (High-A) - 1 game 17-Aug
- Ryan Strain (infielder, b. 1980, Colorado)
- 2004: Salem-Keizer Volcanoes, Northwest League (short-season) - 1 game 16-Aug
- Cody Strait (outfielder, b. 1983, Texas)
- 2010: Lake County Fielders, Northern League (independent) - 1 game 23-Aug
- Don Strange (pitcher, b. 1967, Massachusetts)
- 1991: Durham Bulls, Carolina League (High-A) - 1 game 15-Aug
- Doug Strange (infielder, b. 1964, South Carolina)
- 1997: Montreal Expos, National League (MLB) - 1 game 14-Sep
- Dallas Strankman (pitcher, b. 1978)
- 2007: El Paso Diablos, American Association (independent) - 1 game 12-Aug
- Stephen Strasburg (pitcher, b. 1988, California)
- 2014: Washington Nationals, Major League Baseball - 1 game 31-Mar
- 2016: Washington Nationals, Major League Baseball - 1 game 29-May
- 2019: Washington Nationals, Major League Baseball - 1 game 26-Sep
- Chris Stratton (pitcher, b. 1990, Mississippi)
- 2016: Scottsdale Scorpions, Arizona Fall League - 1 game 14-Oct
- 2021: Pittsburgh Pirates, Major League Baseball - 1 game 1-Oct
- Hunter Stratton (pitcher, b. 1996, Tennessee)
- 2019: Bradenton Marauders, Florida State League (High-A) - 1 game 16-Apr
- 2023: Indianapolis Indians, International League (AAA) - 1 game 1-Jul
- 2023: Pittsburgh Pirates, Major League Baseball - 2 games 27-Sep 29-Sep
- Rob Stratton (outfielder, b. 1977, California)
- 1998: Pittsfield Mets, New York-Penn League (short-season) - 1 game 30-Jul
- 2001: Binghamton Mets, Eastern League (AA) - 1 game 22-Jul
- Tyler Straub (infielder, b. 1993, New Mexico)
- 2018: Windy City ThunderBolts, Frontier League (independent) - 1 game 4-Aug
- Steven Strausbaugh (catcher, b. 1985, North Carolina)
- 2008: Staten Island Yankees, New York-Penn League (short-season) - 1 game 5-Sep
- Brad Strauss (utility, b. 1971, New Jersey)
- 2001: Camden Riversharks, Atlantic League (independent) - 2 games 13-May 7-Sep
- 2002: Camden Riversharks, Atlantic League (independent) - 2 games 6-Sep 11-Sep
- 2003: Camden Riversharks, Atlantic League (independent) - 3 games 25-Jul 20-Aug 17-Sep
- 2004: Camden Riversharks, Atlantic League (independent) - 6 games 19-Jun g2 17-Jul 18-Jul 24-Aug 29-Aug 26-Sep
- 2005: Camden Riversharks, Atlantic League (independent) - 3 games 24-Jun 24-Aug 18-Sep
- 2006: Camden Riversharks, Atlantic League (independent) - 1 game 16-Sep
- 2007: Camden Riversharks, Atlantic League (independent) - 2 games 3-Jul 31-Aug
- Myles Straw (outfielder, b. 1994, California)
- 2017: Buies Creek Astros, Carolina League (High-A) - 2 games 11-Jun 3-Jul
- 2018: Fresno Grizzlies, Pacific Coast League (AAA) - 1 game 13-Aug
- 2018: Houston Astros, Major League Baseball - 1 game 29-Sep g2
- 2019: Houston Astros, Major League Baseball - 1 game 19-Jul
- 2021: Houston Astros, Major League Baseball - 1 game 2-May
- 2022: Cleveland Guardians, Major League Baseball - 1 game 30-Jul
- 2023: Cleveland Guardians, Major League Baseball - 1 game 30-Sep
- Darryl Strawberry (outfielder, b. 1962, California)
- Josh Strawn (pitcher, b. 1988, Florida)
- 2013: Long Island Ducks, Atlantic League (independent) - 1 game 28-Sep
- Cody Strayer (pitcher, b. 1993, Ohio)
- 2018: Salina Stockade, Can-Am League (independent) - 1 game 28-Jun
- Michael Streaman (pitcher, b. 1986)
- 2011: New York Federals, Can-Am League (independent) - 1 game 28-Jul
- Chad Strickland (catcher, b. 1972)
- 1992: Appleton Foxes, Midwest League (Low-A) - 1 game 13-Aug
- Geoff Strickland (infielder, b. 1984, Florida)
- 2006: Tri-City Dust Devils, Northwest League (short-season) - 1 game 23-Aug
- 2007: Asheville Tourists, South Atlantic League (Low-A) - 1 game 1-Sep
- Hunter Strickland (pitcher, b. 1988, Georgia)
- 2018: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 15-Aug
- 2021: Tampa Bay Rays, Major League Baseball - 2 games 14-Apr 25-Apr
- 2024: Los Angeles Angels, Major League Baseball - 2 games 16-Apr 17-Apr
- Samuel Strickland (pitcher, b. 1999, Alabama)
- 2021: FCL Braves, Florida Complex League (rookie) - 1 game 26-Aug g2
- Scott Strickland (pitcher, b. 1976, Texas)
- 1999: Montreal Expos, National League (MLB) - 1 game 3-Oct
- 2000: Montreal Expos, Major League Baseball - 1 game 11-Sep g2
- 2001: Montreal Expos, Major League Baseball - 1 game 5-Oct
- 2002: New York Mets, Major League Baseball - 2 games 21-Jun 3-Sep g1
- 2008: Scranton/Wilkes-Barre Yankees, International League (AAA) - 1 game 7-Sep
- Spencer Strider (pitcher, b. 1998, Ohio)
- 2022: Atlanta Braves, Major League Baseball - 1 game 15-Aug
- Ryan Strieby (first base/outfield, b. 1985, Washington)
- 2013: Long Island Ducks, Atlantic League (independent) - 2 games 28-Sep 29-Sep
- 2014: Camden Riversharks, Atlantic League (independent) - 2 games 2-Aug day 7-Aug
- 2015: Camden Riversharks, Atlantic League (independent) - 1 game 13-Aug
