This vital artery in the southern half of the county is eventually joined by, and becomes, CR 509 as it gets closer to the heart of Paterson.
| Mile | Street Name | Feature (South to North) |
| 0.00 | CR 601 BEGINS, Clifton City | |
| 0.00 | Entering Clifton City | |
| 0.07 | Main Ave | [Shopping center entrance {signal}] |
| 0.24 | Main Ave | [NJ 3 East on/off ramp {signal}] |
| 0.28 | Main Ave | NJ 3 {underpass} |
| 0.33 | Main Ave | [NJ 3 West on/off ramp {signal}] |
| 0.36 | Main Ave | (Allwood Rd, CR 602 {signal}) |
| 0.41 | Main Ave | [Bridewell Pl {signal}] |
| 0.62 | Main Ave | [Delawanna Ave, CR 610 {signal}] |
| 1.04 | Entering Passaic City | |
| 1.12 | Main Ave | Lackawanna Railroad {underpass} |
| 1.19 | Main Ave | Brook Ave, CR 608 {signal} |
| 1.59 | Main Ave | Van Houten Ave, CR 614 {signal} |
| 1.86 | Main Ave | Aycrigg Ave {signal} |
| 2.03 | Main Ave | (Lafayette Ave) [NJ 21 on-ramp] {signal} |
| 2.13 | Main Ave | Paulison Ave, CR 618 {signal} |
| 2.29 | Main Ave | Gregory Ave {signal} |
| 2.41 | Main Ave | Prospect St {signal} |
| 2.49 | Main Ave | (Pennington Ave, CR 607) [NJ 21 on-ramp] {signal} |
| 2.64 | Main Ave | (Passaic Ave) [Passaic St] {signal} |
| 2.73 | Main Ave | (Broadway, CR 622) [Washington Pl] {signal} |
| 2.79 | Main Ave | [Jefferson St] {signal} |
| 2.83 | Main Ave | Lexington Ave, CR 625 |
| 3.00 | Main Ave | Monroe St {signal} |
| 3.31 | Main Ave | Harrison St {signal} |
| 3.42 | Main Ave | Summer St {signal} |
| 3.55 | Main Ave | Highland Ave, (CR 613) {signal} |
| 3.61 | Entering Clifton City | |
| 3.65 | Main Ave | Weasel Brook {bridge} |
| 3.84 | Main Ave | (DeMott Ave, CR 615) |
| 3.89 | Main Ave | Madison Ave {signal} |
| 3.96 | Main Ave | Clifton Ave, CR 611 {signal} |
| 4.02 | Main Ave | Harding Ave {signal} |
| 4.09 | Main Ave | Union Ave {signal} |
| 4.20 | Main Ave | Washington Ave {signal} |
| 4.42 | Main Ave | Piaget Ave, CR 628 {signal} |
| 4.52 | Main Ave | US 46 {overpass} |
| 4.97 | Main Ave | Garden State Pkwy, NJ 444 {underpass} |
| 5.22 | Main Ave | Crooks Ave, CR 630 {signal} |
| 5.22 | Entering Paterson City | |
| 5.64 | Main St | Gould Ave {signal} |
| 5.77 | Main St | (Montclair Ave) {signal} |
| 5.99 | Main St | [Madison Ave, CR 649] {signal} |
| 6.12 | Main St | Erie-Lackawanna Railroad connector {underpass} |
| 6.35 | Main St | (Barclay St, CR 621) [hospital entrance] {signal} |
| 6.64 | Main St | (Lackawanna Plaza, CR 509) |
| 6.64 | CR 601 ENDS, Paterson City | |