The road begins at the Newark-Pompton Turnpike in Pequannock as Jackson Avenue, crosses NJ 23, and then crosses the Pequannock River into Wayne, ending at Black Oak Ridge Road. It runs almost due east and west.
| Mile | Street Name | Feature (West to East) |
| 0.00 | CR 680 BEGINS, Wayne Twp | |
| 0.00 | Pompton Plains Cross Rd | Pequannock River {bridge} |
| 0.13 | Pompton Plains Cross Rd | Unnamed stream {bridge} |
| 0.55 | Pompton Plains Cross Rd | Black Oak Ridge Rd, US 202 {signal} |
| 0.55 | CR 680 ENDS, Wayne Twp | |