- Christian Stringer (infielder, b. 1990, Texas)
- 2014: Kannapolis Intimidators, South Atlantic League (Low-A) - 1 game 9-Aug
- Ross Stripling (pitcher, b. 1989, Pennsylvania)
- 2016: Los Angeles Dodgers, Major League Baseball - 1 game 13-Sep
- 2021: Toronto Blue Jays, Major League Baseball - 2 games 24-May 22-Sep
- 2023: San Francisco Giants, Major League Baseball - 1 game 11-Aug
- Mark Strittmatter (catcher, b. 1969, New York)
- 1994: New Haven Ravens, Eastern League (AA) - 1 game 10-Jul
- 1995: New Haven Ravens, Eastern League (AA) - 4 games 4-Jul 27-Aug 9-Sep 12-Sep
- 1998: Colorado Springs Sky Sox, Pacific Coast League (AAA) - 1 game 21-Aug g1
- Ian Strom (outfielder, b. 1994, Massachusetts)
- 2017: Columbia Fireflies, South Atlantic League (Low-A) - 1 game 23-Aug
- Marcus Stroman (pitcher, b. 1991, New York)
- 2015: Toronto Blue Jays, Major League Baseball - 1 game 12-Sep g2
- Skyler Stromsmoe (utility, b. 1984, Alberta)
- 2011: Richmond Flying Squirrels, Eastern League (AA) - 1 game 4-Aug
- Alan Strong (pitcher, b. 1996, California)
- 2018: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 6-Sep
- 2019: Bowling Green Hot Rods, Midwest League (Low-A) - 1 game 30-May
- Jackson Strong (outfielder, b. 2003, New York)
- Mike Strong (pitcher, b. 1988, Minnesota)
- 2015: Biloxi Shuckers, Southern League (AA) - 1 game 29-Jul
- Seth Strong (infielder, b. 1996, Ohio)
- 2021: Bakersfield Train Robbers, Pecos League (independent) - 1 game 17-Jul
- Zach Strong (infielder, b. 1981, New Mexico)
- Pedro Strop (pitcher, b. 1985, Dominican Republic)
- 2014: Chicago Cubs, Major League Baseball - 1 game 20-Jul
- 2018: Chicago Cubs, Major League Baseball - 1 game 4-Aug
- Drew Strotman (pitcher, b. 1996, California)
- 2019: Salt River Rafters, Arizona Fall League - 1 game 16-Oct
- Kade Strowd (pitcher, b. 1997, Texas)
- 2022: Aberdeen IronBirds, South Atlantic League (High-A) - 1 game 8-May g2
- Nick Struck (pitcher, b. 1989, Oregon)
- 2015: Long Island Ducks, Atlantic League (independent) - 2 games 25-Sep 27-Sep
- Chase Strumpf (infielder, b. 1998, Georgia)
- 2022: Tennessee Smokies, Southern League (AA) - 3 games 12-Jun 15-Jul 6-Aug
- 2024: Iowa Cubs, International League (AAA) - 1 game 21-Sep
- Michael Stryffeler (pitcher, b. 1996, Ohio)
- 2021: Arkansas Travelers, Double-A Central - 2 games 22-Jul 15-Sep
- Peter Strzelecki (pitcher, b. 1994, New York)
- 2022: Milwaukee Brewers, Major League Baseball - 1 game 29-Sep
- Baron Stuart (pitcher, b. 1999, Florida)
- 2023: Tampa Tarpons, Florida State League (Low-A) - 2 games 18-Jun 20-Jul
- 2023: Mesa Solar Sox, Arizona Fall League - 1 game 14-Oct
- Champ Stuart (outfielder, b. 1992, Florida)
- 2016: Great Britain, World Baseball Classic - 3 games 23-Sep 24-Sep 25-Sep
- 2016: Scottsdale Scorpions, Arizona Fall League - 1 game 12-Oct
- 2017: Binghamton Rumble Ponies, Eastern League (AA) - 1 game 18-Aug g1
- 2018: Binghamton Rumble Ponies, Eastern League (AA) - 3 games 9-May 28-May 20-Jun
- Cory Stuart (pitcher, b. 1982, British Columbia)
- 2005: Staten Island Yankees, New York-Penn League (short-season) - 1 game 26-Aug g1
- Rich Stuart (outfielder, b. 1976, New York)
- 1999: Cedar Rapids Kernels, Midwest League (Low-A) - 1 game 4-Sep
- Shawn Stuart (pitcher, b. 1988, California)
- 2013: Tri-City Dust Devils, Northwest League (short-season) - 1 game 22-Aug
- Aaron Stubblefield (infielder, b. 1992, Missouri)
- 2019: Roswell Invaders, Pecos League (independent) - 2 games 9-Jul 13-Jul
- C.J. Stubbs (catcher/first base, b. 1996, California)
- 2022: Asheville Tourists, South Atlantic League (High-A) - 2 games 4-Jul 17-Jul
- 2024: Rochester Red Wings, International League (AAA) - 1 game 21-Sep
- Drew Stubbs (outfielder, b. 1984, Texas)
- 2011: Cincinnati Reds, Major League Baseball - 1 game 26-Sep
- 2014: Colorado Rockies, Major League Baseball - 1 game 9-Sep
- 2015: Colorado Rockies, Major League Baseball - 1 game 1-Aug
- Franklin Stubbs (first base/outfield, b. 1960, North Carolina)
- Garrett Stubbs (catcher, b. 1993, California)
- 2015: Quad Cities River Bandits, Midwest League (Low-A) - 1 game 5-Sep
- 2016: Glendale Desert Dogs, Arizona Fall League - 1 game 13-Oct
- 2019: Round Rock Express, Pacific Coast League (AAA) - 1 game 23-Jul
- 2021: Houston Astros, Major League Baseball - 1 game 14-Sep
- 2022: Philadelphia Phillies, Major League Baseball - 1 game 25-Sep
- 2023: Philadelphia Phillies, Major League Baseball - 1 game 27-Sep
- Eric Stuckenschneider (outfielder, b. 1971, Missouri)
- 1994: Yakima Bears, Northwest League (short-season) - 1 game 8-Sep
- Denver Stuckey (infielder, b. 1980, Missouri)
- 2003: Evansville Otters, Frontier League (independent) - 2 games 4-Jul 26-Jul
- Granger Studdard (outfielder, b. 1995, Texas)
- 2017: Greenville Drive, South Atlantic League (Low-A) - 1 game 23-Aug
- Ted Stuka (pitcher, b. 1997, California)
- Cody Stull (pitcher, b. 1992, Indiana)
- 2019: Midland RockHounds, Texas League (AA) - 1 game 22-Jul
- Everett Stull (pitcher, b. 1971, Kansas)
- 2007: Grays, Can-Am League (independent) - 1 game 17-Jun
- Eric Stults (pitcher, b. 1979, Indiana)
- 2009: Albuquerque Isotopes, Pacific Coast League (AAA) - 1 game 24-Aug
- 2012: San Diego Padres, Major League Baseball - 1 game 13-Aug
- Peyton Stumbo (pitcher, b. 2002, California)
- Brian Stumpf (pitcher, b. 1972, Illinois)
- 1999: Lehigh Valley Black Diamonds, Atlantic League (independent) - 1 game 31-May
- Daniel Stumpf (pitcher, b. 1991, Texas)
- 2016: Philadelphia Phillies, Major League Baseball - 1 game 8-Apr
- 2017: Detroit Tigers, Major League Baseball - 1 game 2-Sep
- Mitchell Stumpo (pitcher, b. 1996, North Carolina)
- 2021: Salt River Rafters, Arizona Fall League - 2 games 18-Oct 21-Oct
- Cole Stupp (pitcher, b. 2000, Georgia)
- 2024: FCL Tigers, Florida Complex League (rookie) - 1 game 1-Jul
- Tyler Sturdevant (pitcher, b. 1985, Colorado)
- 2009: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 14-Sep
- 2011: Kinston Indians, Carolina League (High-A) - 1 game 28-May
- 2016: Durham Bulls, International League (AAA) - 2 games 21-Aug 1-Sep
- 2016: Tampa Bay Rays, Major League Baseball - 1 game 25-Aug
- Tim Sturdy (pitcher, b. 1978, Arizona)
- 2002: New Britain Rock Cats, Eastern League (AA) - 1 game 30-Jun
- Cole Sturgeon (outfielder, b. 1991, Kentucky)
- Tanyon Sturtze (pitcher, b. 1970, Massachusetts)
- 2002: Tampa Bay Devil Rays, Major League Baseball - 1 game 25-Sep
- 2004: New York Yankees, Major League Baseball - 1 game 6-Oct
- Kyle Stutes (pitcher, b. 1982, Texas)
- 2007: San Antonio Missions, Texas League (AA) - 1 game 15-Aug
- Michael Stutes (pitcher, b. 1986, Louisiana)
- 2011: Philadelphia Phillies, Major League Baseball - 1 game 23-Jul
- Chris Stynes (infielder, b. 1973, New York)
- 1993: Dunedin Blue Jays, Florida State League (High-A) - 1 game 12-Aug
- 1997: Cincinnati Reds, National League (MLB) - 1 game 25-Aug day
- 1998: Cincinnati Reds, National League (MLB) - 1 game 19-Aug
- 2000: Cincinnati Reds, Major League Baseball - 1 game 12-Aug
- Albert Suarez (pitcher, b. 1989, Venezuela)
- 2017: San Francisco Giants, Major League Baseball - 1 game 2-Aug
- Alixon Suarez (catcher, b. 1994, Venezuela)
- 2014: Lowell Spinners, New York-Penn League (short-season) - 2 games 31-Jul 13-Aug g2
- Andrew Suarez (pitcher, b. 1992, Florida)
- 2023: Memphis Redbirds, International League (AAA - 1 game 6-Jun
- Eugenio Suarez (infielder, b. 1991, Venezuela)
- 2011: Connecticut Tigers, New York-Penn League (short-season) - 1 game 21-Aug
- 2016: Cincinnati Reds, Major League Baseball - 1 game 7-Aug
- 2019: Cincinnati Reds, Major League Baseball - 1 game 20-Sep
- 2021: Cincinnati Reds, Major League Baseball - 2 games 18-Sep 1-Oct
- 2022: Seattle Mariners, Major League Baseball - 2 games 26-Apr 28-Apr
- 2023: Seattle Mariners, Major League Baseball - 1 game 10-Sep
- Gabe Suarez (utility, b. 1984, Colorado)
- 2006: Tri-City Dust Devils, Northwest League (short-season) - 1 game 23-Aug
- 2007: Road Warriors, Atlantic League (independent) - 1 game 3-Jul
- 2007: Long Island Ducks, Atlantic League (independent) - 1 game 18-Sep
- 2008: Camden Riversharks, Atlantic League (independent) - 6 games 19-Jun 19-Jul 13-Sep g1 13-Sep g2 17-Sep 28-Sep
- 2010: Newark Bears, Atlantic League (independent) - 1 game 6-Aug
- 2015: Joplin Blasters, American Association (independent) - 1 game 31-Jul
- Iggy Suarez (infielder, b. 1981, New York)
- 2006: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 14-Apr
- 2007: Portland Sea Dogs, Eastern League (AA) - 1 game 6-Sep
- 2008: Portland Sea Dogs, Eastern League (AA) - 2 games 4-Aug 3-Sep
- 2010: Somerset Patriots, Atlantic League (independent) - 3 games 6-Aug 6-Sep 24-Sep
- 2011: Lancaster Barnstormers, Atlantic League (independent) - 1 game 26-Jul
- 2012: Sugar Land Skeeters, Atlantic League (independent) - 2 games 25-Jul 26-Jul
- 2013: Bridgeport Bluefish, Atlantic League (independent) - 1 game 7-Aug
- Jose Suarez (pitcher, b. 1998, Venezuela)
- 2018: Salt Lake Bees, Pacific Coast League (AAA) - 1 game 7-Aug
- 2021: Los Angeles Angels, Major League Baseball - 1 game 11-Jul
- Jose Suarez (outfielder, b. 2004, Dominican Republic)
- 2024: Palm Beach Cardinals, Florida State League (Low-A) - 2 games 28-Aug g2 15-Sep
- Kervin Suarez (utility, b. 1998, Venezuela)
- 2019: Greenville Drive, South Atlantic League (Low-A) - 1 game 30-Apr
- Luis Suarez (infielder, b. 1978, Florida)
- 1999: Winston-Salem Warthogs, Carolina League (High-A) - 1 game 8-Aug
- Michael Suarez (pitcher, b. 1995, Venezuela)
- 2017: Everett AquaSox, Northwest League (short-season) - 1 game 3-Aug
- Ranger Suarez (pitcher, b. 1995, Venezuela)
- 2019: Philadelphia Phillies, Major League Baseball - 1 game 27-Sep
- 2021: Philadelphia Phillies, Major League Baseball - 1 game 9-Sep
- 2022: Philadelphia Phillies, Major League Baseball - 1 game 16-Apr
- 2023: Philadelphia Phillies, Major League Baseball - 1 game 27-Sep
- Robert Suarez (pitcher, b. 1991, Venezuela)
- 2024: San Diego Padres, Major League Baseball - 1 game 1-Sep
- Damon Sublett (utility, b. 1985, Kansas)
- 2007: Staten Island Yankees, New York-Penn League (short-season) - 3 games 22-Jul 1-Aug 10-Sep
- 2010: Trenton Thunder, Eastern League (AA) - 3 games 5-Sep 9-Sep 18-Sep
- 2011: Trenton Thunder, Eastern League (AA) - 1 game 3-Aug
- Mark Suchowiecki (pitcher, b. 1983, New York)
- 2009: New Jersey Jackals, Can-Am League (independent) - 2 games 7-Aug 13-Aug
- Garrett Suchey (pitcher, b. 1994, Alabama)
- 2018: Lexington Legends, South Atlantic League (Low-A) - 1 game 13-Sep
- Michael Suchy (outfielder, b. 1993, Florida)
- 2016: Bradenton Marauders, Florida State League (High-A) - 1 game 30-Aug
- 2017: Altoona Curve, Eastern League (AA) - 1 game 13-Sep
- 2018: Trois-Rivieres Aigles, Can-Am League (independent) - 2 games 18-Jul day 8-Sep
- Jesus Sucre (catcher, b. 1988, Venezuela)
- 2017: Tampa Bay Rays, Major League Baseball - 1 game 24-Sep
- 2018: Tampa Bay Rays, Major League Baseball - 2 games 31-Mar 21-Sep
- Bill Sudakis (catcher/infielder, b. 1946, Illinois; d. 2021, California)
- 1974: New York Yankees, American League (MLB) - 1 game 25-Apr
- Tsutomu Sudoh (outfielder, b. 1973)
- 1997: Allentown Ambassadors, Northeast League (independent) - 1 game 8-Aug
- Nick Sued (catcher, b. 1972)
- 1991: Burlington Indians, Appalachian League (rookie) - 1 game 16-Aug
- Bruedlin Suero (pitcher, b. 1990, Dominican Republic)
- 2012: Princeton Rays, Appalachian League (rookie) - 1 game 17-Aug g1
- Estuar Suero (outfielder, b. 2005, Dominican Republic)
- 2024: FCL Pirates, Florida Complex League (rookie) - 1 game 4-May
- Ignacio Suero (catcher, b. 1973, Dominican Republic)
- 1999: Massachusetts Mad Dogs, Northeast League (independent) - 2 games 20-Jun 17-Jul
- Ovandy Suero (utility, b. 1982, Dominican Republic)
- 2008: Northwest Arkansas Naturals, Texas League (AA) - 1 game 11-Aug
- Wander Suero (pitcher, b. 1991, Dominican Republic)
- 2014: Potomac Nationals, Carolina League (High-A) - 1 game 24-May
- Jarret Sues (pitcher, b. 1981, New Jersey)
- 2005: North Shore Spirit, Can-Am League (independent) - 1 game 23-Jul
- Adrian Sugastey (catcher, b. 2002, Panama)
- 2022: Scottsdale Scorpions, Arizona Fall League - 1 game 12-Oct
- Jason Sugden (outfielder, b. 1981, Pennsylvania)
- Taylor Sugg (pitcher, b. 1997, North Carolina)
- 2022: Gateway Grizzlies, Frontier League (independent) - 1 game 13-Jul
- Andy Sugilio (outfielder, b. 1996, Dominican Republic)
- Colby Suggs (pitcher, b. 1991, Texas)
- 2015: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 15-Apr
- Kyle Suire (infielder, b. 1985, Louisiana)
- 2008: Brooklyn Cyclones, New York-Penn League (short-season) - 1 game 27-Aug
- Luis Suisbel (infielder, b. 2003, Venezuela)
- 2023: Modesto Nuts, California League (Low-A) - 1 game 10-Aug
- Jerrick Suiter (outfielder, b. 1993, Indiana)
- 2016: Bradenton Marauders, Florida State League (High-A) - 1 game 30-Aug
- 2017: Altoona Curve, Eastern League (AA) - 2 games 3-Sep 13-Sep
- Michael Suk (pitcher, b. 1990)
- 2015: Sussex County Miners, Can-Am League (independent) - 1 game 6-Aug
- 2016: Sussex County Miners, Can-Am League (independent) - 1 game 16-Aug g2
- Matt Sulentic (outfielder, b. 1987, New Jersey)
- 2006: Kane County Cougars, Midwest League (Low-A) - 1 game 7-Aug
- Anthony Sullivan (pitcher, b. 1984, New York)
- 2008: Worcester Tornadoes, Can-Am League (independent) - 1 game 18-Jul
- 2009: Worcester Tornadoes, Can-Am League (independent) - 2 games 1-Sep 3-Sep
- Brett Sullivan (catcher/outfielders, b. 1994, California)
- 2019: Montgomery Biscuits, Southern League (AA) - 2 games 29-May 27-Jul
- Carl Sullivan (outfielder, b. 1968, Texas)
- 1990: South Bend White Sox, Midwest League (Low-A) - 1 game 14-Aug
- Connor Sullivan (pitcher, b. 1992, New York)
- 2014: Taos Blizzard, Pecos League (independent) - 1 game 21-Jul
- Cory Sullivan (outfielder, b. 1979, Oklahoma)
- 2005: Colorado Rockies, Major League Baseball - 1 game 2-Oct
- 2009: New York Mets, Major League Baseball - 4 games 4-Sep 18-Sep 20-Sep 21-Sep
- Jason Sullivan (infielder, b. 1980)
- 2004: Sioux City Explorers, Northern League (independent) - 1 game 11-Jul
- Jerry Sullivan (pitcher, b. 1988, New Jersey)
- 2014: El Paso Chihuahuas, Pacific Coast League (AAA) - 1 game 25-Jul
- Josh Sullivan (pitcher, b. 1984, Arkansas)
- 2006: Tri-City Dust Devils, Northwest League (short-season) - 1 game 23-Aug
- 2011: Tulsa Drillers, Texas League (AA) - 1 game 2-Sep
- Kevin Sullivan (catcher/outfielder, b. 1977, Wisconsin)
- 2005: Lincoln Saltdogs, Northern League (independent) - 1 game 11-Aug
- Kevin Sullivan (catcher, b. 1979)
- 2008: Southern Maryland Blue Crabs, Atlantic League (independent) - 1 game 1-Sep
- Mike Sullivan (pitcher, b. 1968)
- 1994: New Britain Red Sox, Eastern League (AA) - 1 game 21-Aug g1
- Ryan Sullivan (infielder, b. 1981, Illinois)
- 2003: Gateway Grizzlies, Frontier League (independent) - 1 game 29-Jul
- 2004: Gateway Grizzlies, Frontier League (independent) - 1 game 25-Jul
- 2007: Gateway Grizzlies, Frontier League (independent) - 1 game 7-Aug
- Scott Sullivan (pitcher, b. 1971, Alabama)
- 1997: Cincinnati Reds, National League (MLB) - 1 game 25-Aug day
- 2000: Cincinnati Reds, Major League Baseball - 1 game 12-Aug
- 2003: Cincinnati Reds, Major League Baseball - 1 game 4-Jul
- Ted Sullivan (pitcher, b. 1977, District of Columbia)
- 1999: Mahoning Valley Scrappers, New York-Penn League (short-season) - 1 game 10-Sep
- Zach Sullivan (outfielder, b. 1995, New York)
- 2015: Greensboro Grasshoppers, South Atlantic League (Low-A) - 2 games 15-Apr 10-Aug
- 2016: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 22-Aug
- 2018: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 30-May
- Beau Sulser (pitcher, b. 1994, California)
- 2019: Peoria Javelinas, Arizona Fall League - 1 game 18-Oct
- Cole Sulser (pitcher, b. 1990, California)
- 2019: Tampa Bay Rays, Major League Baseball - 3 games 6-Sep 8-Sep 22-Sep
- 2021: Baltimore Orioles, Major League Baseball - 2 games 16-Aug 19-Aug
- 2022: Jacksonville Jumbo Shrimp, International League (AAA) - 1 game 22-Sep
- 2024: Tampa Bay Rays, Major League Baseball - 2 games 12-Aug 1-Sep
- Houston Summers (infielder, then pitcher, b. 1987, North Carolina)
- 2006: Yakima Bears, Northwest League (short-season) - 1 game 23-Aug
- 2010: Batavia Muckdogs, New York-Penn League (short-season) - 1 game 5-Aug
- Jake Summers (outfielder, b. 1987)
- 2014: Trinidad Triggers, Pecos League (independent) - 1 game 22-Jul
- Johnathan Summers (infielder, b. 1976, California)
- 2000: Shreveport Captains, Texas League (AA) - 1 game 20-Aug
- Andrew Summerville (pitcher, b. 1995, Washington)
- 2017: State College Spikes, New York-Penn League (short-season) - 1 game 4-Sep
- Kaazim Summerville (outfielder, b. 1978, New Jersey)
- 2001: Staten Island Yankees, New York-Penn League (short-season) - 1 game 6-Jul
- 2002: Greensboro Bats, South Atlantic League (Low-A) - 2 games 24-Jun 14-Jul
- Alex Sumner (infielder, b. 1986)
- 2011: New York Federals, Can-Am League (independent) - 2 games 22-Jun 23-Jun
- Kale Sumner (catcher/infielder, b. 1991, Hawaii)
- 2013: Staten Island Yankees, New York-Penn League (short-season) - 1 game 6-Aug
- 2014: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 23-Apr
- Christian Sumoza (pitcher, b. 2000, Venezuela)
- 2019: GCL Yankees West, Gulf Coast League (rookie) - 1 game 26-Aug g2
- Luis Sumoza (outfielder, b. 1988, Venezuela)
- 2008: Lowell Spinners, New York-Penn League (short-season) - 1 game 21-Aug
- Richard Sunagawa (infielder, b. 1999, Japan)
- 2022: Carolina Gigantes, Liga Clemente (winter) - 1 game 2-Dec
- Cody Sundbeck (pitcher, b. 1978, Texas)
- 2001: South Bend Silver Hawks, Midwest League (Low-A) - 1 game 30-Jul
- Jack Sundberg (outfielder, b. 1993, Connecticut)
- 2017: Potomac Nationals, Carolina League (High-A) - 1 game 3-Jul
- Jared Sundstrom (outfielder, b. 2001, California)
- 2024: Peoria Javelinas, Arizona Fall League - 2 games 10-Oct 12-Oct
- Wen-Hua Sung (pitcher, b. 1996, Taiwan)
- 2021: Fort Wayne TinCaps, High-A Central - 1 game 18-Sep
- Carlos Suniaga (pitcher, b. 1997, Venezuela)
- 2021: Fort Myers Mighty Mussels, Low-A Southeast - 1 game 20-Aug
- John Suomi (catcher, b. 1980, Ontario)
- 2004: Modesto A's, California League (High-A) - 3 games 11-Aug 19-Aug g1 19-Aug g2
- 2008: Reading Phillies, Eastern League (AA) - 1 game 4-Aug
- 2012: Lehigh Valley IronPigs, International League (AAA) - 1 game 22-Jul
- 2013: Lehigh Valley IronPigs, International League (AAA) - 1 game 2-Sep
- Jeff Suppan (pitcher, b. 1975, Oklahoma)
- 1995: Trenton Thunder, Eastern League (AA) - 1 game 3-Jul
- 1995: Pawtucket Red Sox, International League (AAA) - 1 game 2-Sep
- 2011: Omaha Storm Chasers, Pacific Coast League (AAA) - 1 game 1-Sep
- Rayne Supple (pitcher, b. 1997, Vermont)
- 2019: Boise Hawks, Northwest League (short-season) - 1 game 5-Jul
- B.J. Surhoff (catcher/outfielder, b. 1964, New York)
- 1992: Milwaukee Brewers, American League (MLB) - 1 game 14-Aug g1
- 1995: Milwaukee Brewers, American League (MLB) - 1 game 16-Aug
- 1996: Baltimore Orioles, American League (MLB) - 5 games 13-Jul g1 13-Jul g2 18-Sep 19-Sep g1 19-Sep g2
- 1997: Baltimore Orioles, American League (MLB) - 2 games 4-Jul g1 4-Jul g2
- 1998: Baltimore Orioles, American League (MLB) - 1 game 11-Jul
- 2000: Atlanta Braves, Major League Baseball - 1 game 26-Sep
- 2005: Baltimore Orioles, Major League Baseball - 1 game 21-Sep
- Miguel Suriel (utility, b. 1976, Dominican Republic)
- 1999: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 11-Aug
- Eric Surkamp (pitcher, b. 1987, Ohio)
- 2011: Richmond Flying Squirrels, Eastern League (AA) - 1 game 4-Aug
- 2014: Charlotte Knights, International League (AAA) - 1 game 25-May
- Andrew Susac (catcher, b. 1990, California)
- 2014: Fresno Grizzlies, Pacific Coast League (AAA) - 1 game 25-Jul
- Daniel Susac (catcher, b. 2001, California)
- 2023: Lansing Lugnuts, Midwest League (High-A) - 1 game 28-Jun
- 2024: Mesa Solar Sox, Arizona Fall League - 2 games 9-Oct 12-Oct
- Steve Susdorf (outfielder, b. 1986, California)
- 2012: Reading Phillies, Eastern League (AA) - 1 game 7-Apr
- 2012: Lehigh Valley IronPigs, International League (AAA) - 2 games 3-Jul 22-Jul
- 2013: Lehigh Valley IronPigs, International League (AAA) - 1 game 2-Sep
- Zac Susi (catcher, b. 1996, Connecticut)
- 2019: Greensboro Grasshoppers, South Atlantic League (Low-A) - 1 game 1-May
- Norberto Susini (catcher/infielder, b. 1989, New York)
- 2015: New Jersey Jackals, Can-Am League (independent) - 1 game 6-Aug
- Tim Susnara (catcher, b. 1996, California)
- 2017: Hillsboro Hops, Northwest League (short-season) - 1 game 4-Aug
- Rick Sutcliffe (pitcher, b. 1956, Missouri)
- 1984: Chicago Cubs, National League (MLB) - 1 game 8-Sep
- Brent Suter (pitcher, b. 1989, Illinois)
- 2023: Colorado Rockies, Major League Baseball - 2 games 22-Aug 23-Aug
- John Sutey (outfielder, b. 1972, Washington)
- 1991: Bristol Tigers, Appalachian League (rookie) - 1 game 16-Aug
- Alex Sutherland (catcher, b. 1971, Venezuela)
- 1997: Adirondack Lumberjacks, Northeast League (independent) - 1 game 3-Aug
- 1998: Adirondack Lumberjacks, Northeast League (independent) - 1 game 19-Jul
- Casey Sutherland (pitcher, b. 1996, Florida)
- 2019: GCL Red Sox, Gulf Coast League (rookie) - 1 game 21-Aug g2
- Wladimir Sutil (infielder, b. 1984, Venezuela)
- 2005: Tri-City ValleyCats, New York-Penn League (short-season) - 1 game 17-Jul
- Bruce Sutter (pitcher, b. 1953, Pennsylvania; d. 2022, Georgia)
- 1977: Chicago Cubs, National League (MLB) - 1 game 12-Jul
- Bradley Suttle (infielder, b. 1986, Texas)
- 2008: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 18-Aug
- Eric Suttle (outfielder, b. 1984, Georgia)
- 2007: Southern Illinois Miners, Frontier League (independent) - 1 game 7-Aug
- Drew Sutton (utility, b. 1983, Arkansas)
- 2006: Salem Avalanche, Carolina League (High-A) - 1 game 14-Apr
- 2007: Corpus Christi Hooks, Texas League (AA) - 1 game 8-Aug
- 2012: Pittsburgh Pirates, Major League Baseball - 1 game 29-Jul
- 2013: Pawtucket Red Sox, International League (AAA) - 1 game 2-Sep
- Joe Sutton (catcher, b. 1974, West Virginia)
- 1998: Hickory Crawdads, South Atlantic League (Low-A) - 1 game 29-Aug
- Larry Sutton (first baseman, b. 1970, California)
- 1994: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 4-Aug
- 2002: Sacramento RiverCats, Pacific Coast League (AAA) - 1 game 15-Aug
- Jack Suwinski (outfielder, b. 1998, Illinois)
- 2017: Fort Wayne TinCaps, Midwest League (Low-A) - 1 game 19-Aug
- 2023: Pittsburgh Pirates, Major League Baseball - 4 games 4-May 24-Sep 27-Sep 29-Sep
- Ichiro Suzuki (outfielder, b. 1973, Japan)
- 2001: Seattle Mariners, Major League Baseball - 1 game 2-Sep
- 2008: Seattle Mariners, Major League Baseball - 1 game 31-Aug
- 2012: New York Yankees, Major League Baseball - 3 games 31-Jul 22-Sep 1-Oct
- 2013: New York Yankees, Major League Baseball - 2 games 12-Aug 25-Sep
- 2014: New York Yankees, Major League Baseball - 4 games 5-Sep 10-Sep 19-Sep 22-Sep
- 2015: Miami Marlins, Major League Baseball - 2 games 14-Sep 16-Sep
- 2016: Miami Marlins, Major League Baseball - 2 games 4-Jul 28-Aug
- Kurt Suzuki (catcher, b. 1983, Hawaii)
- 2009: Oakland Athletics, Major League Baseball - 1 game 14-Aug
- 2011: Oakland Athletics, Major League Baseball - 1 game 23-Aug
- 2012: Washington Nationals, Major League Baseball - 2 games 19-Aug 11-Sep
- 2016: Minnesota Twins, Major League Baseball - 1 game 18-Sep
- 2017: Atlanta Braves, Major League Baseball - 2 games 25-Sep g2 27-Sep
- 2018: Atlanta Braves, Major League Baseball - 2 games 25-May 28-Aug
- 2019: Washington Nationals, Major League Baseball - 1 game 26-Sep
- 2021: Los Angeles Angels, Major League Baseball - 3 games 10-Apr 27-Jun 11-Jul
- 2022: Los Angeles Angels, Major League Baseball - 2 games 22-Aug 25-Aug
- Seiya Suzuki (outfielder, b. 1994, Japan)
- 2022: Chicago Cubs, Major League Baseball - 1 game 30-Sep
- 2024: Chicago Cubs, Major League Baseball - 2 games 23-Sep 28-Sep
- Matt Svanson (pitcher, b. 1999, Illinois)
- 2021: Dunedin Blue Jays, Low-A Southeast - 2 games 13-Aug 18-Aug
- 2022: Dunedin Blue Jays, Florida State League (Low-A) - 1 game 31-May
- 2024: Glendale Desert Dogs, Arizona Fall League - 1 game 10-Oct
- Dale Sveum (infielder, b. 1963, California)
- 1992: Chicago White Sox, American League (MLB) - 1 game 15-Aug
- 1997: Pittsburgh Pirates, National League (MLB) - 2 games 13-Aug 24-Sep
- Rusty Swackhamer (outfielder, b. 1978, Ohio)
- 2001: Chillicothe Paints, Frontier League (independent) - 1 game 18-Aug
- Wes Swackhamer (outfielder, b. 1983, California)
- Derek Swafford (infielder, b. 1975, California)
- Jordan Swagerty (pitcher, b. 1989, Texas)
- 2011: Springfield Cardinals, Texas League (AA) - 1 game 2-Sep
- Travis Swaggerty (outfielder, b. 1997, Louisiana)
- Dan Swain (outfielder, b. 1994, Illinois)
- 2017: Hillsboro Hops, Northwest League (short-season) - 1 game 29-Jul
- Matthew Swain (pitcher, b. 1997, Georgia)
- 2022: Fort Myers Mighty Mussels, Florida State League (Low-A) - 3 games 8-Apr 20-May g2 22-May
- 2023: Cedar Rapids Kernels, Midwest League (High-A) - 1 game 25-Jun g2
- Shannon Swaino (catcher/first base, b. 1974)
- 1996: Vermont Expos, New York-Penn League (short-season) - 1 game 7-Jul
- Craig Swan (pitcher, b. 1950, California)
- 1984: New York Mets, National League (MLB) - 1 game 17-Apr
- Eriq Swan (outfielder, b. 2001, Georgia)
- 2024: Glendale Desert Dogs, Arizona Fall League - 1 game 10-Oct
- Pedro Swann (outfielder, b. 1970, Delaware)
- 1997: Greenville Braves, Southern League (AA) - 1 game 11-Aug
- 2002: Syracuse SkyChiefs, International League (AAA) - 1 game 1-Sep
- 2003: Ottawa Lynx, International League (AAA) - 1 game 17-Aug
- Will Swanner (catcher/first base, b. 1991, California)
- 2015: New Britain Rock Cats, Eastern League (AA) - 1 game 16-Aug
- Cole Swanson (pitcher, b. 1992, California)
- 2013: Orem Owlz, Pioneer League (rookie) - 1 game 19-Aug
- Dansby Swanson (infielder, b. 1994, Georgia)
- Erik Swanson (pitcher, b. 1993, North Dakota)
- 2019: Seattle Mariners, Major League Baseball - 1 game 19-Aug
- 2021: Seattle Mariners, Major League Baseball - 2 games 11-Jul 4-Aug
- 2022: Seattle Mariners, Major League Baseball - 1 game 26-Apr
- Matt Swanson (pitcher, b. 1982, California)
- 2007: Lynchburg Hillcats, Carolina League (High-A) - 1 game 25-Aug
- Nic Swanson (pitcher, b. 1999, Oklahoma)
- 2024: Surprise Saguaros, Arizona Fall League - 1 game 12-Oct
- David Swartzbaugh (pitcher, b. 1968, Ohio)
- 1996: Iowa Cubs, American Association (AAA) - 1 game 12-Aug
- 1998: Iowa Cubs, Pacific Coast League (AAA) - 1 game 17-Aug
- Anthony Swarzak (pitcher, b. 1985, Florida)
- 2016: New York Yankees, Major League Baseball - 2 games 4-Aug 13-Aug
- 2018: New York Mets, Major League Baseball - 1 game 15-Jul
- 2019: Atlanta Braves, Major League Baseball - 2 games 13-Aug 29-Sep
- Chris Swauger (first base/outfield, b. 1986, Florida)
- 2011: Springfield Cardinals, Texas League (AA) - 1 game 2-Sep
- Kyle Sweat (pitcher, b. 1985)
- 2009: Midwest Sliders of Ypsilanti, Frontier League (independent) - 1 game 25-Jul
- Brian Sweeney (pitcher, b. 1974, New York)
- 2004: Portland Beavers, Pacific Coast League (AAA) - 1 game 20-Aug
- Darnell Sweeney (utility, b. 1991, Florida)
- 2015: Philadelphia Phillies, Major League Baseball - 1 game 30-Sep
- 2016: Lehigh Valley IronPigs, International League (AAA) - 2 games 4-May 30-May
- 2017: Louisville Bats, International League (AAA) - 1 game 20-Aug
- Jake Sweeney (pitcher, b. 2000, Indiana)
- 2019: GCL Pirates, Gulf Coast League (rookie) - 1 game 24-Aug g1
- 2022: Bradenton Marauders, Florida State League (Low-A) - 3 games 27-Apr 9-Jun 6-Sep
- James Sweeney (catcher, b. 1983, Texas)
- 2002: Tri-City Dust Devils, Northwest League (short-season) - 1 game 13-Aug
- Kane Sweeney (first baseman, b. 1992, Illinois)
- 2016: Staten Island Yankees, New York-Penn League (short-season) - 1 game 8-Aug
- 2016: Charleston RiverDogs, South Atlantic League (Low-A) - 1 game 3-Sep
- Mark Sweeney (pitcher, b. 1968)
- 1991: Watertown Indians, New York-Penn League (short-season) - 1 game 11-Aug 3-Sep
- Mark Sweeney (first base/outfield, b. 1969, Massachusetts)
- 1994: Vancouver Canadians, Pacific Coast League (AAA) - 3 games 9-Sep 10-Sep 11-Sep
- 1997: San Diego Padres, National League (MLB) - 2 games 22-Aug
- 2000: Milwaukee Brewers, Major League Baseball - 1 game 13-Sep
- 2008: Los Angeles Dodgers, Major League Baseball - 1 game 27-Jul
- Matt Sweeney (pitcher, b. 1983, New Jersey)
- 2006: Reading Phillies, Eastern League (AA) - 1 game 14-Apr
- Matt Sweeney (infielder, b. 1988, Maryland)
- 2009: Rancho Cucamonga Quakes, California League (High-A) - 1 game 26-Aug
- 2009: Charlotte Stone Crabs, Florida State League (High-A) - 1 game 5-Sep
- Mike Sweeney (catcher/first base, b. 1973, California)
- 1995: Wilmington Blue Rocks, Carolina League (High-A) - 1 game 31-Aug
- 2000: Kansas City Royals, Major League Baseball - 1 game 22-Jul day
- 2002: Kansas City Royals, Major League Baseball - 1 game 21-Jun
- 2005: Kansas City Royals, Major League Baseball - 1 game 7-Aug
- Ryan Sweeney (outfielder, b. 1985, Iowa)
- 2009: Oakland Athletics, Major League Baseball - 1 game 14-Aug
- 2011: Oakland Athletics, Major League Baseball - 1 game 23-Aug
- 2014: Chicago Cubs, Major League Baseball - 1 game 20-Jul
- Tim Sweeney (infielder, b. 1980, New Jersey)
- 2008: Newark Bears, Atlantic League (independent) - 2 games 19-Jun 19-Jul
- Trey Sweeney (infielder, b. 2000, Kentucky)
- Andrew Sweet (utility, b. 1983)
- 2008: River City Rascals, Frontier League (independent) - 1 game 16-Aug
- Devin Sweet (pitcher, b. 1996, North Carolina)
- 2021: Peoria Javelinas, Arizona Fall League - 2 games 16-Oct 20-Oct
- Jon Sweet (catcher, b. 1971, Indiana)
- 1997: Carolina Mudcats, Southern League (AA) - 1 game 13-Aug
- 1999: Altoona Curve, Eastern League (AA) - 1 game 1-Aug
- Leland Swenson (infielder, b. 1977, Minnesota)
- 2003: St. Paul Saints, Northern League (independent) - 1 game 27-Jul
- Mike Swenson (pitcher, b. 1972, New York)
- 1995: New Jersey Cardinals, New York-Penn League (short-season) - 1 game 25-Jun
- Chris Swiatkiewicz (pitcher, b. 1976, Minnesota)
- 2005: Sioux City Explorers, Northern League (independent) - 1 game 8-Aug
- Blake Swihart (catcher, b. 1992, Texas)
- 2015: Boston Red Sox, Major League Baseball - 1 game 28-Sep
- 2016: Pawtucket Red Sox, International League (AAA) - 1 game 4-May
- 2018: Boston Red Sox, Major League Baseball - 1 game 4-Jul
- Matt Swilley (pitcher, b. 1990, California)
- 2015: Joplin Blasters, American Association (independent) - 1 game 31-Jul
- Tyler Swinburnson (pitcher, b. 1975, California)
- 1997: Watertown Indians, New York-Penn League (short-season) - 1 game 25-Jul
- R.J. Swindle (pitcher, b. 1983, British Columbia)
- 2010: Durham Bulls, International League (AAA) - 1 game 29-Jul
- Jermaine Swinton (first base/outfield, b. 1972, New York)
- 1993: Asheville Tourists, South Atlantic League (Low-A) - 1 game 19-Aug
- Josh Swirchak (infielder, b. 1993, Virginia)
- 2015: State College Spikes, New York-Penn League (short-season) - 1 game 8-Aug
- 2015: Peoria Chiefs, Midwest League (Low-A) - 1 game 4-Sep
- Nick Swisher (first base/outfield, b. 1980, Ohio)
- 2004: Sacramento RiverCats, Pacific Coast League (AAA) - 2 games 20-Aug 21-Aug
- 2005: Oakland Athletics, Major League Baseball - 1 game 7-Aug
- 2009: New York Yankees, Major League Baseball - 1 game 16-Apr
- 2010: New York Yankees, Major League Baseball - 2 games 17-Aug 21-Sep
- 2011: New York Yankees, Major League Baseball - 4 games 23-Aug 28-Aug day 19-Sep 30-Sep
- 2012: New York Yankees, Major League Baseball - 3 games 31-Jul 22-Sep 1-Oct
- 2015: Atlanta Braves, Major League Baseball - 1 game 23-Sep
- Jon Switzer (pitcher, b. 1979, Kentucky)
- 2001: Hudson Valley Renegades, New York-Penn League (short-season) - 1 game 26-Aug
- Ron Swoboda (outfielder, b. 1944, Maryland)
- 1967: New York Mets, National League (MLB) - 1 game 9-Jul
- 1970: New York Mets, National League (MLB) - 1 game 13-Sep
- Matt Swynenberg (pitcher, b. 1989, Iowa)
- 2014: Auburn Doubledays, New York-Penn League (short-season) - 1 game 30-Jul
- Chad Sykes (pitcher, b. 1996, North Carolina)
- 2021: Tri-City Dust Devils, High-A West - 1 game 10-Jul
- Derrick Sylve (pitcher, b. 1992, New Hampshire)
- 2019: Roswell Invaders, Pecos League (independent) - 1 game 9-Jul
- 2020: Indy Windstorm, Liberation League (independent) - 1 game 22-Sep
- Jeremy Synan (outfielder, b. 1986, North Carolina)
- 2011: Jacksonville Suns, Southern League (AA) - 1 game 7-Aug
- Noah Syndergaard (pitcher, b. 1992, Texas)
- 2017: New York Mets, Major League Baseball - 1 game 1-Oct
- 2018: New York Mets, Major League Baseball - 2 games 6-May 30-Sep
- 2019: New York Mets, Major League Baseball - 1 game 29-Sep
- Marshall Szabo (infielder, b. 1983, Georgia)
- 2005: Lake County Captains, South Atlantic League (Low-A) - 1 game 7-Apr
- 2006: Lake County Captains, South Atlantic League (Low-A) - 1 game 26-Jun
- Thomas Szapucki (pitcher, b. 1996, New Jersey)
- 2021: New York Mets, Major League Baseball - 1 game 30-Jun
- Joe Szekely (catcher, b. 1961, Texas)
- 1990: Syracuse Chiefs, International League (AAA) - 1 game 18-Aug
- 1991: Richmond Braves, International League (AAA) - 1 game 17-Aug
- Trent Szkutnik (pitcher, b. 1993, Michigan)
- 2017: West Michigan Whitecaps, Midwest League (Low-A) - 1 game 21-Aug
- Charlie Szykowny (infielder, b. 2000, Illinois)
- 2024: Scottsdale Scorpions, Arizona Fall League - 2 games 9-Oct 12-Oct
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